Mlembi: Janice Evans
Tsiku La Chilengedwe: 1 Kulayi 2021
Sinthani Tsiku: 16 Novembala 2024
Anonim
Calcineurin Inhibitors (Tacrolimus and Cyclosporine) IL2 - Mechanism of action, adverse effects
Kanema: Calcineurin Inhibitors (Tacrolimus and Cyclosporine) IL2 - Mechanism of action, adverse effects

Zamkati

Cyclosporine imapezeka momwe idapangidwira komanso ngati chinthu china chomwe chimasinthidwa (kusinthidwa) kuti mankhwala azitha kulowa m'thupi. Choyambirira cyclosporine ndi cyclosporine (chosinthidwa) chimalowetsedwa ndi thupi mosiyanasiyana, kotero sizingasinthane wina ndi mnzake. Tengani mtundu wa cyclosporine womwe adakupatsani dokotala. Dokotala wanu akakupatsani mankhwala olembedwa, onetsetsani kuti watsimikiza mtundu wa cyclosporine womwe muyenera kulandira. Nthawi iliyonse mukadzaza mankhwala anu, yang'anani dzina lanu pamasamba anu kuti mutsimikizire kuti mwalandira cyclosporine yofanana. Lankhulani ndi wamankhwala wanu ngati dzina lake silikudziwika kapena simukudziwa kuti mwalandira cyclosporine yoyenera.

Kutenga cyclosporine kapena cyclosporine (kusinthidwa) kumachulukitsa chiopsezo choti mungakhale ndi matenda kapena khansa, makamaka lymphoma (khansa ya gawo lina la chitetezo chamthupi) kapena khansa yapakhungu. Izi zitha kukhala zowopsa mukatenga cyclosporine kapena cyclosporine (kusinthidwa) ndi mankhwala ena omwe amachepetsa magwiridwe antchito amthupi monga azathioprine (Imuran), chemotherapy ya khansa, methotrexate (Rheumatrex), sirolimus (Rapamune), ndi tacrolimus (Prograf) . Uzani dokotala wanu ngati mumamwa mankhwala aliwonse, komanso ngati mwakhalapo ndi khansa yamtundu uliwonse. Pofuna kuchepetsa chiopsezo cha khansa yapakhungu, konzekerani kupeŵa kuwala kwa dzuwa kosafunikira kapena kuvala zovala zokutetezani, magalasi a dzuwa, ndi zotchingira dzuwa mukamalandira chithandizo. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: zilonda zapakhosi, malungo, kuzizira, ndi zizindikilo zina za matenda; zizindikiro ngati chimfine; kutsokomola; zovuta kukodza; kupweteka pokodza; malo ofiira, otukuka, kapena otupa pakhungu; zilonda zatsopano kapena kusintha pakhungu; ziphuphu kapena misa paliponse mthupi lanu; thukuta usiku; zotupa zotupa m'khosi, kukhwapa, kapena kubuula; kuvuta kupuma; kupweteka pachifuwa; kufooka kapena kutopa komwe sikuchoka; kapena kupweteka, kutupa, kapena kukhuta m'mimba.


Cyclosporine ndi cyclosporine (kusinthidwa) kungayambitse kuthamanga kwa magazi komanso kuwonongeka kwa impso. Uzani dokotala wanu ngati mwakhalapo ndi matenda a kuthamanga kwa magazi kapena matenda a impso. Muuzeni dokotala ngati mukumwa mankhwala aliwonse awa: amphotericin B (Amphotec, Fungizone); cimetidine (Tagamet); ciprofloxacin (Cipro); colchicine; fenofibrate (Antara, Lipophen, Tricor); gemfibrozil (Lopid); gentamicin; ketoconazole (Nizoral); melphalan (Alkeran); mankhwala osagwiritsa ntchito kutupa monga diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), ndi sulindac (Clinoril); ranitidine (Zantac); tobramycin (Tobi); trimethoprim yokhala ndi sulfamethoxazole (Bactrim, Septra); ndi vancomycin (Vancocin). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: chizungulire; kutupa kwa mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi; kuthamanga, kupuma pang'ono; nseru; kapena kugunda kwamtima kosazolowereka.

Ngati muli ndi psoriasis, uzani dokotala wanu za mankhwala onse a psoriasis ndi mankhwala omwe mukugwiritsa ntchito kale. Chiwopsezo choti ungakhale ndi khansa yapakhungu ndichachikulu ngati udapatsidwa mankhwala ndi PUVA (psoralen ndi UVA; chithandizo cha psoriasis chomwe chimaphatikiza mankhwala am'kamwa kapena apakhungu ndi chiwonetsero cha kuwala kwa ultraviolet A); methotrexate (Rheumatrex) kapena mankhwala ena omwe amapondereza chitetezo cha mthupi; UVB (kupezeka kwa kuwala kwa ultraviolet B kuchiza psoriasis); phula lamakala; kapena mankhwala a radiation. Simuyenera kulandira chithandizo ndi PUVA, UVB, kapena mankhwala omwe amaletsa chitetezo chamthupi mukamamwa cyclosporine (osinthidwa) kuchiza psoriasis.


Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu limayankhira cyclosporine kapena cyclosporine (kusinthidwa).

Cyclosporine ndi cyclosporine (kusinthidwa) amagwiritsidwa ntchito ndi mankhwala ena kupewa kupewetsa kukana (kuukira kwa chiwalo choikidwa ndi chitetezo chamthupi cha munthu amene adalandira chiwalo) mwa anthu omwe alandila impso, chiwindi, ndi mtima. Cyclosporine (modified) imagwiritsidwanso ntchito payokha kapena ndi methotrexate (Rheumatrex) kuchiza matenda a nyamakazi (nyamakazi yoyambitsidwa ndi kutupa kwa malo amalumikizidwe) mwa odwala omwe zizindikiro zawo sizinathetse vuto la methotrexate yokha. Cyclosporine (modified) imagwiritsidwanso ntchito pochizira psoriasis (matenda akhungu momwe mawonekedwe ofiira ofiira am'madera ena amthupi) mwa odwala ena omwe sanathandizidwe ndi mankhwala ena. Cyclosporine ndi cyclosporine (zosinthidwa) zili m'kalasi la mankhwala otchedwa immunosuppressants. Amagwira ntchito pochepetsa kuchepa kwa chitetezo cha mthupi.


Cyclosporine ndi cyclosporine (zosinthidwa) zonse zimabwera ngati kapisozi ndi yankho (madzi) oti atenge pakamwa. Cyclosporine nthawi zambiri amatengedwa kamodzi patsiku. Cyclosporine (kusinthidwa) nthawi zambiri amatengedwa kawiri patsiku. Ndikofunikira kutenga mitundu yonse ya cyclosporine nthawi zonse. Tengani cyclosporine kapena cyclosporine (kusinthidwa) nthawi yomweyo (m) tsiku lililonse, ndipo lolani nthawi yofanana pakati pa mlingo ndi chakudya tsiku lililonse.Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani cyclosporine kapena cyclosporine (kusinthidwa) chimodzimodzi monga mwalamulo. Musamamwe mankhwala ochepera kapena kumwa pafupipafupi kuposa momwe adalangizire dokotala.

Dokotala wanu mwina angasinthe kuchuluka kwa cyclosporine kapena cyclosporine (kusinthidwa) mukamalandira chithandizo. Ngati mukumwa mtundu uliwonse wa cyclosporine kuti muteteze kukanidwa, dokotala wanu angakuyambitseni kuchuluka kwa mankhwala ndikuchepetsa pang'ono mlingo wanu. Ngati mukumwa cyclosporine (kusinthidwa) kuti muchiritse nyamakazi kapena psoriasis, dokotala wanu mwina angakuyambitseni pamlingo wochepa wa mankhwalawo ndikuwonjezera mlingo wanu pang'onopang'ono. Dokotala wanu amathanso kuchepetsa mlingo wanu ngati mutakumana ndi zovuta zamankhwala. Uzani dokotala wanu momwe mukumvera mukamalandira chithandizo.

Cyclosporine (kusinthidwa) kumathandiza kuletsa zizindikiro za psoriasis ndi nyamakazi, koma sikuchiza izi. Ngati mukumwa cyclosporine (osinthidwa) kuti muchiritse psoriasis, zitha kutenga milungu iwiri kapena kupitilira apo kuti zizindikilo zanu ziyambe kusintha, komanso masabata 12 mpaka 16 kuti mumve bwino mankhwalawo. Ngati mukumwa cyclosporine (kusinthidwa) kuchiza nyamakazi, zimatha kutenga masabata 4 mpaka 8 kuti zizindikilo zanu ziziyenda bwino. Pitirizani kumwa cyclosporine (kusinthidwa) ngakhale mukumva bwino. Osasiya kumwa cyclosporine (kusinthidwa) osalankhula ndi dokotala. Dokotala wanu akhoza kuchepetsa mlingo wanu pang'onopang'ono.

Mutha kuwona fungo losazolowereka mukatsegula chithuza cha makapisozi a cyclosporine. Izi ndi zachilendo ndipo sizitanthauza kuti mankhwalawa awonongeka kapena ndiosavomerezeka kugwiritsa ntchito.

Njira yothetsera cyclosporine (yosinthidwa) yamlomo imatha kusungunuka kapena kukhala yotupa ngati itakumana ndi kutentha kotsika 68 ° F (20 ° C). Mutha kugwiritsa ntchito yankho ngakhale litasungunuka, kapena mutha kuyambiranso yankho kukhala madzi powalola kuti lizitentha kutentha (77 ° F [25 ° C]).

Cyclosporine ndi cyclosporine (kusinthidwa) yankho la m'kamwa liyenera kusakanizidwa ndi madzi musanagwiritse ntchito. Cyclosporine (modified) solution ya m'kamwa imatha kusakanizidwa ndi madzi a lalanje kapena madzi apulo koma sayenera kusakanizidwa ndi mkaka. Njira yothetsera cyclosporine m'kamwa imatha kusakanizidwa ndi mkaka, mkaka wa chokoleti, kapena msuzi wa lalanje. Muyenera kusankha chakumwa chimodzi pamndandanda woyenera ndipo nthawi zonse sakanizani mankhwala anu ndi chakumwa.

Kuti mutenge yankho lamtundu uliwonse pakamwa, tsatirani izi:

  • Dzazani kapu (osati pulasitiki) chikho chomwe mwasankha.
  • Chotsani chivundikirocho pamwamba pa jakisoni wa dosing amene amabwera ndi mankhwala anu.
  • Ikani nsonga ya syringe mu botolo la yankho ndikubwerera pa plunger kuti mudzaze sirinjiyo ndi kuchuluka kwa yankho lomwe dokotala wakupatsani.
  • Gwirani syringe pamwamba pa madzi mugalasi lanu ndikudina pa plunger kuti muike mankhwalawo mugalasi.
  • Onetsetsani kusakaniza bwino.
  • Imwani zamadzimadzi zonse mugalasi nthawi yomweyo.
  • Thirani pang'ono zakumwa zomwe mwasankha mugalasi, zungulirani galasi mozungulira kuti muzimutsuka, ndikumwa madziwo.
  • Yanikani kunja kwa sirinjiyo ndi chopukutira choyera ndikubwezeretsani chivundikirocho. Osasamba syringe ndi madzi. Ngati mukuyenera kutsuka jakisoni, onetsetsani kuti wauma kwathunthu musanagwiritse ntchito kuyeza mlingo wina.

Cyclosporine ndi cyclosporine (kusinthidwa) nthawi zina amagwiritsidwanso ntchito pochiza matenda a Crohn (matenda omwe thupi limagwiritsa ntchito gawo la m'mimba, kumayambitsa kupweteka, kutsegula m'mimba, kuchepa thupi, ndi malungo) komanso kupewa kukana kwa omwe alandila kapamba kapena ziphuphu za cornea. Lankhulani ndi dokotala wanu za kuopsa kokugwiritsa ntchito mankhwalawa.

Mankhwalawa amatha kupatsidwa ntchito zina. Funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge cyclosporine kapena cyclosporine (kusinthidwa),

  • uzani dokotala ndi wamankhwala ngati muli ndi vuto la cyclosporine, cyclosporine (kusinthidwa), mankhwala ena aliwonse, kapena chilichonse chosagwira ntchito mu cyclosporine kapena cyclosporine (modified) capsules kapena solution. Funsani wamankhwala wanu kuti awonetse mndandanda wazinthu zosagwira.
  • Uzani dokotala wanu komanso wamankhwala mankhwala omwe akupatsani, osapatsirana, mavitamini, ndi zakudya zomwe mumamwa, kapena mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe adatchulidwa mu gawo la CHENJEZO CHENJEZO ndi zina mwa izi: acyclovir (Zovirax); allopurinol (Zyloprim); amiodarone (Cordarone); ma angiotensin otembenuza enzyme (ACE) zoletsa monga benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (perivopril) ), ramipril (Altace), ndi trandolapril (Mavik); Otsutsana ndi angiotensin II monga candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), ndi valsartan (Diovan); mankhwala ena oletsa mafungal monga fluconazole (Diflucan), ndi itraconazole (Sporanox); azithromycin (Zithromax); bromocriptine (Parlodel); zotchinga calcium monga diltiazem (Cardizem), nicardipine (Cardene), ndi verapamil (Calan); carbamazepine (Tegretol); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), ndi simvastatin (Zocor); clarithromycin (Biaxin); dalfopristin ndi quinupristin kuphatikiza (Synercid); danazol; digoxin (Lanoxin); ma diuretics ('mapiritsi amadzi') kuphatikiza amiloride (Midamor), spironolactone (Aldactone), ndi triamterene (Dyazide); erythromycin; HIV protease inhibitors monga indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Fortovase); imatinib (Gleevec); metoclopramide (Reglan); methylprednisolone (Medrol); nafcillin; octreotide (Sandostatin); njira zakulera zam'kamwa (mapiritsi olera); mndandanda (Xenical); phenobarbital; phenytoin (Dilantin); zowonjezera potaziyamu; prednisolone (Wodwala); repaglinide (Prandin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sulfinpyrazone (Anturane); terbinafine (Lamisil); ndi ticlopidine (Ticlid). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala pazotsatira.
  • ngati mukumwa sirolimus (Rapamune), tengani maola 4 mutatenga cyclosporine kapena cyclosporine (kusinthidwa).
  • uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
  • auzeni adotolo ngati mwakhala mukukhalapo ndi zina mwazomwe zatchulidwa mgawo la CHENJEZO LOFUNIKA kapena zina mwazinthu izi: cholesterol yochepa, kuchuluka kwama magnesium m'magazi anu, vuto lililonse lomwe limapangitsa kuti thupi lanu lisamavutike kupeza zakudya, kapena matenda a chiwindi.
  • Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukatenga mtundu uliwonse wa cyclosporine, itanani dokotala wanu. Mitundu yonse iwiri ya cyclosporine imatha kuonjezera chiwopsezo kuti mwana wanu abadwe molawirira kwambiri.
  • uzani dokotala wanu ngati mukuyamwitsa kapena mukukonzekera kuyamwitsa.
  • mulibe katemera osalankhula ndi dokotala.
  • muyenera kudziwa kuti cyclosporine imatha kukula kwamatenda owonjezera m'kamwa mwanu. Onetsetsani kuti mukutsuka mano anu mosamala ndikuwona dotolo wamankhwala pafupipafupi mukamalandira chithandizo kuti muchepetse chiopsezo choti mudzakhale ndi zotsatirazi.

Pewani kumwa madzi amphesa kapena kudya zipatso zamphesa mukamamwa cyclosporine kapena cyclosporine (kusinthidwa).

Dokotala wanu angakuuzeni kuti muchepetse potaziyamu pazakudya zanu. Tsatirani malangizowa mosamala. Lankhulani ndi dokotala wanu za kuchuluka kwa zakudya zokhala ndi potaziyamu monga nthochi, prunes, zoumba, ndi madzi a lalanje omwe mungakhale nawo pazakudya zanu. Mitundu yambiri yamchere imakhala ndi potaziyamu, chifukwa chake lankhulani ndi adotolo kuti muwagwiritse ntchito mukamalandira mankhwala.

Mukaiwala kumwa mlingo, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Cyclosporine ndi cyclosporine (kusinthidwa) kumatha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • mutu
  • kutsegula m'mimba
  • kutentha pa chifuwa
  • mpweya
  • kukulitsa tsitsi kumaso, mikono, kapena kumbuyo
  • kukula kwa minofu yowonjezera pamatama
  • ziphuphu
  • kuchapa
  • kugwedezeka kosalamulirika kwa gawo lina la thupi lanu
  • kutentha kapena kumva kulasalasa m'manja, mikono, mapazi, kapena miyendo
  • kupweteka kwa minofu kapena molumikizana
  • kukokana
  • kupweteka kapena kupanikizika pamaso
  • mavuto a khutu
  • kukulitsa mawere mwa amuna
  • kukhumudwa
  • kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikiro izi, kapena zomwe zalembedwa mgawo la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu:

  • kutuluka mwachilendo kapena kuphwanya
  • khungu lotumbululuka
  • chikasu cha khungu kapena maso
  • kugwidwa
  • kutaya chidziwitso
  • kusintha kwamakhalidwe kapena malingaliro
  • zovuta kuwongolera mayendedwe amthupi
  • kusintha kwa masomphenya
  • chisokonezo
  • zidzolo
  • zofiirira pakhungu
  • kutupa kwa manja, mikono, mapazi, akakolo, kapena miyendo yakumunsi

Cyclosporine ndi cyclosporine (kusinthidwa) kumatha kuyambitsa zovuta zina. Lankhulani ndi dokotala wanu ngati mukukumana ndi mavuto ena mukamamwa mankhwala.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu komanso chosafikirika ndi ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Musasunge mankhwalawa mufiriji ndipo musawumitse. Kutaya yankho lililonse lotsala pakatha miyezi iwiri mutangotsegula botolo.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

  • chikasu cha khungu kapena maso
  • kutupa kwa mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi.

Musalole kuti wina aliyense amwe mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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Idasinthidwa Komaliza - 12/15/2015

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