Ruxolitinib

Zamkati

• Musanatenge ruxolitinib,
• Ruxolitinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Ruxolitinib amagwiritsidwa ntchito pochizira myelofibrosis (khansa ya m'mafupa momwe mafupa amalowetsedwa ndimatenda ofiira ndipo zimayambitsa kuchepa kwama cell). Amagwiritsidwanso ntchito pochiza polycythemia vera (PV; khansa yomwe ikukula pang'onopang'ono yamagazi momwe mafupa amapangira maselo ofiira ochulukirapo) mwa anthu omwe sanathe kuchiritsidwa bwino ndi hydroxyurea. Ruxolitinib imagwiritsidwanso ntchito pochizira matenda olumikizidwa ndi matenda (GVHD; vuto la kupatsirana kwa hematopoietic stem-cell [HSCT; njira yomwe imalowetsa m'mafupa odwala ndi mafupa athanzi]) mwa akulu ndi ana azaka 12 kapena kupitilira apo omwe adathandizidwa osapambana ndi mankhwala a steroid. Ruxolitinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito pochiza myelofibrosis ndi PV poletsa zikwangwani zomwe zimapangitsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa. Zimagwira ntchito pochiza GVHD potsekereza ma cell omwe amayambitsa GVHD.

Ruxolitinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kawiri patsiku. Tengani ruxolitinib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ruxolitinib ndendende momwe mwalangizira. Musatenge pang'ono kapena pang'ono, kapena muzitenga nthawi zambiri kuposa momwe adanenera dokotala.

Ngati mukuchiritsidwa ndi myelofibrosis kapena PV dokotala wanu akhoza kukuyambitsani pa mlingo wochepa wa ruxolitinib kwa milungu inayi yoyambirira yamankhwala, ndipo pang'onopang'ono muwonjezere mlingo wanu pambuyo pake, osapitilira kamodzi milungu iwiri iliyonse. Ngati mukulandira GVHD adotolo anu angakuyambitseni pa mlingo wochepa wa ruxolitinib ndipo akhoza kukulitsa mlingo wanu pakatha masiku atatu akuchipatala.

Kumeza mapiritsi lonse; musatafune kapena kuwaphwanya.

Ngati simungathe kukhala ndi chakudya pakamwa ndikukhala ndi chubu cha nasogastric (NG), dokotala wanu angakuuzeni kuti mutenge ruxolitinib kudzera pa chubu ya nasogastric (NG). Dokotala wanu kapena wamankhwala akufotokozerani momwe mungakonzekerere ruxolitinib kuti mupereke kudzera mu chubu la NG.

Dokotala wanu adzaitanitsa kuyezetsa magazi musanachitike komanso mukamalandira chithandizo kuti muwone momwe zimakukhudzirani ndi mankhwalawa. Dokotala wanu akhoza kukulitsa kapena kuchepa mlingo wanu wa ruxolitinib mukamalandira chithandizo, kapena angakuuzeni kuti musiye kumwa ruxolitinib kwakanthawi. Izi zimadalira momwe mankhwalawa amakuthandizirani, zotsatira zoyesa labu, komanso ngati mukumana ndi zovuta zina. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kutenga ruxolitinib ngakhale mutakhala bwino. Osasiya kumwa ruxolitinib osalankhula ndi dokotala. Ngati dokotala angaganize kuti asiye mankhwala anu ndi ruxolitinib, dokotala wanu akhoza kuchepetsa mlingo wanu pang'onopang'ono.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ruxolitinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ruxolitinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu ruxolitinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: Mankhwala oletsa antifungal kuphatikiza itraconazole (Sporanox), ketoconazole, ndi voriconazole (Vfend); carbamazepine (Carbatrol, Equetro, Tegretol, ena); kumvetsetsa; efavirenz (Sustiva, ku Atripla, Symfi); fluconazole (Diflucan); HIV protease inhibitors kuphatikiza indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra, Viekira Pak), ndi saquinavir (Invirase); mibefradil (Posicor); nefazodone; nevirapine (Viramune); phenytoin (Dilantin, Phenytek); pioglitazone (Actos, ku Oseni, Duetact); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, Rifater); telaprevir (Incivik); ndi telithromycin (Ketek). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.Mankhwala ena ambiri amathanso kulumikizana ndi ruxolitinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati muli ndi kuchepa kwa magazi m'thupi, matenda, ngati muli ndi dialysis, kapena ngati mwakhala mukuzungulira munthu yemwe ali ndi chifuwa chachikulu (TB, matenda opatsirana m'mapapo) kapena adachezera kapena kukhala komwe kuli TB. Komanso muuzeni dokotala ngati mwakhalapo ndi TB, cholesterol, khansa yapakhungu, hepatitis B kapena matenda ena a chiwindi, kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga ruxolitinib, itanani dokotala wanu. Simuyenera kuyamwitsa mukamamwa ruxolitinib komanso kwa masabata awiri mutatha kumwa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ruxolitinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chizungulire
• mutu
• kutopa
• kufooka
• kupuma movutikira
• kunenepa
• mpweya
• kupweteka m'mimba
• kutsegula m'mimba
• kudzimbidwa
• nseru
• kuyabwa
• zidzolo
• kupweteka kwa minofu kapena molumikizana
• kutupa kwa mikono, miyendo kapena ziwalo zina za thupi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kutuluka mwazi kwachilendo kapena kulemera kapena kuphwanya
• malungo, zilonda zapakhosi, kuzizira, chifuwa, kupweteka pachifuwa, thukuta usiku, pafupipafupi, kuwawa, kukodza mwachangu, ndi zizindikilo zina za matenda
• kuwotcha, kuyabwa, kuyabwa, kapena kumva khungu mbali imodzi ya thupi kapena nkhope ndi zotupa zopweteka kapena zotupa zomwe zimawonekera patatha masiku angapo.
• zilonda zatsopano, zotupa, kapena kusintha kwa khungu kapena kusintha kwina pakhungu
• khungu lotumbululuka, kutopa, kapena kupuma pang'ono (makamaka mukamachita masewera olimbitsa thupi)
• kuvuta kusuntha kapena kusunga malire, kufooka kwa miyendo kapena mikono yomwe imangokulirakulira, kuvutika kumvetsetsa kapena kuyankhula, kusaiwala kukumbukira, mavuto amaso, kapena kusintha umunthu

Ruxolitinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kutuluka mwachilendo kapena kuphwanya
• chizungulire
• mutu
• kutopa
• malungo, zilonda zapakhosi, kuzizira, chifuwa, ndi zizindikiro zina za matenda

Sungani maimidwe onse ndi dokotala wanu ndi labotale.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Jakafi