Zovuta

Zamkati

• Musanatenge chisokonezo,
• Riociguat ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Osatenga riociguat ngati muli ndi pakati kapena mukukonzekera kutenga pakati. Riociguat atha kuvulaza mwana wosabadwayo. Ngati mukugonana ndipo mutha kutenga pakati, musayambe kumwa ziphuphu mpaka mayeso apakati atawonetsa kuti mulibe pakati. Muyenera kugwiritsa ntchito njira zodalirika zolerera mukamalandira chithandizo komanso kwa mwezi umodzi mutasiya kugwiritsa ntchito mankhwala osokoneza bongo. Musamagonane mosadziteteza. Lankhulani ndi dokotala wanu za njira zolerera zomwe zili zothandiza zomwe zingakuthandizeni. Itanani dokotala wanu nthawi yomweyo ngati mwaphonya msambo kapena mukuganiza kuti mutha kukhala ndi pakati mukatenga riociguat.

Ngati ndinu kholo kapena wosamalira mkazi yemwe anali asanakule msinkhu, yang'anani mwana wanu pafupipafupi kuti muwone ngati akukula zizindikiro zakusandulika (masamba a m'mawere, tsitsi labanja) ndipo mulole dokotala kuti adziwe zosintha zilizonse. Mwana wanu amatha msinkhu asanayambe kusamba.

Chifukwa cha ziwopsezo zobadwa ndi ziwombankhanga, riociguat imapezeka pokhapokha kudzera mu pulogalamu yapadera yogawa yogawa. Pulogalamu yotchedwa Adempas Risk Evaluation and Mitigation Strategies (REMS) Program yakhazikitsidwa kwa odwala onse azimayi kuti awonetsetse kuti ali ndi pakati mwezi uliwonse akamalandira chithandizo komanso kwa mwezi umodzi atasiya riociguat. amalembetsa ndi Adempas REMS Program. Mukamalembetsa mudzasankha mankhwala apadera ovomerezeka omwe angatumize mankhwala anu. Funsani dokotala wanu ngati muli ndi mafunso okhudza momwe mudzalandire mankhwala anu.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi riociguat ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kuti mupeze Chithandizo cha Mankhwala.

Lankhulani ndi dokotala wanu za kuopsa kotenga riociguat.

Riociguat amagwiritsidwa ntchito pochiza matenda oopsa a m'mapapo mwanga (PAH; kuthamanga kwa magazi m'mitsempha yomwe imanyamula magazi kumapapu). Riociguat imagwiritsidwanso ntchito pochiza matenda oopsa a thromboembolic pulmonary (CTEPH; kuthamanga kwa magazi m'mitsempha yam'mapapo yoyambitsidwa ndimagazi am'magazi omwe amachepetsa kapena kutseka magazi) mwa achikulire omwe sangathe kuchitidwa opaleshoni kapena omwe achitidwa opaleshoni omwe akupitilizabe kukhala ndi magazi m'mapapo kuthamanga pambuyo pa opaleshoni. Riociguat atha kupititsa patsogolo kuthekera kochita masewera olimbitsa thupi mwa anthu omwe ali ndi PAH ndi CTEPH ndipo atha kuchepetsa kuchepa kwa zizindikiritso mwa anthu omwe ali ndi PAH. Riociguat ali mgulu la mankhwala otchedwa soluble guanylate cyclase (sGC) othandizira. Zimagwira ntchito pochepetsa mitsempha yamagazi m'mapapu kuti magazi azitha kuyenda mosavuta.

Riociguat amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya katatu patsiku. Tengani ma riociguat mozungulira nthawi yomweyo (tsiku) tsiku lililonse ndikukhazikitsani miyezo yanu pafupifupi 6 mpaka 8 maola kupatukana. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani riociguat ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati simungathe kumeza piritsi lonse, mutha kuphwanya phale ndikusakaniza zomwe zili mkatimo ndi madzi ochepa kapena chakudya chofewa monga maapulosi. Kumeza chisakanizo mutangosakaniza.

Dokotala wanu akhoza kukuyambitsani pamlingo wochepa wa riociguat ndikuwonjezera pang'onopang'ono, osapitilira kamodzi pamasabata awiri alionse. Dokotala wanu akhoza kuchepetsa mlingo wanu ngati mukukumana ndi zovuta.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge chisokonezo,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi riociguat, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa pamapiritsi a riociguat. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo ngati mukumwa kapena mwangotenga kumene nitrate monga isosorbide dinitrate (Isordil, mu BiDil), isosorbide mononitrate (Monoket), kapena nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, ena) ,; phosphodiesterase inhibitors (PDE-5) monga avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), kapena vardenafil (Levitra, Staxyn); kapena ngati mukumwa dipyridamole (Persantine, mu Aggrenox), kapena theophylline (Theo-24, Theochron, Theolair, ena). Dokotala wanu angakuwuzeni kuti musamamwe riociguat ngati mukumwa imodzi mwa mankhwalawa. Musatenge riociguat mkati mwa maola 24 musanatenge kapena mutatenga sildenafil kapena mkati mwa maola 24 kale kapena maola 48 mutatenga tadalafil.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal ena monga itraconazole (Onmel, Sporanox) ndi ketoconazole (Extina, Nizoral, Xolegel); HIV protease inhibitors kuphatikiza ritonavir (Norvir, ku Kaletra); mankhwala ena okomoka monga carbamazepine (Epitol, Equetro, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); ndi mankhwala othamanga magazi. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• ngati mukumwa maantacid okhala ndi aluminium hydroxide kapena magnesium hydroxide (Maalox, Mylanta, Tums, ena), tengani ola limodzi isanathe kapena ola limodzi mutatenga riociguat.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala ngati muli ndi matenda oopsa a m'mapapo ndi chibayo (PH-IIP; matenda am'mapapo). Dokotala wanu angakuuzeni kuti musatengere riociguat.
• auzeni adotolo ngati mukusuta fodya kapena kuyamba kapena kusiya kusuta mukamalandira mankhwala. Uzaninso dokotala wanu ngati mwangotuluka kumene m'mimba, kusanza, kapena kutuluka thukuta kwambiri komwe kumatha kuyambitsa kusowa kwa madzi m'thupi (kutaya madzi ambiri amthupi); Kutuluka kulikonse m'mapapu anu; ngati mwakhalapo ndi njira yokuletsani kutsokomola magazi; ngati muli ndi kuthamanga kwa magazi, matenda am'mapapo mwa veno-occlusive (kutsekeka kwamitsempha m'mapapu); kapena matenda a mtima, impso, kapena chiwindi.
• Uzani dokotala wanu ngati mukuyamwitsa. Osamayamwa mukamamwa riociguat.
• Muyenera kudziwa kuti riociguat imatha kuyambitsa chizungulire komanso kupepuka mutu. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Ngati mwaphonya kutenga riociguat kwa masiku opitilira 3, itanani dokotala wanu. Dokotala wanu angafune kuyambiranso mankhwala anu pamlingo wotsika.

Riociguat ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kudzimbidwa
• kutentha pa chifuwa
• kukhumudwa m'mimba
• nseru
• kusanza
• kutsegula m'mimba
• kutupa kwa manja anu, miyendo, mapazi, ndi akakolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kukhosomola pinki, chifuwa chozizira kapena magazi
• kukomoka
• kupweteka pachifuwa
• kupuma movutikira

Riociguat ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu. Dokotala wanu amayang'ana kuthamanga kwa magazi kwanu nthawi zonse mukamalandira chithandizo cha riociguat.

Musalole kuti aliyense azimwa mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Adempas^®