Kuyeza kwa DNA Kwamasana Osanachitike

Zamkati

• Kodi kuyezetsa magazi opanda khungu (preDatal cell-free (cfDNA) ndi chiyani?
• Amagwiritsidwa ntchito yanji?
• Chifukwa chiyani ndikufunika kuyesedwa kwapakati pa cfDNA?
• Kodi chimachitika ndi chiyani pakuwunika kwa CFDNA asanabadwe?
• Kodi ndiyenera kuchita chilichonse kukonzekera mayeso amenewa?
• Kodi pali zoopsa zilizonse pamayeso?
• Kodi zotsatirazi zikutanthauza chiyani?
• Kodi pali china chilichonse chomwe ndiyenera kudziwa chakuwunika kwa preDatal preDatal?
• Zolemba

Kodi kuyezetsa magazi opanda khungu (preDatal cell-free (cfDNA) ndi chiyani?

Kuyeza kwapakati pa kubereka kwa DNA (cfDNA) ndi kuyezetsa magazi kwa amayi apakati. Pakati pa mimba, DNA ina ya mwana wosabadwa imazungulira m'magazi a mayiyo. Kuwunika kwa cfDNA kumayang'ana DNA iyi kuti mudziwe ngati mwanayo ali ndi vuto la Down syndrome kapena matenda ena obwera chifukwa cha trisomy.

Matenda a trisomy ndi matenda am'magromosomes. Ma chromosomes ndi magawo am'maselo anu omwe ali ndi majini anu. Chibadwa ndi mbali za DNA zomwe zapatsidwa kuchokera kwa amayi ndi abambo anu. Amanyamula zidziwitso zomwe zimatsimikizira mikhalidwe yanu yapadera, monga kutalika ndi mtundu wamaso.

• Anthu nthawi zambiri amakhala ndi ma chromosomes 46, ogawika m'magulu 23 awiriawiri, m'selo iliyonse.
• Ngati limodzi la awiriawiri ili ndi kromosomu yowonjezera, limatchedwa trisomy. Trisomy imayambitsa kusintha momwe thupi ndi ubongo zimakulira.
• Mu Down syndrome, palinso mtundu wina wa chromosome 21. Izi zimadziwikanso kuti trisomy 21. Down syndrome ndimatenda ofala kwambiri a chromosome ku United States.
• Matenda ena a trisomy ndi a Edwards syndrome (trisomy 18), pomwe pali chromosome 18, ndi Patau syndrome (trisomy 13), pomwe pali chromosome 13. Matendawa ndi osowa koma owopsa kuposa Down syndrome. Ana ambiri omwe ali ndi trisomy 18 kapena trisomy 13 amamwalira mchaka choyamba chamoyo.

Kuwunika kwa cfDNA kuli ndi chiopsezo chachikulu kwa inu ndi mwana wanu, koma sikungakuuzeni motsimikiza ngati mwana wanu ali ndi vuto la chromosome. Wothandizira zaumoyo wanu adzafunika kuyitanitsa mayeso ena kuti atsimikizire kapena kuthana ndi matenda.

Mayina ena: DNA ya fetus yopanda ma cell, cffDNA, kuyesa kwa prenatal koopsa, NIPT

Amagwiritsidwa ntchito yanji?

Kuunika kwa cfDNA nthawi zambiri kumagwiritsidwa ntchito kuwonetsa ngati mwana wanu wosabadwa ali pachiwopsezo chowopsa cha vuto limodzi la chromosome:

• Down syndrome (trisomy 21)
• Matenda a Edwards (trisomy 18)
• Matenda a Patau (trisomy 13)

Kuwunikira kungagwiritsidwenso ntchito kuti:

• Dziwani za jenda la mwana (zogonana). Izi zitha kuchitika ngati ultrasound ikuwonetsa kuti maliseche a khanda sakhala omveka bwino ngati amuna kapena akazi. Izi zitha kuyambitsidwa ndi vuto lama chromosomes ogonana.
• Fufuzani mtundu wamagazi a Rh. Rh ndi mapuloteni omwe amapezeka m'maselo ofiira amwazi. Ngati muli ndi puloteni, mumayesedwa kuti ndinu Rh. Ngati simutero, ndinu Rh negative. Ngati mulibe Rh ndipo mwana wanu wosabadwa ali ndi kachilombo ka Rh, chitetezo cha mthupi lanu chitha kuwononga magazi amwana wanu. Mukazindikira kuti mulibe Rh musanabadwe, mutha kumwa mankhwala kuti muteteze mwana wanu ku mavuto owopsa.

Kuunikira kwa cfDNA kumatha kuchitika sabata la 10 lokhala ndi pakati.

Chifukwa chiyani ndikufunika kuyesedwa kwapakati pa cfDNA?

Ambiri opereka chithandizo chamankhwala amalimbikitsa kuwunika kumeneku kwa amayi apakati omwe ali pachiwopsezo chachikulu chokhala ndi mwana yemwe ali ndi vuto la chromosome. Mutha kukhala pachiwopsezo chachikulu ngati:

• Muli ndi zaka 35 kapena kupitilira apo. Msinkhu wa mayi ndiye chiopsezo chachikulu chokhala ndi mwana wokhala ndi Down syndrome kapena matenda ena a trisomy. Chiwopsezo chimakula mzimayi akamakalamba.
• Wakhala ndi mwana wina yemwe ali ndi vuto la chromosome.
• Ululu wanu wa fetal sanawonekere bwino.
• Zotsatira zina zoyeserera asanabadwe sizinali zachilendo.

Ena othandizira azaumoyo amalimbikitsa kuwunika amayi onse apakati. Izi ndichifukwa choti kuwunika kulibe chiopsezo chilichonse ndipo kumakhala kolondola kwambiri poyerekeza ndi mayeso ena oyeza asanabadwe.

Inu ndi wothandizira zaumoyo muyenera kukambirana ngati kuwunika kwa cfDNA kuli koyenera kwa inu.

Kodi chimachitika ndi chiyani pakuwunika kwa CFDNA asanabadwe?

Katswiri wa zamankhwala adzatenga magazi kuchokera mumtsinje uli m'manja mwanu, pogwiritsa ntchito singano yaying'ono. Singanoyo italowetsedwa, magazi ang'onoang'ono amatengedwa mu chubu choyesera. Mutha kumva kuluma pang'ono singano ikamalowa kapena kutuluka. Izi nthawi zambiri zimatenga mphindi zosakwana zisanu.

Kodi ndiyenera kuchita chilichonse kukonzekera mayeso amenewa?

Mungafune kulankhula ndi mlangizi wa majini musanayezedwe. Phungu wamtundu ndi katswiri wophunzitsidwa mwapadera pama genetics ndi kuyesa kwa majini. Akhoza kufotokoza zomwe zingachitike komanso zomwe zingatanthauze kwa inu ndi mwana wanu.

Kodi pali zoopsa zilizonse pamayeso?

Palibe chiopsezo kwa mwana wanu wosabadwa ndipo chiopsezo chochepa kwambiri kwa inu. Mutha kukhala ndi ululu pang'ono kapena kuvulala pamalo pomwe singano idayikidwapo, koma zizindikiro zambiri zimatha msanga.

Kodi zotsatirazi zikutanthauza chiyani?

Ngati zotsatira zanu zinali zoipa, sizokayikitsa kuti mwana wanu ali ndi Down syndrome kapena matenda ena a trisomy. Ngati zotsatira zanu zinali zabwino, zikutanthauza kuti pali chiopsezo chowonjezeka kuti mwana wanu ali ndi vuto limodzi. Koma sangakuuzeni motsimikiza ngati mwana wanu wakhudzidwa. Kuti mudziwe zambiri zovomerezeka mudzafunika mayeso ena, monga amniocentesis ndi chorionic villus sampling (CVS). Mayeserowa nthawi zambiri amakhala otetezeka, koma amakhala ndi chiopsezo chochepa chopita padera.

Ngati muli ndi mafunso pazotsatira zanu, lankhulani ndi omwe amakuthandizani azaumoyo komanso / kapena mlangizi wa majini.

Dziwani zambiri zamayeso a labotale, magawo owerengera, ndi zotsatira zakumvetsetsa.

Kodi pali china chilichonse chomwe ndiyenera kudziwa chakuwunika kwa preDatal preDatal?

Kufufuza kwa cfDNA sikulondola kwa azimayi omwe ali ndi pakati pa ana opitilira mmodzi (mapasa, mapasa atatu, kapena kupitilira apo).

Zolemba

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Zomwe zili patsamba lino siziyenera kugwiritsidwa ntchito m'malo mwa chithandizo chamankhwala kapena upangiri. Lumikizanani ndi othandizira azaumoyo ngati muli ndi mafunso okhudzana ndi thanzi lanu.