Angapo endocrine neoplasia (MEN) I

Matenda angapo a endocrine neoplasia (MEN) mtundu wa I ndi matenda omwe gland imodzi kapena zingapo zimagwira ntchito mopitilira muyeso kapena zimapanga chotupa. Imaperekedwa kudzera m'mabanja.

Matenda a Endocrine omwe amakhudzidwa kwambiri ndi awa:

• Miphalaphala
• Parathyroid
• Chiberekero

AMUNA Ndimayambitsidwa ndi chilema mu jini chomwe chimanyamula nambala ya protein yotchedwa menin. Vutoli limayambitsa zotupa zamatenda osiyanasiyana kuti ziwonekere mwa munthu yemweyo, koma osati nthawi yomweyo.

Vutoli limatha kuchitika msinkhu uliwonse, ndipo limakhudza amuna ndi akazi mofananamo. Mbiri ya banja yamatendawa imabweretsa chiopsezo.

Zizindikiro zimasiyanasiyana malinga ndi munthu, ndipo zimadalira kuti ndimatenda ati omwe akukhudzidwa. Zitha kuphatikiza:

• Kupweteka m'mimba
• Nkhawa
• Mdima wakuda, wodikira
• Kumva kutupa mukatha kudya
• Kutentha, kupweteka, kapena njala m'mimba mwa m'mimba kapena m'munsi pachifuwa yomwe imatsitsidwa ndi ma antacids, mkaka, kapena chakudya
• Kuchepetsa chidwi chogonana
• Kutopa
• Mutu
• Kusowa kwa msambo (mwa akazi)
• Kutaya njala
• Kutaya thupi kapena tsitsi (mwa amuna)
• Kusintha kwamaganizidwe kapena kusokonezeka
• Kupweteka kwa minofu
• Nseru ndi kusanza
• Kuzindikira kuzizira
• Kuchepetsa mwangozi
• Mavuto masomphenya
• Kufooka

Wothandizira zaumoyo adzayesa thupi ndikufunsa mafunso okhudza mbiri yanu yazachipatala. Mayesero otsatirawa akhoza kuchitika:

• Mulingo wama cortisol wamagazi
• CT scan pamimba
• Kujambula kwa CT pamutu
• Kusala shuga wamagazi
• Kuyesedwa kwachibadwa
• Kuyesa kwa insulini
• MRI ya pamimba
• MRI ya mutu
• Seramu adrenocorticotropic hormone
• Seramu calcium
• Seramu follicle yolimbikitsa mahomoni
• Seramu gastrin
• Seramu glucagon
• Seramu luteinizing mahomoni
• Seramu ya parathyroid hormone
• Seramu prolactin
• Seramu chithokomiro cholimbikitsa mahomoni
• Ultrasound ya m'khosi

Opaleshoni yochotsa matendawa nthawi zambiri amachiza. Mankhwala otchedwa bromocriptine atha kugwiritsidwa ntchito m'malo mochita opareshoni ya zotupa za pituitary zomwe zimatulutsa hormone ya prolactin.

Matenda a parathyroid, omwe amayang'anira kupanga calcium, amatha kuchotsedwa. Komabe, ndizovuta kuti thupi lizitha kuyendetsa kashiamu popanda tiziwalo timene timatulutsa, kotero kuchotsedwa kwathunthu kwa parathyroid sikuchitika koyamba.

Mankhwala amapezeka kuti achepetse kuchuluka kwa asidi m'mimba omwe amayamba chifukwa cha zotupa (gastrinomas), ndikuchepetsa ziwopsezo.

Mankhwala amtundu wa Hormone amaperekedwa ngati matenda onse atachotsedwa kapena osatulutsa mahomoni okwanira.

Zotupa za pituitary ndi parathyroid nthawi zambiri zimakhala zopanda khansa (zabwino), koma zotupa zina zimatha kukhala khansa (zoyipa) ndikufalikira ku chiwindi. Izi zitha kuchepetsa chiyembekezo cha moyo.

Zizindikiro za matenda a zilonda zam'mimba, shuga wambiri m'magazi, calcium yochulukirapo m'magazi, komanso kuwonongeka kwa pituitary nthawi zambiri zimayankha kuchipatala.

Zotupazo zimatha kubwereranso. Zizindikiro ndi zovuta zimadalira ma gland omwe akukhudzidwa. Kufufuza pafupipafupi ndi omwe amakupatsani ndikofunikira.

Itanani omwe akukuthandizani mukawona zisonyezo za MEN I kapena muli ndi mbiri yabanja ya vutoli.

Kuwunika abale apamtima a anthu omwe akhudzidwa ndi vutoli ndikofunikira.

Matenda a Wermer; AMUNA I

• Matenda a Endocrine

Tsamba la National Comprehensive Cancer Network. Malangizo azachipatala mu oncology (NCCN guideines): zotupa za neuroendocrine. Mtundu 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Idasinthidwa pa Marichi 5, 2019. Idapezeka pa Marichi 8, 2020.

Newey PJ, Thakker RV. Angapo endocrine neoplasia. Mu: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, olemba. Buku la Williams la Endocrinology. Wolemba 14th. Philadelphia, PA: Elsevier; 2020: chap 42.

Nieman LK, Spiegel AM. Matenda a Polyglandular. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 218.

Thakker RV. Mitundu yambiri ya endocrine neoplasia mtundu 1. Mu: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Akuluakulu ndi Ana. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2016: chap 148.