Mlembi: Virginia Floyd
Tsiku La Chilengedwe: 13 Ogasiti 2021
Sinthani Tsiku: 1 Epulo 2025
Anonim
NIACINAMIDE - IS IT WORTH THE HYPE? DERMATOLOGISTS WEIGH IN
Kanema: NIACINAMIDE - IS IT WORTH THE HYPE? DERMATOLOGISTS WEIGH IN

Zamkati

Pali mitundu iwiri ya vitamini B3. Mtundu umodzi ndi niacin, winayo ndi niacinamide. Niacinamide imapezeka muzakudya zambiri kuphatikiza yisiti, nyama, nsomba, mkaka, mazira, masamba obiriwira, nyemba, ndi chimanga. Niacinamide imapezekanso m'mavitamini B ambiri othandizira mavitamini ena a B. Niacinamide amathanso kupangidwa mthupi kuchokera kuma niacin azakudya.

Osasokoneza niacinamide ndi niacin, NADH, nicotinamide riboside, inositol nicotinate, kapena tryptophan. Onani mindandanda yapaderadera pamitu iyi.

Niacinamide amatengedwa pakamwa popewa kuchepa kwa vitamini B3 ndi zinthu zina monga pellagra. Amathenso kumwa pakamwa pa ziphuphu, matenda ashuga, khansa yapakamwa, nyamakazi, ndi zina zambiri. Komabe, palibe umboni wabwino wasayansi wotsimikizira izi.

Niacinamide imagwiritsidwanso ntchito pakhungu paziphuphu, chikanga, ndi khungu lina. Palibenso umboni wabwino wotsimikizira izi.

Mankhwala Achilengedwe Pazonse mitengo yogwira ntchito potengera umboni wasayansi molingana ndi muyeso wotsatirawu: Wogwira Mtima, Wogwira Mtima, Mwinanso Wogwira Ntchito, Mwinanso Wosagwira Ntchito, Mwinanso Wosagwira Ntchito, Wosagwira Ntchito, Ndi Umboni Wosakwanira Wowerengera.

Kuchita bwino kwa NIACINAMIDE ndi awa:


Zothandiza ...

  • Matenda omwe amayamba chifukwa cha kuchepa kwa niacin (pellagra). Niacinamide imavomerezedwa ndi US Food and Drug Administration (FDA) kuti agwiritse ntchito izi. Niacinamide nthawi zina imakondedwa kuposa niacin chifukwa siyimayambitsa "kuthamanga," (kufiira, kuyabwa ndi kumva kulasalasa), zotsatira zoyipa za mankhwala a niacin.

Mwina zothandiza ...

  • Ziphuphu. Kafukufuku woyambirira akuwonetsa kuti kumwa mapiritsi okhala ndi niacinamide ndi zosakaniza zina kwa masabata asanu ndi atatu kumathandiza khungu kuwonekera mwa anthu omwe ali ndi ziphuphu. Kafukufuku wina akuwonetsa kuti kugwiritsa ntchito kirimu wokhala ndi niacinamide kumawongolera khungu kwa anthu omwe ali ndi ziphuphu.
  • Matenda a shuga. Kafukufuku wina akuwonetsa kuti kumwa niacinamide kungathandize kupewa kutaya kwa insulin mwa ana ndi akulu omwe ali pachiwopsezo cha mtundu woyamba wa matenda ashuga. Zitha kupewanso kuchepa kwa kapangidwe ka insulini ndikuchepetsa kuchuluka kwa insulin yofunikira mwa ana omwe apezeka ndi matenda a shuga a mtundu woyamba. Komabe, niacinamide sikuwoneka ngati ikulepheretsa kukula kwa matenda ashuga amtundu wa 1 mwa ana omwe ali pachiwopsezo. Mwa anthu omwe ali ndi matenda a shuga amtundu wachiwiri, niacinamide imawoneka ngati ikuthandizira kuteteza kupangika kwa insulin ndikusintha kuwongolera kwa magazi.
  • Mlingo waukulu wa phosphate m'magazi (hyperphosphatemia). Kuchuluka kwa magazi a phosphate kumatha chifukwa cha kuchepa kwa ntchito ya impso. Kwa anthu omwe ali ndi vuto la impso omwe ali ndi hemodialysis ndipo ali ndi magazi ambiri a phosphate, kumwa niacinamide kumawoneka kuti kumachepetsa milingo ya phosphate ikamamenyedwa kapena popanda zomangiriza za phosphate.
  • Khansara ya mutu ndi khosi. Kafukufuku akuwonetsa kuti kumwa niacinamide mukalandira radiotherapy ndi mtundu wa mankhwala omwe amatchedwa carbogen atha kuthandizira kuchepetsa kukula kwa chotupa ndikuwonjezera kupulumuka kwa anthu ena omwe ali ndi khansa ya kholingo. Kutenga niacinamide polandira radiotherapy ndi carbogen kumawoneka ngati kopindulitsa anthu omwe ali ndi khansa ya kholingo amenenso ali ndi magazi. Zikuwonekeranso kuti zimathandiza anthu omwe ali ndi zotupa zomwe zimasowa mpweya.
  • Khansa yapakhungu. Kutenga niacinamide kumawoneka ngati kothandiza kupewa khansa yatsopano yapakhungu kapena mawanga otsogola (actinic keratosis) kuti asapangidwe mwa anthu omwe ali ndi mbiri ya khansa yapakhungu kapena actinic keratosis.
  • Nyamakazi. Kutenga niacinamide kumawoneka kuti kumathandizira kusinthasintha kwamalumikizidwe ndikuchepetsa kupweteka ndi kutupa kwa anthu omwe ali ndi osteoarthritis. Komanso, anthu ena omwe ali ndi osteoarthritis omwe amatenga niacinamide angafunikire kumwa mankhwala ochepa opweteka.

Mwina sizothandiza kwa ...

  • Chotupa chaubongo. Kafukufuku woyambirira akuwonetsa kuti kuchiza anthu omwe achotsedwa zotupa muubongo ndi niacinamide, radiotherapy, ndi carbogen sikumapangitsa kukhala ndi moyo poyerekeza ndi radiotherapy kapena radiotherapy ndi carbogen.
  • Khansara ya chikhodzodzo. Kuchiza anthu omwe ali ndi khansa ya chikhodzodzo ndi niacinamide, radiotherapy, ndi carbogen sikuwoneka kuti kumachepetsa kukula kwa chotupa kapena kupititsa patsogolo kupulumuka poyerekeza ndi radiotherapy kapena radiotherapy ndi carbogen.

Umboni wosakwanira woti ungagwire bwino ntchito ...

  • Matenda amaso omwe amatsogolera ku kutaya kwamaso mwa okalamba (kuchepa kwa makanda kapena AMD). Kafukufuku woyambirira akuwonetsa kuti kutenga niacinamide, vitamini E, ndi lutein kwa chaka kumathandizira momwe diso limagwirira ntchito bwino kwa anthu omwe ali ndi vuto lakukhala ndi vuto laukalamba chifukwa cha kuwonongeka kwa diso.
  • Khungu lokalamba. Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito zonona zokhala ndi 5% niacinamide kumaso kumathandiza blotchiness, makwinya, kusinthasintha, komanso kufiira kwa azimayi omwe ali ndi khungu lokalamba chifukwa cha kuwonongeka kwa dzuwa.
  • Chikanga (atopic dermatitis). Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito kirimu wokhala ndi 2% niacinamide kumachepetsa kuchepa kwamadzi ndikuwonjezera kutenthetsa madzi, komanso kumachepetsa kufiira ndi makulitsidwe, mwa anthu omwe ali ndi chikanga.
  • Matenda a chidwi-kuchepa kwa matenda (ADHD). Pali umboni wotsutsana wokhudzana ndi phindu la niacinamide kuphatikiza mavitamini ena ochizira ADHD.
  • Kufiira kwa khungu komwe kumachitika chifukwa chovulala kapena kukwiya (erythema). Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito kirimu wokhala ndi niacinamide kumachepetsa kufiira kwa khungu, kuuma, ndi kuyabwa komwe kumachitika chifukwa cha ziphuphu zamankhwala isotretinoin.
  • Matenda a impso a nthawi yayitali (matenda a impso kapena CKD). Kafukufuku woyambirira akuwonetsa kuti kumwa niacinamide sikungathandize kuchepetsa kuyabwa kwa anthu omwe ali ndi matenda a impso.
  • Zikopa zakuda kumaso (melasma). Kafukufuku woyambirira akuwonetsa kuti kuthira mafuta okhala ndi 5% niacinamide kapena 2% niacinamide ndi 2% tranexamic acid kwa milungu 4-8 kumathandiza kupeputsa khungu mwa anthu okhala ndi zigamba zakuda.
  • Khansa yomwe imayamba m'maselo oyera (omwe si a Hodgkin lymphoma). Kafukufuku woyambirira akuwonetsa kuti kutenga niacinamide ngati gawo la mankhwala ndi mankhwala otchedwa vorinostat atha kuthandiza anthu omwe ali ndi lymphoma kuti apite kukakhululukidwa.
  • Khungu lomwe limayambitsa kufiira pankhope (rosacea). Kafukufuku woyambirira akuwonetsa kuti kumwa mapiritsi okhala ndi niacinamide ndi zosakaniza zina kwa masabata asanu ndi atatu kumathandiza khungu kuwonekera mwa anthu omwe ali ndi rosacea.
  • Woyipa, khungu lakhungu pamutu ndi nkhope (seborrheic dermatitis). Kafukufuku woyambirira akuwonetsa kuti kugwiritsa ntchito kirimu wokhala ndi 4% niacinamide kumatha kuchepetsa kufiira ndi khungu pakhungu mwa anthu omwe ali ndi seborrheic dermatitis.
  • Kuledzera.
  • Matenda a Alzheimer.
  • Nyamakazi.
  • Chepetsani kukumbukira komanso kulingalira komwe kumachitika bwino ndi ukalamba.
  • Matenda okhumudwa.
  • Kuthamanga kwa magazi.
  • Matenda oyenda.
  • Matenda a Premenstrual (PMS).
  • Zochitika zina.
Umboni wina umafunikira kuti muyese niacinamide pazogwiritsidwa ntchito izi.

Niacinamide itha kupangidwa kuchokera ku niacin mthupi. Niacin amatembenuzidwa kukhala niacinamide ikamamwa mopitilira zomwe zimafunikira thupi. Niacinamide imasungunuka mosavuta m'madzi ndipo imalowa bwino ikamamwa.

Niacinamide imafunika kuti mafuta ndi shuga azigwira bwino ntchito mthupi komanso kuti akhale ndi maselo athanzi.

Mosiyana ndi niacin, niacinamide ilibe phindu lililonse pamankhwala ndipo sichiyenera kugwiritsidwa ntchito pochiza mafuta ambiri m'magazi. Mukamamwa: Niacinamide ndi WABWINO WABWINO kwa achikulire ambiri akamwetsedwa mu kuchuluka kwa ndalama zomwe akufuna. Mosiyana ndi niacin, niacinamide siyimayambitsa kutuluka. Komabe, niacinamide imatha kubweretsa zovuta zazing'ono monga kupweteka m'mimba, mpweya, chizungulire, kuthamanga, kuyabwa, ndi mavuto ena. Pochepetsa chiopsezo cha zotsatirazi, achikulire ayenera kupewa kumwa niacinamide mu Mlingo wopitilira 35 mg patsiku.

Mlingo wa 3 magalamu patsiku wa niacinamide ukatengedwa, zotsatira zoyipa zazikulu zimatha kuchitika. Izi zimaphatikizapo mavuto a chiwindi kapena shuga wambiri wamagazi.

Mukagwiritsidwa ntchito pakhungu: Niacinamide ndi WOTSATIRA BWINO. Kirimu cha Niacinamide chimatha kuyambitsa kuwotcha pang'ono, kuyabwa, kapena kufiira.

Chenjezo lapadera & machenjezo:

Mimba ndi kuyamwitsa: Niacinamide ndi WABWINO WABWINO kwa amayi apakati ndi oyamwitsa akamwetsedwa muyezo woyenera. Kuchuluka kwakukulu kwa niacin kwa amayi apakati kapena oyamwitsa ndi 30 mg patsiku kwa azaka zosakwana zaka 18, ndi 35 mg patsiku kwa azaka zopitilira 18.

Ana: Niacinamide ndi WABWINO WABWINO akamwedwa pakamwa pamlingo woyenera wa gulu lililonse. Koma ana ayenera kupewa kumwa miyezo ya niacinamide pamwamba pa malire apamwamba, omwe ndi 10 mg ya ana azaka zapakati pa 1-3, 15 mg ya ana azaka 4-8, 20 mg ya ana azaka 9-13, komanso 30 mg wa ana azaka 14-18.

Nthendayi: Niacinamide imatha kupangitsa kuti chifuwa chiwonjezeke kwambiri chifukwa chimapangitsa kuti histamine, mankhwala omwe amayambitsa matendawa, amasulidwe.

Matenda a shuga: Niacinamide itha kuwonjezera shuga m'magazi. Anthu omwe ali ndi matenda a shuga omwe amatenga niacinamide ayenera kuwunika shuga wawo mosamala.

Matenda a gallbladder: Niacinamide imatha kukulitsa matenda a ndulu.

Gout: Zambiri za niacinamide zimatha kubweretsa gout.

Dialysis ya impso: Kutenga niacinamide kumawoneka kuti kumawonjezera chiwopsezo cha kuchepa kwa magazi m'magazi mwa anthu omwe ali ndi vuto la impso omwe ali ndi dialysis.

Matenda a chiwindi: Niacinamide itha kukulitsa kuwonongeka kwa chiwindi. Musagwiritse ntchito ngati muli ndi matenda a chiwindi.

Zilonda zam'mimba kapena m'mimba: Niacinamide imatha kukulitsa zilonda. Musagwiritse ntchito ngati muli ndi zilonda.

Opaleshoni: Niacinamide ikhoza kusokoneza kuwongolera shuga wamagazi nthawi komanso pambuyo pochitidwa opaleshoni. Lekani kumwa niacinamide osachepera masabata awiri asanachite opareshoni.

Wamkati
Samalani ndi kuphatikiza uku.
Carbamazepine (Tegretol)
Carbamazepine (Tegretol) yawonongeka ndi thupi. Pali nkhawa ina kuti niacinamide imatha kuchepa momwe thupi limagwetsera carbamazepine (Tegretol) mwachangu. Koma palibe zambiri zokwanira kuti mudziwe ngati izi ndi zofunika.
Mankhwala omwe angawononge chiwindi (Hepatotoxic drug)
Niacinamide imatha kuvulaza chiwindi, makamaka ikagwiritsidwa ntchito kwambiri. Kutenga niacinamide pamodzi ndi mankhwala omwe amathanso kuwononga chiwindi kumatha kuonjezera chiwopsezo cha chiwindi. Musamamwe niacinamide ngati mukumwa mankhwala omwe angawononge chiwindi.

Mankhwala ena omwe angawononge chiwindi ndi monga acetaminophen (Tylenol ndi ena), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporaconazole) erythromycin (Erythrocin, Ilosone, ena), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), ndi ena ambiri.
Mankhwala omwe amachepetsa kugwetsa magazi (Anticoagulant / Antiplatelet drug)
Niacinamide imachedwetsa magazi kugundana. Kutenga niacinamide pamodzi ndi mankhwala omwe amachepetsa pang'onopang'ono kutseka kungapangitse mwayi wovulala ndi magazi.

Mankhwala ena omwe amachepetsa kugwetsa magazi ndi monga aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), ndi ena.
Primidone (Mysoline)
Primidone (Mysoline) imathyoledwa ndi thupi. Pali nkhawa kuti niacinamide imatha kuchepa momwe thupi limagwetsera primidone (Mysoline) mwachangu. Koma palibe zambiri zokwanira kuti mudziwe ngati izi ndi zofunika.
Zitsamba ndi zowonjezera zomwe zingawononge chiwindi
Niacinamide imatha kuwononga chiwindi, makamaka ikagwiritsidwa ntchito kwambiri. Kutenga niacinamide pamodzi ndi zitsamba zina kapena zowonjezera zomwe zingawononge chiwindi zitha kuwonjezera ngozi. Zina mwazinthu izi ndi androstenedione, tsamba la borage, chaparral, comfrey, dehydroepiandrosterone (DHEA), germander, kava, mafuta a pennyroyal, yisiti wofiira, ndi ena.
Zitsamba ndi zowonjezera zomwe zingachedwetse magazi kugunda
Niacinamide imachedwetsa magazi kugundana. Kugwiritsa ntchito niacinamide pamodzi ndi zitsamba zina ndi zowonjezera zomwe zimachedwetsanso kugwirana kwa magazi kumatha kuonjezera mwayi wamagazi mwa anthu ena. Zitsamba zina zamtunduwu ndi Angelica, clove, danshen, adyo, ginger, Panax ginseng, ndi ena.
Palibe zochitika zodziwika ndi zakudya.
Mlingo wotsatira udaphunziridwa pakufufuza kwasayansi:

ACHIKULU

NDI PAKAMWA:
  • Zonse: Zina mwazinthu zowonjezera zowonjezera sizikhoza kulemba niacinamide padera pa chizindikirocho. M'malo mwake, atha kulembedwa pansi pa niacin. Niacin imayesedwa mu kufanana kwa niacin (NE). Mlingo wa 1 mg wa niacinamide ndi wofanana ndi 1 mg NE. Ndalama zolandilidwa tsiku lililonse (RDAs) za niacinamide mwa akulu ndi 16 mg NE ya amuna, 14 mg NE ya azimayi, 18 mg NE ya azimayi apakati, ndi 17 mg NE ya azimayi oyamwitsa.
  • Kwa ziphuphu: Mapiritsi okhala ndi 750 mg ya niacinamide, 25 mg ya zinc, 1.5 mg yamkuwa, ndi 500 mcg wa folic acid (Nicomide) kamodzi kapena kawiri tsiku lililonse agwiritsidwa ntchito. Komanso, mapiritsi 1-4 okhala ndi niacinamide, azelaic acid, zinc, vitamini B6, mkuwa, ndi folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) amatengedwa tsiku lililonse.
  • Kwa kusowa kwa vitamini B3 monga pellagra: 300-500 mg patsiku la niacinamide amapatsidwa magawo awiri.
  • Kwa matenda ashuga: Niacinamide 1.2 magalamu / m2 (thupi) kapena 25-50 mg / kg imagwiritsidwa ntchito tsiku ndi tsiku pochepetsa kukula kwa matenda ashuga amtundu woyamba. Komanso 0,5 magalamu a niacinamide katatu patsiku amagwiritsidwa ntchito kuchepetsa kukula kwa matenda ashuga amtundu wa 2.
  • Pamlingo waukulu wa phosphate m'magazi (hyperphosphatemia): Niacinamide kuchokera 500 mg mpaka 1.75 magalamu tsiku lililonse m'magulu ogawanika amagwiritsidwa ntchito kwa masabata 8-12.
  • Khansa ya kholingo: 60 mg / kg ya niacinamide amapatsidwa maola 1-1.5 asanapume carbogen (2% carbon dioxide ndi 98% oxygen) isanachitike komanso nthawi ya radiotherapy.
  • Kwa khansa yapakhungu kupatula khansa ya pakhungu: 500 mg ya niacinamide kamodzi kapena kawiri tsiku lililonse kwa miyezi 4-12.
  • Pochiza matenda a nyamakazi: 3 magalamu a niacinamide patsiku m'magawo awiri kwa milungu 12.
PA CHIKOPA:
  • Ziphuphu: Gel osakaniza 4% niacinamide kawiri tsiku lililonse.
ANA

  • Zonse: Malipiro azakudya tsiku lililonse (RDAs) a niacinamide mwa ana ndi 2 mg ya makanda azaka 0-6, 4 mg NE ya makanda miyezi 7-12, 6 mg NE ya ana azaka 1-3, 8 mg NE kwa ana azaka 4-8, 12 mg NE kwa ana azaka 9-13, 16 mg NE kwa amuna azaka 14-18, ndi 14 mg NE azimayi azaka 14-18.
  • Kwa ziphuphu: Kwa ana osachepera zaka 12, mapiritsi 1-4 okhala ndi niacinamide, azelaic acid, zinc, vitamini B6, mkuwa, ndi folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) amatengedwa tsiku lililonse.
  • Kwa pellagra: 100-300 mg ya niacinamide imaperekedwa tsiku lililonse m'magulu osiyanasiyana.
  • Kwa mtundu wa 1 shuga1.2 magalamu / m2 (thupi) kapena 25-50 mg / kg ya niacinamide imagwiritsidwa ntchito tsiku ndi tsiku pochepetsa kapena kupititsa patsogolo matenda ashuga amtundu wa 1.
3-Pyridine Carboxamide, 3-Pyridinecarboxamide, Amide de l'Acide Nicotinique, B ovuta Vitamini, Complexe de Vitamines B, Niacinamida, Nicamid, Nicosedine, Nicotinamide, Nicotinic Acid Amide, Nicotylamidum, Pyridine-3-carboxamide, , Vitamini B3.

Kuti mudziwe zambiri za momwe nkhaniyi idalembedwera, chonde onani Mankhwala Achilengedwe Pazonse njira.


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