Pembrolizumab jekeseni

Zamkati

• Jekeseni wa Pembrolizumab imagwiritsidwa ntchito: Jakisoni wa Pembrolizumab ali mgulu la mankhwala otchedwa ma monoclonal antibodies. Zimagwira ntchito pothandiza chitetezo cha mthupi chanu kuti muchepetse kapena kuletsa kukula kwa maselo a khansa.
• Asanalandire jakisoni wa pembrolizumab,
• Jekeseni wa Pembrolizumab ungayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Jekeseni wa Pembrolizumab imagwiritsidwa ntchito: Jakisoni wa Pembrolizumab ali mgulu la mankhwala otchedwa ma monoclonal antibodies. Zimagwira ntchito pothandiza chitetezo cha mthupi chanu kuti muchepetse kapena kuletsa kukula kwa maselo a khansa.

• kuchiza khansa yapakhungu (mtundu wa khansa yapakhungu) yomwe singachiritsidwe ndi opaleshoni kapena yafalikira mbali zina za thupi, kapena kuphatikiza ndi mankhwala ena a chemotherapy kuti athetse ndi kupewa kubwerera kwa khansa yapakhungu pambuyo pochitidwa opaleshoni kuti muchotse ndi zotupa zilizonse zomwe zakhudzidwa mfundo;
• kuchiza mitundu ina ya khansa ya m'mapapo yomwe siing'onoting'ono (NSCLC) yomwe singachiritsidwe ndi opaleshoni, mankhwala ena a chemotherapy, kapena mankhwala a radiation kapena omwe afalikira mbali zina za thupi kapena kukulirakulira panthawi kapena atalandira platinamu mankhwala a chemotherapy (cisplatin, carboplatin), kapena kuphatikiza mankhwala ena a chemotherapy (paclitaxel, pemetrexed) kuchiza mitundu ina ya NSCLC yomwe yafalikira mbali zina za thupi;
• kuchiza mtundu wina wa khansa yamutu ndi khosi yomwe imangobwerera kapena kufalikira mbali zina za thupi ndipo singathe kuchotsedwa ndi opaleshoni. Itha kugwiritsidwanso ntchito kuphatikiza fluorouracil ndi platinamu yomwe imakhala ndi mankhwala a chemotherapy (cisplatin, carboplatin) yochizira khansa yamutu ndi khosi yomwe imabwereranso kapena kufalikira mbali zina za thupi ndipo singathe kuchitidwa opaleshoni. Pembrolizumab imagwiritsidwanso ntchito pochiza khansa yamutu ndi khosi yomwe yawonjezeka kapena kufalikira mbali zina za thupi nthawi kapena itatha mankhwala a chemotherapy;
• kuchiza mtundu wina wa Hodgkin's lymphoma (matenda a Hodgkin) mwa ana ndi akulu omwe sanakhale bwino ndi mankhwala ena a chemotherapy kapena adachira koma adabweranso atalandira chithandizo ndi mankhwala ena a chemotherapy komanso mwa ana atachiritsidwa kawiri kapena kuposa ndi mankhwala ena a chemotherapy ;
• kuchiza mtundu wina wa main-mediastinal B-cell lymphoma (PMBCL; non-Hodgkin lymphoma) mwa ana ndi akulu omwe sanakhale bwino ndi mankhwala ena a chemotherapy kapena obwerera pambuyo pochiritsidwa kawiri kapena kuposa ndi mankhwala ena a chemotherapy;
• kuchiza mtundu wina wa khansa ya m'mitsempha (khansara ya chikhodzodzo ndi ziwalo zina za mkodzo) yomwe yafalikira kumatenda oyandikira kapena ziwalo zina za thupi mwa anthu omwe sangalandire platinamu yokhala ndi mankhwala a chemotherapy (cisplatin, carboplatin) , kapena yemwe khansa idakulirakulira mkati kapena pambuyo pake atachiritsidwa ndi mankhwala a chemotherapy awa;
• kuchiza mtundu wina wa khansa ya chikhodzodzo mwa anthu omwe sanakhale bwino ndi mankhwala ena (Bacillus Calmette-Guerin; chithandizo cha BCG) ndi omwe sangathe kapena omwe asankha kuti asamalandire opaleshoni kuti achotse chikhodzodzo;
• kuchiza mitundu ina ya khansa yoyipa (khansa yomwe imayamba m'matumbo akulu) ndi mitundu ina ya zotupa zolimba ngati chithandizo choyamba kwa ana ndi akulu omwe sangachiritsidwe ndi opaleshoni kapena yomwe yafalikira mbali zina za thupi kapena mwa iwo zinaipiraipira atalandira chithandizo ndi mankhwala ena a chemotherapy;
• kuchiza mitundu ina ya khansa yam'mimba (khansa yam'mimba) kapena khansa yomwe imapezeka mdera lomwe limakumana ndi kholingo (chubu pakati pakhosi ndi m'mimba) lomwe labwerera kapena lomwe lafalikira mbali zina za thupi nthawi kapena itatha 2 kapena mitundu yambiri ya mankhwala a chemotherapy;
• kuchiza mtundu wina wa khansa yam'mimba yomwe yabwerera ndipo yafalikira kumatenda oyandikira kapena ziwalo zina za thupi mutalandira chithandizo ndi mankhwala amodzi kapena angapo a chemotherapy ndipo sangathe kuchiritsidwa ndi opaleshoni kapena mankhwala a radiation;
• kuchiza mitundu ina ya khansa ya pachibelekero (khansa yomwe imayamba potsegulira chiberekero [chiberekero] yomwe yabwerera kapena kufalikira mbali zina za thupi mukamalandira chithandizo kapena mankhwala ena a chemotherapy;
• kuchiza mitundu ina ya hepatocellular carcinoma (HCC; mtundu wa khansa ya chiwindi) mwa anthu omwe kale sanathandizidwe bwino ndi sorafenib (Nexafar);
• kuchiza Merkel cell carcinoma (MCC; mtundu wa khansa yapakhungu) mwa ana ndi akulu omwe abwerera ndikufalikira kumatupi oyandikira kapena ziwalo zina za thupi;
• kuphatikiza ndi axitinib (Inlyta) kuchiza matenda a renal cell carcinoma (RCC; mtundu wa khansa womwe umayamba mu impso);
• kuphatikiza ndi lenvatinib (Lenvima) yothana ndi khansa yamtundu wina wa endometrium (chiberekero cha chiberekero) yomwe yafalikira mbali zina za thupi kapena kuipiraipira panthawi kapena mutalandira chithandizo cha mankhwala a chemotherapy kapena omwe sangachiritsidwe ndi opaleshoni kapena radiation mankhwala;
• kuchiza mitundu ina ya zotupa zolimba zomwe zafalikira mbali zina za thupi kapena sizingachiritsidwe ndi kuchitidwa opaleshoni kwa akulu ndi ana omwe kale adachitidwa mosapambana ndi mankhwala ena a chemotherapy ndipo alibe njira zina zokhutiritsa;
• kuchiza mitundu ina ya khungu la squamous cell carcinoma (CSCC; khansa yapakhungu) yomwe yabwerera kapena kufalikira mbali zina za thupi ndipo sangathe kuchiritsidwa ndi opaleshoni kapena mankhwala a radiation;
• komanso kuphatikiza ndi chemotherapy yochizira mtundu wina wa khansa ya m'mawere yomwe yabwerera kumatumba oyandikira kapena yafalikira mbali zina za thupi ndipo sangathe kuchiritsidwa ndi opareshoni.

Jekeseni wa Pembrolizumab umabwera ngati ufa wothira madzi ndikubaya jakisoni (mumtsempha) kwa mphindi 30 ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Nthawi zambiri amabayidwa kamodzi milungu itatu kapena isanu ndi umodzi malinga ngati dokotala akuuzani kuti mulandire chithandizo.

Jekeseni wa Pembrolizumab imatha kuyambitsa mavuto ena mkati, kapena atangomulowetsa mankhwalawo. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kuthamanga, kutentha thupi, kuzizira, kugwedezeka, chizungulire, kukomoka, kupuma movutikira, kupuma movutikira, kuyabwa, zidzolo, kapena ming'oma.

Dokotala wanu akhoza kuchedwetsa kapena kuyimitsa chithandizo chanu ndi jakisoni wa pembrolizumab, kapena kukupatsani mankhwala owonjezera, kutengera kuyankha kwanu kwa mankhwalawo ndi zovuta zina zilizonse zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa pembrolizumab ndipo nthawi iliyonse yomwe mumalandira mankhwala. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa pembrolizumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la pembrolizumab, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jakisoni ya pembrolizumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mudalandirapo chiwalo kapena mafupa ndipo ngati mwakhalapo ndi mankhwala owonjezera poizoni pachifuwa chanu; matenda amadzimadzi okhaokha (momwe chitetezo cha mthupi chimagwirira gawo labwino la thupi) monga matenda a Crohn (momwe chitetezo chamthupi chimagwirira ntchito m'mimba chomwe chimayambitsa kupweteka, kutsegula m'mimba, kuwonda, ndi malungo), ulcerative colitis (zomwe zimayambitsa kutupa ndi zilonda m'kati mwa kholingo [matumbo akulu] ndi thumbo), kapena lupus (momwe chitetezo chamthupi chimagwirira ziwalo ndi ziwalo zambiri kuphatikiza khungu, mafupa, magazi, ndi impso); matenda ashuga; mavuto a chithokomiro; mtundu uliwonse wamatenda am'mapapo kapena kupuma; kapena matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyezetsa mimba musanayambe mankhwala. Simuyenera kutenga pakati mukalandila jakisoni ya pembrolizumab komanso kwa miyezi 4 mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukalandira jakisoni wa pembrolizumab, itanani dokotala wanu mwachangu. Jekeseni wa Pembrolizumab itha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukalandira jakisoni wa pembrolizumab, komanso kwa miyezi 4 mutapatsidwa mankhwala omaliza.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Jekeseni wa Pembrolizumab ungayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kulumikizana kapena kupweteka kwa msana
• kutupa kwa thupi kapena nkhope
• kusintha kwa khungu
• kutopa kwambiri kapena kusowa mphamvu
• malungo
• nseru
• kusanza

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• matuza kapena khungu losenda; kufiira kwa khungu; zidzolo; kapena kuyabwa
• zilonda zopweteka kapena zilonda mkamwa, mphuno, pakhosi, kapena maliseche
• kupuma movutikira
• kupweteka pachifuwa
• chifuwa chatsopano kapena chowonjezeka
• kutsegula m'mimba
• chimbudzi chakuda, chodikira, chomata, kapena chomwe chili ndi magazi kapena ntchofu
• kupweteka kwambiri m'mimba
• nseru kwambiri ndi kusanza
• kuchuluka kapena kuchepa kwa njala
• ludzu lowonjezeka
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• Kutuluka magazi kapena kuvulala mosavuta
• kugunda kwamtima mwachangu
• kusintha kwa kulemera (kupindula kapena kutaya)
• kutayika tsitsi
• thukuta lowonjezeka
• kumva kuzizira
• kuzama kwa mawu kapena kukodola
• kutupa patsogolo pa khosi (goiter)
• kulira ndi kufooka kwa mapazi, miyendo, manja, ndi mikono
• kupweteka kwambiri kapena kosalekeza, kupweteka kwa minofu
• kufooka kwakukulu kwa minofu
• chizungulire kapena mutu wopepuka
• kukomoka
• kusintha kuchuluka kapena mtundu wa mkodzo
• kupweteka kapena kumva kutentha pamene ukukodza
• magazi mkodzo
• kusintha kwa masomphenya
• kumva kusokonezeka

Jekeseni wa Pembrolizumab ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu limayankhira jakisoni wa pembrolizumab. Nthawi zina, dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi pembrolizumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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