Antiphospholipid Syndrome: Zomwe zili, Zoyambitsa ndi Chithandizo

Zamkati

• Zizindikiro zazikulu
• Zomwe zimayambitsa matendawa
• Momwe matendawa amapangidwira
• Momwe mankhwalawa amachitikira
• Chithandizo pa mimba

Antiphospholipid Antibody Syndrome, yemwenso amadziwika kuti Hughes kapena SAF kapena SAAF, ndi matenda osowa mthupi omwe amadziwika kuti ndiosavuta kupanga thrombi m'mitsempha ndi mitsempha yomwe imasokoneza magazi, zomwe zingayambitse mutu, kupuma movutikira komanso matenda amtima, mwachitsanzo.

Malinga ndi chifukwa chake, SAF imatha kugawidwa m'magulu atatu:

1. Choyambirira, momwe mulibe chifukwa chenicheni;
2. Sekondale, zomwe zimachitika chifukwa cha matenda ena, ndipo nthawi zambiri zimakhudzana ndi Systemic Lupus Erythematosus. Sekondale APS imathanso kuchitika, ngakhale ndiyosowa kwambiri, yokhudzana ndi matenda ena amthupi okha, monga scleroderma ndi nyamakazi ya nyamakazi, mwachitsanzo;
3. Zovuta, womwe ndi mtundu woopsa kwambiri wa APS momwe ma thrombi amapangidwira m'malo osachepera 3 osachepera sabata limodzi.

APS imatha kuchitika pamisinkhu iliyonse komanso amuna kapena akazi okhaokha, komabe imakonda kwambiri azimayi azaka zapakati pa 20 ndi 50. Chithandizochi chiyenera kukhazikitsidwa ndi dokotala kapena rheumatologist ndipo cholinga chake ndikuletsa mapangidwe a thrombi ndikupewa zovuta, makamaka pamene mayi ali ndi pakati.

Zizindikiro zazikulu

Zizindikiro zazikulu za APS ndizokhudzana ndi kusintha kwamachitidwe a coagulation komanso kupezeka kwa thrombosis, zazikuluzikulu ndizo:

• Kupweteka pachifuwa;
• Kupuma kovuta;
• Mutu;
• Nseru;
• Kutupa kwa miyendo yakumtunda kapena yakumunsi;
• Kuchepetsa kuchuluka kwa mapaleti;
• Kuchotsa mimba kwadzidzidzi kapena kusintha kwa placenta, popanda chifukwa chomveka.

Kuphatikiza apo, anthu omwe amapezeka kuti ali ndi APS amakhala ndi vuto la impso, matenda amtima kapena sitiroko, mwachitsanzo, chifukwa chopanga thrombi yomwe imasokoneza kayendedwe ka magazi, kusintha magazi omwe amafika ku ziwalo. Mvetsetsani kuti thrombosis ndi chiyani.

Zomwe zimayambitsa matendawa

Antiphospholipid Antibody Syndrome ndimomwe zimakhalira zokha, zomwe zikutanthauza kuti chitetezo chamthupi chokha chimagunda maselo mthupi. Poterepa, thupi limatulutsa ma antiphospholipid antibodies omwe amalimbana ndi phospholipids omwe amapezeka m'maselo amafuta, zomwe zimapangitsa kuti magazi azitha kuzungulirana ndikupanga thrombi.

Chifukwa chenicheni chomwe chitetezo cha mthupi chimatulutsa mtundu uwu wa antibody sichidziwikebe, koma amadziwika kuti ndiwofala kwambiri kwa anthu omwe ali ndi matenda ena amthupi, monga Lupus, mwachitsanzo.

Momwe matendawa amapangidwira

Kuzindikira kwa Antiphospholipid Antibody Syndrome kumatanthauzidwa ndi kupezeka kwa njira imodzi yazachipatala ndi labotale, ndiko kuti, kupezeka kwa chizindikiritso cha matendawa ndikuzindikira kwa autoantibody m'mwazi.

Zina mwazomwe dokotala amalingalira ndi magawo a thrombosis ya arterial kapena venous, kupezeka kwa kutaya mimba, kubadwa msanga, matenda amthupi komanso kupezeka kwa zoopsa za thrombosis. Njira zamankhwala izi ziyenera kutsimikiziridwa kudzera pakuyesa kapena kuyesa labotale.

Ponena za njira za labotale kupezeka kwa mtundu umodzi wa anti-antiphospholipid antibody, monga:

• Lupus anticoagulant (AL);
• Chithandizo;
• Anti beta2-glycoprotein 1.

Ma antibodies awa amayenera kuyesedwa nthawi ziwiri zosiyana, pakadutsa miyezi iwiri.

Kuti matendawa akhale othandiza kwa APS, ndikofunikira kuti njira zonse ziwiri zitsimikizidwe kudzera pamayeso omwe adachitika kawiri ndikudutsa miyezi itatu.

Momwe mankhwalawa amachitikira

Ngakhale kulibe mankhwala omwe angachiritse APS, ndizotheka kuchepetsa chiopsezo cha kupangika kwa magazi ndipo, chifukwa chake, kuwoneka kwa zovuta monga thrombosis kapena infarction, pogwiritsa ntchito mankhwala osokoneza bongo, monga Warfarin, omwe ndi amlomo ntchito, kapena Heparin, yomwe imagwiritsidwa ntchito kudzera m'mitsempha.

Nthawi zambiri, anthu omwe ali ndi APS omwe amalandira mankhwala opatsirana pogonana amatha kukhala ndi moyo wabwinobwino, ndikofunikira nthawi zonse kusankhidwa ndi dokotala kuti asinthe kuchuluka kwa mankhwala, pakafunika kutero.

Komabe, kuti zithandizire bwino, ndikofunikabe kupewa zizolowezi zina zomwe zingawononge zotsatira za ma anticoagulants, monga zimachitikira kudya zakudya ndi vitamini K, monga sipinachi, kabichi kapena broccoli, mwachitsanzo. Onetsetsani zodzitetezera zina zomwe muyenera kutsatira mukamagwiritsa ntchito mankhwala opha tizilombo.

Chithandizo pa mimba

Nthawi zina, monga nthawi yapakati, adotolo amalimbikitsa kuti chithandizocho chichitike ndi Heparin yojambulidwa yomwe imalumikizidwa ndi Aspirin kapena Immunoglobulin yolumikizira, kuti muchepetse zovuta monga kuchotsa mimba, mwachitsanzo.

Ndi chithandizo choyenera, pali mwayi waukulu kuti mayi wapakati yemwe ali ndi APS azitha kukhala ndi pakati, komabe ndikofunikira kuti amuyang'anire mosamalitsa ndi azamba, popeza ali pachiwopsezo chachikulu chotaya padera, kubadwa msanga kapena pre-eclampsia. Phunzirani momwe mungazindikire zizindikiro za preeclampsia.