Tezacaftor ndi Ivacaftor

Zamkati

• Musanatenge tezacaftor ndi ivacaftor,
• Tezacaftor ndi ivacaftor zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, siyani kumwa tezacaftor ndi ivacaftor ndipo itanani dokotala nthawi yomweyo:

Kuphatikiza kwa tezacaftor ndi ivacaftor kumagwiritsidwa ntchito limodzi ndi ivacaftor pochizira mitundu ina ya cystic fibrosis (matenda obadwa nawo omwe amayambitsa mavuto kupuma, chimbudzi, ndi kubereka) mwa akulu ndi ana azaka 6 kapena kupitilira apo. Tezacaftor ndi ivacaftor ziyenera kugwiritsidwa ntchito mwa anthu omwe ali ndi chibadwa china. Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti akuthandizeni kusankha ngati mankhwalawa ndi oyenera kwa inu. Tezacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) okonza. Ivacaftor ali mgulu la mankhwala otchedwa cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Mankhwala onsewa amagwira ntchito pokonzanso magwiridwe antchito a thupi m'thupi kuti muchepetse kuchuluka kwa ntchofu m'mapapu ndikusintha zina za cystic fibrosis.

Kuphatikiza kwa tezacaftor ndi ivacaftor ndi ivacaftor kumabwera ngati mapiritsi oti atenge pakamwa. Mankhwalawa amabwera phukusi lokhala ndi milungu inayi ya mankhwala. Mlingo uliwonse watsiku ndi tsiku uli ndi mapiritsi osiyanasiyana: piritsi limodzi ndi kuphatikiza tezacaftor ndi ivacaftor ndipo piritsi linalo ndi ivacaftor. Tengani tezacaftor ndi ivacaftor (piritsi 1 wachikaso) m'mawa uliwonse m'mawa ndi chakudya chamafuta ndi ivacaftor (piritsi limodzi la buluu) madzulo aliwonse ndi chakudya chamafuta, patadutsa maola 12. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani mankhwalawa monga momwe adanenera. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Tengani kuphatikiza tezacaftor ndi ivacaftor ndi ivacaftor ndi zakudya zamafuta monga mazira, batala, mtedza, chiponde, pizza tchizi, ndi mkaka wonse (monga mkaka wonse, tchizi, ndi yogurt). Lankhulani ndi dokotala wanu za zakudya zina zamafuta zoti mudye ndi mankhwalawa.

Kuphatikiza kwa tezacaftor ndi ivacaftor limodzi ndi ivacaftor kumayang'anira cystic fibrosis, koma sikuchiritsa. Pitirizani kumwa mankhwalawa ngakhale mutakhala bwino. Osasiya kumwa mankhwalawa osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge tezacaftor ndi ivacaftor,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la tezacaftor, ivacaftor, mankhwala ena aliwonse, kapena chilichonse mwazosakaniza tezacaftor ndi ivacaftor ndi mapiritsi a ivacaftor. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maantibayotiki ena monga clarithromycin (Biaxin, mu PrevPac), erythromycin (EES, E-Mycin, Ery-Tab, Erythrocin), ndi telithromycin (Ketek); maantifungal ena monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), ndi voriconazole (Vfend); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Wothandizira, Zortress); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, ku Rifamate, ku Rifater, Rimactane); mankhwala (Rapamune); kapena tacrolimus (Astagraf, Prograf). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi tezacaftor ndi ivacaftor, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. Dokotala wanu mwina angakuuzeni kuti musatenge wort ya St. John mukamamwa tezacaftor ndi ivacaftor limodzi ndi ivacaftor.
• uzani dokotala wanu ngati mwakhalapo ndi matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga tezacaftor ndi ivacaftor limodzi ndi ivacaftor, itanani dokotala wanu.
• Muyenera kudziwa kuti mankhwalawa akhoza kukupangitsani kugona. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Musadye zipatso zamphesa kapena malalanje a Seville kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mukukumbukira kuchuluka kwa piritsi lililonse pasanathe maola 6 kuchokera nthawi yomwe munayenera kumwa, tengani mlingo womwe umasowa nthawi yomweyo ndi chakudya chokhala ndi mafuta. Komabe, ngati maola opitilira 6 adutsa kuchokera nthawi yoti mutenge piritsi lililonse, tulukani mulingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Tezacaftor ndi ivacaftor zitha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• Kuchuluka kwa mphuno
• chizungulire

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, siyani kumwa tezacaftor ndi ivacaftor ndipo itanani dokotala nthawi yomweyo:

• chikasu cha khungu kapena maso
• kusowa chilakolako
• nseru
• kusanza
• mipando yotumbululuka
• kupweteka m'mimba
• mkodzo wakuda

Tezacaftor ndi ivacaftor zimatha kuyambitsa ng'ala (mitambo yamaso ya diso yomwe imatha kuyambitsa mavuto owonera) mwa ana ndi achinyamata. Ana ndi achinyamata omwe amatenga tezacaftor ndi ivacaftor ayenera kukaonana ndi dokotala wamaso asanafike komanso akamamwa mankhwala. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopatsa tezacaftor ndi ivacaftor kwa mwana wanu.

Tezacaftor ndi ivacaftor zimatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzalamula kuti ayesedwe diso (kwa ana ndi achinyamata) ndi mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira tezacaftor ndi ivacaftor.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Symdeko^®