Cobimetinib

Zamkati

• Musanatenge cobimetinib,
• Cobimetinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Cobimetinib imagwiritsidwa ntchito limodzi ndi vemurafenib (Zelboraf) kuchiza mitundu ina ya khansa ya khansa (mtundu wa khansa yapakhungu) yomwe singathe kuchiritsidwa ndi opaleshoni kapena yomwe yafalikira mbali zina za thupi. Cobimetinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Cobimetinib imabwera ngati piritsi kuti itenge pakamwa kapena wopanda chakudya. Nthawi zambiri amatengedwa kamodzi tsiku lililonse kwa masiku 21 oyambira masiku 28. Tengani cobimetinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani cobimetinib ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati musanza mutatenga cobimetinib musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa kuchuluka kwa cobimetinib kapena kuimitsa kwanthawi zonse kapena kwakanthawi. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha cobimetinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge cobimetinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la cobimetinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a cobimetinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: anticoagulants (magazi ochepetsa magazi) monga warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Epitol, Tegretol), ciprofloxacin (Cipro), clarithromycin (Biaxin, ku Prevpac), efavirenz (Sustiva, inustustin, Atripla), erythromycin (EES, E-Mycin, Erythrocin), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral), nefazodone, nelfinavir (Viracept), phenytoin Rifin (Rifadin, Rimactane, ku Rifamate, ku Rifater), ndi ritonavir (Norvir, ku Kaletra, ku Viekira Pak). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi cobimetinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort. Musatenge St. John's Wort mukatenga cobimetinib.
• Uzani dokotala wanu ngati mwakhalapo kapena munakhalapo ndi khungu lina kupatula khansa ya pakhungu; kutaya magazi; mavuto a masomphenya; vuto lililonse lomwe limakhudza minofu yanu; kapena matenda a mtima kapena chiwindi.
• Muyenera kudziwa kuti cobimetinib imachepetsa kubereka mwa abambo ndi amai. Komabe, musaganize kuti inu kapena mnzanuyo simungakhale ndi pakati. Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Gwiritsani ntchito njira yodalirika yolerera popewa kutenga mimba mukamachiza komanso kwa milungu iwiri mutasiya kumwa cobimetinib. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga cobimetinib, itanani dokotala wanu mwachangu. Cobimetinib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa cobimetinib komanso kwa masabata awiri mutatha kumwa.
• konzani kupewa kupezeka kwa kuwala kwadzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zodzitetezera, magalasi ofunikira, mankhwala am'milomo ndi zoteteza ku dzuwa (SPF 30 kapena kupitilira apo). Cobimetinib imatha kupangitsa khungu lanu kumvetsetsa kuwala kwa dzuwa.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Cobimetinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• Zilonda zam'kamwa
• kutayika tsitsi
• kutsegula m'mimba

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• Ziphuphu zomwe zimaphimba gawo lalikulu la thupi lanu, zotupa, kapena khungu losenda
• kusintha kwa khungu
• chida chatsopano
• zilonda pakhungu kapena chifuwa chofiira chomwe chimatuluka magazi kapena sichichira
• kusintha kukula kapena mtundu wa mole
• kutuluka mwachilendo kapena kuphwanya
• kukhala kapena chimbudzi chakuda
• magazi mkodzo
• kutuluka kwachilendo kwachilendo
• mutu
• chizungulire
• kugunda kwamtima msanga, kosasinthasintha, kapena kwamphamvu
• kukhosomola kapena kupuma
• kupuma movutikira
• kutupa kwa nkhope, mikono, miyendo, akakolo, kapena mapazi
• kutopa
• kupweteka kwa minofu kapena kufooka
• kusintha masomphenya, kuphatikiza kuwona ma halos (mawonekedwe osalongosoka mozungulira zinthu)
• chikasu cha khungu kapena maso
• mkodzo wamtundu wakuda (tiyi)
• kupweteka kumtunda chakumanja kwam'mimba
• nseru
• kusanza
• kusowa chilakolako

Cobimetinib itha kuonjezera chiwopsezo kuti udzadwala khansa yatsopano yapakhungu. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Cobimetinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu lingayankhire panthawi ndi pambuyo pake. Dokotala wanu amayang'ana khungu lanu ngati lingasinthe, miyezi iwiri iliyonse mukamalandira chithandizo, komanso kwa miyezi 6 mutalandira chithandizo.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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