Wotsogolera

Zamkati

• Musanatenge ceritinib,
• Ceritinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

Ceritinib imagwiritsidwa ntchito pochiza khansa ina yam'mapapo yam'mapapo (NSCLC) yomwe yafalikira mbali zina za thupi. Ceritinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Ceritinib imabwera ngati kapisozi ndi piritsi yoti mutenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya kamodzi patsiku. Tengani ceritinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ceritinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati mumasanza mukalandira ceritinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa kuchuluka kwa ceritinib, kukuthandizani ndi mankhwala ena, kapena kukuuzani kuti musiye kumwa ceritinib kwakanthawi mukamalandira chithandizo. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zina zomwe mungakumane nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha ceritinib.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ceritinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ceritinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a ceritinib kapena mapiritsi. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone); anagrelide (Agrylin); maanticoagulants ('oonda magazi') monga warfarin (Coumadin, Jantoven); zotchinga beta monga atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal) ndi sotalol (Betapace, Sorine, Sotylize); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); mankhwala ena opatsirana pogonana (HIV) kapena matenda opatsirana m'thupi (AIDS) monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); chloroquine; mankhwala enaake; chilonda; ciprofloxacin (Cipro); citalopram (Celexa); kumvetsetsa; clonidine (Catapres, Kapvay); corticosteroids; cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); diltiazem (Cardizem, Dilacor, Tiazac); disopyramide (Norpace); dofetilide (Tikosyn); donepezil (Aricept); dronearone (Multaq); escitalopram (Lexapro); fentanyl (Abstral, Actiq, Duragesic, Fentora, Subsys); zachilengedwe (Tambocor); fluconazole (Diflucan); haloperidol (Haldol); ibutilide (Corvert); itraconazole (Onmel, Sporanox, Tolsura); ketoconazole; levofloxacin; methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; ondansetron (Zuplenz, Zofran); pentamidine (Pentam); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); pioglitazone (Actos, ku Duetact, Oseni); kupeza; quinidine (mu Nuedexta); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, mu Rifater); sildenafil (Revatio); mankhwala (Rapamune); tacrolimus (Astagraf, Prograf); thioridazine; vardenafil (Levitra, Staxyn); ndi verapamil (Calan, Covera, Isoptin, Verelan). Mankhwala ena ambiri amatha kulumikizana ndi ceritinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• auzeni adotolo ngati mwakhalapo ndi matenda ashuga kapena shuga wambiri wamagazi, kulephera kwa mtima, kugunda kwamtima kosazolowereka, kutalikitsa kwa QT (kugunda kwamtima kosasunthika komwe kumatha kubweretsa kukomoka, kutaya chidziwitso, kukomoka, kapena kufa mwadzidzidzi), otsika potaziyamu kapena magnesium m'magazi anu, kapamba (kutupa kwa kapamba), kapena chiwindi cha chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, kapena konzekerani kutenga pakati. Simuyenera kutenga pakati mukamamwa ceritinib. Muyenera kuyezetsa musanalandire chithandizo chamankhwala, ndipo muyenera kugwiritsa ntchito njira yoletsa kuteteza mimba mukamalandira chithandizo komanso kwa miyezi isanu ndi umodzi mutatha kumwa. Ngati ndinu wamwamuna wokhala ndi mkazi yemwe angakhale ndi pakati, muyenera kugwiritsa ntchito njira yoletsa kuteteza mimba mukamalandira chithandizo komanso kwa miyezi itatu mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Ceritinib ikhoza kuvulaza mwana wanu wosabadwa. Ngati inu kapena mnzanu mumakhala ndi pakati mukamamwa ndi ceritinib, itanani dokotala wanu mwachangu.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mukamamwa ceritinib komanso kwa milungu iwiri musanamwe mankhwala.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa ceritinib.
• muyenera kudziwa kuti mutha kukhala ndi hyperglycemia (kuwonjezera shuga m'magazi anu) mukamamwa mankhwalawa. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi mukamamwa ceritinib: ludzu lokwanira, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kupweteka mutu, kusaganiza bwino kapena kuyang'ana, mpweya umanunkhira ngati zipatso, kapena kutopa.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 12 a mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ceritinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kutsegula m'mimba
• kusanza
• kudzimbidwa
• kupweteka m'mimba
• kutentha pa chifuwa
• zovuta kumeza
• kusowa chilakolako
• kuonda
• kutopa
• zidzolo
• kuyabwa
• kusintha kwa masomphenya
• minofu, fupa, mkono wakumbuyo, kapena kupweteka kwa mwendo
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

• kupweteka kumtunda chakumanja kwam'mimba
• kuvulaza kapena kutuluka mwachilendo
• mkodzo wakuda
• chikasu cha khungu ndi maso
• kuchepa kudya
• zizindikiro ngati chimfine
• kuyabwa
• kupuma movutikira
• malungo, kuzizira, zilonda zapakhosi, kutsokomola kosalekeza komanso kuchulukana, kapena zizindikilo zina za matenda
• kupweteka pachifuwa kapena kusapeza bwino
• kusintha kwa kugunda kwa mtima
• kugunda kwa mtima
• chizungulire
• wamisala
• kukomoka
• kupweteka kosalekeza komwe kumayambira kumtunda kumanzere kapena pakati pamimba koma kumafalikira kumbuyo
• kugwidwa

Ceritinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira ceritinib. Dokotala wanu ayeneranso kuyitanitsa mayeso a labu musanayambe mankhwala anu kuti mudziwe ngati khansa yanu ingathe kuchiritsidwa ndi ceritinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zykadia^®