Zomwe Zimapanga Mantle Cell Lymphoma Mosiyana ndi Ma Lymphomas Ena?

Zamkati

• MCL ndi B-cell non-Hodgkin's lymphoma
• MCL imakonda kukhudza amuna achikulire
• MCL ndiyosowa kwenikweni
• Imafalikira kuchokera kudera lazovala
• Zimakhudzana ndi kusintha kwapadera kwa majini
• Ndi yaukali komanso yovuta kuchiza
• Ikhoza kuthandizidwa ndi mankhwala ochiritsira
• Kutenga

Lymphoma ndi khansa yamagazi yomwe imayamba mu ma lymphocyte, mtundu wa khungu loyera lamagazi. Ma lymphocyte amatenga gawo lofunikira m'thupi lanu. Akakhala ndi khansa, amachulukirachulukira ndikukula kukhala zotupa.

Pali mitundu yambiri ya lymphoma. Njira zochiritsira ndi malingaliro zimasiyanasiyana malinga ndi mtundu wina. Tengani kamphindi kuti mudziwe momwe mantle cell lymphoma (MCL) amafanizira ndi mitundu ina ya matendawa.

MCL ndi B-cell non-Hodgkin's lymphoma

Pali mitundu iwiri yayikulu ya lymphoma: Hodgkin's lymphoma ndi non-Hodgkin's lymphoma. Pali magulu opitilira 60 a non-Hodgkin's lymphoma. MCL ndi amodzi mwa iwo.

Pali mitundu iwiri yayikulu ya ma lymphocyte: T ma lymphocyte (T maselo) ndi ma lymphocyte (B cell). MCL imakhudza maselo a B.

MCL imakonda kukhudza amuna achikulire

Malinga ndi American Cancer Society, Hodgkin's lymphoma nthawi zambiri imakhudza achinyamata, makamaka anthu azaka za m'ma 20. Poyerekeza, MCL ndi mitundu ina ya non-Hodgkin's lymphoma imakonda kwambiri achikulire. Lymphoma Research Foundation inanena kuti anthu ambiri omwe ali ndi MCL ndi amuna azaka zopitilira 60.

Zonsezi, lymphoma ndi imodzi mwa mitundu yambiri ya khansa yomwe imakhudza ana ndi achinyamata. Koma mosiyana ndi mitundu ina ya lymphoma, MCL ndiyosowa kwambiri mwa achinyamata.

MCL ndiyosowa kwenikweni

MCL sichidziwika kwenikweni kuposa mitundu ina ya lymphoma. Imakhala pafupifupi 5% yamatenda onse am'magazi, malinga ndi American Cancer Society. Izi zikutanthauza kuti MCL imayimira pafupifupi 1 mwa 20 ma lymphomas.

Mofananamo, mtundu wofala kwambiri wa non-Hodgkin's lymphoma umafalitsa B-cell lymphoma yayikulu, yomwe imakhala pafupifupi 1 mwa 3 ma lymphomas.

Chifukwa ndizosowa, madokotala ambiri sangakhale osadziwa njira zaposachedwa za kafukufuku ndi chithandizo cha MCL. Ngati kuli kotheka, ndibwino kuti mukachezere oncologist yemwe amagwiritsa ntchito lymphoma kapena MCL.

Imafalikira kuchokera kudera lazovala

MCL imadziwika ndi dzina loti imakhazikika m'gawo lazovala zamitsempha. Malo ovala zovala ndi mphete ya ma lymphocyte omwe azungulira pakatikati mwa mwanabele.

Pomwe imapezeka, MCL imakhala ikufalikira kumatenda ena am'mimba, komanso minofu ina ndi ziwalo zina. Mwachitsanzo, imatha kufalikira mpaka m'mafupa, m'mimba, m'matumbo. Nthawi zambiri, zimatha kukhudza ubongo wanu ndi msana.

Zimakhudzana ndi kusintha kwapadera kwa majini

Kutupa ma lymph node ndi chizindikiro chofala kwambiri cha MCL ndi mitundu ina ya lymphoma. Ngati dokotala akukayikira kuti muli ndi lymphoma, amatenga khungu kuchokera kumatupa otupa kapena ziwalo zina za thupi lanu kuti muwone.

Pansi pa microscope, maselo a MCL amawoneka ofanana ndi mitundu ina ya lymphoma. Koma nthawi zambiri, maselowa amakhala ndi zolemba zomwe zingathandize dokotala kudziwa mtundu wa lymphoma. Kuti mupeze matenda, dokotala wanu adzayitanitsa mayeso kuti awone ngati pali ma protein ndi mapuloteni.

Dokotala wanu amathanso kuyitanitsa mayeso ena, monga CT scan, kuti adziwe ngati khansara yafalikira. Akhozanso kuyitanitsa mafupa, matumbo, kapena ziwalo zina.

Ndi yaukali komanso yovuta kuchiza

Mitundu ina ya non-Hodgkin's lymphoma ndiyotsika pang'ono kapena yaulesi. Izi zikutanthauza kuti amakonda kukula pang'onopang'ono, koma nthawi zambiri amakhala osachiritsika. Chithandizo chingathandize kuchepetsa khansa, koma otsika kwambiri a lymphoma nthawi zambiri amabwereranso, kapena kubwerera.

Mitundu ina ya non-Hodgkin's lymphoma ndi yapamwamba kwambiri kapena yamwano. Amakonda kukula msanga, koma nthawi zambiri amachiritsidwa. Chithandizo choyambirira chikapambana, ma lymphoma apamwamba samabwereranso.

MCL ndi yachilendo chifukwa imawonetsa ma lymphomas apamwamba komanso otsika. Monga ma lymphomas ena apamwamba, nthawi zambiri amakula msanga. Koma monga ma lymphomas otsika, nthawi zambiri samachiritsidwa. Anthu ambiri omwe ali ndi MCL amapumula atalandira chithandizo choyamba, koma khansa imabwereranso pakatha zaka zochepa.

Ikhoza kuthandizidwa ndi mankhwala ochiritsira

Monga mitundu ina ya lymphoma, MCL itha kuchiritsidwa ndi imodzi mwanjira izi:

• kudikira kudikira
• mankhwala a chemotherapy
• mankhwala monoclonal
• kuphatikiza chemotherapy ndi mankhwala a antibody otchedwa chemoimmunotherapy
• mankhwala a radiation
• tsinde lothandizira

Food and Drug Administration (FDA) yavomerezanso mankhwala anayi omwe amayang'ana kwambiri MCL:

• bortezomib (Velcade)
• lenalidomide (Wowonjezera)
• ibrutinib (Imbruvica)
• acalabrutinib (Calquence)

Mankhwala onsewa avomerezedwa kuti agwiritsidwe ntchito pakubwezeretsanso, mankhwala ena atayesedwa kale. Bortezomib idavomerezedwanso ngati mankhwala oyamba, omwe atha kugwiritsidwa ntchito njira zina zisanachitike. Mayesero angapo azachipatala akuchitika kuti aphunzire kugwiritsa ntchito lenalidomide, ibrutinib, ndi acalabrutinib ngati mankhwala oyamba, nawonso.

Kuti mudziwe zambiri zamankhwala omwe mungasankhe, lankhulani ndi dokotala wanu. Ndondomeko yawo yothandizirayi itengera zaka zanu komanso thanzi lanu, komanso komwe khansa ikukula mthupi lanu.

Kutenga

MCL ndiyosowa ndikovuta kuchiza. Koma mzaka zaposachedwa, njira zatsopano zamankhwala zapangidwa ndikuvomerezedwa kuti zithandizire khansa yamtunduwu. Mankhwala atsopanowa athandiza kwambiri anthu omwe ali ndi MCL.

Ngati ndi kotheka, ndibwino kuti mupite kukaonana ndi katswiri wa khansa yemwe amadziwa bwino zamankhwala am'mimba, kuphatikiza MCL. Katswiriyu atha kukuthandizani kuti mumvetsetse ndikuyeza zomwe mungasankhe.