Devil's Claw: Ubwino, Zotsatira zoyipa ndi Mlingo

Zamkati

• Kodi Mdyerekezi Ndi Chiyani?
• Angachepetse Kutupa
• Itha Kukweza Osteoarthritis
• Zitha Kuchepetsa Zizindikiro za Gout
• Athandize Kupweteka Kumbuyo
• Angalimbikitse Kuchepetsa Kunenepa
• Zotsatira zoyipa ndi kuyanjana
• Mlingo Wotchulidwa
• Mfundo Yofunika Kwambiri

Chiwombankhanga cha Devil, chotchedwa sayansi Harpagophytum amatha, ndi chomera ku South Africa. Ili ndi dzina loopsa chifukwa cha zipatso zake, zomwe zimabala ziwonetsero zingapo zing'onozing'ono.

Pachikhalidwe, mizu ya chomerachi imagwiritsidwa ntchito kuchiza matenda osiyanasiyana, monga malungo, kupweteka, nyamakazi, ndi kudzimbidwa (1).

Nkhaniyi ikufotokoza zabwino zomwe zingachitike chifukwa cha claw wa satana.

Kodi Mdyerekezi Ndi Chiyani?

Chiwombankhanga cha Devil ndi chomera chamaluwa cha banja la sesame. Muzu wake umanyamula mitundu ingapo yazomera ndipo imagwiritsidwa ntchito ngati chowonjezera cha zitsamba.

Makamaka, claw wa satana amakhala ndi iridoid glycosides, gulu la mankhwala omwe awonetsa zotsutsana ndi zotupa ().

Kafukufuku wina koma osati onse akuwonetsa kuti iridoid glycosides itha kukhala ndi zotsatira za antioxidant. Izi zikutanthauza kuti chomeracho chimatha kuthana ndi zovuta zowononga maselo amolekyulu osakhazikika otchedwa ma radicals aulere (3,,).

Pazifukwa izi, zowonjezera zowonjezera za satana zimaphunziridwa ngati njira yothetsera zovuta zokhudzana ndi zotupa, monga nyamakazi ndi gout. Kuphatikiza apo, akuti akufuna kuchepetsa kupweteka ndipo atha kuthandizira kuchepa thupi.

Mutha kupeza zowonjezeretsa za satana zam'matumbo monga zolembera ndi makapisozi, kapena kukhala ufa wabwino. Amagwiritsidwanso ntchito ngati chophatikizira mu tiyi wazitsamba osiyanasiyana.

Chiwombankhanga cha Devil ndi chowonjezera cha zitsamba chomwe chimagwiritsidwa ntchito makamaka ngati njira ina yothandizira nyamakazi ndi kupweteka. Zimabwera m'njira zosiyanasiyana, kuphatikiza zowonjezera, makapisozi, ufa ndi tiyi wazitsamba.

Angachepetse Kutupa

Kutupa ndiko kuyankha kwachilengedwe kwa thupi lanu kuvulala ndi matenda. Mukadula chala chanu, bwezani bondo lanu kapena kugwa ndi chimfine, thupi lanu limayankha poyambitsa chitetezo chamthupi ().

Ngakhale kutupa kwina ndikofunikira kuteteza thupi lanu kuti lisavulazidwe, kutupa kosatha kumatha kuwononga thanzi. M'malo mwake, kafukufuku wopitilira adalumikiza kutupa kwakanthawi ndi matenda amtima, matenda ashuga komanso zovuta zamaubongo (,,).

Zachidziwikire, palinso zinthu zomwe zimadziwika ndi kutupa, monga matenda am'matumbo (IBD), nyamakazi ndi gout (, 11,).

Chiwombankhanga cha Devil's chafunsidwa ngati njira yothetsera mikhalidwe yotupa chifukwa ili ndi mankhwala omwe amatchedwa iridoid glycosides, makamaka harpagoside. Poyesa-chubu ndi maphunziro a nyama, harpagoside yathetsa mayankho otupa ().

Mwachitsanzo, kafukufuku wama mbewa adawonetsa kuti harpagoside idapondereza kwambiri machitidwe a cytokines, omwe ndi mamolekyulu mthupi lanu omwe amadziwika kuti amalimbikitsa kutupa ().

Ngakhale claw wa satana sanaphunzire kwambiri mwa anthu, umboni woyambirira ukusonyeza kuti ikhoza kukhala njira ina yothanirana ndi zotupa.

Chiwombankhanga cha Mdyerekezi chimakhala ndi mankhwala omwe amatchedwa iridoid glycosides, omwe awonetsedwa kuti amathetsa kutupa m'mayeso oyeserera ndi maphunziro a nyama.

Itha Kukweza Osteoarthritis

Osteoarthritis ndimatenda ofala kwambiri a nyamakazi, omwe amakhudza akulu opitilira 30 miliyoni ku US ().

Zimachitika pamene chophimba choteteza kumapeto kwa mafupa anu olumikizana - wotchedwa karotila - chimatha. Izi zimapangitsa mafupa kuphatikana palimodzi, zomwe zimapangitsa kutupa, kuuma ndi kupweteka (16).

Kafukufuku wapamwamba kwambiri amafunikira, koma kafukufuku wapano akuwonetsa kuti claw wa satana atha kukhala othandiza pakuchepetsa kupweteka komwe kumakhudzana ndi nyamakazi.

Mwachitsanzo, kafukufuku wina wazachipatala wokhudza anthu 122 omwe ali ndi nyamakazi ya m'maondo ndi mchiuno adati 2,610 mg wa claw wa satana tsiku lililonse atha kukhala othandiza pakuchepetsa kupweteka kwa nyamakazi ngati diacerein, mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza matendawa ().

Mofananamo, kafukufuku wa miyezi iwiri mwa anthu 42 omwe ali ndi matenda amitsempha osachiritsika adapeza kuti kuwonjezera tsiku lililonse ndi claw wa satana kuphatikiza turmeric ndi bromelain, zomwe zimaganiziridwa kuti zimakhala ndi zotsutsana ndi zotupa komanso, zimachepetsa kupweteka kwapakati pa 46% ().

Kafukufuku akuwonetsa kuti claw wa satana atha kuthandiza kuthana ndi kupweteka kwamalumikizidwe komwe kumakhudzana ndi osteoarthritis ndipo kumatha kukhala kotheka ngati kupweteka kwa diacerein.

Zitha Kuchepetsa Zizindikiro za Gout

Gout ndi mtundu wina wofala wa nyamakazi, wodziwika ndi kutupa kowawa komanso kufiira m'malo olumikizirana mafupa, nthawi zambiri kumapazi, akakolo ndi maondo ().

Zimayambitsidwa ndi kuchuluka kwa uric acid m'magazi, omwe amapangidwa pomwe purines - mankhwala omwe amapezeka muzakudya zina - amawonongeka ().

Mankhwala, monga nonsteroidal anti-inflammatory drugs (NSAIDs), amagwiritsidwa ntchito pochepetsa kupweteka ndi kutupa komwe kumayambitsidwa ndi gout.

Chifukwa cha zotsatira zake zotsutsana ndi zotupa komanso kuthekera kochepetsa ululu, claw wa satana waperekedwa ngati njira yothandizira ena omwe ali ndi gout (20).

Komanso, ofufuza ena amati akhoza kuchepetsa uric acid, ngakhale umboni wa sayansi ndi wocheperako. Mu kafukufuku wina, kuchuluka kwakukulu kwa claw wa satana kunachepetsa uric acid mu mbewa (21, 22).

Ngakhale kuyesa-kuyesa ndi kafukufuku wazinyama kumawonetsa kuti claw wa satana atha kupondereza kutupa, maphunziro azachipatala othandizira kuthandizira kwake kwa gout makamaka sakupezeka.

Kutengera kafukufuku wocheperako, claw wa satana wafotokozedwa kuti athetse vuto la gout chifukwa chotsutsana ndi zotupa komanso kuthekera kochepetsa uric acid.

Athandize Kupweteka Kumbuyo

Kupweteka kwakumbuyo kumakhala cholemetsa kwa ambiri. M'malo mwake, akuti pafupifupi 80% ya achikulire amakumanapo nawo nthawi ina (23).

Pamodzi ndi zotsatira zotsutsana ndi zotupa, claw wa satana amawonetsa kuthekera ngati mankhwala ochepetsa ululu, makamaka kupweteka kwakumbuyo. Ochita kafukufuku amati izi ndi harpagoside, yomwe imagwira ntchito mwazomera zam'madzi mwa satana.

Pakafukufuku wina, kuchotsa kwa harpagoside kumawoneka kotheka kugwira ntchito ngati mankhwala osagwiritsa ntchito zotupa (NSAID) otchedwa Vioxx. Pambuyo pa masabata a 6, opweteka m'munsi mwa otenga nawo gawo adachepetsedwa ndi 23% ndi harpagoside ndi 26% ndi NSAID ().

Komanso, maphunziro awiri azachipatala adapeza kuti magalamu a 50-100 a harpagoside patsiku anali othandiza kwambiri pakuchepetsa kupweteka kwakumbuyo poyerekeza ndi chithandizo chilichonse, koma maphunziro ena amafunikira kuti atsimikizire izi (,).

Chiwombankhanga cha Mdyerekezi chikuwonetsa kuthekera ngati mankhwala ochepetsa ululu, makamaka kupweteka kwakumbuyo. Ochita kafukufuku amati izi zimapangidwa ndi chomera cha satana chotchedwa harpagoside. Komabe, kafukufuku wambiri amafunika kutsimikizira izi.

Angalimbikitse Kuchepetsa Kunenepa

Kuphatikiza pakuchepetsa kupweteka ndi kutupa, claw wa satana atha kupondereza chilakolako polumikizana ndi hormone ya njala ghrelin ().

Ghrelin amabisidwa m'mimba mwanu. Imodzi mwa ntchito zake zoyambirira ndikuwonetsa ubongo wanu kuti ndi nthawi yoti mudye powonjezera chilakolako ().

Pakafukufuku wama mbewa, nyama zomwe zidalandira ufa wa mdierekezi wa satana zidadya chakudya chochepa kwambiri m'maola anayi otsatirawa kuposa omwe amathandizidwa ndi placebo ().

Ngakhale zotsatirazi ndizosangalatsa, zochepetsera izi sizinaphunzire mwa anthu. Chifukwa chake, umboni wokwanira wothandizira kugwiritsa ntchito claw wa satana pakuchepetsa thupi sikupezeka pakadali pano.

Chiwombankhanga cha Devil chikhoza kupondereza zochita za ghrelin, mahomoni m'thupi lanu omwe amachulukitsa njala ndikuwonetsa ubongo wanu kuti ndi nthawi yoti mudye. Komabe, kafukufuku wokhudzana ndi anthu pankhaniyi sakupezeka.

Zotsatira zoyipa ndi kuyanjana

Chiwombankhanga cha Mdyerekezi chikuwoneka ngati chotetezeka mukamamwa mankhwala opitirira 2,610 mg tsiku lililonse, ngakhale zotsatira zazitali sizinafufuzidwe (29).

Zotsatira zoyipa zomwe zimanenedwa ndizochepa, zomwe zimafala kwambiri kutsekula m'mimba. Zotsatira zoyipa zimaphatikizaponso zovuta zina, kupweteka mutu ndi kutsokomola ().

Komabe, zikhalidwe zina zitha kukuyikani pachiwopsezo chachikulu pakuchitapo kanthu koopsa (31):

• Matenda amtima: Kafukufuku wasonyeza kuti claw wa satana amatha kukhudza kugunda kwa mtima, kugunda kwa mtima komanso kuthamanga kwa magazi.
• Matenda ashuga: Claw wa Devil amatha kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera zotsatira za mankhwala ashuga.
• Miyala yamiyala: Kugwiritsa ntchito claw wa satana kumatha kukulitsa mapangidwe a bile ndikupangitsa mavuto kukhala ovuta kwa iwo omwe ali ndi ndulu.
• Zilonda zam'mimba: Kupanga asidi m'mimba kumatha kuchuluka ndikugwiritsa ntchito claw wa satana, komwe kumatha kukulitsa zilonda zam'mimba.

Mankhwala wamba amathanso kulumikizana ndi claw wa satana, kuphatikiza mankhwala osagwiritsa ntchito anti-inflammatory (NSAIDs), ochepetsa magazi komanso ochepetsa asidi m'mimba (31):

• NSAIDs: Chiwombankhanga cha Devil chingachedwetse kuyamwa kwa ma NSAID otchuka, monga Motrin, Celebrex, Feldene ndi Voltaren.
• Opaka magazi: Claw wa Devil atha kupititsa patsogolo zotsatira za Coumadin (yemwenso amadziwika kuti warfarin), zomwe zingayambitse magazi ochulukirapo komanso kuvulaza.
• Kuchepetsa asidi am'mimba: Chiwombankhanga cha Devil chingachepetse zotsatira za kuchepetsa asidi m'mimba, monga Pepcid, Prilosec ndi Prevacid.

Ili si mndandanda wokhudzana ndi mankhwala. Kuti mukhale otetezeka, nthawi zonse kambiranani za momwe mumagwiritsira ntchito zowonjezera zowonjezera ndi dokotala wanu.

Kwa anthu ambiri, chiopsezo cha zotsatirapo za claw wa satana nchochepa. Komabe, zingakhale zosayenera kwa anthu omwe ali ndi matenda enaake komanso omwe amamwa mankhwala ena.

Mlingo Wotchulidwa

Chiwombankhanga cha Mdyerekezi chingapezeke ngati chotulutsa chokhazikika, kapisozi, piritsi kapena ufa. Amagwiritsidwanso ntchito ngati chophatikizira mu tiyi wazitsamba.

Posankha chowonjezera, yang'anani kuchuluka kwa harpagoside, chinthu chogwira ntchito mu uzimu wa satana.

Mlingo wa 600-2,610 mg wa claw wa satana tsiku lililonse wagwiritsidwa ntchito m'maphunziro a osteoarthritis ndi kupweteka kwa msana. Kutengera ndende yotulutsa, izi zimafanana ndi 50-100 mg ya harpagoside patsiku (,,,).

Kuphatikiza apo, chowonjezera chotchedwa AINAT chagwiritsidwa ntchito ngati njira yothetsera kufooka kwa mafupa. AINAT ili ndi 300 mg ya claw wa satana, komanso 200 mg ya turmeric ndi 150 mg ya bromelain - zowonjezera zina ziwiri zomwe zimakhulupirira kuti zimakhala ndi zotsutsana ndi zotupa ().

Pazinthu zina, maphunziro okwanira kuti adziwe kuchuluka kwa mankhwala sakupezeka.Kuphatikiza apo, claw wa satana wagwiritsidwa ntchito mpaka chaka chimodzi m'maphunziro. Komabe, claw wa satana amawoneka kuti ndiwotheka kwa anthu ambiri omwe amamwa mpaka 2,610 mg patsiku (29).

Kumbukirani kuti zovuta zina, monga matenda amtima, matenda ashuga, miyala ya impso ndi zilonda zam'mimba, zitha kukulitsa chiopsezo chanu chazovuta mukatenga claw wa satana.

Komanso, mulingo uliwonse wa claw wa satana ungasokoneze mankhwala omwe mungakhale mukumwa. Izi zimaphatikizapo mankhwala osagwiritsa ntchito steroidal anti-inflammatory (NSAIDs), opopera magazi ndi ochepetsa asidi m'mimba.

Chiwombankhanga cha Mdyerekezi chikuwoneka kuti ndi chopindulitsa pa Mlingo wa 600-2610 mg patsiku. Kafukufuku wowonjezereka amafunikira kuti adziwe ngati milanduyi ndiyothandiza komanso yotetezeka kwakanthawi.

Mfundo Yofunika Kwambiri

Claw wa Devil atha kuthetsa ululu womwe umayambitsidwa ndi zotupa monga nyamakazi ndipo amatha kupondereza ma hormone amanjala.

Mankhwala a tsiku ndi tsiku a 600-2,610 mg amawoneka kuti ndi otetezeka, koma palibe malingaliro aboma omwe alipo.

Zotsatira zoyipa nthawi zambiri zimakhala zofatsa, koma claw wa satana atha kukulitsa zovuta zina zathanzi ndikuyanjana ndi mankhwala ena.

Monga ndi zowonjezera zonse, claw wa satana ayenera kugwiritsidwa ntchito mosamala. Onetsetsani kuti mwalankhula ndi dokotala musanamwe.