Kodi Ndiyenera Kudziwa Chiyani Zokhudza Zotsatira Zazithandizo Zamtundu wa CML? Mafunso a Dokotala Wanu

Zamkati

• Kodi ndiyenera kudziwa chiyani za zoyipa zamankhwala a CML?
• Thandizo la Tyrosine kinase inhibitor (TKI)
• Thandizo la biologic
• Chemotherapy
• Kupanga khungu la tsinde
• Splenectomy
• Kodi pali njira zina zothetsera mavuto?
• Kodi zotsatirapo zake zimatha pambuyo poti mankhwala atha?
• Kodi ndingapeze kuti thandizo?
• Kutenga

Chidule

Ulendo wanu ndi matenda a myeloid leukemia (CML) atha kuphatikizira mankhwala osiyanasiyana. Zonsezi zitha kukhala ndi zovuta zina kapena zovuta zina. Sikuti aliyense amayankha momwemo kuchitira, motero nthawi zina dokotala wanu amatha kusintha mapulani anu.

Zitha kuthandizira kukambirana ndi adotolo pasadakhale za kuwopsa kwa zotsatirapo zake. Zokambirana izi zitha kukuthandizani kukhala okonzeka, makamaka ngati zosankha zanu zisintha.

Ikhoza kukupatsaninso dongosolo lamachitidwe. Pemphani kuti mudziwe zambiri zamomwe mungayambitsire zokambirana ndi dokotala kuti muthe kumverera bwino.

Kodi ndiyenera kudziwa chiyani za zoyipa zamankhwala a CML?

Ndondomeko yanu yothandizira CML ingaphatikizepo:

• mankhwala, monga omwe amagwiritsidwa ntchito pochiritsa kapena chemotherapy
• kusuntha kwa tsinde
• biologic kapena immunotherapy
• opaleshoni

Zonsezi zimabwera ndi chiopsezo cha zotsatirapo kapena zovuta. Kumbukirani, ngati dokotala akuvomereza chithandizo, aweruza phindu lomwe lingapezeke pamankhwalawa kuposa zoopsa zake.

Nthawi zonse muyenera kuuza dokotala ngati zovuta zanu sizachilendo, zosatheka kuzikwaniritsa, kapena zimakupangitsani kuda nkhawa. Zotsatira zoyipa zambiri zitha kuchiritsidwa ndi mankhwala, mankhwala ena, kapena posintha dongosolo lanu la mankhwala.

Dokotala wanu angakupatseni zambiri zamomwe mungathetsere zovuta zapanyumba komanso nthawi yomwe muyenera kupita kuchipatala.

Thandizo la Tyrosine kinase inhibitor (TKI)

TKIs ndi mtundu wa chithandizo chofunikira, kutanthauza kuti amagwiritsidwa ntchito kupha maselo a khansa osawononga maselo athanzi. Mwachitsanzo, mankhwala omwe ndi TKIs ndi awa:

• imatinib mesylate (Gleevec)
• dasatinib (Sprycel)
• alirezatalischi (Tasigna)
• bosutinib (Bosulif)
• ponatinib (Iclusig)

Kwa anthu ambiri, bosutinib ndi ponatinib amagwiritsidwa ntchito pokhapokha mankhwala ena a TKI atayesedwa.

Zotsatira zoyipa zamankhwala a TKI ndi awa:

• nseru
• kusanza
• khungu louma kapena loyabwa
• kutopa
• kupweteka kwa minofu
• kupweteka pamodzi

Mankhwala aliwonse a TKI atha kukhala ndi zovuta zake. Zomwe mukudziwa zimadalira mankhwala omwe mumamwa komanso momwe mungayankhire.

Nthawi zina, chithandizo cha TKI chitha kukhala ndi zovuta zina, monga kuchepa magazi, matenda, kapena kutuluka magazi. Izi ndizosowa. Zotsatira zina zosafunikira kwenikweni zimaphatikizapo mavuto amtima, mavuto a chiwindi, mavuto am'mapapo, kapena kusungunuka kwamadzi kuzungulira mtima ndi mapapo.

Gulu lanu lazachipatala lidzakuyang'anirani ngati muli ndi zovuta zina. Mukawona kusintha kwadzidzidzi komwe mukuganiza kuti kungakhale zotsatira zoyipa za mankhwala anu, dziwitsani dokotala wanu.

Thandizo la biologic

Mankhwalawa amatchedwanso immunotherapy. Mwachitsanzo, anthu ena amalandila chithandizo monga interferon alfa kuti athetse CML. Zitha kulamulidwa kukweza kuchuluka kwamagazi ochepa.

Zotsatira zoyipa za interferon alfa ndizo:

• khungu lofiira komanso loyabwa
• zizindikiro za chimfine
• nseru
• kusanza
• kusowa njala
• kutopa
• zowawa pakamwa
• kutsegula m'mimba
• kutayika tsitsi
• jaundice

Ndizothekanso kuti interferon alfa ipangitse kusagwirizana ndi anthu ena, koma izi ndizochepa.

Chemotherapy

Chemotherapy imagwira ntchito poletsa mitundu ina yamaselo kukula, kuphatikizapo khansa. Mankhwalawa amatha kupha maselo kapena kuwaletsa kuti asagawane.

Pali mankhwala ambiri a chemotherapy, ndipo nthawi zina amaphatikizidwa ndi mankhwala ena. Mankhwala omwe anthu omwe amalandira chithandizo cha CML amalandira ndi cytarabine ndi interferon alfa.

Zotsatira zoyipa za chemotherapy ya CML ndi monga:

• zowawa pakamwa
• chikhure
• kutopa
• kutayika tsitsi
• kutsegula m'mimba
• kudzimbidwa
• kusowa chilakolako
• nseru
• kusanza
• mavuto obereka

Dokotala wanu akhoza kukupatsirani zambiri pazomwe zingachitike chifukwa cha mankhwala omwe mungalandire.

Kupanga khungu la tsinde

Kusintha kwa khungu la tsinde kumabwezeretsanso maselo athanzi mthupi.

Pali mitundu yosiyanasiyana ya zosintha zomwe zimagwiritsidwa ntchito pa CML. Anthu omwe amalandila kusintha kwa maselo amtundu wa allogeneic amalandira maselo kuchokera kwa omwe amapereka. Anthu awa ali pachiwopsezo cha matenda omwe amatchedwa kumezanitsa motsutsana ndi matenda obwera nawo (GVHD).

GVHD imachitika pamene ma cell a omwe amapereka amateteza maselo amthupi. Chifukwa cha chiopsezo ichi, anthu amalandira mankhwala kuti athetse chitetezo cha mthupi tsiku limodzi kapena awiri asanafike. Ngakhale atalandira mankhwala oteteza, ndizotheka kuti munthu adziwe GVHD, koma ndizochepa.

Splenectomy

Anthu ena omwe ali ndi CML amatha kuchotsedwa nthenda zawo. Cholinga cha opaleshoniyi ndikukulitsa kuchuluka kwa maselo amwazi wamagazi kapena kupewa mavuto ngati limba ndi lalikulu kwambiri chifukwa cha CML.

Ndi opaleshoni iliyonse, zovuta ndizotheka. Zovuta za njirayi zitha kuphatikiza:

• matenda
• nseru
• kusanza
• ululu
• kuchepetsa chitetezo cha mthupi

Gulu lanu lazachipatala lidzachitapo kanthu kuti muchepetse chiopsezo chanu pazovuta zilizonse zokhudzana ndi opaleshoni. Anthu ambiri amachira pochita opareshoni milungu inayi mpaka isanu ndi umodzi.

Kodi pali njira zina zothetsera mavuto?

Dokotala wanu akhoza kukuthandizani kuthana ndi zovuta zamankhwala a CML. Nthawi zina, izi zitha kutanthauza kusintha kukhala mankhwala atsopano.

Zitha kutanthauzanso kugwiritsa ntchito mankhwala owonjezera kuti muthane ndi zovuta zina. Mwachitsanzo, dokotala wanu angakulimbikitseni kusankha mankhwala kapena mankhwala kuti muchepetse mseru kapena kuchiritsa zotupa pakhungu.

Palinso zinthu zomwe mungachite kunyumba kuti muzitha kuthana ndi zovuta:

• Kutentha ndi kuchita masewera olimbitsa thupi kungathandize kutopa.
• Kuteteza khungu lanu ku dzuwa kumatha kuthandizira ndi zotupa.

Mukamalandira chithandizo cha CML, mutha kuchitapo kanthu kuti mukhale omasuka. Pitirizani kulankhulana momasuka ndi dokotala wanu.

Kodi zotsatirapo zake zimatha pambuyo poti mankhwala atha?

Malinga ndi Leukemia and Lymphoma Society, anthu ena atha kukhala ndi zovuta pambuyo poti mankhwala awo atha.

Anthu ambiri okhala ndi CML amatenga ma TKI kwa moyo wawo wonse. Ndi kuyang'aniridwa ndi zamankhwala, anthu ena amatha kumwa pang'ono. Ndikofunika kuti musasinthe mlingo wanu pokhapokha dokotala atakuuzani.

Yankho lanu pa dongosolo lanu la mankhwala lingasinthe pakapita nthawi. Muthanso kukhala ndi zovuta zina mukasintha mankhwala a TKI. Dokotala wanu akhoza kukuwuzani zomwe mungayembekezere kutengera mankhwala omwe mukumwa.

Kodi ndingapeze kuti thandizo?

Anthu ambiri omwe ali ndi CML amapeza chidziwitso chofunikira komanso ubale kudzera polumikizana ndi ena omwe ali ndi vutoli. Zingakhale zothandiza komanso zotonthoza kulankhula ndi anthu omwe adagawana nawo kapena zokumana nazo zofananira.

Dokotala wanu kapena chipatala chapafupi angakuthandizeni kupeza magulu othandizira. Leukemia & Lymphoma Society imapereka zidziwitso zamagulu othandizira kudzera m'machaputala awo. American Cancer Society ilinso ndi zinthu zapaintaneti zomwe mungafikire.

Kutenga

Njira zonse zamankhwala zimabwera ndi zotsatirapo zoyipa, koma sizitanthauza kuti mudzakumana nazo. Anthu osiyanasiyana amakhala ndi mayankho osiyanasiyana pamankhwala. Pogwirizana ndi dokotala wanu, mutha kuthana ndi zovuta zilizonse zomwe mungakumane nazo.