Matenda a Chylomicronemia

Chylomicronemia syndrome ndi vuto lomwe thupi silimaphwanya mafuta (lipids) molondola. Izi zimayambitsa tinthu ta mafuta totchedwa ma chylomicrons kuti timere m'magazi. Vutoli limafalikira kudzera m'mabanja.

Chylomicronemia syndrome imatha kupezeka chifukwa cha matenda osowa omwe majeremusi omwe amatchedwa lipoprotein lipase (LpL) amathyoledwa kapena akusowa. Zitha kuyambidwanso chifukwa chakusowa kwa chinthu chachiwiri chotchedwa apo C-II, chomwe chimayambitsa LpL. LpL nthawi zambiri imapezeka mu mafuta ndi minofu. Zimathandiza kuthetsa lipids ena. LpL ikasowa kapena ikasweka, tinthu tating'onoting'ono tomwe timatchedwa chylomicrons timakhala m'mwazi. Izi zimadziwika kuti chylomicronemia.

Zofooka za apolipoprotein CII ndi apolipoprotein AV zimayambitsanso matendawa. Zimatha kuchitika anthu omwe amakonda kukhala ndi triglycerides (monga omwe ali ndi mabanja omwe ali ndi hyperlipidemia kapena a hypertriglyceridemia) amakhala ndi matenda ashuga, kunenepa kwambiri kapena kupezeka ndi mankhwala ena.

Zizindikiro zimatha kuyambira ali akhanda ndikuphatikizapo:

• Kupweteka m'mimba chifukwa cha kapamba (kutupa kwa kapamba).
• Zizindikiro za kuwonongeka kwa mitsempha, monga kutaya kumverera m'mapazi kapena miyendo, komanso kukumbukira kukumbukira.
• Mafuta achikaso a khungu pakhungu lotchedwa xanthomas. Kukula uku kumatha kuwonekera kumbuyo, matako, mapazi, kapena mawondo ndi zigongono.

Kuyezetsa thupi ndi mayeso atha kuwonetsa:

• Kukulitsa chiwindi ndi ndulu
• Kutupa kwa kapamba
• Mafuta amaika pansi pa khungu
• Mwinanso mafuta amasungidwa mu diso la diso

Chosanjikiza chowoneka bwino chidzawonekera magazi atazungulira pamakina a labotale. Mzerewu umachokera ku ma chylomicrons m'magazi.

Mulingo wa triglyceride ndiwokwera kwambiri.

Chakudya chopanda mafuta, chopanda mowa chimafunika. Muyenera kusiya kumwa mankhwala ena omwe angapangitse kuti zizindikilo ziwonjezeke. Osasiya kumwa mankhwala musanalankhule ndi omwe amakuthandizani. Zinthu monga kuchepa madzi m'thupi ndi matenda a shuga zimatha kukulitsa zizindikilo. Akapezeka, izi ziyenera kuthandizidwa ndikuwongoleredwa.

Zakudya zopanda mafuta zitha kuchepetsa zizindikilo kwambiri.

Mukapanda kuchiritsidwa, ma chylomicrons owonjezera amatha kuyambitsa kapamba. Vutoli limakhala lopweteka kwambiri komanso lingawononge moyo.

Funsani chithandizo chamankhwala nthawi yomweyo ngati mukumva kupweteka m'mimba kapena zizindikiro zina za kapamba.

Itanani omwe akukuthandizani ngati muli ndi mbiri yaumwini kapena yabanja yama mulingo apamwamba a triglyceride.

Palibe njira yoletsera wina kuti asalandire matendawa.

Kutchuka kwa lipoprotein lipase kusowa; Matenda odziwika bwino a hyperchylomicronemia, Type I hyperlipidemia

• Matenda a hepatomegaly
• Xanthoma pa bondo

Genest J, Libby P. Lipoprotein zovuta ndi matenda amtima. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: chap 48.

Robinson JG. Matenda amadzimadzi amadzimadzi. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 195.