Kodi Ibuprofen ingakulitse zizindikiro za COVID-19?

Zamkati

• Nchifukwa chiyani ibuprofen ingayambitse matendawa?
• Zomwe zimadziwika
• Zomwe muyenera kuchita ngati muli ndi zizindikiro

Kugwiritsa ntchito mankhwala a Ibuprofen ndi mankhwala ena osagwiritsidwa ntchito ndi anti-inflammatory (NSAIDs) panthawi yomwe ali ndi kachilombo ka SARS-CoV-2 amaonedwa kuti ndi otetezeka, chifukwa sikunali kotheka kutsimikizira ubale womwe ulipo pakati pa kugwiritsa ntchito mankhwalawa ndikuwonjezeka kwa zizindikiro za kupuma kwa mliri wa COVID- 19.

Kuphatikiza apo, kafukufuku yemwe adachitika ku Israeli ^[1] anayang'anira odwala omwe amagwiritsa ntchito ibuprofen kwa sabata imodzi asanapezeke ndi COVID-19 komanso akamachiza chithandizo chazizindikiro pamodzi ndi paracetamol ndipo adapeza kuti kugwiritsa ntchito ibuprofen sikokhudzana ndi kukulitsa matenda azachipatala.

Chifukwa chake, palibe umboni kuti kugwiritsa ntchito ibuprofen kumatha kukulitsa matenda ndi kufa kwa COVID-19, chifukwa chake, kugwiritsa ntchito mankhwalawa kukuwonetsedwa ndi azaumoyo, ndipo akuyenera kugwiritsidwa ntchito pothandizidwa ndi azachipatala.

Nchifukwa chiyani ibuprofen ingayambitse matendawa?

Kafukufuku wofalitsidwa munyuzipepalayi Lancet Mankhwala Opuma ^[2] akuti ibuprofen imatha kukulitsa zizindikiritso mwa anthu omwe ali ndi matenda opatsirana a ma virus, chifukwa mankhwalawa amatha kukulitsa kutulutsa kwa ACE, komwe ndi kulandila komwe kumapezeka m'maselo amunthu komanso komwe kumamangiranso ku coronavirus yatsopano. Mawuwa adatengera kuti odwala matenda ashuga komanso omwe ali ndi matenda oopsa omwe ali ndi ziwonetsero zambiri za ACE receptors, amagwiritsa ntchito ibuprofen ndi ma NSAID ena ndipo adapanga ma COVID-19 ovuta.

Kafukufuku wina adachitika ndi makoswe a matenda ashuga^[3], adalimbikitsa kugwiritsa ntchito ibuprofen kwa masabata 8 pamlingo wochepa kuposa momwe amathandizira, zomwe zimapangitsa kuti kuwonetseredwa kwa enzyme 2 (ACE2) ya angiotensin yotembenuza minofu ya mtima.

Enzyme yomweyi, ACE2, ikuwoneka kuti ndi imodzi mwazinthu zolowera mavairasi am'banja la coronavirus m'maselo, ndipo pachifukwa ichi, asayansi ena amaganiza kuti ngati pali kuwonjezeka kwa kufotokozera kwa enzyme iyi mwa anthu, makamaka mapapo, ndizotheka kuti kachilomboka kangachuluke mofulumira, ndikupangitsa zizindikilo zowopsa.

Zomwe zimadziwika

Ngakhale kuti kafukufukuyu adatulutsa zakusagwirizana pakati pa ibuprofen ndi COVID-19, World Health Organisation ndi akuluakulu ena azaumoyo adati palibe umboni uliwonse wasayansi wosonyeza kuti kugwiritsa ntchito ibuprofen sikungakhale kotetezeka, chifukwa zotsatira zomwe zidaperekedwa zimangodalira malingaliro komanso ayi maphunziro aumunthu achitidwadi. Kuphatikiza apo, kafukufuku wina wasonyeza kuti ^[4]:

• Palibe umboni wachindunji woti ibuprofen imatha kulumikizana ndi SARS-CoV-2;
• Palibe umboni kuti ibuprofen ndi yomwe imapangitsa kuti mawu azigwiritsa ntchito angiotensin potembenuza ma enzyme;
• Kafukufuku wina wa mu vitro wasonyeza kuti ibuprofen ikhoza "kuthyola" cholandilira cha ACE, zomwe zimapangitsa kuti zikhale zovuta kulumikizana kwa ma cell-virus ndikuchepetsa chiopsezo chotenga kachilombo kudzera mu njirayi;
• Palibe umboni kuti kugwiritsa ntchito ibuprofen kumatha kukulitsa kapena kuwonjezera chiopsezo chotenga matenda.

Komabe, maphunziro owonjezera amafunikirabe kutsimikizira kuti kulibe ubale pakati pa SARS-CoV-2 ndikugwiritsa ntchito ibuprofen kapena ma NSAID ena ndikuwonetsetsa kuti mankhwalawa akugwiritsidwa ntchito bwino.

Zomwe muyenera kuchita ngati muli ndi zizindikiro

Pankhani ya zizindikiro zochepa za COVID-19, monga malungo, chifuwa chachikulu komanso kupweteka mutu, mwachitsanzo, kuwonjezera pa kudzipatula, tikulimbikitsidwa kukaonana ndi adotolo kuti malangizo aperekedwe ngati mankhwala omwe angagwiritsidwe ntchito kuti athetse chizindikiro, kugwiritsa ntchito paracetamol kapena ibuprofen kungasonyezedwe, komwe kuyenera kugwiritsidwa ntchito molingana ndi upangiri wa zamankhwala.

Komabe, pamene zizindikilozo zimakhala zovuta kwambiri, ndipo pakhoza kukhala zovuta kupuma ndi kupweteka pachifuwa, chinthu chabwino ndichakuti munthuyo apite kuchipatala kuti matenda a COVID-19 athe kutsimikiziridwa ndipo chithandizo chodziwika bwino chitha kuyambika ndi chithandizo. cholinga choletsa zovuta zina ndikulimbikitsa moyo wa munthu. Mvetsetsani momwe mankhwala amathandizira COVID-19.