Mayeso a ACTH

Zamkati

• Momwe mayeso a ACTH amachitikira
• Chifukwa chomwe mayeso a ACTH amachitikira
• Zotsatira zamayeso a ACTH zitha kutanthauza chiyani
• Kuopsa kwa mayeso a ACTH
• Zomwe muyenera kuyembekezera mayeso a ACTH

Kuyesa kwa ACTH ndi chiyani?

Hormone ya Adrenocorticotropic (ACTH) ndi mahomoni opangidwa mkati, kapena kutsogolo, kwamatenda am'mutu muubongo. Ntchito ya ACTH ndikuwongolera magawo a steroid hormone cortisol, yomwe imatuluka mu adrenal gland.

ACTH imadziwikanso kuti:

• timadzi adrenocorticotropic
• seramu adrenocorticotropic hormone
• kwambiri-tcheru ACTH
• corticotropin
• cosyntropin, yomwe ndi mankhwala osokoneza bongo a ACTH

Kuyezetsa kwa ACTH kumayesa kuchuluka kwa ACTH ndi cortisol m'magazi ndikuthandizira dokotala kudziwa matenda omwe amakhudzana ndi cortisol yochulukirapo kapena yaying'ono mthupi. Zomwe zingayambitse matendawa ndi awa:

• kulephera kwa pituitary kapena adrenal
• chotupa cha pituitary
• chotupa cha adrenal
• chotupa m'mapapo

Momwe mayeso a ACTH amachitikira

Dokotala wanu akhoza kukulangizani kuti musamwe mankhwala aliwonse a steroid musanayesedwe. Izi zingakhudze kulondola kwa zotsatira.

Kuyesaku kumachitika koyamba m'mawa. Mlingo wa ACTH umakhala wapamwamba kwambiri mukangodzuka kumene. Dokotala wanu angakonzekeretseni mayeso m'mawa kwambiri.

Miyezo ya ACTH imayesedwa pogwiritsa ntchito magazi. Kuyeza magazi kumatengedwa pokoka magazi mumitsempha, nthawi zambiri kuchokera mkatikati mwa chigongono. Kupereka sampuli yamagazi kumaphatikizapo izi:

1. Wothandizira zaumoyo amayamba kutsuka malowa ndi mankhwala opha tizilombo toyambitsa matenda.
2. Kenako, adzakulunga bandi yotanuka m'manja mwako. Izi zimapangitsa kuti mtsempha utuluke ndi magazi.
3. Adzakulowetsani mofatsa singano ya singano mumitsempha yanu ndikusonkhanitsa magazi anu mu chubu cha syringe.
4. Chubu ikadzaza, singano imachotsedwa. Chotchinga chotchinga chimachotsedwa, ndipo malo obowolapo amafundidwa ndi yopyapyala wosaletsa magazi.

Chifukwa chomwe mayeso a ACTH amachitikira

Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kwa ACTH ngati muli ndi zizindikiro za cortisol yochulukirapo kapena yocheperako. Zizindikirozi zimatha kusiyanasiyana pakati pa munthu ndi munthu ndipo nthawi zambiri zimakhala chizindikiro cha mavuto ena azaumoyo.

Ngati muli ndi mulingo wokwanira wa cortisol, mutha kukhala ndi:

• kunenepa kwambiri
• nkhope yozungulira
• wosalimba, khungu loonda
• mizere yofiirira pamimba
• minofu yofooka
• ziphuphu
• kuchuluka kwa ubweya wa thupi
• kuthamanga kwa magazi
• potaziyamu otsika
• mulingo wapamwamba wa bicarbonate
• kuchuluka kwa shuga
• matenda ashuga

Zizindikiro za cortisol yotsika ndi monga:

• minofu yofooka
• kutopa
• kuonda
• kuchuluka kwa khungu khungu kumadera omwe sanafike padzuwa
• kusowa chilakolako
• kuthamanga kwa magazi
• shuga wambiri wamagazi
• magulu otsika a sodium
• misinkhu potaziyamu
• milingo yambiri ya calcium

Zotsatira zamayeso a ACTH zitha kutanthauza chiyani

Makhalidwe abwinobwino a ACTH ndi ma picogramu 9 mpaka 52 pa mamililita. Mitengo yofanana imatha kusiyanasiyana pang'ono kutengera labotale. Dokotala wanu adzakufotokozerani zotsatira za mayeso anu.

Mulingo wapamwamba wa ACTH ukhoza kukhala chizindikiro cha:

• Matenda a Addison
• adrenal hyperplasia
• Matenda a Cushing
• chotupa cha ectopic chomwe chimapanga ACTH
• adrenoleukodystrophy, zomwe ndizosowa kwambiri
• Matenda a Nelson, omwe ndi osowa kwambiri

Mulingo wotsika wa ACTH ukhoza kukhala chizindikiro cha:

• chotupa cha adrenal
• Matenda a Cushing's exogenous
• hypopituitarism

Kutenga mankhwala a steroid kumatha kuyambitsa ACTH, chifukwa chake onetsetsani kuti muwauze adotolo ngati muli ndi ma steroids.

Kuopsa kwa mayeso a ACTH

Mayeso amwazi nthawi zambiri amalekerera. Anthu ena ali ndi mitsempha yaying'ono kapena yayikulu, yomwe imatha kupangitsa kuti kuyezetsa magazi kukhale kovuta. Komabe, zoopsa zomwe zimayesedwa ndimagazi ngati mayeso a ACTH ndizochepa.

Zowopsa zodziwika zokoka magazi ndi monga:

• kutaya magazi kwambiri
• mutu wopepuka kapena kukomoka
• hematoma, kapena kuphatikiza magazi pansi pakhungu
• matenda pamalopo

Zomwe muyenera kuyembekezera mayeso a ACTH

Kuzindikira matenda a ACTH kumatha kukhala kovuta kwambiri. Dokotala wanu angafunikire kuyitanitsa mayeso ambiri a labotale ndikuwunika thupi asanadziwe.

Kwa zotupa zobisa za ACTH, nthawi zambiri opaleshoni imawonetsedwa. Nthawi zina, mankhwala monga cabergoline amatha kugwiritsidwa ntchito poyerekeza milingo ya cortisol. Hypercortisolism chifukwa cha zotupa za adrenal nthawi zambiri zimafunikanso kuchitidwa opaleshoni.