CMV - gastroenteritis / colitis

CMV gastroenteritis / colitis ndikutupa kwa m'mimba kapena m'matumbo chifukwa chamatenda a cytomegalovirus.

Vuto lomweli lingayambitsenso:

• Matenda a m'mapapo
• Matenda kumbuyo kwa diso
• Matenda a khanda akadali m'mimba

Cytomegalovirus (CMV) ndimatenda amtundu wa herpes. Zimakhudzana ndi kachilombo kamene kamayambitsa nkhuku.

Matenda a CMV ndiofala kwambiri. Imafalikira ndi malovu, mkodzo, madontho opumira, kugonana, komanso kuthiridwa magazi. Anthu ambiri amawululidwa pena pake, koma nthawi zambiri, kachilomboka kamatulutsa zizindikilo zofatsa kapena zosawoneka mwa anthu athanzi.

Matenda akulu a CMV amatha kuchitika mwa anthu omwe ali ndi chitetezo chamthupi chofooka chifukwa cha:

• Edzi
• Chemotherapy chithandizo cha khansa
• Pakadutsa kapena pambuyo pake m'mafupa kapena kuikapo ziwalo
• Ulcerative colitis kapena matenda a Crohn

Nthawi zambiri, matenda akulu a CMV okhudzana ndi thirakiti la GI achitika mwa anthu omwe ali ndi chitetezo chamthupi chokwanira.

Matenda a m'mimba a CMV atha kukhudza gawo limodzi kapena thupi lonse. Zilonda zimatha kupezeka m'mimba, m'mimba, m'matumbo ang'onoang'ono, kapena m'matumbo. Zilondazi zimagwirizanitsidwa ndi zizindikiro monga:

• Kupweteka m'mimba
• Zovuta kumeza kapena kupweteka ndikumeza
• Nseru
• Kusanza

Pamene matumbo akukhudzidwa, zilondazo zimatha kuyambitsa:

• Kupweteka m'mimba
• Zojambula zamagazi
• Kutsekula m'mimba
• Malungo
• Kuchepetsa thupi

Matenda owopsa kwambiri amatha kutuluka m'mimba kapena kubowo kudzera pakhoma (zotumphukira).

Mayeso omwe angachitike ndi awa:

• Enema wa Barium
• Colonoscopy yokhala ndi biopsy
• Pamwamba endoscopy (EGD) yokhala ndi biopsy
• Chopondapo chikhalidwe kuthana ndi zina zomwe zimayambitsa matenda
• Upper GI ndi matumbo ang'onoang'ono

Kuyesa kwa labotale kudzachitika pazitsanzo za minofu yotengedwa m'mimba kapena m'matumbo. Mayesowa, monga chikhalidwe cha m'mimba kapena m'mimba kapena biopsy, amadziwika ngati kachilomboka kali m'thupi.

Kuyezetsa magazi kwa CMV kumachitika kuti mupeze ma antibodies a kachilombo ka CMV m'magazi anu.

Kuyezetsa magazi kwina komwe kumayang'ana kupezeka ndi kuchuluka kwa tiziromboti m'magazi kumatha kuchitidwanso.

Chithandizo chimatanthauza kuti muchepetse matenda ndikuthana ndi zisonyezo.

Mankhwala olimbana ndi kachilomboka amaperekedwa. Mankhwalawa amatha kuperekedwa kudzera mumitsempha (IV), ndipo nthawi zina pakamwa, kwa milungu ingapo. Mankhwala omwe amagwiritsidwa ntchito kwambiri ndi ganciclovir ndi valganciclovir, ndi foscarnet.

Nthawi zina, chithandizo chanthawi yayitali chitha kukhala chofunikira. Mankhwala otchedwa CMV hyperimmune globulin atha kugwiritsidwa ntchito ngati mankhwala ena sagwira ntchito.

Mankhwala ena atha kukhala:

• Mankhwala oletsa kapena kuchepetsa kutsegula m'mimba
• Zopweteka (analgesics)

Zakudya zopatsa thanzi kapena zopatsa thanzi zomwe zimaperekedwa kudzera mu mtsempha (IV) zitha kugwiritsidwa ntchito kuthana ndi kutayika kwa minofu chifukwa cha matendawa.

Mwa anthu omwe ali ndi chitetezo chamthupi chokwanira, zizindikilo zimatha popanda chithandizo nthawi zambiri.

Zizindikiro zimakhala zowopsa kwa iwo omwe ali ndi chitetezo chamthupi chofooka. Zotsatira zake zimadalira momwe kuchepa kwa chitetezo cha mthupi komanso matenda a CMV ali.

Anthu omwe ali ndi Edzi atha kukhala ndi zotulukapo zoyipa kuposa omwe ali ndi chitetezo chamthupi chofooka chifukwa cha chifukwa china.

Matenda a CMV amakhudza thupi lonse, ngakhale kuli kokha zizindikiro za m'mimba. Momwe munthu amagwirira ntchito zimadalira momwe mankhwala antivirose amagwirira ntchito.

Mankhwala omwe amagwiritsidwa ntchito polimbana ndi kachilomboka angayambitse mavuto. Mtundu wa zoyipa zimadalira mankhwala omwe agwiritsidwa ntchito. Mwachitsanzo, mankhwala a ganciclovir amachepetsa kuchuluka kwama cell oyera. Mankhwala ena, foscarnet, atha kubweretsa mavuto a impso.

Itanani omwe akukuthandizani ngati muli ndi zizindikiro za CMV gastroenteritis / colitis.

Pali chiopsezo chachikulu chotenga kachilombo ka CMV mwa anthu omwe alandila chiwalo kuchokera kwa wopereka chithandizo wa CMV. Kumwa mankhwala ochepetsa mphamvu ya kachilombo ka HIV ganciclovir (Cytovene) ndi valganciclovir (Valcyte) pakamwa musanafike kumachepetsa mwayi wanu wopeza matenda ena kapena kuyambitsanso matenda akale.

Anthu omwe ali ndi Edzi omwe amathandizidwa ndimankhwala ochepetsa mphamvu ya kachilombo ka HIV sangakhale ndi kachilombo ka CMV.

Colitis - cytomegalovirus; Gastroenteritis - cytomegalovirus; Matenda a CMV m'mimba

• Matumbo a m'mimba
• Kutsegula m'mimba ndi m'mimba
• CMV (cytomegalovirus)

Britt WJ. Cytomegalovirus. Mu: Bennett JE, Dolin R, Blaser MJ, olemba., Eds. Mandell, Douglas, ndi Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020: chap 137.

Dupont HL, PC ya Okhuysen. Yandikirani kwa wodwala yemwe akuganiza kuti ali ndi matenda opatsirana. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 267.

Larson AM, Issaka RB, Hockenbery DM. Matenda am'mimba ndi chiwindi cha ziwalo zolimba komanso kupatsirana kwa hematopoietic cell. Mu: Feldman M, Friedman LS, Brandt LJ, olemba. Sleisenger ndi Matenda a Mimba ndi a Fordtran Amatenda a Chiwindi. 11th ed. Philadelphia, PA: Elsevier; 2021: chaputala 36.

Wilcox CM. Zotsatira za m'mimba za matenda a kachilombo ka HIV. Mu: Feldman M, Friedman LS, Brandt LJ, olemba. Sleisenger ndi Matenda a Mimba ndi a Fordtran Amatenda a Chiwindi. 11th ed. Philadelphia, PA: Elsevier; 2021: mutu 35.