Jekeseni wa Idecabtagene Vicleucel

Zamkati

• Asanalandire jekeseni wa valkucel wa idecabtagene,
• Idecabtagene vicleucel imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Idecabtagene vicleucel jekeseni imatha kuyambitsa matenda oopsa kapena owopsa omwe amatchedwa cytokine release syndrome (CRS). Dokotala kapena namwino adzakuyang'anirani mosamala mukamalowetsedwa komanso kwa milungu ingapo pambuyo pake. Uzani dokotala wanu ngati muli ndi vuto lotupa kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Mupatsidwa mankhwala kwa mphindi 30 mpaka 60 musanalowetsedwe kuti muthane ndi vuto la idecabtagene vicleucel. Ngati mukumane ndi zizindikiro zotsatirazi mukamudyetsedwa, uzani dokotala nthawi yomweyo: malungo, kuzizira, kugunda kwamtima kapena kusakhazikika, kupweteka kwa minofu, kugwedezeka, kutsegula m'mimba, kutopa, kufooka, kupuma movutikira, kupuma movutikira, chifuwa, chisokonezo, nseru, kusanza, chizungulire, kapena mutu wopepuka.

Idecabtagene vicleucel jekeseni imatha kuyambitsa machitidwe owopsa kapena owopsa amoyo. Izi zimatha kuchitika atalandira chithandizo ndi idecabtagene vicleucel. Uzani dokotala wanu ngati mudagwidwa, kudwala sitiroko, kapena kukumbukira kukumbukira. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka mutu, chizungulire, kuvutika kugona kapena kugona, kusakhazikika, kusokonezeka, nkhawa, kugwedezeka kosalamulirika kwa gawo lina la thupi, kutaya chikumbumtima, kubvutika, kugwidwa, kutaya kusamala, kapena kuvutika kuyankhula.

Jekeseni wa valkucel wa Idecabtagene ungayambitse kuchepa kwakukulu kwamitundu ina yamagazi m'magazi anu. Izi zitha kuyambitsa zizindikilo zina ndipo zitha kuonjezera chiopsezo kuti mutenga matenda akulu kapena magazi. Ngati mukumane ndi zizindikiro zotsatirazi mukalandira chithandizo, uzani dokotala nthawi yomweyo: malungo, kumva kutopa, kapena kuvulala kapena kutuluka magazi.

Idecabtagene vicleucel imapezeka pokhapokha pulogalamu yapadera yogawa yogawa. Pulogalamu ya Abecma REMS (Risk Evaluation and Mitigation Strategy) yakhazikitsidwa chifukwa cha kuwopsa kwa CRS, dongosolo lamanjenje, komanso mavuto am'magazi. Mutha kulandila mankhwala kuchokera kwa adotolo ndi malo azaumoyo omwe amatenga nawo mbali pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza pulogalamuyi.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi idecabtagene vicleucel ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Idecabtagene vicleucel jekeseni amagwiritsidwa ntchito pochiza mitundu ina ya myeloma (mtundu wa khansa ya m'mafupa) mwa akulu omwe khansa yabwerera kapena yosamvera mankhwala ena anayi. Idecabtagene vicleucel jekeseni ili m'kalasi la mankhwala otchedwa autologous cellular immunotherapy, mtundu wa mankhwala omwe amakonzedwa pogwiritsa ntchito maselo am'magazi a wodwalayo. Zimagwira ntchito poyambitsa chitetezo cha mthupi (gulu la maselo, zotupa, ndi ziwalo zomwe zimateteza thupi kuti lisagwidwe ndi mabakiteriya, mavairasi, ma cell a khansa, ndi zinthu zina zomwe zimayambitsa matenda) kulimbana ndi ma cell a khansa.

Idecabtagene vicleucel jakisoni amabwera ngati kuyimitsidwa (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino muofesi ya udokotala kapena malo olowerera. Nthawi zambiri amaperekedwa kwakanthawi kokwanira mphindi 30 ngati gawo limodzi. Musanalandire mankhwala anu a idecabtagene vicleucel, dokotala kapena namwino wanu adzakupatsani mankhwala ena a chemotherapy kuti akonzekeretse thupi lanu kuti likhale ndi idecabtagene vicleucel.

Musanaperekedwe jakisoni wanu wa idecabtagene vicleucel, mayeso am'magazi anu oyera azitengedwa kumalo osungira maselo pogwiritsa ntchito leukapheresis (njira yomwe imachotsa maselo oyera amthupi). Chifukwa mankhwalawa amapangidwa kuchokera m'maselo anu, ayenera kuperekedwa kwa inu nokha. Ndikofunika kukhala munthawi yake komanso kuti musaphonye nthawi yomwe mumakonzekera kusonkhanitsidwa kwama cell kapena kulandira mankhwala anu. Muyenera kukonzekera kukhala mkati mwa maola awiri kuchokera komwe mudalandira mankhwala anu a idecabtagene vicleucel kwa milungu yosachepera 4 mutamwa mankhwala. Wothandizira zaumoyo wanu adzawona ngati chithandizo chanu chikugwira ntchito ndikukuyang'anirani zotsatira zoyipa zilizonse. Lankhulani ndi dokotala wanu za momwe mungakonzekerere leukapheresis ndi zomwe muyenera kuyembekezera mukamachita izi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa valkucel wa idecabtagene,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la idecabtagene vicleucel, mankhwala ena aliwonse, dimethyl sulfoxide (DMSO), kapena china chilichonse mu jakisoni wa idecabtagene vicleucel. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma steroids monga dexamethasone, methylprednisolone (Medrol), prednisolone, ndi prednisone (Rayos). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala ngati mwakhalapo ndi zotulukapo zamankhwala am'mbuyomu monga kupuma kapena kugunda kwamtima mosasinthasintha. Komanso, uzani dokotala wanu ngati mwakhalapo ndi matenda am'mapapo, impso, mtima, kapena chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kuyezetsa mimba musanayambe idecabtagene vicleucel. Mukakhala ndi pakati mukalandira idecabtagene vicleucel, itanani dokotala wanu mwachangu. Idecabtagene vicleucel itha kuvulaza mwana wosabadwayo.
• Muyenera kudziwa kuti jekeseni wa idecabtagene vicleucel imatha kukupangitsani kugona komanso kuyambitsa chisokonezo, kufooka, chizungulire, khunyu, komanso mavuto amgwirizano. Osayendetsa galimoto kapena kugwiritsa ntchito makina kwa masabata osachepera 8 mutatha kumwa mankhwala a idecabtagene vicleucel.
• musapereke magazi, ziwalo, ziwalo, kapena maselo kuti mumupatse mukalandira jekeseni wanu wa idecabtagene vicleucel.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera musanalankhule ndi dokotala kwa milungu isanu ndi umodzi musanayambe chemotherapy, panthawi yomwe mumalandira mankhwala opatsirana pogonana, mpaka dokotala wanu atakuwuzani kuti chitetezo chamthupi chanu chayamba.

Ngati mwaphonya nthawi yosankhidwa kuti mudzatenge maselo anu, muyenera kuyimbira dokotala wanu ndi malo osonkhanitsira nthawi yomweyo. Ngati mwaphonya nthawi yomwe mwasankhidwa kuti mulandire muyeso wa idecabtagene vicleucel, muyenera kuyimbira dokotala nthawi yomweyo.

Idecabtagene vicleucel imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kuonda
• kusowa chilakolako
• kupweteka pakamwa
• pakamwa pouma
• maso owuma

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• amachepetsa kukodza pafupipafupi kapena kuchuluka
• kutupa kwa maso, nkhope, milomo, lilime, mmero, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• zovuta kumeza
• zidzolo
• ming'oma
• kuyabwa

Idecabtagene vicleucel imatha kukulitsa chiopsezo chokhala ndi khansa ina. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Idecabtagene vicleucel ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani nthawi yonse yokumana ndi dokotala wanu, malo osungira maselo, ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jekeseni wa idecabtagene vicleucel.

Musanapite kukayezetsa labotale, auzeni adotolo ndi ogwira nawo ntchito kuti mukulandira idecabtagene vicleucel. Mankhwalawa angakhudze zotsatira za mayeso ena a labotale.

Funsani wamankhwala wanu mafunso aliwonse omwe mungakhale nawo pankhani ya jekeseni wa vocucuc ya videucel.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Abecma^®