Kusowa kobadwa ndi antithrombin III

Kulephera kwa Congenital antithrombin III ndimatenda amtundu omwe amachititsa kuti magazi aumbike mopitilira muyeso.

Antithrombin III ndi mapuloteni m'magazi omwe amatseka magazi osadziwika kuti apange. Zimathandiza kuti thupi likhale ndi thanzi labwino pakati pa magazi ndi magazi. Kuperewera kwa kubadwa kwa antithrombin III ndi matenda obadwa nawo. Zimachitika munthu akalandira mtundu umodzi wosazolowereka wa jini la antithrombin III kuchokera kwa kholo lomwe lili ndi matendawa.

Mtundu wabwinobwino umabweretsa kutsika kwa mapuloteni a antithrombin III. Kuchepetsa kwa antithrombin III kumatha kuyambitsa magazi osagwirizana (thrombi) omwe amatha kuletsa kuyenda kwa magazi ndikuwononga ziwalo.

Anthu omwe ali ndi vutoli nthawi zambiri amakhala ndi magazi ali aang'ono. Ayeneranso kukhala ndi abale awo omwe ali ndi vuto lakutseka magazi.

Anthu nthawi zambiri amakhala ndi zizindikilo za magazi. Kuundana kwamagazi mmanja kapena m'miyendo nthawi zambiri kumayambitsa kutupa, kufiira, komanso kupweteka. Magazi akatuluka pomwe adapangira ndikupita mbali ina ya thupi, amatchedwa thromboembolism. Zizindikiro zimadalira komwe magazi amaundana amapita. Malo ofala ndi mapapo, pomwe khungu limatha kuyambitsa chifuwa, kupuma movutikira, kupweteka kwinaku mukupuma kwambiri, kupweteka pachifuwa, ngakhale kufa. Kuundana kwamagazi komwe kumapita kuubongo kumatha kuyambitsa stroke.

Kuyezetsa thupi kumatha kuwonetsa:

• Mwendo wotupa kapena mkono
• Kupuma kochepa kumamveka m'mapapu
• Kugunda kwamtima mwachangu

Wothandizira zaumoyo amathanso kuyitanitsa kukayezetsa magazi kuti muwone ngati muli ndi antithrombin III yotsika.

Magazi amagwiritsidwa ntchito ndi mankhwala ochepetsa magazi (omwe amatchedwanso anticoagulants). Kutenga nthawi yayitali bwanji kumwa mankhwalawa kumatengera kukula kwa magazi m'mwazi ndi zina. Kambiranani izi ndi omwe akukuthandizani.

Izi zitha kukupatsirani zambiri zakubadwa kwa antithrombin III kusowa:

• National Organisation for Rare Disways - rarediseases.org/rare-diseases/antithrombin-deficiency
• Buku Lofotokozera za NLM Genetics - ghr.nlm.nih.gov/condition/hereditary-antithrombin-deficiency

Anthu ambiri amakhala ndi zotulukapo zabwino ngati amakhalabe ndi mankhwala antiticoagulant.

Kuundana kwamagazi kumatha kuyambitsa imfa. Kuundana kwa magazi m'mapapu ndi koopsa kwambiri.

Onani omwe akukuthandizani ngati muli ndi zizindikilo za vutoli.

Munthu akangopezeka ndi vuto la antithrombin III, mamembala onse apabanja ayenera kuwunikidwa kuti adziwe matendawa. Mankhwala ochepetsa magazi amatha kuteteza kuundana kwamagazi ndikupewera zovuta kuundana.

Chosowa - antithrombin III - kobadwa nako; Kuperewera kwa Antithrombin III - kobadwa nako

• Kutsekeka kwamagazi

Anderson JA, Hogg KE, Weitz JI. Ma Hypercoagulable. Mu: Hoffman R, Benz EJ, Silberstein LE, et al, olemba. Hematology: Mfundo Zoyambira ndi Zochita. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2018: chap 140.

Schafer AI. Matenda a thrombotic: mayiko osakanikirana. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 176.