Eculizumab - Ndi chiyani?

Zamkati

• Ndi chiyani
• Mtengo
• Momwe mungagwiritsire ntchito
• Zotsatira zoyipa
• Nthawi yosagwiritsidwa ntchito

Eculizumab ndi antioclonal antibody, yogulitsidwa malonda pansi pa dzina la Soliris. Zimathandizira kuyankha kotupa ndikuchepetsa kuthekera kwa thupi kulimbana ndi maselo amwazi wake, makamaka kuwonetsedwa kuti kumenya matenda osowa omwe amatchedwa usiku paroxysmal hemoglobinuria.

Ndi chiyani

Mankhwala a Soliris amawonetsedwa pochiza matenda amwazi wotchedwa paroxysmal nocturnal hemoglobinuria; Matenda am'magazi ndi impso zotchedwa atypical hemolytic uremic syndrome, pomwe pakhoza kukhala thrombocytopenia ndi kuchepa magazi m'thupi, kuphatikiza magazi kuundana, kutopa ndi kulephera kwa ziwalo zosiyanasiyana, zomwe zikuwonetsedwanso zochizira matenda a Myasthenia gravis.

Mtengo

Ku Brazil, mankhwalawa amavomerezedwa ndi Anvisa, ndipo amaperekedwa ndi SUS kudzera pamilandu, osagulitsidwa kuma pharmacies.

Momwe mungagwiritsire ntchito

Mankhwalawa ayenera kupakidwa ngati jakisoni kuchipatala. Nthawi zambiri, chithandizo chimachitidwa ndikudontha mumtsempha, kwa mphindi pafupifupi 45, kamodzi pa sabata, kwa milungu isanu, mpaka pomwe kusintha kumapangidwe kuti agwiritsidwe ntchito masiku 15 aliwonse.

Zotsatira zoyipa

Eculizumab nthawi zambiri imaloledwa, zomwe zimakhala zofala kwambiri kumayambiriro kwa mutu. Komabe, zoyipa monga thrombocytopenia, kuchepa kwa magazi ofiira, kupweteka m'mimba, kudzimbidwa, kutsekula m'mimba, kusagaya bwino, nseru, kupweteka pachifuwa, kuzizira, malungo, kutupa, kutopa, kufooka, nsungu, gastroenteritis, kutupa kumatha kuchitika. , nyamakazi, chibayo, meningococcal meningitis, kupweteka kwa minofu, kupweteka kwa msana, kupweteka kwa khosi, chizungulire, kuchepa kwa kulawa, kugwedezeka mthupi, kukomoka mwadzidzidzi, kutsokomola, kupweteka kwa mmero, mphuno yodzaza, thupi loyabwa, kugwa kuchokera ku tsitsi, khungu louma.

Nthawi yosagwiritsidwa ntchito

Soliris sayenera kugwiritsidwa ntchito kwa anthu omwe sagwirizana ndi chilichonse mwazomwe zimapangidwira, komanso ngati atapezeka ndi Neisseria meningitidis, anthu omwe alibe katemera wa meningitis.

Mankhwalawa ayenera kugwiritsidwa ntchito pokhapokha ali ndi pakati, pansi pa upangiri wa zamankhwala ndipo ngati kuli kofunikira, chifukwa imadutsa pa placenta ndipo imatha kusokoneza kayendedwe ka magazi a mwana. Kugwiritsiridwa ntchito kwake sikukuwonetsedwanso panthawi yoyamwitsa, kotero ngati mayi akuyamwitsa, ayenera kuyimilira kwa miyezi 5 atagwiritsa ntchito mankhwalawa.