Matenda Osakanikirana Olumikizana

Zamkati

• Kodi matenda ophatikizika ophatikizika ndi ati?
• Zizindikiro zake ndi ziti?
• Zimayambitsa chiyani?
• Kodi pali zoopsa zilizonse?
• Kodi amapezeka bwanji?
• Amachizidwa bwanji?
• Maganizo ake ndi otani?

Kodi matenda ophatikizika ophatikizika ndi ati?

Matenda osakanikirana osakanikirana (MCTD) ndimatenda achilengedwe omwe amapezeka mthupi. Nthawi zina amatchedwa matenda olowererana chifukwa zizindikiro zake zambiri zimakumana ndi zovuta zina zamatenda, monga:

• zokhudza zonse lupus erythematosus
• scleroderma
• polymyositis

Milandu ina ya MCTD imagawana zizindikilo ndi nyamakazi ya nyamakazi.

Palibe mankhwala a MCTD, koma nthawi zambiri amatha kuyendetsedwa ndi mankhwala komanso kusintha kwa moyo.

Popeza nthendayi imatha kukhudza ziwalo zosiyanasiyana monga khungu, minofu, dongosolo logaya chakudya ndi mapapo, komanso malo anu olumikizirana, chithandizo chimalimbikitsidwa kuthana ndi madera akuluakulu okhudzidwa.

Mawonedwe azachipatala atha kukhala ochepera pang'ono kufikira owopsa, kutengera makina omwe akukhudzidwa.

Othandizira pamizere yoyamba monga nonsteroidal anti-inflammatory agents amatha kugwiritsidwa ntchito koyambirira, koma odwala ena angafunike chithandizo chamankhwala opitilira muyeso ndi mankhwala a antimalarial hydroxychloroquine (Plaquenil) kapena othandizira ena osintha matenda ndi biologics.

Malinga ndi National Institutes of Health, zaka 10 zopulumuka kwa anthu omwe ali ndi MCTD ndi pafupifupi 80%. Izi zikutanthauza kuti 80 peresenti ya anthu omwe ali ndi MCTD akadali ndi moyo zaka 10 atapezeka.

Zizindikiro zake ndi ziti?

Zizindikiro za MCTD nthawi zambiri zimawoneka motsatizana kwa zaka zingapo, osati zonse mwakamodzi.

Pafupifupi 90 peresenti ya anthu omwe ali ndi MCTD ali ndi zochitika za Raynaud. Ichi ndi chikhalidwe chodziwika bwino ndi kuzizira kozizira, zala zakufa zomwe zimakhala buluu, zoyera, kapena zofiirira. Nthawi zina zimachitika miyezi kapena zaka zizindikiro zina zisanachitike.

Zizindikiro zowonjezera za MCTD zimasiyanasiyana malinga ndi munthu, koma zina mwazofala kwambiri ndi izi:

• kutopa
• malungo
• kupweteka m'magulu angapo
• zidzolo
• kutupa m'malo olumikizirana mafupa
• kufooka kwa minofu
• kutengeka kozizira ndikusintha kwa manja ndi mapazi

Zizindikiro zina zotheka ndi izi:

• kupweteka pachifuwa
• kutupa m'mimba
• Reflux ya asidi
• kuvuta kupuma chifukwa cha kuthamanga kwa magazi m'mapapo kapena kutupa kwa mapapo
• kuumitsa kapena kuumitsa zigamba za khungu
• manja otupa

Zimayambitsa chiyani?

Zomwe zimayambitsa MCTD sizikudziwika. Ndi vuto lokhazikika mthupi lanu, kutanthauza kuti limakhudza chitetezo chamthupi mwanu molakwika ndikuukira minofu yathanzi.

MCTD imachitika pamene chitetezo cha mthupi lanu chimaukira minofu yolumikizana yomwe imapereka chimango cha ziwalo za thupi lanu.

Kodi pali zoopsa zilizonse?

Anthu ena omwe ali ndi MCTD ali ndi mbiri yabanja, koma ofufuza sanapeze cholumikizira chodziwika bwino cha majini.

Malinga ndi Genetic and Rare Diseases Information Center (GARD), azimayi ali ndi mwayi wochulukirapo katatu kuposa amuna kukhala ndi vutoli. Zitha kugunda msinkhu uliwonse, koma zaka zoyambira zimakhala pakati pa zaka 15 ndi 25.

Kodi amapezeka bwanji?

MCTD ikhoza kukhala yovuta kuzindikira chifukwa imatha kufanana ndi zinthu zingapo. Zitha kukhala ndi ziwalo zazikulu za scleroderma, lupus, myositis kapena nyamakazi kapena kuphatikiza kwa mavutowa.

Kuti mupeze matenda, dokotala wanu adzakuyesani. Adzakufunsaninso za mbiri yakale yazizindikiro zanu. Ngati ndi kotheka, lembani zizindikilo zanu, muzindikire nthawi yomwe zimachitika komanso kutalika kwake. Izi zithandizira dokotala wanu.

Ngati dokotala azindikira zizindikiro zamatenda a MCTD, monga kutupa mozungulira mafupa, kuthamanga, kapena umboni wosazindikira kuzizira, atha kuyitanitsa kuyezetsa magazi kuti awone ngati ali ndi ma antibodies ena okhudzana ndi MCTD, monga anti-RNP, komanso kupezeka Zizindikiro zotupa.

Angathenso kuyitanitsa mayeso kuti ayang'ane kupezeka kwa ma antibodies omwe amagwirizana kwambiri ndi matenda ena omwe amadzichiritsira okha kuti athe kupeza matenda oyenera komanso / kapena kutsimikizira matenda omwe amapezeka.

Amachizidwa bwanji?

Mankhwala angathandize kuthana ndi zizindikiro za MCTD. Anthu ena amangofunika chithandizo cha matenda awo akawuka, koma ena angafunike chithandizo chanthawi yayitali.

Mankhwala ogwiritsira ntchito MCTD ndi awa:

• Mankhwala osagwiritsidwa ntchito poletsa kutupa (NSAIDs). Ma NSAID owerengera, monga ibuprofen (Advil, Motrin) ndi naproxen (Aleve), amatha kuthana ndi mafupa komanso kutupa.
• Corticosteroids. Mankhwala a Steroid, monga prednisone, amatha kuthana ndi kutupa ndikuthandizira kuyimitsa chitetezo chanu cha mthupi kuti chisawononge matupi athanzi. Chifukwa zimatha kubweretsa zovuta zambiri, monga kuthamanga kwa magazi, ng'ala, kusinthasintha kwamaganizidwe, komanso kunenepa, nthawi zambiri zimagwiritsidwa ntchito kwakanthawi kochepa kuti mupewe zoopsa zazitali.
• Mankhwala osokoneza bongo. Hydroxychloroquine (Plaquenil) itha kuthandizira ndi MCTD yofatsa ndipo mwina ingathandize kupewa kuwonongeka.
• Oletsa ma calcium. Mankhwala monga nifedipine (Procardia) ndi amlodipine (Norvasc) amathandizira kuthana ndi zochitika za Raynaud.
• Odwala matenda opatsirana pogonana. MCTD yowopsa ingafune chithandizo chanthawi yayitali ndi ma immunosuppressants, omwe ndi mankhwala omwe amalepheretsa chitetezo chanu chamthupi. Zitsanzo zambiri zimaphatikizapo azathioprine (Imuran, Azasan) ndi mycophenolate mofetil (CellCept). Mankhwalawa amatha kuchepa panthawi yapakati chifukwa cha kuthekera kwa zovuta za fetus kapena poyizoni.
• Mankhwala osokoneza bongo. Matenda oopsa a m'mapapo ndi omwe amachititsa kufa pakati pa anthu omwe ali ndi MCTD. Madokotala amatha kupereka mankhwala ngati bosentan (Tracleer) kapena sildenafil (Revatio, Viagra) kuti ateteze kuthamanga kwa magazi m'mapapo.

Kuphatikiza pa mankhwala, kusintha kwamachitidwe angapo kungathandizenso:

• Maganizo ake ndi otani?

  Ngakhale zili ndi zovuta zambiri, MCTD imatha kuwonetsa komanso kukhalabe matenda ofatsa mpaka ochepa.

  Komabe, odwala ena amatha kupita patsogolo ndikukhala ndi matenda oyipa kwambiri okhudzana ndi ziwalo zazikulu monga mapapu.

  Matenda ambiri ophatikizika amadziona ngati matenda amisili yambiri ndipo amayenera kuwonedwa choncho. Kuwunika ziwalo zazikulu ndi gawo lofunikira pakuwongolera zamankhwala.

  Pankhani ya MCTD, kuwunikanso kwakanthawi kachitidwe kuyenera kuphatikiza zizindikilo ndi zizindikiritso zokhudzana ndi:

  • SLE
  • polymyositis
  • scleroderma

  Chifukwa MCTD imatha kukhala ndimatendawa, ziwalo zazikulu monga mapapo, chiwindi, impso, ndi ubongo zimatha kutenga nawo mbali.

  Lankhulani ndi dokotala wanu za kukhazikitsa njira yayitali yothandizira ndi kuyang'anira yomwe imagwira ntchito bwino pazizindikiro zanu.

  Kutumiza kwa katswiri wa rheumatology kungakhale kothandiza chifukwa cha kuthekera kwa matendawa.