Dapagliflozin

Zamkati

• Musanatenge dapagliflozin,
• Mankhwalawa amatha kusintha shuga m'magazi anu. Muyenera kudziwa zizindikiro za shuga wotsika kwambiri komanso zomwe muyenera kuchita ngati muli ndi izi.
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Ngati mukumane ndi izi, siyani kumwa dapagliflozin ndipo itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:
• Ngati mukumane ndi zizindikiro zotsatirazi za ketoacidosis, lekani kumwa dapagliflozin ndipo itanani dokotala mwamsanga kapena pitani kuchipatala mwadzidzidzi. Ngati kuli kotheka, fufuzani ketoni mumkodzo wanu ngati muli ndi zizindikirozi, ngakhale shuga lanu la magazi liri lochepera 250 mg / dL:

Dapagliflozin imagwiritsidwa ntchito limodzi ndi zakudya komanso masewera olimbitsa thupi, ndipo nthawi zina ndi mankhwala ena, kuti muchepetse shuga m'magazi mwa achikulire omwe ali ndi matenda a shuga a mtundu wa 2 (momwe shuga wamagazi umakhala wokwera kwambiri chifukwa thupi silimatulutsa kapena kugwiritsa ntchito insulini mwachizolowezi). Dapagliflozin imagwiritsidwanso ntchito pochepetsa chiopsezo chofunikiranso kuchipatala chifukwa cha kulephera kwa mtima kwa achikulire omwe ali ndi matenda a shuga a mtundu wachiwiri komanso matenda a mtima ndi mitsempha yamagazi kapena omwe ali ndi zoopsa zingapo zopangitsa matenda amtima ndi magazi. Dapagliflozin imagwiritsidwanso ntchito kwa akulu omwe ali ndi vuto la mtima kuti achepetse chiopsezo chofunidwa kuchipatala ndikufa chifukwa cha matenda amtima ndi mtsempha wamagazi. Dapagliflozin ali mgulu la mankhwala otchedwa sodium-glucose co-transporter 2 (SGLT2) inhibitors. Amachepetsa shuga wamagazi popangitsa impso kuchotsa shuga wambiri mkodzo. Dapagliflozin sagwiritsidwa ntchito pochiza matenda ashuga amtundu wa 1 (momwe thupi silitulutsire insulini, chifukwa chake, silingathe kuwongolera kuchuluka kwa shuga m'magazi) kapena matenda ashuga ketoacidosis (vuto lalikulu lomwe lingachitike ngati shuga wa magazi sakuchiritsidwa ).

Popita nthawi, anthu omwe ali ndi matenda ashuga komanso shuga wambiri m'magazi amatha kukhala ndi mavuto owopsa kapena owopsa, kuphatikizapo matenda amtima, sitiroko, mavuto a impso, kuwonongeka kwa mitsempha, komanso mavuto amaso. Kutenga dapagliflozin, kusintha kusintha kwa moyo wanu (mwachitsanzo, zakudya, kuchita masewera olimbitsa thupi, kusiya kusuta), komanso kuwunika shuga wanu wamagazi pafupipafupi kungakuthandizeni kuthana ndi matenda anu ashuga komanso kukhala ndi thanzi labwino. Mankhwalawa amathanso kuchepetsa mwayi wokhala ndi vuto la mtima, sitiroko, kapena zovuta zina zokhudzana ndi matenda ashuga monga impso kulephera, kuwonongeka kwamitsempha (dzanzi, miyendo yozizira kapena mapazi; kuchepa kwa kugonana kwa amuna ndi akazi), mavuto amaso, kuphatikiza kusintha kutaya masomphenya, kapena matenda a chiseyeye. Dokotala wanu ndi ena othandizira zaumoyo adzakambirana nanu za njira yabwino yothetsera matenda anu ashuga.

Dapagliflozin imabwera ngati piritsi kuti itenge pakamwa. Amatengedwa nthawi zambiri popanda kapena kudya kamodzi patsiku m'mawa. Tengani dapagliflozin mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani dapagliflozin ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Dokotala wanu akhoza kukuyambitsani pamlingo wochepa wa dapagliflozin ndikuwonjezera mlingo wanu ngati mukufunika.

Dapagliflozin amawongolera matenda amtundu wa 2 koma samachiritsa. Pitirizani kumwa dapagliflozin ngakhale mutakhala bwino. Osasiya kumwa dapagliflozin osalankhula ndi dokotala.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi dapagliflozin ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kuti mupeze Chithandizo cha Mankhwala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge dapagliflozin,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la dapagliflozin, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a dapagliflozin. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: zoletsa ma angiotensin zotembenuza enzyme (ACE) monga benazepril (Lotensin, ku Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc, Uniretic), perindopril (Aceon, ku Prestalia), ramipril (Altace), ndi trandolapril (Mavik, ku Tarka); angiotensin receptor blockers (ARB) monga azilsartan (Edarbi, ku Edarbyclor), candesartan (Atacand, ku Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, ku Avalide), losartan (Cozaar, ku Hyzaar), olmesartan (Benicar, ku Azor, ku Benicar HCT, ku Tribenzor), telmisartan (Micardis, ku Micardis HCT, ku Twynsta); aspirin ndi mankhwala ena osagwiritsa ntchito kutupa (NSAIDS) monga ibuprofen (Advil, Motrin) ndi naproxen (Aleve, Naprosyn); Mankhwala a shuga monga glimepiride (Amaryl, mu Duetact), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), repaglinide (Prandin, ku Prandimet), ndi tolbutamide; okodzetsa ('mapiritsi amadzi'); ndi insulini.
• uzani dokotala wanu ngati muli ndi dialysis komanso ngati mwakhalapo ndi matenda a impso. Dokotala wanu angakuuzeni kuti musatenge dapagliflozin.
• uzani dokotala wanu ngati mumamwa mowa nthawi zonse kapena nthawi zina mumamwa mowa wambiri nthawi yochepa (kumwa mopitirira muyeso) kapena ngati mumadya zakudya zochepa. Komanso muuzeni dokotala ngati mwakhalapo ndi vuto la mtima, matenda opatsirana kuphatikizapo kapamba (kutupa kwa kapamba) kapena kuti mwachitidwapo opaleshoni kapamba, matenda amikodzo kapena mavuto okodza, kuthamanga kwa magazi, matenda a yisiti m'dera lanu, matenda a impso kapena chiwindi. Ngati ndinu amuna, uzani dokotala ngati simunadulidwepo. Muuzeni dokotala wanu, ngati mukudya pang'ono chifukwa cha matenda, opaleshoni kapena kusintha kwa zakudya zanu, kapena mwakhala mukutsekula m'mimba posachedwa, kusanza, osamwa madzi okwanira, kukhala padzuwa nthawi yayitali, kapena thukuta kwambiri, zomwe zingayambitse kuchepa kwa madzi m'thupi (kutaya madzi ambiri amthupi).
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Osamayamwa mukamwa dapagliflozin. Mukakhala ndi pakati mukatenga dapagliflozin, itanani dokotala wanu.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa dapagliflozin. Dokotala wanu angakuuzeni kuti musiye kumwa dapagliflozin masiku osachepera atatu musanachite opaleshoni.
• mowa ungayambitse kusintha kwa magazi. Funsani dokotala wanu za zakumwa zoledzeretsa pamene mukumwa dapagliflozin.
• muyenera kudziwa kuti dapagliflozin imatha kuyambitsa chizungulire, mutu wopepuka, komanso kukomoka mukadzuka mwachangu pamalo abodza. Ngati muli ndi vutoli, itanani dokotala wanu. Vutoli limafala kwambiri mukayamba kumwa dapagliflozin. Pofuna kupewa vutoli, tulukani pabedi pang'onopang'ono, ndikupumitsa mapazi anu pansi kwa mphindi zingapo musanayimirire.
• funsani dokotala wanu choti muchite mukadwala, mutenga matenda kapena malungo, mukumva kupsinjika kwachilendo, kapena mukavulala. Izi zimatha kukhudza shuga wamagazi komanso kuchuluka kwa dapagliflozin yomwe mungafune.

Onetsetsani kuti mukutsatira zolimbitsa thupi komanso malingaliro azakudya zomwe adokotala anu kapena odyetsa. Ndikofunika kudya zakudya zopatsa thanzi komanso kuchita masewera olimbitsa thupi nthawi zonse.

Tsatirani malangizo a dokotala anu zakumwa madzi okwanira tsiku lonse mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Mankhwalawa amatha kusintha shuga m'magazi anu. Muyenera kudziwa zizindikiro za shuga wotsika kwambiri komanso zomwe muyenera kuchita ngati muli ndi izi.

Dapagliflozin ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kukodza kwambiri, kuphatikizapo usiku
• ludzu lowonjezeka

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kukodza pafupipafupi, mwachangu, kuwotcha, kapena kupweteka
• mkodzo womwe mitambo, yofiira, pinki, kapena bulauni
• mkodzo wamphamvu
• kuchepa kwa mkodzo
• kupweteka kwa m'chiuno kapena kwammbali
• (mwa akazi) kununkhira kwa ukazi, kumaliseche koyera kapena koterako (kumatha kukhala kotupa kapena kuwoneka ngati kanyumba kanyumba), kapena kuyabwa kumaliseche
• (mwa amuna) kufiira, kuyabwa, kapena kutupa kwa mbolo; zidzolo pa mbolo; kutuluka koyipa kuchokera ku mbolo; kapena kupweteka pakhungu lozungulira mbolo
• kumva kutopa, kufooka, kapena kusakhazikika; pamodzi ndi malungo ndi ululu, kukoma mtima, kufiira, ndi kutupa kwa maliseche kapena malo apakati pa maliseche ndi thumbo
• kutupa kwa miyendo kapena mapazi

Ngati mukumane ndi izi, siyani kumwa dapagliflozin ndipo itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• zidzolo
• ming'oma
• kuyabwa
• kuvuta kupuma kapena kumeza
• kutupa kwa nkhope, mmero, lilime, milomo, pakamwa, kapena maso
• ukali

Ngati mukumane ndi zizindikiro zotsatirazi za ketoacidosis, lekani kumwa dapagliflozin ndipo itanani dokotala mwamsanga kapena pitani kuchipatala mwadzidzidzi. Ngati kuli kotheka, fufuzani ketoni mumkodzo wanu ngati muli ndi zizindikirozi, ngakhale shuga lanu la magazi liri lochepera 250 mg / dL:

• nseru
• kusanza
• kupweteka kwa m'mimba
• kutopa
• kuvuta kupuma

Dapagliflozin ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu atha kuyitanitsa mayeso ena a labotale musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira dapagliflozin.

Magazi anu a shuga amayenera kuyang'aniridwa pafupipafupi kuti mudziwe momwe mungayankhire dapagliflozin. Dokotala wanu adzaitanitsa mayeso ena a labu, kuphatikiza glycosylated hemoglobin (HbA1c), kuti muwone yankho lanu ku dapagliflozin. Dokotala wanu adzakuwuzani momwe mungayang'anire kuyankha kwanu kwa mankhwalawa poyeza kuchuluka kwa shuga wamagazi kunyumba. Tsatirani malangizowa mosamala.

Musanayezetsedwe kwa labotale, uzani adotolo ndi ogwira nawo ntchito kuti mukumwa dapagliflozin. Chifukwa cha momwe mankhwalawa amagwirira ntchito, mkodzo wanu ukhoza kuyesa kuti mukhale ndi shuga.

Muyenera kuvala chibangili chizindikiritso cha ashuga kuti mutsimikizire kuti mumalandira chithandizo chadzidzidzi pakagwa mwadzidzidzi.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Farxiga^®

• Qtern^® (yokhala ndi Dapagliflozin, Saxagliptin)
• Zovuta^® XR (yokhala ndi Dapagliflozin, Metformin, Saxagliptin)
• Xigduo^® XR (yokhala ndi Dapagliflozin, Metformin)