Mayeso a CPK isoenzymes

Chiyeso cha creatine phosphokinase (CPK) isoenzymes chimayeza mitundu yosiyanasiyana ya CPK m'magazi. CPK ndi enzyme yomwe imapezeka makamaka mu mtima, ubongo, ndi mafupa.

Muyenera kuyesa magazi. Izi zitha kuchotsedwa pamitsempha. Mayesowa amatchedwa venipuncture.

Ngati muli mchipatala, mayesowa amatha kubwereza masiku awiri kapena atatu. Kukwera kapena kutsika kwathunthu kwa CPK kapena CPK isoenzymes kungathandize wothandizira zaumoyo wanu kuzindikira zina.

Palibe kukonzekera kwapadera komwe kumafunikira nthawi zambiri.

Uzani wothandizira wanu za mankhwala onse omwe mukumwa. Mankhwala ena amatha kusokoneza zotsatira za mayeso. Mankhwala omwe angakulitse miyezo ya CPK ndi awa:

• Mowa
• Amphotericin B
• Mankhwala ena oletsa ululu
• Cocaine
• Sinthanitsani mankhwala
• Zolemba
• Steroids, monga dexamethasone

Mndandanda uwu suli wophatikizapo.

Mutha kumva kupweteka pang'ono singano ikaikidwa kuti mutenge magazi. Anthu ena amangomva kuwawa kapena kuluma. Pambuyo pake, pakhoza kukhala kupindika.

Kuyesaku kumachitika ngati mayeso a CPK akuwonetsa kuti mulingo wanu wonse wa CPK wakwera. Kuyesa kwa CPK isoenzyme kungathandize kupeza gwero lenileni la minofu yowonongeka.

CPK imapangidwa ndi zinthu zitatu zosiyana:

• CPK-1 (yotchedwanso CPK-BB) imapezeka makamaka muubongo ndi m'mapapu
• CPK-2 (yotchedwanso CPK-MB) imapezeka makamaka mumtima
• CPK-3 (yomwe imadziwikanso kuti CPK-MM) imapezeka makamaka m'mitsempha yamafupa

Mulingo woposa wabwinobwino wa CPK-1:

Chifukwa CPK-1 imapezeka makamaka muubongo ndi m'mapapu, kuvulala kulikonse mwanjira izi kumatha kukulitsa milingo ya CPK-1. Kuchulukitsa kwa CPK-1 kumatha kukhala chifukwa cha:

• Khansara yaubongo
• Kuvulala kwaubongo (chifukwa cha kuvulala kwamtundu uliwonse kuphatikiza, kupweteka, kapena kutuluka magazi muubongo)
• Chithandizo chamagetsi
• Matenda a m'mapapo mwanga
• Kulanda

Mulingo woposa wabwinobwino wa CPK-2:

Mulingo wa CPK-2 umakwera 3 mpaka 6 maola mutadwala mtima. Ngati palibenso kuwonongeka kwa minofu yamtima, msinkhu umakwera maola 12 mpaka 24 ndikubwerera kumaola 12 mpaka 48 pambuyo poti minofu yamwalira.

Kuchuluka kwa magulu a CPK-2 atha kukhalanso chifukwa cha:

• Kuvulala kwamagetsi
• Kutsekemera kwa mtima (kudodometsa mtima kwa achipatala)
• Kuvulala kwamtima (mwachitsanzo, pangozi yagalimoto)
• Kutupa kwa minofu yamtima nthawi zambiri chifukwa cha kachilombo (myocarditis)
• Tsegulani opaleshoni yamtima

Mulingo woposa-wabwinobwino wa CPK-3 nthawi zambiri umakhala chizindikiro chovulala kwa minofu kapena kupsinjika kwa minofu. Zitha kukhala chifukwa cha:

• Kuphwanya kuvulala
• Kuwonongeka kwa minofu chifukwa cha mankhwala osokoneza bongo kapena kusayenda nthawi yayitali (rhabdomyolysis)
• Kusokonekera kwa minofu
• Myositis (mafupa am'mimba kutupa)
• Kulandira majakisoni ambiri amitsempha
• Kuyesa kwaposachedwa kwamitsempha ndi minofu (electromyography)
• Kugwidwa kwaposachedwa
• Opaleshoni yaposachedwa
• Kuchita masewera olimbitsa thupi

Zinthu zomwe zingakhudze zotsatira zoyeserera zimaphatikizira catheterization yamtima, jakisoni wamitsempha, opaleshoni yaposachedwa, komanso kuchita masewera olimbitsa thupi mwamphamvu komanso kwakanthawi kapena kulepheretsa.

Kuyesa kwa Isoenzyme pazinthu zina kumakhala pafupifupi 90%.

Pangani phosphokinase - isoenzymes; Chilengedwe kinase - isoenzymes; CK - isoenzymes; Matenda a mtima - CPK; Utsi - CPK

• Kuyezetsa magazi

Anderson JL. Gawo lakwera kukwera kwamphamvu kwam'mapapo amtima ndi zovuta zamatenda am'mnyewa wamtima. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 73.

Marshall WJ, Day A, Lapsley M. Plasma mapuloteni ndi michere. Mu: Marshall WJ, Tsiku A, Lapsley M, eds. Chipatala Chemistry. 8th ed. Philadelphia, PA: Elsevier; 2017: mutu 16.

Nagaraju K, Gladue HS, Lundberg IE. Matenda otupa a minofu ndi myopathies ena. Mu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, olemba. Kelley ndi Firestein's Bookbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2017: mutu 85.

Selcen D. Matenda a minofu. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 421.