Kuchepetsa

Virilization ndimikhalidwe yomwe mzimayi amakhala ndimikhalidwe yokhudzana ndi mahomoni amphongo (androgens), kapena mwana akangobadwa kumene amakhala ndi mawonekedwe a mahomoni achimuna pakubadwa.

Virilization itha kuyambitsidwa ndi:

• Kuchulukitsa kwa testosterone
• Kugwiritsa ntchito anabolic steroids (kupititsa patsogolo ntchito kapena kukhudzana ndi kutumizidwanso kwa amuna ndi akazi)

Kwa anyamata kapena atsikana obadwa kumene, vutoli limatha kuyambitsidwa ndi:

• Mankhwala ena omwe mayi amatenga panthawi yapakati
• Kobadwa nako adrenal hyperplasia mu khanda kapena mayi
• Matenda ena mwa mayi (monga zotupa m'mimba mwake kapena ma adrenal gland omwe amatulutsa mahomoni amphongo)

Atsikana omwe akutha msinkhu, vutoli limatha kuyambitsidwa ndi:

• Matenda a Polycystic ovary
• Mankhwala ena, kapena anabolic steroids
• Kobadwa nako adrenal hyperplasia
• Zotupa za thumba losunga mazira, kapena adrenal glands omwe amatulutsa mahomoni amphongo (androgens)

Kwa amayi achikulire, vutoli limatha kuyambitsidwa ndi:

• Mankhwala ena, kapena anabolic steroids
• Zotupa za thumba losunga mazira kapena adrenal glands omwe amatulutsa mahomoni amphongo

Zizindikiro za virilization mwa mkazi nthawi zambiri zimadalira mulingo wa testosterone mthupi.

Mulingo wotsika (wamba):

• Tsitsi lakuthwa, lakuda mdima kapena malo amadevu
• Wonjezerani tsitsi la thupi
• Khungu lamafuta kapena ziphuphu
• Msambo wosasamba

Mulingo wofikira (zachilendo):

• Dazi la amuna
• Kutayika kogawa mafuta achikazi
• Kuchepetsa kukula kwa mawere

Mlingo wapamwamba (wosowa):

• Kukulitsa kwa clitoris
• Kuzama kwa mawu
• Mchitidwe wamphongo wamwamuna

Mayeso atha kuphatikiza:

• Kuyesa magazi kuti mupeze testosterone yochuluka mwa akazi
• CT scan, MRI, kapena ultrasound kuti athetse zotupa m'mimba mwake ndi adrenal gland

Ngati virilization imayamba chifukwa chokhala ndi ma androgens (mahomoni achimuna) mwa achikulire achikulire, zizindikilo zambiri zimatha mahomoni atayimitsidwa. Komabe, kukulitsa mawu ndikumatha kuwonetsedwa ndi ma androgens.

• Kupanga kwa mahomoni a Hypothalamus

Gooren LJ. Endocrinology yokhudza kugonana komanso kudziwika kuti ndi amuna kapena akazi. Mu: Jameson JL, De Groot LJ, de Kretser DM, et al, olemba. Endocrinology: Akuluakulu ndi Ana. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2016: chap 124.

Styne DM, Grumbach MM. Physiology ndi zovuta zakutha msinkhu. Mu: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, olemba. Buku la Williams la Endocrinology. Wolemba 13. Philadelphia, PA: Elsevier; 2016: chap 25.