Pseudomembranous matenda a m'matumbo

Pseudomembranous colitis amatanthauza kutupa kapena kutukusira kwamatumbo akulu (colon) chifukwa cha kuchuluka kwa Clostridioides amakhala (C kusiyanasiyana) mabakiteriya.

Matendawa ndi omwe amachititsa kutsekula m'mimba mutagwiritsa ntchito maantibayotiki.

Pulogalamu ya C kusiyanasiyana mabakiteriya nthawi zambiri amakhala m'matumbo. Komabe, mabakiteriya ambiri amatha kukula mukamamwa maantibayotiki. Mabakiteriya amatulutsa poizoni wamphamvu yemwe amayambitsa kutupa ndi kutuluka magazi mkatikati mwa kholalo.

Maantibayotiki aliwonse angayambitse vutoli. Mankhwala omwe amachititsa vutoli nthawi zambiri ndi ampicillin, clindamycin, fluoroquinolones, ndi cephalosporins.

Osamalira azaumoyo mchipatala amatha kupatsira mabakiteriyawa kuchokera kwa munthu wina kupita kwa wina.

Pseudomembranous colitis siachilendo kwa ana, ndipo kawirikawiri mwa ana. Nthawi zambiri zimawoneka mwa anthu omwe ali mchipatala. Komabe, zikuchulukirachulukira kwa anthu omwe amamwa maantibayotiki ndipo samakhala mchipatala.

Zowopsa ndi izi:

• Ukalamba
• Kugwiritsa ntchito maantibayotiki
• Kugwiritsa ntchito mankhwala omwe amachepetsa chitetezo chamthupi (monga mankhwala a chemotherapy)
• Opaleshoni yaposachedwa
• Mbiri ya pseudomembranous colitis
• Mbiri ya ulcerative colitis ndi matenda a Crohn

Zizindikiro zake ndi izi:

• Zilonda zam'mimba (zochepa mpaka zovuta)
• Zojambula zamagazi
• Malungo
• Limbikitsani kuyendetsa matumbo
• Kutsekula m'madzi (nthawi zambiri kasanu kapena kasanu patsiku)

Mayesero otsatirawa akhoza kuchitika:

• Colonoscopy kapena sigmoidoscopy yosinthasintha
• Immunoassay ya C yosakanikirana ndi poizoni mu chopondapo
• Kuyesa kwatsopano kwatsopano monga PCR

Maantibayotiki kapena mankhwala ena omwe akuyambitsa vutoli ayenera kuyimitsidwa. Metronidazole, vancomycin, kapena fidaxomicin nthawi zambiri amagwiritsidwa ntchito kuthana ndi vutoli, koma mankhwala ena amathanso kugwiritsidwa ntchito.

Njira zamagetsi zamagetsi kapena madzi amadzimadzi omwe amaperekedwa kudzera mu mtsempha angafunike kuthana ndi kuchepa kwa madzi m'thupi chifukwa cha kutsegula m'mimba. Nthawi zambiri, opaleshoni imafunika kuchiza matenda omwe amangokulira kapena osayankha maantibayotiki.

Maantibayotiki a nthawi yayitali angafunike ngati C kusiyanasiyana Matenda amabwereranso. Chithandizo chatsopano chotchedwa fecal microbiota transplant ("stool transplant") chathandizanso ku matenda omwe amabwerera.

Wothandizira anu angathenso kukuuzani kuti mutenge maantibiotiki ngati matenda abwerera.

Malingaliro ake amakhala abwino nthawi zambiri, ngati palibe zovuta. Komabe, munthu mmodzi mwa anthu asanu aliwonse amene ali ndi matendawa akhoza kubwerera ndipo amafunika mankhwala ena.

Zovuta zingaphatikizepo:

• Kutaya madzi m'thupi ndi kusalingana kwa electrolyte
• Kuwonongeka kwa (una kudutsa) m'matumbo
• Megakoloni woopsa
• Imfa

Itanani omwe akukuthandizani ngati muli ndi izi:

• Zimbudzi zilizonse zamagazi (makamaka atamwa maantibayotiki)
• Magawo asanu kapena angapo otsekula m'mimba patsiku loposa 1 mpaka 2 masiku
• Kupweteka kwambiri m'mimba
• Zizindikiro zakusowa madzi m'thupi

Anthu omwe adakhalapo ndi pseudomembranous colitis ayenera kuuza omwe amawapatsa mankhwala asanatengere maantibayotiki. Ndikofunikanso kusamba m'manja kuti mupewe kupatsira kachiromboka kwa anthu ena. Omwe amaletsa mowa samagwira ntchito nthawi zonse C kusiyanasiyana.

Matenda opatsirana omwe amayambitsidwa ndi maantibayotiki; Colitis - pseudomembranous; Matenda opatsirana; C difficile - pseudomembranous

• Dongosolo m'mimba
• Zakudya zam'mimba ziwalo

Gerding DN, Johnson S. Clostridial matenda. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: mutu 280.

Gerding DN, Wachinyamata VB. Donskey CJ. Clostridiode amasiyana (kale Chosalala cha Clostridium) matenda. Mu: Bennett JE, Dolin R, Blaser MJ, olemba., Eds. Mandell, Douglas, ndi Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020: chap 243.

Kelly CP, Khansa S. Matenda otsekula m'mimba okhudzana ndi maantibayotiki komanso clostridioides amakhala matenda. Mu: Feldman M, Friedman LS, Brandt LJ, olemba. Sleisenger ndi Matenda a Mimba ndi a Fordtran Amatenda a Chiwindi. 11th ed. Philadelphia, PA: Elsevier; 2021: mutu 112.

McDonald LC, Gerding DN, Johnson S, ndi al. Malangizo azachipatala a clostridium difficile Infection mwa akulu ndi ana: Kusinthidwa kwa 2017 ndi Infectious Diseases Society of America (IDSA) ndi Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018; 66 (7): 987-994. PMID: 29562266 pubed.ncbi.nlm.nih.gov/29562266/.