Pulayimale amyloidosis

Pulayimale amyloidosis ndimatenda achilendo momwe mapuloteni achilendo amakhala m'matumba ndi ziwalo. Ziphuphu za mapuloteni osadziwika amatchedwa ma amyloid deposits.

Zomwe zimayambitsa matenda amyloidosis sizimamveka bwino. Chibadwa chingatenge gawo.

Vutoli limakhudzana ndi kupanga mapuloteni osazolowereka komanso owonjezera. Mapuloteni achilendo amakhala m'matumba ena. Izi zimapangitsa kuti ziwalozo zizigwira bwino ntchito.

Primary amyloidosis imatha kubweretsa zinthu monga:

• Matenda a Carpal
• Kuwonongeka kwa minofu ya mtima (cardiomyopathy) kumabweretsa kukanika kwa mtima
• Kutsekula m'mimba
• Kutupa kwa chiwindi komanso kulephera kugwira ntchito
• Impso kulephera
• Nephrotic syndrome (gulu la zizindikilo zomwe zimaphatikizapo mapuloteni mumkodzo, kuchuluka kwa mapuloteni m'magazi, kuchuluka kwama cholesterol, kuchuluka kwa triglyceride, ndi kutupa mthupi lonse)
• Mavuto amitsempha (neuropathy)
• Orthostatic hypotension (kuthamanga kwa magazi mukayimirira)

Zizindikiro zimadalira ziwalo zomwe zakhudzidwa. Matendawa amatha kukhudza ziwalo ndi minofu yambiri, kuphatikizapo lilime, matumbo, mafupa ndi minofu yosalala, misempha, khungu, mitsempha, mtima, chiwindi, ndulu, ndi impso.

Zizindikiro zimatha kuphatikizira izi:

• Nyimbo yachilendo
• Kutopa
• Kuchuluka kwa manja kapena mapazi
• Kupuma pang'ono
• Khungu limasintha
• Kumeza mavuto
• Kutupa m'manja ndi m'miyendo
• Lilime lotupa
• Kufooka kwa dzanja
• Kuchepetsa thupi kapena kunenepa

Zizindikiro zina zomwe zingachitike ndi matendawa:

• Kuchepetsa mkodzo
• Kutsekula m'mimba
• Kuwopsya kapena kusintha mawu
• Ululu wophatikizana
• Kufooka

Wothandizira zaumoyo adzakufunsani. Mudzafunsidwa za mbiri yanu yazachipatala komanso zomwe zidachitika. Kuyezetsa thupi kumatha kuwonetsa kuti watupa chiwindi kapena ndulu, kapena zizindikiritso zamitsempha.

Njira yoyamba yodziwira amyloidosis iyenera kukhala kuyesa magazi ndi mkodzo kuti mufufuze mapuloteni achilendo.

Mayeso ena amatengera zizindikilo zanu komanso chiwalo chomwe chingakhudzidwe. Mayesero ena ndi awa:

• Mimba ya ultrasound kuti muwone chiwindi ndi ndulu
• Mayeso amtima, monga ECG, kapena echocardiogram, kapena MRI
• Ntchito ya impso imayesa kuti aone ngati ali ndi vuto la impso (nephrotic syndrome)

Mayeso omwe angathandize kutsimikizira kuti matendawa ndi awa:

• Mimba yam'mimba yolakalaka mafuta
• Kutupa kwa mafupa
• Kuchepetsa minofu yamtima
• Zowonongeka za mucosa

Chithandizo chingaphatikizepo:

• Chemotherapy
• Kupanga khungu la tsinde
• Kuika thupi

Ngati vutoli limayambitsidwa ndi matenda ena, matendawa amayenera kuchitidwa mwamphamvu. Izi zitha kukonza zizindikilo kapena kuchepetsa matendawa. Zovuta monga mtima kulephera, impso kulephera, ndi mavuto ena nthawi zina amatha kuchiritsidwa, zikafunika.

Momwe mumakhalira bwino zimatengera ziwalo zomwe zakhudzidwa. Kuphatikizidwa kwa mtima ndi impso kumatha kubweretsa kufooka kwa ziwalo ndikufa. Thupi lathunthu (systemic) amyloidosis imatha kubweretsa imfa m'zaka ziwiri.

Itanani omwe akukuthandizani ngati muli ndi zizindikiro za matendawa. Imbani foni ngati mwapezeka kuti muli ndi matendawa ndipo muli:

• Kuchepetsa mkodzo
• Kuvuta kupuma
• Kutupa kwa akakolo kapena ziwalo zina za thupi zomwe sizimatha

Palibe choletsa kudziwika cha primary amyloidosis.

Amyloidosis - pulayimale; Unyolo wa kuwala kwa Immunoglobulin amyloidosis; Pulayimale systemic amyloidosis

• Amyloidosis wa zala
• Amyloidosis wa nkhope

Gertz MA, Buadi FK, Lacy MQ, Hayman SR. Matenda a immunoglobulin amyloidosis (primary amyloidosis). Mu: Hoffman R, Benz EJ, Silberstein LE, et al, olemba. Hematology: Mfundo Zoyambira ndi Zochita. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2018: chap 88.

Hawkins PN. Amyloidosis.Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, olemba. Zamatsenga. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2019: mutu 177.