Harvoni (ledipasvir / sofosbuvir)

Zamkati

• Harvoni ndi chiyani?
• Harvoni generic
• Zotsatira za Harvoni
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Kupewa kudzipha
• Zotsatira zoyipa zazitali
• Zotsatira zoyipa atalandira chithandizo
• Kuchepetsa thupi kapena kunenepa
• Zizindikiro zosiya
• Ululu wophatikizana
• Zotsatira za diso
• Kutaya tsitsi
• Ziphuphu / kuyabwa
• Kutsekula m'mimba
• Matenda okhumudwa
• Kutopa
• Kusowa tulo (kuvuta kugona)
• Mutu
• Khansa ya chiwindi / khansa
• Mtengo wa Harvoni
• Thandizo lazachuma komanso inshuwaransi
• Harvoni amagwiritsa ntchito
• Mlingo wa Harvoni
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa hepatitis C
• Kutalika kwa chithandizo
• Ndingatani ngati ndaphonya mlingo?
• Kutsatira dongosolo lanu la mankhwala a Harvoni
• Harvoni ndi mowa
• Harvoni ndi ribavirin
• Zotsatira za Ribavirin
• Ribavirin ndi mimba
• Ribavirin ndi kuyamwitsa
• Kuyanjana kwa Harvoni
• Harvoni ndi mankhwala ena
• Harvoni ndi ribavirin
• Harvoni ndi omeprazole kapena ma PPI ena
• Harvoni ndi zitsamba ndi zowonjezera
• Harvoni ndi khofi
• Njira zina ku Harvoni
• Harvoni vs. mankhwala ena
• Harvoni vs. Epclusa
• Harvoni motsutsana ndi Mavyret
• Harvoni vs. Sovaldi
• Harvoni vs. Zepatier
• Momwe mungatenge Harvoni
• Kusunga nthawi
• Kutenga Harvoni ndi chakudya
• Kodi Harvoni akhoza kuphwanyidwa?
• Momwe Harvoni amagwirira ntchito
• Ponena za hepatitis C
• Kodi Harvoni amachiza bwanji matenda a chiwindi a C?
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Harvoni ndi mimba
• Harvoni ndi kuyamwitsa
• Mafunso wamba pa Harvoni
• Kodi ndiyenera kutsatira zakudya zapadera ndikamamwa Harvoni?
• Kodi Harvoni atenga nthawi yayitali bwanji kuti athetse matenda anga a hepatitis C?
• Kodi mtengo wa machiritso a Harvoni ndi uti?
• Kodi matenda a chiwindi a hepatitis C amatha kubwerera atatenga Harvoni?
• Kodi mtundu wa hepatitis C ndi wotani?
• Kuchulukitsitsa kwa Harvoni
• Zizindikiro zambiri za bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Machenjezo a Harvoni
• Chenjezo la FDA: Kutsegulanso kachilombo ka hepatitis B.
• Machenjezo ena
• Kutha kwa Harvoni
• Zambiri za Harvoni
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Harvoni ndi chiyani?

Harvoni ndi mankhwala omwe amadziwika kuti ndi a hepatitis C. Harvoni ali ndi mankhwala awiri: ledipasvir ndi sofosbuvir. Zimabwera ngati piritsi lomwe limatengedwa kamodzi tsiku lililonse kwa masabata a 12.

Harvoni ndi mtundu wa mankhwala otchedwa direct-acting antiviral (DAA). Adavomerezedwa ndi a FDA mu 2014 kuti athetse mitundu ingapo yamitundu yosiyanasiyana ya hepatitis C.

Harvoni amavomerezedwa kuti athetse matenda a chiwindi a C:

• mwa anthu omwe ali ndi matenda amtundu wa hepatitis C 1, 4, 5, ndi 6
• mwa anthu omwe ali ndi cirrhosis kapena alibe
• mwa anthu omwe adalandira chiwindi
• mwa akulu kapena ana omwe ali ndi zaka 12 kapena kupitilira apo kapena omwe amalemera mapaundi osachepera 77

M'maphunziro ambiri azachipatala a Harvoni, kuchuluka kwa kuchiritsa kwa hepatitis C kunali kwakukulu kuposa 90 peresenti. Izi zikutanthauza kuti pafupifupi anthu onse omwe adatenga Harvoni adakwaniritsa kuyankha kwa virologic (SVR). SVR amatanthauza kuti analibe kachilombo koyambitsa matenda m'thupi mwawo milungu 12 kapena kupitilira pomwe mankhwala atatha.

Harvoni generic

Harvoni ili ndi mankhwala awiri piritsi limodzi: ledipasvir ndi sofosbuvir. Pakadali pano palibe mitundu yabwinobwino ya mankhwala osakaniza kapena mankhwalawa. Harvoni imangopezeka ngati mankhwala olembedwa ndi dzina lodziwika.

Komabe, mtundu wa Harvoni ukuyembekezeka kutulutsidwa koyambirira kwa 2019.

Zotsatira za Harvoni

Harvoni imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukatenga Harvoni. Mndandandawu sungaphatikizepo zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Harvoni kapena maupangiri amomwe mungathetsere zovuta, lankhulani ndi dokotala kapena wamankhwala.

Ngati dokotala wanu akupatsaninso ribavirin kuti mutenge ndi Harvoni, mutha kukhala ndi zovuta zina. (Onani "Harvoni ndi ribavirin" pansipa.)

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Harvoni zitha kuphatikiza:

• kutopa
• mutu
• nseru
• kutsegula m'mimba
• kusowa tulo (kuvuta kugona)
• chifuwa
• kufooka
• kupweteka kwa minofu
• dyspnea (kupuma pang'ono)
• kupsa mtima
• chizungulire

Nthawi zina, Harvoni imatha kuyambitsa vuto linalake. Zizindikiro zimatha kuphulika pakhungu, kuyabwa, ndi kutsuka (kutentha kwa khungu ndi kufiira, makamaka kumaso ndi m'khosi).

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Harvoni sizofala, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Kutsegulanso kwa hepatitis B mwa anthu omwe ali ndi matenda a hepatitis C ndi hepatitis B. Anthu ena omwe ali ndi chiwindi cha hepatitis C ndi hepatitis B adayambiranso kachilombo ka hepatitis B pomwe adayamba kulandira chithandizo ndi Harvoni. Kutsegulanso kumatanthauza kuti kachilomboka kamayambanso kugwira ntchito. Kutsegulanso kachilombo ka hepatitis B kumatha kubweretsa kuwonongeka kwa chiwindi, kulephera kwa chiwindi, kapena kufa. Musanayambe kumwa mankhwala ndi Harvoni, dokotala wanu adzakuyesani kuti mupeze hepatitis B. Muyenera kumwa mankhwala kuti muchepetse matenda a chiwindi a B.
• Zowopsa kwambiri. Nthawi zambiri, Harvoni imatha kuyambitsa vuto lalikulu. Zizindikiro zimatha kuphatikiza:
• angioedema (kutupa pansi pa khungu lanu, makamaka m'maziso anu, milomo, manja, kapena mapazi)
• kutupa kwa mmero, mkamwa, ndi lilime
• kuvuta kupuma
• Maganizo ofuna kudzipha. Nthawi zambiri, Harvoni amatha kuyambitsa malingaliro ofuna kudzipha akagwidwa ndi ribavirin kapena pegylated interferon / ribavirin.

Kupewa kudzipha

• Ngati mumadziwa wina yemwe ali pachiwopsezo chodzivulaza, kudzipha, kapena kukhumudwitsa munthu wina:
• Imbani 911 kapena nambala yadzidzidzi yakomweko.
• Khalani ndi munthuyu kufikira akatswiri atafika.
• Chotsani zida zilizonse, mankhwala, kapena zinthu zina zomwe zitha kuvulaza.
• Mverani munthuyo popanda chiweruzo.
• Ngati inu kapena munthu wina amene mumamudziwa ali ndi malingaliro ofuna kudzipha, foni yochepetsera ikhoza kuthandizira. National Suicide Prevention Lifeline imapezeka maola 24 patsiku 1-800-273-8255.

Zotsatira zoyipa zazitali

Zotsatira zoyipa zazitali sizinafotokozedwe ndikugwiritsa ntchito Harvoni.

Komabe, anthu omwe ali ndi matenda a chiwindi (chiwindi cha chiwindi) amatha kupitiliza kukhala ndi zizindikilo za kuwonongeka kwa chiwindi pambuyo poti hepatitis C yawo yachiritsidwa. Ngati muli ndi matenda a chiwindi, dokotala wanu adzafuna kuyang'anitsitsa chiwindi chanu nthawi ndi nthawi mukalandira chithandizo ndi Harvoni.

Zotsatira zoyipa atalandira chithandizo

Zotsatira zoyipa pambuyo pa chithandizo cha Harvoni sizinafotokozeredwe m'maphunziro azachipatala.

Komabe, atamaliza kulandira chithandizo ndi Harvoni, anthu ena amatha kukhala ndi zizindikiro ngati chimfine, monga kupweteka kwa minofu, kuzizira, kutopa, komanso kuvutika kugona. Zotsatirazi mwina zimayambitsidwa ndi thupi lanu mukachira matenda a hepatitis C atachotsedwa.

Ngati muli ndi zizindikiro ngati chimfine mukamaliza mankhwala ndi Harvoni, lankhulani ndi dokotala wanu.

Kuchepetsa thupi kapena kunenepa

Kusintha kwakulemera panthawi yamankhwala a Harvoni sikunanenedwe m'maphunziro azachipatala. Komabe, anthu ena achepetsa thupi ngati chizindikiro cha matenda a chiwindi a hepatitis C. Ngati mwasintha kwambiri thupi, lankhulani ndi dokotala wanu.

Zizindikiro zosiya

Kuyimitsa chithandizo ndi Harvoni sikunayambitse zizindikiro zodzipatula m'maphunziro azachipatala.

Anthu ena amatha kukhala ndi zizindikilo zomwe zimafanana ndi kusiya, monga chimfine chonga chimfine, kupweteka mutu, komanso kupweteka kwa minofu. Komabe, sizikudziwika ngati zizindikirozi zikugwirizana ndi kusiya mankhwala a Harvoni.

Ululu wophatikizana

Kupweteka pamodzi sikunali mbali yotsatira ya Harvoni m'maphunziro azachipatala.

Anthu ambiri omwe ali ndi matenda a hepatitis C amamva kuwawa ngati chizindikiro cha kachilomboka. Izi zitha kukhala zotsatira za kutupa kwanthawi yayitali kapena njira yodzitchinjiriza yokha yolimbana ndi mafupa anu.

Ngati mukumva kuwawa m'malo anu ophatikizana, kambiranani ndi dokotala za njira zothetsera vutoli.

Zotsatira za diso

M'maphunziro azachipatala a Harvoni, anthu omwe amamwa mankhwalawa sanakumane ndi mavuto amaso. Koma pali lipoti limodzi lakuwonongeka kwakanthawi kwakanthawi mutagwiritsa ntchito Harvoni ndi mankhwala a ribavirin. Ndipo munthu wina adanenanso zotupa m'maso ndikuwona m'maso atagwiritsa ntchito sofosbuvir (imodzi mwa mankhwala ku Harvoni) ndi ribavirin.

Komabe, sizikudziwika ngati Harvoni kapena zosakaniza zake zidayambitsa mavuto amaso pamilandu iyi. Komanso, kafukufuku wa 2019 adapeza kuti mankhwala omwewo sanayambitse mavuto amaso mwa anthu omwe ali ndi hepatitis C.

Mulimonsemo, ngati mungakumane ndi vuto lililonse mukamatenga Harvoni, lankhulani ndi dokotala nthawi yomweyo.

Kutaya tsitsi

Kutayika kwa tsitsi sikunatchulidwe ngati zotsatira zoyipa m'maphunziro azachipatala a Harvoni. Anthu ena anena kuti ataya tsitsi akamamwa mankhwalawa, koma sizikudziwika ngati Harvoni ndiye adayambitsa tsitsi lawo.

Ndikofunika kuzindikira kuti kutayika kwa tsitsi kumatha kukhala chizindikiro cha matenda a chiwindi a hepatitis C. Vuto la hepatitis C virus (HCV) limalepheretsa chiwindi chanu kugwira bwino ntchito. Muyenera chiwindi chathanzi kuti mupeze michere kuchokera pachakudya chomwe mumadya. Chifukwa chake ngati simungathe kupeza michere yomwe thupi lanu limafuna, mutha kutaya tsitsi.

Ngati mukudandaula za kutayika kwa tsitsi, lankhulani ndi dokotala wanu.

Ziphuphu / kuyabwa

Ziphuphu zakhungu zidanenedwa mwa anthu ena omwe adatenga Harvoni m'maphunziro azachipatala, koma sizikudziwika kuti anali wamba bwanji. Nthawi zina, anthu anali ndi matuza ndi kutupa kwa khungu, nawonso. Izi zimatha kuyambitsidwa ndi zovuta za Harvoni.

Khungu lotupa komanso zotupa ndi zizindikiro za matenda a chiwindi a hepatitis C. Kuphatikiza apo, amatha kukhala zizindikilo zowononga chiwindi. Lankhulani ndi dokotala wanu ngati mukukumana ndi zotupa kapena khungu loyipa.

Kutsekula m'mimba

M'maphunziro azachipatala a Harvoni, pakati pa 3 peresenti ndi 7 peresenti ya anthu adakumana ndi matenda otsekula m'mimba akamalandira chithandizo. Kutsekula m'mimba kumatha kutha ndi kugwiritsa ntchito mankhwalawa.

Ngati muli ndi matenda otsekula m'mimba, kapena otsekula m'mimba omwe amatha masiku angapo, lankhulani ndi dokotala nthawi yomweyo.

Matenda okhumudwa

Matenda okhumudwa ndi zotsatira zosazolowereka za Harvoni. M'maphunziro azachipatala, anthu ochepera 5% omwe adatenga Harvoni adakumana ndi kukhumudwa. Kuphatikiza apo, malingaliro ofuna kudzipha adachitika mwa ochepera 1 peresenti ya anthu omwe adatenga Harvoni ndi ribavirin kapena pegylated interferon / ribavirin.

Anthu ambiri omwe ali ndi chiwindi cha hepatitis C amatha kukhumudwa chifukwa chopezeka. Ngati mukumva kuti mukuvutika maganizo, kambiranani ndi dokotala wanu za njira zokuthandizani kuti mukhale osangalala. Ndipo ngati mukuganiza zodzipweteka nokha, itanani dokotala wanu nthawi yomweyo.

Kutopa

Kutopa, kapena kusowa kwa mphamvu, ndi gawo lofala la Harvoni. M'maphunziro azachipatala, mpaka 18 peresenti ya anthu omwe adatenga Harvoni adatopa.

Kutopa kumatha ndi kupitiliza kugwiritsa ntchito Harvoni. Komabe, ngati kutopa kwanu kuli kovuta ndipo kumakhudza moyo wanu, lankhulani ndi dokotala wanu.

Kusowa tulo (kuvuta kugona)

M'maphunziro azachipatala, kusowa tulo kudachitika mpaka anthu 6 peresenti omwe adatenga Harvoni. Izi zimatha kuchoka ndikupitiliza kugwiritsa ntchito mankhwalawa.

Njira zokuthandizira kugona kwanu zimaphatikizapo kutsatira ndandanda yanthawi zonse yogona komanso kusunga zamagetsi, monga mafoni am'manja, kuchipinda kwanu. Ngati kusowa tulo kwanu kukuvutitsani ndipo sikupita, kambiranani ndi dokotala za njira zina zokuthandizani kugona.

Mutu

Mutu ndi gawo lofala la Harvoni. M'maphunziro azachipatala, mpaka 29 peresenti ya anthu omwe adatenga Harvoni adamva mutu. Ngati mukumva kupweteka mutu mukamatenga Harvoni, lankhulani ndi dokotala wanu za njira zokuthandizani kuwathira.

Khansa ya chiwindi / khansa

Harvoni ndi mankhwala omwe amatchedwa anti-virus (DAA). Kuchiza matenda a chiwindi a C ndi ma DAA kumathandiza kupewa zotsatira zazitali, monga khansa ya chiwindi. Komabe, pakhala pali malipoti a khansa ya chiwindi mwa anthu omwe adachiritsidwa ndi hepatitis C ndi chithandizo cha Harvoni.

Kafukufuku wina wazachipatala adapeza kuti anthu omwe ali ndi cirrhosis omwe amathandizidwa ndi DAA anali ndi chiopsezo chachikulu chokhala ndi khansa ya chiwindi poyerekeza ndi omwe alibe matenda a chiwindi. Komabe, anthu opanda cirrhosis amatha kukhalabe ndi khansa ya chiwindi.

Ngati mukudandaula za chiopsezo chanu chokhala ndi khansa ya chiwindi, lankhulani ndi dokotala wanu.

Mtengo wa Harvoni

Monga mankhwala onse, mtengo wa Harvoni umasiyana.

Mtengo wanu weniweni umatengera inshuwaransi yanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Harvoni, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Gilead Sciences, Inc., wopanga Harvoni, amapereka pulogalamu yotchedwa Harvoni Support Path. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 855-769-7284 kapena pitani patsamba lino.

Harvoni amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Harvoni kuti athetse mavuto ena.

Harvoni ndivomerezedwa ndi FDA pochiza kachilombo ka hepatitis C (HCV). Harvoni atha kulembedwa kuti:

• Akuluakulu ndi ana (azaka 12 kapena kupitirira kapena omwe amalemera mapaundi 77) omwe:
• ali ndi mtundu wa HCV 1, 4, 5, kapena 6. Ma genotypes ndi mitundu yosiyanasiyana ya kachilomboka.
• kukhala kapena kulipira chiwindi. Cirrhosis ndi mabala akulu m'chiwindi omwe amalepheretsa kugwira ntchito moyenera. Cirrhosis yolipidwa ndi matenda am'mimba omwe nthawi zambiri samayambitsa zizindikiro.
• Akuluakulu omwe:
• ali ndi genotype 1 komanso matenda opatsirana pogonana. Cirrhosis yofooka ndipamene chiwindi chimalephera ndikupangitsa mavuto azaumoyo. Anthu omwe ali ndi matenda enaake owopsa amafunika kumwa Harvoni ndi mankhwala ena achiwiri, ribavirin (Rebetol).
• ali ndi genotype 1 kapena 4 ndipo adakhala ndi chiwindi.

Tebulo ili likuwonetsa yemwe ali woyenera kulandira chithandizo cha Harvoni:

Mlingo wa Harvoni

Harvoni amalembedwa ngati mlingo umodzi: Piritsi lomwe lili ndi 90 mg ya ledipasvir ndi 400 mg ya sofosbuvir, yotengedwa kamodzi patsiku.

Nthawi zina, adokotala amatha kukupatsani mankhwala achiwiri oti mutenge ndi Harvoni. Mwachitsanzo, mutha kupatsidwa ribavirin (Rebetol) kuphatikiza ndi Harvoni.

Izi zitha kuchitika ngati mwayamba kuwononga matenda am'mimba (zizindikiro zoopsa za matenda a chiwindi) kapena ngati mwamwa mankhwala enaake kuti muthane ndi hepatitis C m'mbuyomu. Mlingo wanu wa ribavirin umadalira kulemera kwanu, ntchito ya impso, ndi zina zaumoyo.

Zotsatira izi zikufotokozera mulingo woyenera wa Harvoni.

Mitundu ya mankhwala ndi mphamvu

Harvoni imapezeka mwamphamvu imodzi. Imabwera piritsi limodzi lomwe lili ndi 90 mg ya ledipasvir ndi 400 mg ya sofosbuvir.

Mlingo wa hepatitis C

Mlingo wothandizira hepatitis C ndi piritsi limodzi (90 mg ledipasvir / 400 mg sofosbuvir), yotengedwa kamodzi patsiku.

Kutalika kwa chithandizo

Kutenga nthawi yayitali bwanji Harvoni kudalira mtundu wanu wa hepatitis C (mtundu wa virus). Zidzadaliranso kugwira ntchito kwa chiwindi, komanso chithandizo chilichonse cha hepatitis C chomwe mwayesapo kale.

Anthu ambiri amatenga Harvoni kwa milungu 12, koma chithandizo chitha kukhalanso milungu 8 kapena 24. Dokotala wanu adzakuuzani nthawi yoyenera ya chithandizo kwa inu.

Ndingatani ngati ndaphonya mlingo?

Ndikofunika kutenga Harvoni tsiku lililonse nthawi yonse yomwe dokotala akukupatsani. Kusowa kapena kudumpha Mlingo kumatha kuyambitsa kachilomboka kukhala kogonjetsedwa ndi Harvoni. Kugonjetsedwa kumatanthauza kuti mankhwalawa sakugwiranso ntchito kwa inu.

Kugwiritsa ntchito chida chokumbutsirani kungakuthandizeni kukumbukira kutenga Harvoni tsiku lililonse.

Ngati mwaphonya mlingo, imwani mukamakumbukira. Ngati simukumbukira mpaka tsiku lotsatira, musatenge Mlingo wa Harvoni mwakamodzi. Izi zitha kuwonjezera ngozi zoyipa. Ingotenga mlingo wanu wanthawi zonse wa Harvoni.

Kutsatira dongosolo lanu la mankhwala a Harvoni

Ndikofunika kwambiri kuti mutenge mapiritsi anu a Harvoni ndendende monga momwe dokotala wakupangirirani. Izi ndichifukwa choti kutsatira dongosolo lanu la chithandizo kumawonjezera mwayi wanu wochiritsa matenda anu a chiwindi a C (HCV). Zimathandizanso kuchepetsa mavuto omwe amabwera chifukwa cha HCV, monga khansa ya chiwindi ndi chiwindi.

Mlingo wosowa ukhoza kupangitsa Harvoni kukhala wosagwira ntchito pochiza HCV yanu. Nthawi zina, ngati mwaphonya mlingo, HCV yanu singachiritsidwe.

Onetsetsani kuti mukutsatira malangizo a dokotala wanu ndikutenga piritsi limodzi la Harvoni tsiku lililonse kuti mukalandire chithandizo chokwanira. Kugwiritsa ntchito chida chokumbutsirani kungakuthandizeni kutsimikiza kuti mumatenga Harvoni tsiku lililonse.

Ngati muli ndi mafunso kapena nkhawa zokhudzana ndi chithandizo chanu, lankhulani ndi dokotala wanu. Amatha kuthana ndi mavuto anu ndikukuthandizani kupeza chithandizo chamankhwala a hepatitis C.

Harvoni ndi mowa

Kumwa mowa mukamamwa Harvoni kumatha kuonjezera mavuto ena kuchokera ku Harvoni. Zotsatirazi zikuphatikizapo:

• kutopa
• mutu
• nseru
• kutsegula m'mimba

Kuphatikiza apo, matenda a chiwindi a C komanso kumwa mowa mopitirira muyeso kumayambitsa zipsera ndi kutupa m'chiwindi. Kuphatikiza ziwirizi kumawonjezera chiopsezo cha matenda a chiwindi ndi chiwindi.

Mowa amathanso kukupangitsani kuti musamamwe mankhwala anu molamulidwa ndi adotolo. Mwachitsanzo, zingakupangitseni kuiwala kumwa mankhwala anu panthawi yoyenera. Mlingo wosowa wa Harvoni ungapangitse kuti usamagwire bwino ntchito pochiza HCV yanu.

Pazifukwa zonsezi, muyenera kupewa kumwa mowa mukakhala ndi matenda a chiwindi a C. Izi ndizowona makamaka mukamathandizidwa ndi Harvoni. Ngati mukuvutika kupewa mowa, lankhulani ndi dokotala wanu.

Harvoni ndi ribavirin

Harvoni nthawi zambiri amatengedwa okha kuti akachiritse matenda a chiwindi a C. Komabe, nthawi zina, amatengedwa ndi mankhwala ena otchedwa ribavirin (Rebetol).

Dokotala wanu akhoza kukupatsani ribavirin ndi Harvoni ngati:

• adasokoneza matenda a chiwindi
• adamuyika chiwindi
• sanalandire chithandizo china ndi mankhwala ena a hepatitis C m'mbuyomu

Harvoni ndi ribavirin amagwiritsidwa ntchito limodzi mwa anthu munthawi izi chifukwa kafukufuku wamankhwala adawonetsa kuchiritsa kwakukulu ndi mankhwala osakanikirana kuposa Harvoni yekha.

Chithandizo cha ribavirin chimakhala milungu 12. Ribavirin imabwera ngati mapiritsi omwe mumamwa kawiri patsiku. Mlingo womwe mumatenga utengera kulemera kwanu. Zitha kukhalanso potengera ntchito yanu ya impso ndi hemoglobin.

Zotsatira za Ribavirin

Ribavirin imatha kuyambitsa zovuta zingapo zofala komanso zoyipa. Imabweranso ndi machenjezo ofunikira.

Chenjezo la bokosi

Ribavirin ali ndi chenjezo lolembedwa kuchokera ku FDA. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Chenjezo la bokosi la Ribavirin limalangiza kuti:

• Ribavirin sayenera kugwiritsidwa ntchito payokha kuti athetse matenda a chiwindi a C chifukwa sagwira ntchito paokha.
• Ribavirin imatha kuyambitsa mtundu wamatenda amwazi otchedwa hemolytic anemia. Vutoli limatha kubweretsa matenda amtima kapena kufa. Chifukwa cha chiopsezo ichi, anthu omwe ali ndi matenda oopsa kapena osakhazikika a mtima sayenera kumwa ribavirin.
• Ribavirin akagwiritsidwa ntchito mwa amayi apakati, amatha kuvulaza kapena kupha mwana wosabadwa. Ribavirin sayenera kutengedwa ndi amayi apakati kapena amuna omwe amagonana nawo panthawi yapakati. Oyembekezera ayenera kupewedwanso kwa miyezi isanu ndi umodzi mankhwala a ribavirin atatha. Munthawi imeneyi, lingalirani kugwiritsa ntchito njira yolerera yolerera (kulera).

Zotsatira zina zoyipa

Ribavirin amathanso kuyambitsa zovuta zina, monga:

• kutopa
• kumva kuda nkhawa
• malungo
• mutu
• kumva kupsa mtima
• kusowa chilakolako
• kupweteka kwa minofu kapena kufooka
• nseru
• kusanza

Zotsatira zoyipa koma zoyipa zomwe zimawoneka m'maphunziro azachipatala zimaphatikizapo kuchepa kwa magazi m'thupi, matenda am'mapapo, komanso kapamba. Anaphatikizaponso mavuto amaso, monga matenda opatsirana komanso kusawona bwino.

Ribavirin ndi mimba

Onani "Chenjezo lolembedwa" pamwambapa.

Ribavirin ndi kuyamwitsa

Sidziwika ngati ribavirin imadutsa mkaka wa m'mawere. Kafukufuku wazinyama akuwonetsa kuti ribavirin yotengedwa ndi mayi imatha kuvulaza kuyamwitsa ana. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Ngati mukuganiza za mankhwala a ribavirin mukamayamwitsa, lankhulani ndi dokotala wanu. Angakulimbikitseni kuti musiye kuyamwa kapena kupewa mankhwala a ribavirin.

Kuyanjana kwa Harvoni

Harvoni amatha kuyanjana ndi mankhwala ena angapo. Itha kulumikizananso ndi zowonjezera zowonjezera ndi zakudya.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, ena amatha kusokoneza momwe mankhwala amagwirira ntchito, pomwe ena amatha kuyambitsa zovuta zina.

Harvoni ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Harvoni. Mndandandawu mulibe mankhwala onse omwe atha kuyanjana ndi Harvoni.

Musanatenge Harvoni, onetsetsani kuti mumauza dokotala komanso wamankhwala zonse zamankhwala, zolembera, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Maantibayotiki

Kutenga Harvoni ndi ma antacids, monga Mylanta kapena Tums, kumatha kuchepetsa kuchuluka kwa Harvoni komwe thupi lanu limamwa. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito. Pofuna kupewa kulumikizana uku, patukani mlingo wa Harvoni ndi ma antacids osachepera maola anayi.

Oletsa H2

Kutenga Harvoni ndi mankhwala otchedwa H2 blockers kumatha kuchepetsa kuchuluka kwa Harvoni komwe kumalowa m'thupi lanu. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito yolimbana ndi kachilombo ka hepatitis C.

Ngati mukufuna kutenga H2 blocker ndi Harvoni, muyenera kuwatenga nthawi yomweyo kapena kuwapatula maola 12. Kuwatenga nthawi yomweyo kumapangitsa kuti mankhwalawo asungunuke ndikulowetsedwa ndi thupi lanu zotsatira za choletsa cha H2 zisanayambike. Kuwachotsera maola 12 kumathandizanso kuti mankhwala aliwonse azilowetsedwa ndi thupi lanu osagwirizana ndi mankhwala ena.

Zitsanzo za ma H2 blockers ndi famotidine (Pepcid) ndi cimetidine (Tagamet HB).

Amiodarone

Kutenga Harvoni ndi amiodarone (Pacerone, Nexterone) kumatha kuyambitsa kugunda kwa mtima koopsa, komwe kumatchedwa bradycardia. Malipoti ena anena kuti anthu omwe amatenga amiodarone ndi Harvoni limodzi amafunikira chopangira pacem kuti mtima wawo ugwerebe. Adanenanso kuti anthu ena adadwala matenda amtima.

Kutenga amiodarone ndi Harvoni limodzi sikuvomerezeka. Ngati mukuyenera kutenga Harvoni ndi amiodarone palimodzi, dokotala wanu amayang'anitsitsa momwe mtima wanu ukugwirira ntchito.

Digoxin

Kutenga Harvoni ndi digoxin (Lanoxin) kumatha kukulitsa digoxin mthupi lanu. Magulu a Digoxin omwe ali okwera kwambiri amatha kubweretsa zovuta zowopsa.

Ngati mukufuna kutenga Harvoni ndi digoxin palimodzi, dokotala wanu amayang'anitsitsa kuchuluka kwanu kwa digoxin. Amatha kusintha mlingo wanu wa digoxin kuti muchepetse zovuta.

Mankhwala olanda

Kutenga Harvoni ndi mankhwala ena olanda kumatha kuchepetsa kuchuluka kwa Harvoni komwe thupi lanu limamwa. Izi zitha kuchepetsa mphamvu ya Harvoni. Pachifukwa ichi, simuyenera kutenga Harvoni ndi mankhwala olandawa.

Zitsanzo za mankhwala olanda omwe mungapewe mukamatenga Harvoni ndi awa:

• carbamazepine (Carbatrol, Equetro, Tegretol)
• phenytoin (Dilantin, Phenytek)
• anayankha
• oxcarbazepine (Trileptal)

Maantibayotiki

Mankhwala ena opha maantibayotiki amatha kuchepetsa kuchuluka kwa Harvoni mthupi lanu. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito. Pofuna kupewa izi, pewani kumwa Harvoni ndi maantibayotiki otsatirawa:

• Chinthaka (Mycobutin)
• rifampin (Rifadin, Rimactane)
• rifapentine (Priftin)

Mankhwala a HIV

Kutenga Harvoni ndi mankhwala ena a HIV kumatha kusintha thupi lanu ngati Harvoni kapena mankhwala a HIV. Kuyanjana kumeneku kumatha kupangitsa kuti mankhwalawa asamagwire bwino ntchito kapena kuonjezera chiopsezo chanu chazovuta.

Tenofovir disoproxil fumarate

Kutenga Harvoni ndi mankhwala omwe ali ndi tenofovir disoproxil fumarate kumatha kukulitsa kuchuluka kwa tenofovir mthupi lanu. Izi ziziwonjezera chiopsezo cha zotsatirapo kuchokera ku tenofovir, monga kuwonongeka kwa impso. Ngati mukufuna kumwa Harvoni ndi mankhwala omwe ali ndi tenofovir disoproxil fumarate, dokotala wanu adzakuwunikirani kwambiri zotsatira zake.

Zitsanzo za mankhwala omwe ali ndi tenofovir disoproxil fumarate ndi awa:

• tenofovir (Viread)
• tenofovir ndi emtricitabine (Truvada)
• tenofovir, elvitegravir, cobicistat, ndi emtricitabine (Stribild)
• tenofovir, emtricitabine, ndi rilpivirine (Complera)

Tipranavir ndi ritonavir

Kutenga Harvoni ndi mankhwala a HIV tipranavir (Aptivus) kapena ritonavir (Norvir) kumachepetsa milingo ya Harvoni mthupi lanu. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito. Kutenga Harvoni ndi tipranavir ndi ritonavir sikuvomerezeka.

Mankhwala a cholesterol

Kutenga Harvoni ndi mankhwala a cholesterol otchedwa statins kumatha kukulitsa kuchuluka kwa ma statins mthupi lanu. Izi zimawonjezera chiopsezo chanu pazotsatira za statin, monga kupweteka kwa minofu ndi kuwonongeka.

Ma Statins amaphatikiza mankhwala monga rosuvastatin (Crestor), atorvastatin (Lipitor), ndi simvastatin (Zocor). Mukatenga Harvoni ndi statin, dokotala wanu adzakuyang'anirani mosamala ngati pali zizindikiro za rhabdomyolysis (kuwonongeka kwa minofu).

Rosuvastatin ndi Harvoni siziyenera kutengedwa limodzi. Ma statin ena ayenera kugwiritsidwa ntchito mosamala ndi Harvoni.

Warfarin

Harvoni ingakhudze kuthekera kwa thupi lanu kupanga magazi. Ngati mukufuna kumwa warfarin (Coumadin) mukamalandira chithandizo ndi Harvoni, dokotala wanu amatha kuyesa magazi anu pafupipafupi. Ayeneranso kuwonjezera kapena kuchepetsa kuchuluka kwa warfarin.

Harvoni ndi ribavirin

Palibe kulumikizana pakati pa Harvoni ndi ribavirin (Rebetol). Harvoni ndi yabwino kutenga ndi ribavirin. M'malo mwake, Harvoni imavomerezedwa ndi a FDA kuti atenge ndi ribavirin kwa anthu omwe ali ndi mbiri yazachipatala.

Dokotala wanu akhoza kukupatsani ribavirin kuti mutenge ndi Harvoni ngati:

• adasokoneza matenda a chiwindi
• adamuyika chiwindi
• adalephera kulandira mankhwala ndi mankhwala ena a hepatitis C m'mbuyomu

Harvoni ndi ribavirin amagwiritsidwa ntchito limodzi mwa anthu omwe ali ndi mikhalidwe imeneyi chifukwa maphunziro azachipatala adawonetsa kuchiritsa kwakukulu ndi mankhwala osakanikirana.

Harvoni ndi omeprazole kapena ma PPI ena

Kutenga Harvoni ndi omeprazole (Prilosec) kapena ma proton pump inhibitors (PPIs) kumatha kuchepetsa kuchuluka kwa Harvoni mthupi lanu. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito.

Ngati ndi kotheka, pewani kutenga Harvoni ndi gulu la mankhwalawa. Ngati mukufuna PPI mukamatenga Harvoni, muyenera kutenga Harvoni ndi PPI nthawi yomweyo pamimba yopanda kanthu.

Zitsanzo za ma PPI ena ndi awa:

• esomeprazole (Wowonjezera)
• lansoprazole (Prevacid)
• pantoprazole (Protonix)

Harvoni ndi zitsamba ndi zowonjezera

Kutenga Harvoni ndi wort ya St. John kumatha kuchepetsa kuchuluka kwa Harvoni mthupi lanu. Izi zitha kupangitsa kuti Harvoni asamagwire bwino ntchito. Pofuna kupewa kuyanjana uku, musatenge Harvoni ndi wort ya St.

Zitsamba zina kapena zowonjezera zomwe zingachepetse kuchuluka kwa Harvoni mthupi lanu ndi monga:

• kava kava
• nthula yamkaka
• aloe
• alireza

Mukamalandira chithandizo cha Harvoni, funsani dokotala musanatengere zitsamba kapena zowonjezera.

Harvoni ndi khofi

Palibe zomwe zanenedwa pakati pa Harvoni ndi khofi. Komabe, zina mwazovuta za Harvoni zitha kukulirakulira mukamamwa khofi kapena caffeine wambiri. Mwachitsanzo, kumwa khofi masana kapena madzulo kumatha kukulitsa mavuto anu ogona. Ndipo caffeine imatha kupweteka mutu.

Ngati mumamwa khofi kapena kumwa tiyi kapena khofi pafupipafupi, lankhulani ndi dokotala wanu ngati zili zotetezeka kwa inu mukamalandira mankhwala a Harvoni.

Njira zina ku Harvoni

Mankhwala ena alipo omwe angachiritse matenda a chiwindi a C. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina ya Harvoni, lankhulani ndi dokotala wanu kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Hepatitis C imatha kuchiritsidwa pogwiritsa ntchito mankhwala ena angapo kapenanso kuphatikiza mankhwala. Mankhwala omwe dokotala wanu akusankhirani adzadalira mtundu wanu wa hepatitis C, chiwindi chanu, komanso ngati mudalandirapo hepatitis C m'mbuyomu.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochizira matenda a chiwindi a C ndi awa:

• Epclusa (velpatasvir, sofosbuvir)
• Mavyret (glecaprevir, pibrentasvir)
• Viekira Pak (paritaprevir, ombitasvir, ritonavir, dasubuvir)
• Vosevi (velpatasvir, sofosbuvir, voxilaprevir)
• Zepatier (elbasvir, grazoprevir)
• Rebetol (ribavirin), yomwe imagwiritsidwa ntchito limodzi ndi mankhwala ena

Ma interferon ndi mankhwala akale omwe kale amagwiritsidwa ntchito pochizira matenda a chiwindi a hepatitis C. Komabe, mankhwala atsopano monga Harvoni amayambitsa zovuta zochepa ndipo amakhala ndi machiritso apamwamba kuposa ma interferon. Pazifukwa izi, masiku ano ma interferon samagwiritsidwa ntchito mochizira matenda a chiwindi a C.

Harvoni vs. mankhwala ena

Mutha kudabwa momwe Harvoni amafanizira ndi mankhwala ena omwe amaperekedwa kuti agwiritse ntchito chimodzimodzi. M'munsimu pali kufananizira pakati pa Harvoni ndi mankhwala angapo.

Harvoni vs. Epclusa

Harvoni ili ndi mankhwala awiri piritsi limodzi: ledipasvir ndi sofosbuvir. Epclusa imakhalanso ndi mankhwala awiri piritsi limodzi: velpatasvir ndi sofosbuvir.

Mankhwala onsewa ali ndi mankhwalawa sofosbuvir, omwe amadziwika kuti "msana" wothandizirayo. Izi zikutanthauza kuti dongosolo la chithandizo limakhazikika pamankhwala am'fupa, ndi mankhwala ena omwe amaphatikizidwa limodzi.

Ntchito

Harvoni ndi Epclusa onse ndi ovomerezeka ndi FDA kuti athetse matenda a hepatitis C. Harvoni amatha kuchiza matenda amtundu wa hepatitis C 1, 4, 5, ndi 6, pomwe Epclusa amatha kuchiza mitundu isanu ndi umodzi yamtunduwu.

Mankhwala onsewa amavomerezedwa kuti azichiza anthu popanda matenda enaake, kapena ndi chiwindi chobwezeredwa kapena chowonongeka. Pali kusiyana kochepa kwa omwe amapatsidwa, kutengera mtundu wamatenda, chiwindi, komanso mbiri yazachipatala.

Harvoni ndivomerezedwa ndi FDA kuti athetse matenda a hepatitis C mwa ana azaka 12 kapena kupitilira apo kapena omwe amalemera mapaundi 77. Epclusa sivomerezedwa kuti athetse matenda a hepatitis C mwa ana.

Mafomu azamankhwala ndi makonzedwe

Harvoni ndi Epclusa onse amatengedwa ngati piritsi limodzi kamodzi patsiku. Amatha kutengedwa ndi chakudya kapena pamimba yopanda kanthu.

Kutalika kwa chithandizo cha Harvoni mwina masabata 8, 12, kapena 24. Kutenga nthawi yayitali bwanji Harvoni kudalira genotype yanu, kapena mtundu wa hepatitis C ndi chiwindi chanu. Zidzadaliranso ndi mankhwala anu am'mbuyomu a hepatitis C.

Kutalika kwa chithandizo cha Epclusa ndi masabata khumi ndi awiri.

Zotsatira zoyipa ndi zoopsa

Harvoni ndi Epclusa onse ndi mankhwala omwe amatchedwa antivirals omwe amatenga mwachindunji ndipo amakhala ndi zotsatira zofananira mthupi. Chifukwa cha izi, zimayambitsa zovuta zambiri. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Zotsatira zoyipa zomwe zimachitika ndi Harvoni ndi Epclusa ndi monga:

Zotsatira zoyipa

Zotsatira zoyipa zomwe zingachitike ndi Harvoni ndi Epclusa ndi monga:

• kuyambiranso kwa matenda a chiwindi (ngati matenda am'mbuyomu adayambiranso kugwira ntchito), zomwe zingayambitse chiwindi kapena kufa (onani "machenjezo a Boxed" pansipa)
• kusokonezeka kwakukulu, ndi zizindikiro zomwe zingaphatikizepo kupuma movutikira ndi angioedema (kutupa pansi pa khungu lanu, makamaka m'maso anu, milomo, manja, kapena mapazi)

Machenjezo a m'bokosi

Harvoni ndi Epclusa onse ali ndi chenjezo lochokera ku FDA. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira.

Chenjezo limafotokoza za chiwopsezo cha kuyambiranso kwa matenda a chiwindi a hepatitis B mutayamba mankhwala ndi mankhwalawa. Kutsegulanso kwa chiwindi cha hepatitis B kumatha kubweretsa kuwonongeka kwa chiwindi, chiwindi, kapena kufa.

Dokotala wanu adzakuyesani matenda a hepatitis B musanayambe kumwa Harvoni kapena Epclusa. Ngati mwapezeka kuti muli ndi matenda a hepatitis B, mungafunike kumwa mankhwala kuti muwachiritse.

Kuchita bwino

Malinga ndi malangizo amankhwala, Harvoni ndi Epclusa ndi njira ziwiri zoyambirira zochizira matenda a hepatitis C 1, 4, 5, ndi 6. Malangizo owonjezerawa ndi awa:

• Harvoni ndi njira yoyamba yosankhira ma genotypes 1, 4, 5, ndi 6 mwa ana azaka 12 kapena kupitilira apo (kapena akulemera mapaundi 77 ndi kupitilira apo).
• Epclusa ndi njira yoyamba yosankhira ma genotypes 2 ndi 3.

Harvoni ndi Epclusa adafaniziridwa m'maphunziro azachipatala. Onsewa anapezeka kuti ndi othandiza kwambiri pochiza matenda a chiwindi a C. Komabe, Epclusa atha kuchiritsa anthu ambiri kuposa Harvoni.

Pakafukufuku wina wamankhwala, anthu opitilira 93 peresenti omwe adalandira ledipasvir ndi sofosbuvir, zomwe zimapangidwa ndi Harvoni, adachiritsidwa ndi matenda a chiwindi a hepatitis C. Mlingo wothandizira anthu omwe adalandira velpatasvir ndi sofosbuvir, zomwe zidapangidwa ndi Epclusa, anali wamkulu kuposa 97%.

Kafukufuku wachiwiri adapeza zotsatira zofananira kwa anthu omwe ali ndi chiwindi cha chiwindi. Kafukufuku wina adawonanso kuti Epclusa adachiritsa hepatitis C mwa anthu ambiri kuposa Harvoni.

M'maphunziro onse atatu, SVR inali yokwera pang'ono kwa Epclusa kuposa ya Harvoni. SVR imayimira kuyankha kwa virologic, zomwe zikutanthauza kuti kachilomboka sikangapezekenso mthupi lanu.

Mtengo

Harvoni ndi Epclusa onse ndi mankhwala omwe ali ndi mayina. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Harvoni ndiokwera mtengo kwambiri kuposa Epclusa. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso mankhwala omwe mumagwiritsa ntchito.

Zindikirani: Mitundu yachibadwa ya mankhwala onsewa ikuyembekezeka kutulutsidwa koyambirira kwa 2019. Wopanga akuganiza kuti mtengo wotsatira mankhwala aliwonse udzakhala $ 24,000. Mtengo uwu ndi wocheperako poyerekeza ndi mtengo wamitundu yamaina.

Harvoni motsutsana ndi Mavyret

Harvoni ili ndi mankhwala awiri piritsi limodzi: ledipasvir ndi sofosbuvir. Mavyret mulinso mankhwala awiri piritsi limodzi: glecaprevir ndi pibrentasvir.

Ntchito

Harvoni ndi Mavyret onse amavomerezedwa ndi a FDA kuti athetse matenda a chiwindi a C. Komabe, amagwiritsidwa ntchito pochiza ma genotypes osiyanasiyana munthawi zosiyanasiyana:

• Harvoni imavomerezedwa kuchiza matenda amtundu wa hepatitis C 1, 4, 5, ndi 6. Mavyret imavomerezedwa kuti ithetse ma genotypes onse asanu ndi limodzi.
• Mankhwala onsewa amagwiritsidwa ntchito pochiza anthu omwe alipira matenda a chiwindi. Harvoni itha kugwiritsidwanso ntchito kwa anthu omwe ali ndi matenda a chiwindi, koma Mavyret sangathe.
• Zonsezi zitha kugwiritsidwa ntchito kwa anthu omwe adadwala chiwindi.
• Mavyret itha kugwiritsidwa ntchito kwa anthu omwe ali ndi matenda a impso kapena atapatsidwa impso, koma Harvoni sivomerezedwa ndi izi.
• Harvoni amaloledwa kuchiza matenda a chiwindi a C kwa ana azaka 12 kapena kupitilira apo kapena omwe amalemera mapaundi 77. Mavyret imangovomerezedwa kuti igwiritsidwe ntchito kwa akulu.
• Mankhwala onsewa amavomerezedwa kuti athandize anthu omwe adayesapo mankhwala ena a hepatitis C m'mbuyomu.

Mafomu azamankhwala ndi makonzedwe

Harvoni ndi Mavyret onse amabwera ngati mapiritsi omwe mumamwa kamodzi patsiku. Komabe, pamene mumamwa piritsi limodzi la Harvoni patsiku, mumamwa mapiritsi atatu a Mavyret patsiku.

Harvoni itha kutengedwa ndi wopanda kapena wopanda chakudya, koma Mavyret ayenera kumwedwa ndi chakudya.

Harvoni atha kupatsidwa chithandizo chamasabata 8, 12, kapena 24. Kutalika kwa chithandizo cha Mavyret kumatha kukhala masabata 8, 12, kapena 16. Kutalika kwa chithandizo chomwe dokotala akukulemberani kutengera mtundu wanu wa hepatitis C, chiwindi, komanso mbiri yamankhwala am'mbuyomu a hepatitis C.

Zotsatira zoyipa ndi zoopsa

Harvoni ndi Mavyret ali ndi zovuta zomwezo mthupi. Izi zikutanthauza kuti amayambitsanso zovuta zina. M'munsimu muli zitsanzo za zina mwa zotsatirazi.

Zotsatira zofala kwambiri

Zotsatira zoyipa zomwe zimachitika ndi Harvoni ndi Mavyret ndi monga:

Zotsatira zoyipa

Zotsatira zoyipa zomwe zingachitike ndi Harvoni ndi Mavyret ndi monga:

• kuyambiranso kwa matenda a chiwindi (ngati matenda am'mbuyomu adayambiranso kugwira ntchito), zomwe zimatha kuwononga chiwindi, kufooka kwa chiwindi, kapena kufa (onani "Machenjezo a Boxed" pansipa)
• kukhudzidwa kwambiri, ndi zizindikilo zomwe zingaphatikizepo kupuma movutikira ndi angioedema (kutupa pansi pakhungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi)

Machenjezo a m'bokosi

Harvoni ndi Mavyret onse ali ndi machenjezo ochokera ku FDA. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira.

Chenjezo limafotokoza za chiwopsezo cha kuyambiranso kwa matenda a chiwindi a hepatitis B mutayamba mankhwala ndi mankhwalawa. Kutsegulanso kwa hepatitis B kumatha kubweretsa kuwonongeka kwakukulu kwa chiwindi, kulephera kwa chiwindi, kapena kufa.

Dokotala wanu adzakuyesani matenda a hepatitis B musanayambe kumwa Harvoni kapena Mavyret. Ngati mutapezeka kuti muli ndi hepatitis B, mungafunike kumwa mankhwala kuti muwachiritse.

Kuchita bwino

Harvoni ndi Mavyret sanafananepo ndi maphunziro azachipatala, koma onsewa ndi othandiza pochizira matenda a chiwindi a C.

Malinga ndi malangizo amankhwala, Harvoni ndi Mavyret ndi njira zonse zoyambirira zosankhira hepatitis C genotypes 1, 4, 5, ndi 6. Mavyret ndichisankho choyambirira cha genotypes 2 ndi 3. Kuphatikiza pa izi, pali matenda ena pomwe mankhwala amodzi angalimbikitsidwe kuposa enawo:

• Ana azaka zapakati pa 12 kapena kupitilira apo kapena omwe amalemera mapaundi 77 kapena kupitilira apo: Harvoni ndi njira yoyamba yosankhira ana awa ndi genotypes 1, 4, 5, ndi 6. Mavyret siyikulimbikitsidwa kuti igwiritsidwe ntchito kwa ana.
• Matenda owopsa a impso: Mavyret ndi njira yoyamba yosankhira hepatitis C mwa anthu omwe ali ndi vutoli. Harvoni sichikulimbikitsidwa kwa anthu omwe ali ndi matenda a impso oopsa.
• Kutha kwa chiwindi: Kwa anthu omwe ali ndi matenda enaake am'magazi, Harvoni amalimbikitsidwa kuti agwiritsidwe ntchito ndi ribavirin. Mavyret siyikulimbikitsidwa kwa anthu omwe ali ndi vutoli.
• Kuika impso: Kwa anthu omwe alandila impso, mankhwala onsewa amalimbikitsidwa ngati njira yoyamba kwa anthu omwe ali ndi genotypes 1 kapena 4. (Harvoni imagwiritsidwa ntchito polemba izi) Mavyret ikulimbikitsidwanso kwa anthu omwe ali ndi genotypes 2 , 3, 5, kapena 6 omwe adalandira impso, koma Harvoni ayi.
• Kuika chiwindi: Malangizo amachiritso ogwiritsira ntchito Harvoni ndi Mavyret ndi osiyana ndi omwe ali ndi chiwindi. Amachokera ku genotype ndi chiwindi.

Mtengo

Harvoni ndi Mavyret onse ndi mankhwala omwe amadziwika ndi dzina. Pakadali pano palibe mitundu yabwinobwino ya mankhwala omwe alipo. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Harvoni ndiokwera mtengo kwambiri kuposa Mavyret. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso mankhwala omwe mumagwiritsa ntchito.

Zindikirani: Mtundu wa Harvoni ukuyembekezeka kutulutsidwa koyambirira kwa 2019. Wopanga akuganiza kuti mtengo wakumwa udzakhala $ 24,000. Mtengo uwu ndi wocheperako poyerekeza ndi mtengo wamtundu wa dzina.

Harvoni vs. Sovaldi

Harvoni ndi Sovaldi onse amagwiritsidwa ntchito pochizira matenda a hepatitis C. Harvoni ndi piritsi lomwe lili ndi mankhwala awiri: ledipasvir ndi sofosbuvir. Sovaldi ali ndi mankhwala amodzi: sofosbuvir.

Ntchito

Harvoni ndivomerezedwa ndi FDA kuti athetse matenda a hepatitis C mwa akulu omwe ali ndi genotypes 1, 4, 5, kapena 6. Itha kugwiritsidwanso ntchito kuchiza ana omwe ali ndi zaka 12 kapena kupitilira apo kapena omwe amalemera mapaundi osachepera 77.

Sovaldi amavomerezedwanso kuti athetse matenda a chiwindi a C, koma amagwiritsidwa ntchito kwa achikulire omwe ali ndi genotypes 1, 2, 3, kapena 4. Itha kugwiritsidwanso ntchito kwa ana omwe ali ndi genotypes 2 kapena 3 omwe ali ndi zaka 12 kapena kupitilira kapena omwe amalemera mapaundi 77 kapena kupitilira apo .

Sovaldi imagwiritsidwa ntchito limodzi ndi mankhwala ena kuchiza matenda a chiwindi a C. Silovomerezeka ndi FDA kuti ligwiritsidwe ntchito lokha.

Mafomu azamankhwala ndi makonzedwe

Harvoni ndi Sovaldi onse amabwera ngati mapiritsi omwe mumamwa. Harvoni amatengedwa kamodzi tsiku lililonse kwa masabata 8, 12, kapena 24. Sovaldi amatengedwanso kamodzi tsiku lililonse, koma kwa masabata 12 kapena 24.

Mankhwala onsewa ali ndi sofosbuvir, koma Harvoni ndi mankhwala osakaniza omwe angagwiritsidwe ntchito paokha kwa anthu ena. Sovaldi sagwiritsidwa ntchito paokha kuchiza matenda a chiwindi a C. Amayikidwa ndi mankhwala ena, kuphatikiza pegylated interferon ndi ribavirin (Rebetol). Ma generic a Sovaldi amapezekanso mu mitundu ina ya mankhwala a hepatitis C.

Zotsatira zoyipa ndi zoopsa

Mankhwala onsewa ali ndi sofosbuvir, chifukwa chake amayambitsa zovuta zambiri. Komabe, Sovaldi nthawi zonse amatengedwa limodzi ndi mankhwala ena, omwe atha kugwira ntchito mosiyana ndi Harvoni. Chifukwa cha izi, zoyipa zomwe zimawoneka ndi chithandizo cha Sovaldi zimadalira mankhwala omwe amagwiritsidwa ntchito.

Zotsatira zoyipa komanso zoyipa za Harvoni ndi Sovaldi zikuwonetsedwa pansipa. Zotsatira zoyipa za Sovaldi zomwe zafotokozedwa zimawoneka pomwe Sovaldi amagwiritsidwa ntchito ndi mankhwala ena a hepatitis C monga ribavirin ndi pegylated interferon.

* Harvoni ndi Sovaldi onse ali ndi chenjezo lolembedwa kuchokera ku FDA lothandizira kuyambiranso kwa matenda a hepatitis B. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Harvoni ndi Sovaldi ali ndi ntchito zosiyanasiyana zovomerezeka ndi FDA, koma zonsezi zimagwiritsidwa ntchito pochizira matenda a chiwindi a C. Harvoni ndi othandiza polimbana ndi kachilomboka akagwiritsidwa ntchito payekha kapena ndi ribavirin. Sovaldi imathandiza pochiza matenda a chiwindi a C pokhapokha akagwiritsidwa ntchito limodzi ndi mankhwala ena, monga ribavirin ndi pegylated interferon.

Malinga ndi malangizo amankhwala, Harvoni ndi njira yoyamba yosamalira hepatitis C mwa anthu omwe ali ndi genotypes 1, 4, 5, kapena 6. Imakhalanso njira yoyamba mwa ana azaka 12 kapena kupitilira apo kapena omwe amalemera mapaundi osachepera 77.

Sovaldi salimbikitsidwanso ndi malangizo amankhwala ngati njira yoyamba yosamalira hepatitis C. Izi ndichifukwa choti mankhwala atsopano monga Harvoni amawerengedwa kuti ndi othandiza kwambiri. Mankhwala atsopano amachititsanso zovuta zina zochepa.

Komabe, Sovaldi nthawi zina amalimbikitsidwa ngati chithandizo chachiwiri kwa anthu ena, koma ayenera kugwiritsidwa ntchito limodzi ndi mankhwala ena.

Mtengo

Harvoni ndi Sovaldi ndi mankhwala omwe amadziwika ndi dzina. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa.

Malinga ndi kuyerekezera kwa GoodRx.com, Harvoni nthawi zambiri amawononga ndalama zochepa kuposa Sovaldi. Mtengo weniweni womwe mumalipira mankhwalawa umadalira inshuwaransi yanu komanso mankhwala omwe mumagwiritsa ntchito.

Zindikirani: Mtundu wa Harvoni ukuyembekezeka kutulutsidwa koyambirira kwa 2019. Wopanga akuganiza kuti mtengo wakumwa udzakhala $ 24,000. Mtengo uwu ndi wocheperako poyerekeza ndi mtengo wamtundu wa dzina.

Harvoni vs. Zepatier

Harvoni muli mankhwala ledipasvir ndi sofosbuvir mu piritsi limodzi. Zepatier imakhalanso ndi mankhwala awiri piritsi limodzi: elbasvir ndi grazoprevir.

Ntchito

Harvoni ndi Zepatier onse ndi ovomerezeka ndi FDA kuti athetse kachilombo ka hepatitis C mwa akulu omwe ali ndi genotypes 1 kapena 4. Harvoni imavomerezedwanso pochiza ma genotypes 5 ndi 6 mwa akulu, ndi genotypes 1, 4, 5, kapena 6 mwa ana azaka 12 kapena kupitilira apo kapena amene amalemera mapaundi osachepera 77. Zepatier sivomerezedwa kuti igwiritsidwe ntchito kwa ana.

Harvoni amavomerezedwa kuti athetse kachilombo ka hepatitis C mwa anthu akuluakulu omwe ali ndi matenda a chiwindi kapena omwe adalandira chiwindi. Ndi izi, dokotala wanu atha kupereka ribavirin ndi Harvoni.

Zepatier sivomerezedwa kuti igwiritsidwe ntchito kwa anthu omwe ali ndi matenda owopsa kapena owopsa a chiwindi, kuwonongeka kwa chiwindi, kapena pambuyo poumba chiwindi.

Zepatier ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito kwa anthu omwe ali ndi genotypes 1 ndi 4 omwe ali ndi vuto lotchedwa polymorphism. Ndi vutoli, munthu amakhala ndi kusiyanasiyana kwamitundu (masinthidwe) komwe kumapangitsa kuti vutoli likhale losamva mankhwala. Tizilombo toyambitsa matenda tikalimbana, zimakhala zovuta kuchiza ndi mankhwala ena.

Dokotala wanu adzakuyesani magazi kuti muwone ngati muli ndi imodzi mwazosiyanazi. Mukatero, mungafunike kumwa ribavirin ndi Zepatier.

Mafomu azamankhwala ndi makonzedwe

Harvoni ndi Zepatier onse amabwera ngati piritsi limodzi lomwe limatengedwa kamodzi tsiku lililonse. Iliyonse imatha kumwedwa popanda chakudya.

Chithandizo cha Harvoni chimakhala milungu 8, 12, kapena 24. Chithandizo cha Zepatier chimatha milungu 12 kapena 16. Kutalika kwa chithandizo chomwe dokotala akukuuzani kudzatengera mtundu wanu, chiwindi, komanso mbiri yamankhwala am'mbuyomu a hepatitis C.

Zotsatira zoyipa ndi zoopsa

Harvoni ndi Zepatier ndi mankhwala ofanana ndipo zotsatira zake mthupi zimafanana. Chifukwa chake, zimayambitsa zovuta zofananira zambiri. M'munsimu muli zitsanzo za zovuta zawo.

* Harvoni ndi Zepatier onse ali ndi chenjezo lolembedwa kuchokera ku FDA lothandizira kuyambiranso kwa hepatitis B. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Harvoni ndi Zepatier sanayerekezeredwe m'maphunziro azachipatala, koma onsewa ndi othandiza pochizira matenda a chiwindi a C.

Malinga ndi malangizo amankhwala, onse a Harvoni ndi Zepatier akulimbikitsidwa ngati njira zoyambirira zochizira matenda a hepatitis C mwa akulu omwe ali ndi genotypes 1 ndi 4. Harvoni ndichisankho choyambirira chothandizira ma genotypes 5 ndi 6, koma Zepatier ayi.

Malangizo a Harvoni ndi Zepatier nawonso amasiyanasiyana motere:

• Ana azaka zapakati pa 12 kapena kupitilira apo kapena omwe amalemera mapaundi 77 kapena kupitilira apo: Harvoni ndi njira yoyamba yosankhira ana omwe ali ndi genotypes 1, 4, 5, ndi 6. Zepatier siyiyenera kugwiritsidwa ntchito mwa ana.
• Matenda owopsa a impso: Zepatier ikulimbikitsidwa ngati chisankho choyambirira kwa anthu omwe ali ndi vutoli, pomwe Harvoni sali.
• Kutha kwa chiwindi: Mwa anthu omwe ali ndi matenda a chiwindi, Harvoni amalimbikitsidwa ngati chisankho choyambirira. Zepatier siyikulimbikitsidwa kwa anthu omwe ali ndi vutoli.
• Kuika chiwindi kapena impso: Harvoni ndi njira yoyamba yosamalira hepatitis C mwa anthu omwe adalandira chiwindi kapena impso. Zepatier sivomerezeka kwa anthu omwe ali ndi mikhalidwe imeneyi.

Mtengo

Harvoni ndi Zepatier ndi mankhwala omwe amadziwika ndi dzina. Pakadali pano palibe mafomu omwe angapezeke ngati mankhwala. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Harvoni amawononga ndalama zambiri kuposa Zepatier. Mtengo weniweni womwe mumalipira mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso mankhwala omwe mumagwiritsa ntchito.

Zindikirani: Mtundu wa Harvoni ukuyembekezeka kutulutsidwa koyambirira kwa 2019. Wopanga akuganiza kuti mtengo wakumwa udzakhala $ 24,000. Mtengo uwu ndi wocheperako poyerekeza ndi mtengo wamtundu wa dzina.

Momwe mungatenge Harvoni

Muyenera kutenga Harvoni malinga ndi malangizo a dokotala wanu.

Kusunga nthawi

Harvoni imatha kutengedwa nthawi iliyonse masana. Komabe, muyenera kuyesa kutenga Harvoni nthawi yomweyo tsiku lililonse. Izi zingakuthandizeni kukumbukira kuzitenga ndikuthandizani kukhala ndi mankhwala osagwirizana ndi dongosolo lanu.

Ngati mukumva kutopa mukamalandira mankhwala a Harvoni, yesetsani kumwa mankhwalawa usiku. Izi zitha kukuthandizani kupewa izi.

Kutenga Harvoni ndi chakudya

Harvoni itha kutengedwa ndi wopanda chakudya. Ngati mukumva mseru mutatenga Harvoni, mutha kupewa zotsatirazi pomwa mankhwalawo ndi chakudya.

Kodi Harvoni akhoza kuphwanyidwa?

Sizikudziwika ngati ndibwino kuphwanya mapiritsi a Harvoni, motero ndibwino kuti musawaphwanye. Ngati mukuvutika kumeza mapiritsi a Harvoni, lankhulani ndi dokotala wanu za mankhwala ena omwe angakuthandizeni.

Momwe Harvoni amagwirira ntchito

Harvoni amagwiritsidwa ntchito pochiza matenda opatsirana ndi hepatitis C (HCV).

Ponena za hepatitis C

HCV imafalikira kudzera m'magazi kapena madzi amthupi. Kachilomboka kamangoyambitsa maselo mchiwindi chanu ndipo kamayambitsa kutupa. Izi zimabweretsa zizindikilo monga:

• kupweteka m'mimba mwako (m'mimba)
• malungo
• mkodzo wamtundu wakuda
• kupweteka pamodzi
• jaundice (khungu lanu loyera kapena khungu lanu)

Chitetezo cha anthu ena chitha kulimbana ndi HCV popanda chithandizo. Komabe, anthu ambiri amafunikira mankhwala kuti athetse kachilomboka ndikuchepetsa zotsatira zakanthawi. Zowopsa, zotsatira zazitali za matenda a chiwindi a C zimaphatikizapo matenda a chiwindi (mabala a chiwindi) ndi khansa ya chiwindi.

Kodi Harvoni amachiza bwanji matenda a chiwindi a C?

Harvoni ndi mankhwala oletsa tizilombo toyambitsa matenda (DAA). Mitundu yamtunduwu imathandizira HCV poletsa kachilomboka kuti isadzipanganso (kudzipanga yokha). Mavairasi omwe sangapangitse makope pamapeto pake amafa ndikuchotsedwa mthupi.

Kuchotsa kachilomboka m'thupi lanu kumachepetsa kutupa kwa chiwindi ndikupewa kuwonongeka kwa chiwindi china.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Anthu ena amayamba kumva bwino m'masiku ochepa kapena milungu ingapo kuyambira atayamba kulandira chithandizo ndi Harvoni. Komabe, mufunikirabe kutenga Harvoni kwa nthawi yonse yomwe dokotala akukupatsani.

M'maphunziro azachipatala, anthu opitilira 86% omwe adatenga Harvoni adachiritsidwa atalandira chithandizo miyezi itatu.

Dokotala wanu adzakuyesani magazi anu ngati ali ndi kachilomboka musanachitike komanso mukamalandira chithandizo. Adziyesanso pakadutsa milungu 12 mutamaliza mankhwala. Ngati mulibe kachilombo koyambitsa matenda m'thupi lanu patatha milungu 12 mutalandira chithandizo, mwakwanitsa kuyankha ma virologic response (SVR). Kukwaniritsa SVR kumatanthauza kuti mumachiritsidwa matenda a chiwindi a C.

Harvoni ndi mimba

Sipanakhale maphunziro okwanira mwa anthu kuti adziwe ngati Harvoni ndiwotheka kutenga panthawi yapakati. M'maphunziro a nyama, panalibe vuto lililonse kwa mwana wosabadwa yemwe adawoneka pomwe mayi adalandira Harvoni. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, lankhulani ndi dokotala wanu ngati Harvoni ali woyenera kwa inu.

Chidziwitso: Ngati mukumwa Harvoni ndi ribavirin, mankhwalawa siabwino kugwiritsa ntchito panthawi yapakati (onani "Harvoni ndi ribavirin" pamwambapa).

Harvoni ndi kuyamwitsa

Sidziwika ngati Harvoni amadutsa mkaka wa m'mawere wa anthu. M'maphunziro azinyama, Harvoni adapezeka mkaka wa m'mawere koma sanayambitse mavuto mwa ana. Komabe, maphunziro a nyama samaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Ngati mukuyamwitsa kapena mukukonzekera kuyamwitsa, lankhulani ndi dokotala wanu za zomwe zingakhale zovuta komanso zopindulitsa mukamamwa Harvoni mukamayamwitsa.

Chidziwitso: Ngati mukumwa Harvoni ndi ribavirin, muyenera kukambirana ndi dokotala ngati mungathe kupitiriza kuyamwitsa (onani "Harvoni ndi ribavirin" pamwambapa).

Mafunso wamba pa Harvoni

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Harvoni.

Kodi ndiyenera kutsatira zakudya zapadera ndikamamwa Harvoni?

Ayi, palibe chakudya chapadera chofunikira mukamatenga Harvoni.

Komabe, ngati mukumva nseru kapena kupweteka m'mimba ngati gawo lina la Harvoni, kungakhale kothandiza kudya zakudya zazing'ono ndikupewa zakudya zonona, zokometsera, kapena acidic. Kutenga Harvoni ndi chotupitsa tating'onoting'ono kungathenso kuchepetsa kunyoza.

Kodi Harvoni atenga nthawi yayitali bwanji kuti athetse matenda anga a hepatitis C?

Harvoni ayamba kugwira ntchito nthawi yomweyo kuti athane ndi kachilomboka. Komabe, kuti muchotse matenda a chiwindi a C, muyenera kutenga Harvoni kwa nthawi yayitali yomwe dokotala akukupatsani. Awa atha kukhala masabata 8, 12, kapena 24, kutengera mbiri yanu yazachipatala.

M'maphunziro azachipatala, pafupifupi anthu onse omwe adatenga Harvoni adakwanitsa kupeza yankho la virologic response SVR) atalandira chithandizo chonse. SVR amatanthauza kuti kachilomboko sikanapezekanso m'magazi awo. Munthu akapeza SVR, amawoneka kuti achiritsidwa ndi matenda a chiwindi a C.

Kodi mtengo wa machiritso a Harvoni ndi uti?

Kuchuluka kwa machiritso a Harvoni kumadalira mbali zina za matenda anu a chiwindi a C. Izi zimaphatikizira ngati muli ndi matenda enaake, kapena matenda amtundu wanji wa hepatitis C omwe mudayesapo kale, ndi mtundu wanji wama virus omwe muli nawo.

Mwachitsanzo, m'maphunziro azachipatala a Harvoni, 96 peresenti ya anthu omwe adakwaniritsa izi adachiritsidwa ndi hepatitis C pambuyo pa masabata 12:

• anali ndi genotype 1
• analibe matenda enaake
• analibe mbiri yazithandizo zina zamatenda a hepatitis C.

M'maphunziro omwewo azachipatala, pakati pa 86 peresenti ndi 100 peresenti ya anthu omwe ali ndi mbiri yakale yazachipatala adachiritsidwa matenda a chiwindi a hepatitis C.

Kodi matenda a chiwindi a hepatitis C amatha kubwerera atatenga Harvoni?

Ngati mutenga Harvoni tsiku lililonse monga adalangizidwa ndi dokotala wanu ndikukhala ndi moyo wathanzi, kachilomboka sikuyenera kubwerera.

Komabe, ndizotheka kubwereranso (matendawa ayambirenso). Izi zimachitika mankhwala akachiritsa matenda a chiwindi a C, koma kuyezetsa magazi kumazindikiranso kachilomboka miyezi ingapo mpaka zaka zitatha. M'mayesero azachipatala, mpaka 6 peresenti ya anthu omwe adachitidwa ndi Harvoni adayambiranso.

Komanso, ngati mungayambitsenso matenda a chiwindi a C pambuyo mutamwa mankhwala aliwonse a hepatitis C, kuphatikiza Harvoni, mutha kupatsidwanso kachilomboka. Kupatsanso kachilomboka kumatha kuchitika chimodzimodzi momwe kachilombo koyambirira kanapangidwira.

Kugawana singano zomwe zimagwiritsidwa ntchito pobayira mankhwala osokoneza bongo komanso kugonana popanda kondomu ndizotheka kupatsanso kachilomboka. Kupewa izi kumatha kuthandiza kupewa kuyambukiranso ndi matenda a chiwindi a C.

Kodi mtundu wa hepatitis C ndi wotani?

Pali mitundu isanu ndi umodzi yamatenda amtundu wa hepatitis C omwe amadziwika kuti amapatsira anthu. Matendawa amatchedwa genotypes.

Ma genotypes amadziwika ndi kusiyana kwa ma virus a ma virus. Matenda ofala kwambiri a hepatitis C ku United States ndi genotype 1, koma mitundu ina imawonekeranso apa.

Dokotala wanu adzakuyesani magazi kuti mudziwe mtundu womwe muli nawo. Mtundu wanu wa hepatitis C umathandizira dokotala kuti azindikire mankhwala omwe akuyenera.

Kuchulukitsitsa kwa Harvoni

Mukatenga Harvoni wambiri, mumachulukitsa chiopsezo chanu chazovuta.

Zizindikiro zambiri za bongo

Zizindikiro za bongo za Harvoni zitha kuphatikiza:

• kutopa
• mutu wopweteka kwambiri
• nseru ndi kusanza
• kufooka kwa minofu
• kusowa tulo (kuvuta kugona)
• kupsa mtima

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu kapena funsani malangizo kuchokera ku American Association of Poison Control Center ku 800-222-1222 kapena kudzera pa chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Machenjezo a Harvoni

Mankhwalawa amabwera ndi machenjezo angapo.

Chenjezo la FDA: Kutsegulanso kachilombo ka hepatitis B.

Mankhwalawa ali ndi chenjezo la nkhonya. Ili ndiye chenjezo lalikulu kwambiri kuchokera ku Food and Drug Administration (FDA). Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

• Anthu omwe ali ndi kachilombo ka hepatitis C ndi hepatitis B ayamba kumwa Harvoni, pamakhala chiopsezo chotenga kachilombo ka hepatitis B (HBV). Kutsegulanso kumatanthauza kuti kachilomboka kamayambanso kugwira ntchito. Kukhazikitsanso mphamvu kwa HBV kumatha kubweretsa kufooka kwa chiwindi kapena kufa. Dokotala wanu adzakuyesani HBV musanayambe kumwa mankhwala ndi Harvoni. Mukapezeka kuti muli ndi HBV, mungafunike kumwa mankhwala kuti muwachiritse.

Machenjezo ena

Musanatenge Harvoni, lankhulani ndi dokotala wanu za mbiri yanu. Harvoni sangakhale oyenera kwa inu ngati mukudwala.

Sizikudziwika ngati Harvoni ndiwotetezeka kapena wogwira mtima mwa anthu omwe ali ndi matenda a impso. Izi zimaphatikizapo anthu omwe ali ndi vuto la impso kapena omwe ali ndi matenda amphongo kumapeto omwe amafunikira hemodialysis. Komabe, anthu omwe ali ndi matenda a impso omwe adatenga Harvoni mu kafukufuku wamankhwala a 2018 adathandizidwa bwino ndipo sanakhale ndi zovuta zoyipa.

Ngati muli ndi matenda a impso, lankhulani ndi dokotala wanu ngati Harvoni ali woyenera kwa inu.

Kutha kwa Harvoni

Harvoni akatulutsidwa ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pazolemba zomwe zili m'botolo. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe mankhwalawa adaperekedwa.

Cholinga cha masiku otha ntchitowa ndikutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito.

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mankhwalawo amasungidwira. Mapiritsi a Harvoni amayenera kusungidwa pansi pa 86⁰F (30⁰C) ndikusungidwa mchidebe chomwe adalowamo.

Ngati mwakhala mukugwiritsa ntchito mankhwala omwe adutsa kale, lankhulani ndi wazamalonda wanu ngati mutha kuugwiritsabe ntchito.

Zambiri za Harvoni

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Njira yogwirira ntchito

Harvoni ili ndi mankhwala awiri: ledipasvir ndi sofosbuvir.

Ledipasvir imaletsa mapuloteni a HCV NS5A, omwe amafunikira kuti phosphorylation yamagulu a RNA ayambe kugwira bwino ntchito. Kuletsa kwa NS5A kumalepheretsa kubwereza kwa RNA ndi msonkhano.

Sofosbuvir ndi HCV NS5B polymerase inhibitor yokhala ndi metabolism yogwira (nucleoside analog triphosphate) yomwe imaphatikizidwa mu HCV RNA. Metabolite yogwira imagwira ntchito ngati chotsekera tcheni, kuyimitsa kubwereza kwa HCV.

Harvoni ali ndi zochitika zotsutsana ndi ma HCV genotypes 1, 4, 5, ndi 6.

Pharmacokinetics ndi metabolism

Harvoni ili ndi zinthu ziwiri zothandiza: ledipasvir ndi sofosbuvir.

Ledipasvir imafika pachimake pafupifupi m'maola anayi ndipo ili pafupi kwambiri ndi mapuloteni am'magazi. Metabolism imachitika kudzera pa makutidwe ndi okosijeni kudzera munjira yosadziwika. Hafu ya moyo ndi pafupifupi maola 47. Mankhwala osasintha ndi ma metabolites ake okosijeni amachotsedwa makamaka mu ndowe.

Kukula kwakukulu kwa Sofosbuvir kumachitika mphindi 45 mpaka ola limodzi. Mapuloteni omanga mapuloteni amawerengera pafupifupi 65 peresenti ya mankhwala ozunguza bongo. Sofosbuvir ndi mankhwala osokoneza bongo omwe amasandulika kukhala metabolite (GS-461203) yogwiritsidwa ntchito ndi hydrolysis ndi phosphorylation m'chiwindi. GS-461203 imapanganso dephosphorylated kukhala metabolite yosagwira ntchito.

Mpaka 80 peresenti ya mlingowu amachotsedwa mkodzo. Hafu ya moyo wa kholo ndi mphindi 30, ndipo theka la moyo wa metabolite wosagwira ntchito uli pafupi maola 27.

Zotsutsana

Palibe zotsutsana pakugwiritsa ntchito Harvoni. Fotokozerani za ribavirin yomwe imafotokoza zambiri pazotsutsana kwa anthu omwe alandila Harvoni ndi ribavirin.

Yosungirako

Harvoni iyenera kusungidwa mu chidebe chake choyambirira kutentha kotsika kuposa 86⁰F (30⁰C).

Chodzikanira: MedicalNewsToday yachita zonse zotheka kuti zitsimikizire kuti zidziwitso zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.