Fingolimod

Zamkati

• Musanatenge fingolimod,
• Fingolimod ingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Fingolimod imagwiritsidwa ntchito kupewetsa zigawo za zizindikilo ndikuchepetsa kukulirakulirabe kwa akulu ndi ana azaka 10 zakubadwa kapena kupitilirabe ndimafomu obwerezabwereza (matenda omwe zizindikilo zimayamba nthawi ndi nthawi) a multiple sclerosis (MS; matenda momwe mitsempha sigwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo). Fingolimod ili mgulu la mankhwala otchedwa sphingosine l-phosphate receptor modulators. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

Fingolimod imabwera ngati kapisozi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku kapena wopanda chakudya. Tengani fingolimod mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani fingolimod ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Fingolimod ingayambitse kugunda kwa mtima mwa achikulire ndi ana, makamaka patadutsa maola 6 mutangotenga gawo lanu loyamba, komanso mutatha kumwa koyamba pomwe mlingowo wawonjezeka mwa ana. Mukalandira electrocardiogram (ECG; mayeso omwe amalemba zamagetsi zamagetsi mumtima) musanamwe mankhwala anu oyambiranso patadutsa maola 6 mutamwa. Mukatenga fingolimod yanu yoyamba muofesi ya dokotala kapena chipatala china. Muyenera kukhala kuchipatala kwa maola osachepera asanu ndi limodzi mutamwa mankhwalawo kuti athe kuyang'aniridwa. Mungafunike kukhala kuchipatala kwa nthawi yayitali kuposa maola 6 kapena usiku ngati muli ndi vuto linalake kapena kumwa mankhwala ena omwe angapangitse kuti kugunda kwa mtima kwanu kuzengeke kapena ngati kugunda kwanu kukucheperapo kuposa momwe amayembekezera kapena kukupitilira kuchepa pambuyo pa 6 yoyamba maola. Mwinanso mungafunike kukhala kuchipatala kwa maola osachepera 6 mutatenga mlingo wanu wachiwiri ngati kugunda kwa mtima kwanu kumachedwa kwambiri mukamamwa mankhwala anu oyamba. Uzani dokotala wanu ngati mukuchita chizungulire, kutopa, kupweteka pachifuwa, kapena kugunda kwapang'onopang'ono kapena kosagwirizana nthawi iliyonse mukamalandira chithandizo, makamaka mkati mwa maola 24 mutangotenga mankhwala anu oyamba.

Fingolimod itha kuthandizira kuwongolera sclerosis koma singachiritse. Osasiya kumwa fingolimod osalankhula ndi dokotala. Ngati simutenga fingolimod tsiku limodzi kapena kupitilira apo m'masabata awiri oyambilira, kwa sabata limodzi kapena kupitilira apo pamankhwala achitatu ndi achinayi kapena milungu iwiri kapena kupitilira mwezi woyamba wa chithandizo, lankhulani ndi dokotala musanamwe mankhwala mumayambiranso. Mutha kukumana ndi kuchepa kwa mtima mukamayambiranso kumwa fingolimod, chifukwa chake muyenera kuyambiranso mankhwalawa muofesi ya dokotala wanu.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi fingolimod ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge fingolimod,

• Uzani dokotala ndi wamankhwala ngati muli ndi vuto la fingolimod, Ngati mwakhala ndi vuto losagwirizana ndi fingolimod kapena chilichonse mwazomwe zimaphatikizira ma capsule a fingolimod (zotupa, ming'oma, kutupa kwa nkhope, maso, pakamwa, pakhosi, lilime, milomo, manja, mapazi, akakolo, kapena miyendo yakumunsi), dokotala wanu mwina sangakuuzeni kuti fingolimod. Komanso, uzani dokotala wanu ngati mukugwirizana ndi mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a fingolimod. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• uzani adotolo ngati mukumwa mankhwala osagunda pamtima monga amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), ibutilide (Corvert), procainamide, quinidine (ku Nuedexta), ndi sotalolide (Betapace, Sorine, Sotylize). Dokotala wanu angakuuzeni kuti musamwe fingolimod ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera mavitamini, ndi mankhwala azitsamba omwe mukumwa kapena mukukonzekera kumwa mukamachiza fingolimod. Onetsetsani kuti mwatchulapo izi: beta-blockers monga atenolol (Tenormin, mu Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, ku Dutoprol, ku Lopressor HCT), nadolol (Corgard, mu Corzide), nebivolol (Bystolic, mu Byvalson), propranolol (Inderal LA, Innopran XL), ndi timolol; diltiazem (Cardizem, Cartia, Tiazac, ena); mankhwala enaake; citalopram (Celexa); digoxin (Lanoxin); erythromycin (EES, Ery-Tab, PCE, ena); haloperidol (Haldol); ketoconazole; mankhwala a mavuto amtima; methadone (Dolophine, Methadose); ndi verapamil (Calan, Verelan, ku Tarka).Komanso muuzeni adotolo ngati mukumwa mankhwala aliwonse otsatirawa, kapena ngati mudamwa kale: corticosteroids monga dexamethasone, methylprednisolone, ndi prednisone; mankhwala a khansa; ndi mankhwala ofooketsa kapena kuwongolera chitetezo cha mthupi monga mitoxantrone, natalizumab (Tysabri), ndi teriflunomide (Aubagio), Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi fingolimod, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati mwakhala mukukumana ndi izi m'miyezi isanu ndi umodzi yapita: matenda amtima, angina (kupweteka pachifuwa), sitiroko kapena sitiroko yaying'ono, kapena kulephera kwa mtima. Komanso muuzeni dokotala ngati muli ndi matenda a QT (zomwe zimawonjezera chiopsezo chokhala ndi kugunda kwamtima kosafunikira komwe kumatha kukomoka kapena kufa mwadzidzidzi) kapena mungoli wosasintha wamtima. Dokotala wanu angakuuzeni kuti musatenge fingolimod.
• uzani dokotala wanu ngati munakomoka, munadwala matenda a mtima, sitiroko, kapena sitiroko yaying'ono, kapena ngati muli ndi malungo kapena zizindikiro zina za matenda, ngati muli ndi matenda omwe amabwera ndi kupita kapena omwe samatha, ndipo ngati mwakhalapo kapena mwakhalapo ndi matenda ashuga; kugona tulo (vuto lomwe mumasiya kupuma kangapo usiku) kapena mavuto ena opuma; kuthamanga kwa magazi; uveitis (kutupa kwa diso) kapena mavuto ena amaso; kugunda pang'onopang'ono; misinkhu ya potaziyamu kapena magnesium m'magazi anu; khansa yapakhungu, kapena matenda amtima kapena a chiwindi. Uzaninso dokotala wanu ngati mwalandira katemera posachedwa.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati, kapena mukuyamwitsa. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi iwiri mutatha kumwa. Mukakhala ndi pakati mukatenga fingolimod kapena miyezi iwiri mutatha kumwa mankhwala, pitani kuchipatala.
• mulibe katemera uliwonse mukamachiza fingolimod kapena kwa miyezi iwiri mutatha kumwa mankhwala anu osalankhula ndi dokotala. Lankhulani ndi dokotala wa mwana wanu za katemera yemwe mwana wanu angafunikire kulandira asanayambe chithandizo chake ndi fingolimod.
• uzani dokotala wanu ngati simunakhalepo ndi nthomba ndipo simunalandire katemera wa nthomba. Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti muwone ngati mwapezapo kachilombo ka nkhuku. Mungafunike kulandira katemera wa nthomba ndikudikirira mwezi umodzi musanayambe kumwa mankhwala ndi fingolimod.
• konzani kupewa kupezeka kwa kuwala kwadzuwa kosafunikira kapena kwakanthawi ndi kuwala kwa UV (monga malo okuchenjera) ndi kuvala zovala zoteteza, magalasi, ndi zotchingira dzuwa. Fingolimod imatha kupangitsa khungu lanu kukhala lowopsa pazowopsa za kuwala kwa dzuwa, ndipo kumatha kukulitsa chiopsezo chokhala ndi khansa yapakhungu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, tulukani mlingo womwe mwaphonya ndikuimbira dokotala musanamwe mankhwala ena. Mungafunike kuyang'aniridwa pamene mukuyambiranso mankhwala anu. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Fingolimod ingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kufooka
• kupweteka kwa msana
• kupweteka m'manja kapena m'mapazi
• kutsegula m'mimba
• kupweteka m'mimba
• nseru
• kupweteka mutu kapena migraine
• kutayika tsitsi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kugunda kochedwa mtima
• zidzolo, ming'oma, kuyabwa; kutupa kwa nkhope, diso, pakamwa, pakhosi, lilime kapena milomo; kapena kuvutika kumeza kapena kupuma
• zilonda zapakhosi, kupweteka kwa thupi, malungo, kuzizira, chifuwa, ndi zizindikilo zina za matenda komanso mukamalandira chithandizo komanso kwa miyezi iwiri mutalandira chithandizo
• kupweteka kwa mutu, kuuma kwa khosi, malungo, kuzindikira kuwala, nseru, kapena kusokonezeka mukamalandira chithandizo komanso kwa miyezi iwiri mutalandira chithandizo
• kupweteka, kuwotcha, kufooka, kapena kumva kumva pakhungu, kumva kukhudza, kuthamanga, kapena kuyabwa mukamalandira chithandizo komanso kwa miyezi iwiri mutalandira chithandizo
• kupweteka mutu modzidzimutsa, kusokonezeka, kusintha masomphenya, kapena kugwidwa
• blurry, mithunzi, kapena malo akhungu pakati pa masomphenya anu; kutengeka ndi kuwala; mtundu wachilendo pamasomphenya anu kapena zovuta zina zamasomphenya
• kusintha kwa mole yomwe ilipo kale; malo amdima watsopano pakhungu; zilonda zosachiritsa; zophuka pakhungu lanu monga bampu yomwe imatha kukhala yowala, yoyera yoyera, yoyera khungu, kapena pinki, kapena kusintha kulikonse pakhungu lanu
• kufooka mbali imodzi ya thupi kapena kusakhazikika kwa mikono kapena miyendo yomwe imakulira pakapita nthawi; kusintha kwa malingaliro anu, kukumbukira, kapena kulinganiza; chisokonezo kapena kusintha kwa umunthu; kapena kutaya mphamvu
• kupuma kwatsopano kapena kukulira
• nseru, kusanza, kusowa chilakolako, kupweteka m'mimba, chikasu cha khungu kapena maso, kapena mkodzo wakuda

Fingolimod ikhoza kuonjezera chiopsezo chokhala ndi khansa yapakhungu ndi lymphoma (khansa yomwe imayamba m'maselo omwe amalimbana ndi matenda). Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Kuwonjezeka kwadzidzidzi kwa zizindikiro za MS ndikuwonjezeka kwaulemala kumatha kuchitika patatha miyezi 3 mpaka 6 mutasiya kumwa fingolimod. Uzani dokotala wanu ngati matenda anu a MS achulukirachulukira mukasiya fingolimod.

Fingolimod ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kugunda kwapang'onopang'ono kapena kosasintha

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena a labu, ndi mayeso a khungu ndi maso, ndipo adzawunika kuthamanga kwa magazi musanachitike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti muyambe kumwa kapena kupitiriza kumwa fingolimod.

Musanayezetsedwe kwa labotale, auzeni adotolo ndi ogwira nawo ntchito kuti mukumwa fingolimod.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Gilenya^®