Njira yachiwiri ya amyloidosis

Secondary systemic amyloidosis ndi vuto lomwe mapuloteni achilendo amakhala m'matumba ndi ziwalo. Ziphuphu za mapuloteni osadziwika amatchedwa ma amyloid deposits.

Sekondale amatanthauza kuti zimachitika chifukwa cha matenda ena kapena vuto lina. Mwachitsanzo, vutoli limachitika chifukwa cha matenda a nthawi yayitali kapena kutupa. Mosiyana ndi izi, amyloidosis woyambirira amatanthauza kuti palibe matenda ena omwe amayambitsa vutoli.

Zokhudza zonse zimatanthauza kuti matendawa amakhudza thupi lonse.

Zomwe zimayambitsa sekondale amyloidosis sizikudziwika. Mutha kukhala ndi kachilombo ka amyloidosis ngati muli ndi matenda a nthawi yayitali kapena kutupa.

Izi zitha kuchitika ndi:

• Ankylosing spondylitis - mawonekedwe a nyamakazi omwe amakhudza kwambiri mafupa ndi mafupa a msana
• Bronchiectasis - matenda momwe misewu yayikulu yamapapo m'mapapo imawonongeka ndi matenda opatsirana
• Matenda osteomyelitis - matenda a mafupa
• Cystic fibrosis - matenda omwe amachititsa ntchofu zakuda, zomata m'mapapu, m'mimba, ndi madera ena amthupi, zomwe zimabweretsa matenda opatsirana m'mapapo
• Matenda odziwika bwino a Mediterranean - matenda obadwa nawo amnzeru zingapo komanso kutupa komwe kumakhudza nthawi yayitali pamimba, pachifuwa, kapena pamafundo
• Hairy cell leukemia - mtundu wa khansa yamagazi
• Matenda a Hodgkin - khansa ya minofu yaminyewa
• Matenda a achinyamata a nyamakazi - nyamakazi yomwe imakhudza ana
• Multiple myeloma - mtundu wa khansa yamagazi
• Reiter syndrome - gulu lazomwe zimayambitsa kutupa ndi kutupa kwamafundo, maso, ndi kwamikodzo ndi ziwalo zoberekera)
• Matenda a nyamakazi
• Systemic lupus erythematosus - vuto lodziyimira palokha
• Matenda a chifuwa chachikulu

Zizindikiro za sekondale amyloidosis zimadalira minofu yamthupi yomwe imakhudzidwa ndi ma protein. Izi zimayika kuwonongeka kwaminyewa yabwinobwino. Izi zitha kubweretsa zizindikilo kapena zizindikilo za matendawa, kuphatikiza:

• Magazi pakhungu
• Kutopa
• Kugunda kwamtima kosasintha
• Kuchuluka kwa manja ndi mapazi
• Kutupa
• Kupuma pang'ono
• Kumeza zovuta
• Kutupa mikono kapena miyendo
• Lilime lotupa
• Kufooka kwa dzanja
• Kuchepetsa thupi

Wothandizira zaumoyo adzakufufuza ndikufunsa za zizindikiro zanu.

Mayeso omwe angachitike ndi awa:

• Mimba ya m'mimba (imatha kuwonetsa chiwindi chotupa kapena ndulu)
• Biopsy kapena aspiration ya mafuta pansi pa khungu (mafuta ochepa)
• Chiwindi cha rectum
• Chikopa cha khungu
• Chiwindi cha m'mafupa
• Kuyesa magazi, kuphatikiza creatinine ndi BUN
• Zojambulajambula
• Electrocardiogram (ECG)
• Kuthamanga kwamitsempha
• Kupenda kwamadzi

Zomwe zikuyambitsa amyloidosis ziyenera kuthandizidwa. Nthawi zina, amapatsidwa mankhwala a colchicine kapena mankhwala a biologic (mankhwala omwe amathandizira chitetezo chamthupi).

Momwe munthu amagwirira ntchito zimadalira ziwalo zomwe zakhudzidwa. Zimadaliranso, ngati matenda omwe akuyambitsa amatha kuwongolera. Ngati matendawa amakhudza mtima ndi impso, zimatha kubweretsa kufooka kwa ziwalo ndi kufa.

Mavuto azaumoyo omwe angabwere kuchokera ku sekondale systemic amyloidosis ndi awa:

• Kulephera kwa Endocrine
• Mtima kulephera
• Impso kulephera
• Kulephera kupuma

Itanani omwe akukuthandizani ngati muli ndi zizindikilo za vutoli. Izi ndi zizindikiro zazikulu zomwe zimafunikira chithandizo chamankhwala mwachangu:

• Magazi
• Kugunda kwamtima kosasintha
• Kunjenjemera
• Kupuma pang'ono
• Kutupa
• Kufooka kofooka

Ngati muli ndi matenda omwe amadziwika kuti amachulukitsa chiopsezo cha vutoli, onetsetsani kuti akuchiritsirani. Izi zitha kuthandiza kupewa amyloidosis.

Amyloidosis - yachiwiri zokhudza zonse; AA amyloidosis

• Amyloidosis wa zala
• Amyloidosis wa nkhope
• Ma antibodies

Gertz MA. Amyloidosis. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: mutu 188.

Papa R, Lachmann HJ. Sekondale, AA, Amyloidosis. Rheum Dis Clin Kumpoto Am. 2018; 44 (4): 585-603. PMID: 30274625 www.ncbi.nlm.nih.gov/pubmed/30274625. (Adasankhidwa)