Matenda a Carcinoid

Matenda a Carcinoid ndi gulu la zizindikilo zomwe zimakhudzana ndi zotupa za khansa. Awa ndi zotupa za m'matumbo ang'ono, m'matumbo, zowonjezera, ndi machubu am'mapapo.

Matenda a Carcinoid ndi mawonekedwe azizindikiro omwe nthawi zina amawoneka mwa anthu omwe ali ndi zotupa za khansa. Zotupa izi ndizochepa, ndipo nthawi zambiri zimakula pang'onopang'ono. Zotupa zambiri za khansa zimapezeka m'matumbo ndi m'mapapu.

Matenda a Carcinoid amapezeka mwa anthu ochepa kwambiri omwe ali ndi zotupa za khansa, chotupacho chitafalikira chiwindi kapena mapapo.

Zotupazi zimatulutsa timadzi tambiri ta serotonin, komanso mankhwala ena angapo. Mahomoni amachititsa kuti mitsempha ya magazi izitseguka (kutambasula). Izi zimayambitsa matenda a khansa.

Matenda a carcinoid amapangidwa ndi zizindikilo zinayi zazikulu kuphatikiza:

• Kutuluka (nkhope, khosi, kapena chifuwa chapamwamba), monga mitsempha yambiri yamagazi yomwe imawoneka pakhungu (telangiectasias)
• Kuvuta kupuma, monga kupuma
• Kutsekula m'mimba
• Mavuto amtima, monga mavavu amtima akutuluka, kugunda kwamtima pang'onopang'ono, kutsika kapena kuthamanga kwa magazi

Zizindikiro nthawi zina zimabwera chifukwa cha kuyesetsa, kapena kudya kapena kumwa zinthu monga tchizi wabuluu, chokoleti, kapena vinyo wofiira.

Zambiri mwa zotupazi zimapezeka pakuyesa kapena kuchitira zinthu pazifukwa zina, monga pakuchita opaleshoni m'mimba.

Ngati kuyezetsa kwachitika, wothandizira zaumoyo atha kupeza zizindikilo za:

• Mavuto a valavu yamtima, monga kung'ung'udza
• Matenda a Niacin (pellagra)

Mayeso omwe angachitike ndi awa:

• Magulu 5-HIAA mumkodzo
• Mayeso amwazi (kuphatikizapo serotonin ndi mayeso a magazi a chromogranin)
• Kufufuza kwa CT ndi MRI pachifuwa kapena pamimba
• Zojambulajambula
• Kusanthula kwamagetsi kwama Octreotide

Kuchita opaleshoni kuchotsa chotupacho nthawi zambiri kumakhala chithandizo choyamba. Ikhoza kuchiza matendawa ngati chotupacho chachotsedwa.

Ngati chotupacho chafalikira pachiwindi, chithandizo chimaphatikizapo chimodzi mwa izi:

• Kuchotsa madera a chiwindi omwe ali ndi zotupa
• Kutumiza (kulowetsa) mankhwala mwachindunji m'chiwindi kuti awononge zotupazo

Pamene chotupa chonse sichingachotsedwe, kuchotsa magawo akulu a chotupacho ("debulking") kumatha kuthandizira kuthetsa zizindikirazo.

Octreotide (Sandostatin) kapena lanreotide (Somatuline) jakisoni amaperekedwa kwa anthu omwe ali ndi zotupa za khansa zomwe sizingachotsedwe ndi opaleshoni.

Anthu omwe ali ndi matenda a carcinoid ayenera kupewa mowa, chakudya chambiri, komanso zakudya zomwe zili ndi tyramine (tchizi wakale, peyala, zakudya zambiri zopangidwa), chifukwa zimatha kuyambitsa zizindikilo.

Mankhwala ena wamba, monga serotonin reuptake inhibitors (SSRIs) osankhidwa, monga paroxetine (Paxil) ndi fluoxetine (Prozac), amatha kukulitsa zizindikilo kuwonjezeka kwa serotonin. Komabe, Musaleke kumwa mankhwalawa pokhapokha ngati wothandizira wanu atakuuzani kuti muchite.

Dziwani zambiri za matenda a carcinoid ndikupeza thandizo kuchokera:

• Carcinoid Cancer Foundation - www.carcinoid.org/resource/support-groups/directory/
• Neuroendocrine Tumor Research Foundation - netrf.org/for-patients/

Maganizo a anthu omwe ali ndi matenda a carcinoid nthawi zina amakhala osiyana ndi momwe anthu omwe ali ndi zotupa za khansa alibe matendawa.

Kulosera zamankhwala kumatengera tsamba la chotupa. Mwa anthu omwe ali ndi matendawa, chotupacho chimafalikira mpaka pachiwindi. Izi zimachepetsa kupulumuka. Anthu omwe ali ndi matenda a carcinoid amakhalanso ndi khansa yapadera (chotupa chachiwiri chachikulu) nthawi yomweyo. Ponseponse, kudandaula kumakhala bwino kwambiri.

Zovuta za matenda a carcinoid atha kukhala:

• Kuchulukitsa chiwopsezo chakugwa ndi kuvulala (kuchokera kutsika magazi)
• Kutsekeka kwa matumbo (kuchokera pachotupa)
• Kutuluka m'mimba
• Kulephera kwa valavu yamtima

Mtundu wowopsa wa matenda a carcinoid, vuto la khansa, ukhoza kuchitika ngati zotsatira zoyipa za opaleshoni, mankhwala oletsa ululu kapena chemotherapy.

Lumikizanani ndi omwe amakupatsani mwayi woti mudzakumane nanu ngati mudzakhala ndi matenda a khansa.

Kuchiza chotupacho kumachepetsa chiopsezo cha matenda a carcinoid.

Matenda amadzi; Matenda a Argentaffinoma

• Kutenga kwa Serotonin

Tsamba la National Cancer Institute. Chithandizo cha zotupa m'mimba (Wamkulu) (PDQ) - mtundu wazachipatala. www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-kuchiza-pdq. Idasinthidwa pa Seputembara 16, 2020. Idapezeka pa Okutobala 14, 2020.

Öberg K. zotupa za Neuroendocrine ndi zovuta zina. Mu: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, olemba. Buku la Williams la Endocrinology. Wolemba 14th. Philadelphia, PA: Elsevier; 2020: chap 45.

Wolin EM, Jensen RT. Zotupa za Neuroendocrine. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 219.