Zizindikiro za Cushing's syndrome, zomwe zimayambitsa komanso chithandizo

Zamkati

• Zizindikiro zazikulu
• Zomwe zimayambitsa matenda a Cushing
• Momwe matendawa amapangidwira
• Momwe mankhwalawa amachitikira
• Zovuta zotheka

Matenda a Cushing, omwe amatchedwanso matenda a Cushing kapena hypercortisolism, ndi kusintha kwa mahomoni komwe kumadziwika ndi kuchuluka kwa mahomoni a cortisol m'magazi, zomwe zimabweretsa kuwonekera kwa zizindikilo zina za matendawa monga kunenepa msanga komanso kuchuluka kwamafuta mthupi. m'mimba ndi nkhope, kuphatikiza pakupanga timizereti tofiira mthupi komanso khungu lamafuta lomwe limakonda ziphuphu, mwachitsanzo.

Chifukwa chake, pamaso pazizindikirozi, tikulimbikitsidwa kuti mukaonane ndi katswiri wazamaphunziro kuti mayesedwe amwazi ndi kujambula awonetsedwe, motero, chithandizo choyenera kwambiri chitha kuwonetsedwa, chomwe chingachitike pogwiritsa ntchito mankhwala kapena opaleshoni, Mwachitsanzo.

Zizindikiro zazikulu

Chizindikiro chodziwika kwambiri cha Cushing's syndrome ndikungodziunjikira kwamafuta m'chigawo cham'mimba komanso pankhope, chomwe chimadziwikanso kuti mwezi wathunthu. Kuphatikiza apo, zizindikilo zina zomwe mwina zimakhudzanso matendawa ndi izi:

• Kukula msanga, koma manja ndi miyendo yopyapyala;
• Kuwonekera kwa zingwe zazikulu, zofiira pamimba;
• Kuwonekera kwa nkhope kumaso, makamaka kwa akazi;
• Kuchulukitsa;
• Matenda ashuga, popeza ndizofala kuti m'magazi mumakhala shuga wambiri;
• Kuchepetsa libido ndi chonde;
• Kusamba kosasamba;
• Minofu kufooka;
• Khungu lamafuta ndi ziphuphu;
• Zovuta pakumanga mabala;
• Kutuluka kwa mawanga ofiira.

Nthawi zambiri zimawoneka kuwonekera kwa zizindikilo zingapo nthawi imodzi ndipo ndizofala kwambiri kwa odwala omwe ali ndi matenda monga nyamakazi, mphumu, lupus kapena pambuyo pakuika ziwalo komanso omwe amatenga corticosteroids kwa miyezi ingapo mosiyanasiyana. Pankhani ya ana omwe ali ndi matenda a Cushing, kukula pang'ono, msinkhu wotsika, kuwonjezeka kwa nkhope ndi tsitsi ndi dazi zimawonedwa.

Zomwe zimayambitsa matenda a Cushing

Matendawa amachitika chifukwa cha kuchuluka kwa cortisol m'magazi, zomwe zimatha kuchitika chifukwa cha zochitika zingapo. Zomwe zimayambitsa kuwonjezeka kumeneku komanso zomwe zimalimbikitsa kukula kwa matendawa ndizogwiritsidwa ntchito kwakanthawi komanso kuchuluka kwa ma corticosteroids, omwe nthawi zambiri amawonetsedwa pochiza matenda monga lupus, nyamakazi ndi mphumu, kuphatikiza pakuwonetsedwanso anthu omwe adalandira kale ziwalo.

Kuphatikiza apo, Cushing's syndrome imatha kuchitika chifukwa chokhala ndi timor mu pituitary gland, yomwe imapezeka muubongo, zomwe zimapangitsa kuti ntchito yopanga ACTH isavomerezedwe, motero, kuwonjezeka pakupanga kwa cortisol, komwe kumatha kupezeka m'magulu ambiri m'magazi. Dziwani kuti hormone cortisol ndi ya chiyani.

Momwe matendawa amapangidwira

Kuzindikira kwa Cushing's syndrome kuyenera kupangidwa ndi endocrinologist kutengera kuwunika kwa zizindikilo zomwe zimaperekedwa ndi munthuyo, mbiri yazaumoyo komanso zoyeserera za labotale kapena zojambula.

Chifukwa chake, atha kulimbikitsidwa ndi adotolo kuti ayese magazi a maola 24, malovu ndi mkodzo kuti aone kuchuluka kwa cortisol ndi ACTH yomwe ikuzungulira mthupi. Kuphatikiza apo, kuyesa kolimbikitsidwa ndi dexamethasone kungalimbikitsidwe, omwe ndi mankhwala omwe amalimbikitsa kugwira ntchito kwa khungu la pituitary ndipo, chifukwa chake, atha kuthandiza matendawa. Chifukwa chogwiritsa ntchito dexamethasone, zitha kulimbikitsidwa kuti munthuyo alandilidwe kuchipatala pafupifupi masiku awiri.

Pofuna kudziwa ngati pali chotupa m'matenda a pituitary, adotolo atha kufunsa kuti agwiritse ntchito ma comput tomography kapena maginito amawu. Nthawi zambiri, pamafunika kubwereza mayeso kuti mutsimikizire matendawa ndikuyamba chithandizo choyenera, popeza zizindikilo zina ndizofala pamatenda ena, zomwe zimapangitsa kuti matendawa akhale ovuta.

Momwe mankhwalawa amachitikira

Chithandizo cha matenda a Cushing chiyenera kutsogozedwa ndi endocrinologist ndipo chimasiyanasiyana kutengera chifukwa cha matendawa. Matendawa amayamba chifukwa chogwiritsa ntchito nthawi yayitali ma corticosteroids, kuchepa kwa mankhwala kumawonetsedwa, malinga ndi malangizo a dokotala ndipo, ngati kuli kotheka, kuyimitsidwa kwake.

Kumbali inayi, matenda a Cushing atayamba ndi chotupa, mankhwala nthawi zambiri amaphatikizapo kuchitidwa opaleshoni kuti achotse chotupacho kenako ndikuchita radiotherapy kapena chemotherapy. Kuphatikiza apo, asanachite opareshoni kapena pomwe chotupacho sichingachotsedwe, adotolo amalimbikitsa kuti wodwalayo amwe mankhwala kuti athetse kupanga kwa cortisol.

Pofuna kuchepetsa zizindikilo za matendawa ndikofunikira kudya zakudya zopanda mchere komanso shuga komanso kudya zipatso ndi ndiwo zamasamba tsiku lililonse chifukwa ndi zakudya zokhala ndi mavitamini ndi michere yambiri ndipo zimathandiza kulimbitsa chitetezo chamthupi.

Zovuta zotheka

Chithandizo cha matenda a Cushing sichikuchitika moyenera, nkutheka kuti kuchepa kwa mphamvu m'thupi kumatha kuyika moyo wake pangozi. Izi ndichifukwa choti kuchepa kwa mahomoni kumatha kuyambitsa kusokonezeka kwa impso komanso kulephera kwa ziwalo.