Hepatitis C Genotype 2: Zomwe Muyenera Kuyembekezera

Zamkati

• Chifukwa chiyani zili zofunika kuti ndili ndi genotype 2?
• Kodi matenda a hepatitis C genotype 2 amachiritsidwa bwanji?
• Glecaprevir ndi pibrentasvir (Mavyret)
• Sofosbuvir ndi velpatasvir (Epclusa)
• Daclatasvir (Daklinza) ndi sofosbuvir (Sovaldi)
• Momwe ma genotypes ena amathandizidwira
• Kodi zovuta zingakhale zotani?
• Chiwonetsero

Chidule

Mukalandira matenda a hepatitis C, ndipo musanayambe mankhwala, mufunika kuyesa magazi ena kuti mudziwe mtundu wamatendawa. Pali mitundu isanu ndi umodzi yodziwika bwino ya mtundu wa hepatitis C, kuphatikiza ma 75 subtypes.

Kuyezetsa magazi kumapereka chidziwitso chokwanira cha kachilombo ka HIV kamene kali m'magazi anu.

Kuyesaku sikuyenera kubwerezedwa chifukwa genotype siyimasintha. Ngakhale ndizosazolowereka, ndizotheka kuti mutenge kachilombo kakang'ono kamodzi. Izi zimatchedwa superinfection.

Ku United States, pafupifupi 13 mpaka 15 peresenti ya anthu omwe ali ndi matenda otupa chiwindi a mtundu wa C ali ndi genotype 2. Genotype 1 ndi amene amakhudza anthu 75 pa 100 aliwonse amene ali ndi matenda otupa chiwindi a mtundu wa C.

Kudziwa mtundu wanu wamtunduwu kumakhudza malingaliro anu azithandizo.

Chifukwa chiyani zili zofunika kuti ndili ndi genotype 2?

Kudziwa kuti muli ndi genotype 2 kumapereka chidziwitso chofunikira pazomwe mungasankhe komanso momwe zingathandizire.

Kutengera mtundu wa genotype, madokotala amatha kuchepetsa chithandizo chomwe chingakhale chothandiza komanso kuti muyenera kumwa nthawi yayitali bwanji. Izi zimatha kukulepheretsani kuwononga nthawi ndi mankhwala olakwika kapena kumwa mankhwala kwa nthawi yayitali kuposa momwe muyenera kuchitira.

Ma genotypes ena amayankha mosiyanasiyana kuchipatala kuposa ena. Ndipo kutalika komwe muyenera kumwa mankhwala kumatha kusiyanasiyana kutengera mtundu wanu wamankhwala.

Komabe, genotype singauze madotolo kuti vutoli lipitirira msanga bwanji, momwe zizindikilo zanu zingakhudzire kwambiri, kapena ngati matenda oopsa atha kukhala osachiritsika.

Kodi matenda a hepatitis C genotype 2 amachiritsidwa bwanji?

Sizikudziwika chifukwa chake, koma mwa anthu amathetsa matenda a hepatitis C popanda chithandizo chilichonse. Popeza palibe njira yodziwira yemwe agwere m'gululi, ali ndi matenda opatsirana, dokotala wanu angakulimbikitseni kudikirira miyezi isanu ndi umodzi kuti muthetse kachilomboka, chifukwa kumatha kuwonekera zokha.

Hepatitis C imachiritsidwa ndi mankhwala ochepetsa ma virus omwe amachotsa thupi lanu ndikuletsa kapena kuchepetsa kuwonongeka kwa chiwindi. Nthawi zambiri, mumamwa mankhwala osakanikirana ndi ma virus kwa milungu 8 kapena kupitilira apo.

Pali mwayi wabwino kuti mudzakhala ndi yankho la virologic (SVR) lokhalitsa la mankhwala akumwa. Mwanjira ina, imachiritsidwa kwambiri. Mlingo wa SVR pazinthu zambiri zatsopano za hepatitis C ndizoposa 99 peresenti.

Posankha mankhwala ndikusankha momwe muyenera kumwa, dokotala wanu nthawi zambiri amakambirana izi:

• thanzi lanu lonse
• kuchuluka kwa kachilombo kamene kamapezeka m'thupi lanu (kuchuluka kwa tizilombo)
• kaya muli ndi matenda enaake kapena kuwonongeka kwa chiwindi
• ngati mudalandira kale matenda a chiwindi a C, ndi chithandizo chomwe mudalandira

Glecaprevir ndi pibrentasvir (Mavyret)

Mutha kupatsidwa mankhwalawa ngati mwatsopano kuchipatala kapena mwathandizidwa ndi peginterferon kuphatikiza ribavirin kapena sofosbuvir kuphatikiza ribavirin (RibaPack) ndipo sizinakuchiritse. Mlingowu ndi mapiritsi atatu, kamodzi patsiku.

Mutenga mankhwalawa mpaka liti:

• ngati mulibe matenda enaake: masabata 8
• ngati muli ndi matenda enaake: masabata 12

Sofosbuvir ndi velpatasvir (Epclusa)

Kuphatikizaku ndi njira ina kwa anthu omwe angoyamba kumene kulandira chithandizo, kapena omwe adalandirapo kale. Mudzatenga piritsi limodzi patsiku kwa masabata khumi ndi awiri. Mlingowo ndi wofanana, kaya muli ndi matenda enaake.

Daclatasvir (Daklinza) ndi sofosbuvir (Sovaldi)

Dongosolo ili limavomerezedwa ku genotype ya hepatitis C 3. Siloledwa kuvomereza genotype 2, koma madotolo amatha kuligwiritsa ntchito kwa anthu ena omwe ali ndi genotype iyi.

Mlingowu ndi piritsi limodzi la daclatasvir ndi piritsi limodzi la sofosbuvir kamodzi patsiku.

Mutenga mankhwalawa mpaka liti:

• ngati mulibe matenda enaake: milungu 12
• ngati mukudwala matenda enaake: masabata 16 mpaka 24

Kutsata magazi mwotsatira kudzaulula momwe mukuyankhira kuchipatala.

Chidziwitso: Kugwiritsa ntchito mankhwala osokoneza bongo kumatanthauza kuti mankhwala omwe avomerezedwa ndi a FDA pacholinga chimodzi amagwiritsidwa ntchito pazosiyana zomwe sizinavomerezedwe. Komabe, dokotala amatha kugwiritsabe ntchito mankhwalawa pazifukwa izi. Izi ndichifukwa choti a FDA amayang'anira kuyesa ndi kuvomereza mankhwala, koma osati momwe madotolo amagwiritsira ntchito mankhwala pochizira odwala awo. Chifukwa chake, adotolo amatha kukupatsani mankhwala ngakhale akuganiza kuti ndi bwino kuti musamalire. Phunzirani zambiri zakugwiritsa ntchito mankhwala osokoneza bongo.

Momwe ma genotypes ena amathandizidwira

Chithandizo cha majeremusi 1, 3, 4, 5, ndi 6 chimadaliranso pazinthu zosiyanasiyana monga kuchuluka kwa ma virus komanso kukula kwa chiwindi. Genotypes 4 ndi 6 sizodziwika kwenikweni, ndipo genotypes 5 ndi 6 ndizosowa ku United States.

Mankhwala a ma virus sangaphatikizepo mankhwalawa kapena kuphatikiza kwake:

• daclatasvir (Daklinza)
• elbasvir / grazoprevir (Zepatier)
• glecaprevir / pibrentasvir (Mavyret)
• ledipasvir / sofosbuvir (Harvoni)
• ombitasvir / paritaprevir / ritonavir (Technivie)
• ombitasvir / paritaprevir / ritonavir ndi dasabuvir (Viekira Pak)
• simeprevir (Olysio)
• sofasbuvir (Sovaldi)
• sofosbuvir / velpatasvir (Epclusa)
• sofosbuvir / velpatasvir / voxilaprevir (Vosevi)
• alireza

Kutalika kwa chithandizo kumatha kusiyanasiyana ndi genotype.

Ngati kuwonongeka kwa chiwindi kuli kokwanira, kuperekera chiwindi kungalimbikitsidwe.

Kodi zovuta zingakhale zotani?

Hepatitis C genotype 2 nthawi zambiri imachiritsidwa. Koma matenda opatsirana amatha kubweretsa zovuta zazikulu.

Anthu ambiri omwe ali ndi chiwindi cha hepatitis C samakumana ndi zizindikilo kapena zochepa chabe, ngakhale chiwindi chikuwonongeka.

Miyezi isanu ndi umodzi yoyambirira pambuyo poti matenda akutenga kachilombo ka hepatitis C. Izi ndi zoona ngakhale muli ndi zizindikiro kapena ayi. Ndi chithandizo, ndipo nthawi zina popanda chithandizo, anthu ambiri amachotsa matendawa nthawi imeneyi.

Simungathe kukhala ndi chiwindi chowopsa nthawi yayikulu, ngakhale nthawi zambiri ndizotheka kukhala ndi chiwindi chokwanira.

Ngati muli ndi kachilomboko m'thupi lanu pakatha miyezi isanu ndi umodzi, muli ndi matenda a hepatitis C. Ngakhale zili choncho, matendawa amatenga zaka zambiri kuti apite patsogolo. Mavuto akulu atha kuphatikizira kuwonongeka kwa chiwindi, khansa ya chiwindi, komanso kulephera kwa chiwindi.

Ziwerengero zamavuto amtundu wokha wa 2 zikusowa.

Kwa mitundu yonse ya matenda a chiwindi a hepatitis C ku United States, akuti:

• 75 mpaka 85 mwa anthu 100 omwe ali ndi kachilomboka adzapitiliza kutenga matenda opatsirana
• 10 mpaka 20 imayamba kudwala chiwindi mkati mwa zaka 20 mpaka 30

Anthu akayamba kudwala matenda a chiwindi, amakhala ndi khansa ya chiwindi chaka chilichonse.

Chiwonetsero

Mukalandira chithandizo koyambirira, zimakuthandizani kuti mupewe kuwonongeka kwa chiwindi. Kuphatikiza pa mankhwala osokoneza bongo, mudzafunika kuyesa magazi kuti muwone momwe zikuyendera.

Maganizo a hepatitis C genotype 2 ndiabwino kwambiri. Izi ndi zoona makamaka mukayamba kumwa mankhwala msanga, kachilomboka kasanakhale ndi mwayi wowononga chiwindi.

Mukakwanitsa kuchotsa hepatitis C genotype 2 m'dongosolo lanu, mudzakhala ndi ma antibodies omwe angakuthandizeni kukutetezani ku ziwonetsero zamtsogolo. Koma mutha kukhalabe ndi matenda amtundu wina wa hepatitis kapena mtundu wina wa hepatitis C.