Kodi Ketamine Angathandize Kuthetsa Matenda?

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Matenda okhumudwa ndiofala kuposa momwe mungaganizire. Zimakhudza anthu aku America opitilira 15 miliyoni, ndipo World Health Organisation imaganiza kuti chiwerengerochi chikukula kufika 300 miliyoni mukakulitsa padziko lonse lapansi. Pali njira zingapo zochizira zomwe zilipo kuti zithandizire kuchepetsa zizindikiro zake - lingalirani nkhawa, kusowa tulo, kutopa, komanso kusowa kwa njala pakati pa ena-ndi chithandizo chodziwika bwino chokhala serotonin reuptake inhibitors (kapena SSRIs). Koma kuyambira 2000, madokotala ndi ofufuza akhala akuyesera ketamine-poyambirira mankhwala othandizira kupweteka, omwe tsopano akugwiritsidwa ntchito ngati mankhwala am'misewu chifukwa cha zotsatira zake za hallucinogenic-monga njira ina yothanirana ndi vutoli, malinga ndi Ruben Abagyan, Ph.D. , pulofesa wa zamankhwala ku University of California San Diego (UCSD).

Mwina mukuganiza, "Dikirani! Chiyani?" Ngati munamvapo za ketamine, yomwe imadziwikanso kuti Special K, mukudziwa kuti si nthabwala kapena mankhwala amtundu wa OTC. M'malo mwake, amadziwika kuti ndi dissociative anesthetic (kutanthauza mankhwala osokoneza bongo omwe amapotoza kuzindikira kwa kuwona ndi kumveka, kwinaku akupanga kumverera kwenikweni kwa kudzitchinjiriza kwawekha komanso chilengedwe). Amagwiritsidwa ntchito makamaka ndi veterinarians pochiza kupweteka kwa nyama, koma amathanso kuperekedwa kwa anthu kuti athetse ululu woopsa, makamaka omwe ali ndi vuto la neuropathic, mtundu wa ululu wosaneneka wa mitsempha, malinga ndi kafukufuku wa 2014 wofalitsidwa mu British Journal of Pharmacology.

"Zimadziwika kuti ululu ndi kupsinjika maganizo zimagwirizana," akutero Isaac Cohen, wophunzira wazachipatala yemwe adagwira ntchito pa kafukufukuyu. "Anthu opsinjika maganizo amakhala ndi nkhawa ndipo anthu omwe akumva kupweteka kosatha amatha kukhala opsinjika chifukwa chakuchepa kwa kuyenda, kuchepa kochita masewera olimbitsa thupi, ndi zinthu zina, akuti." Ketamine ndiyapadera chifukwa imatha kuthana ndi zowawa zonse komanso kukhumudwa nthawi imodzi, kumabweretsa zotsatira zabwino pazinthu zonse ziwiri. "Ndipo tsopano asayansi akutsutsa kuti palibe umboni wamba, komanso chidziwitso chazambiri chomwe chikuwonetsa kuti ketamine chitha kuthandiza kuchepetsa zizindikilo za kukhumudwa.

Pakuwunika koyamba konse kwamtundu wake, kofalitsidwa mu Chilengedwe, ofufuza adapeza kuti odwala omwe adalandira ketamine adanenanso zakuchepa. Kafukufukuyu, wochitidwa ndi School of Pharmacy and Pharmaceutical Sciences ku UCSD, amalimbitsa chidziwitso chambiri komanso maphunziro ang'onoang'ono a anthu omwe awonetsanso zotsatira za ketamine.

Chomwe chimasiyanitsa ketamine ndi mankhwala ena, makamaka, ndi momwe zimakhalira mofulumira. "Machiritso apano a FDA ovomerezeka a kuvutika maganizo amalephera kwa mamiliyoni ambiri chifukwa sagwira ntchito mwachangu," akutero Abaygan. Ketamine imagwira ntchito maola angapo. Izi ndizochepa kwambiri kuposa ma SSRIs, mwachitsanzo, omwe angatenge masabata asanu ndi limodzi kapena khumi kuti akwaniritse zonse. Ndipo kusiyana kwa nthawi kumeneko kungakhale nkhani ya moyo kapena imfa, makamaka kwa iwo amene ali ndi malingaliro ofuna kudzipha.

Pakafukufuku wawo, Abaygan ndi gulu lake adawunikiranso zambiri kuchokera ku FDA's Adverse Event Report System, bungwe lomwe limasonkhanitsa zidziwitso za zoyipa (kapena zosakonzekera zamtundu uliwonse) za mankhwala aliwonse ovomerezeka omwe adanenedwa ndi azachipatala ndi madotolo. Makamaka, adapeza odwala 40,000 omwe adapatsidwa mankhwala azowawa ndikuwapatula m'magulu awiri-omwe adatenga ketamine ndi omwe amalandira mankhwala amtundu wina (kupatula ma NSAID).

Zotsatirazo zikuwonetsa "bonasi" yofunika kwambiri, ngakhale itakhala yosakonzekera. Theka la anthu omwe adachiritsa ululu wawo ndi ketamine adanenanso kuti anali okhumudwa kwambiri kuposa omwe adamwa mitundu ina yamankhwala ochepetsa ululu. Ngakhale sitikudziwa ngati ena mwa odwalawa, makamaka omwe ali pa ketamine, anali ndi zizindikiro zowawa asanatenge mankhwala aliwonse, zotsatira zabwino pamaganizo, kuphatikizapo kugwirizana pakati pa ululu ndi kuvutika maganizo, zikhoza kuchititsa kukambirana kwina pakugwiritsa ntchito ketamine. samalani ndi kukhumudwa.

Malinga ndi ofufuzawo, ketamine ndi yotsika mtengo ndipo ngati mudayesapo mankhwala ena atatu olepheretsa kupanikizika osapambana, nthawi zambiri amapangidwa ndi mapulani ambiri a inshuwaransi yazaumoyo. Point kukhala? Osafulumira kulemba ketamine monga hallucinogen. Itha kukhala yapadera kwenikweni. (Ndipo ngati palibe china, anyamata, onani njira izi kuti muchepetse kupsinjika kapena kukhumudwa nthawi iliyonse.)

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