Tofacitinib

Zamkati

• Musanatenge tofacitinib,
• Tofacitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Kutenga tofacitinib kungachepetse kuthekera kwanu kothana ndi matenda ndikuwonjezera chiopsezo choti mutenge matenda akulu, kuphatikizapo mafangasi akulu, bakiteriya, kapena matenda omwe amafalikira mthupi. Matendawa angafunike kuthandizidwa kuchipatala ndipo atha kupha. Uzani dokotala wanu ngati nthawi zambiri mumakhala ndi matenda aliwonse kapena ngati mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Izi zimaphatikizapo matenda ang'onoang'ono (monga mabala otseguka kapena zilonda), matenda omwe amabwera ndikadutsa (monga zilonda zozizira), ndi matenda opatsirana omwe samatha. Uzaninso adotolo ngati mwadwalapo kapena munakhalapo ndi matenda a shuga, kachilombo ka HIV, matenda opatsirana mthupi (Edzi), matenda am'mapapo, kapena vuto lina lililonse lomwe limakhudza chitetezo chamthupi. Muyeneranso kuuza adotolo ngati mukukhala kapena mudakhalako m'malo monga zigwa za Ohio kapena Mississippi komwe matenda ofala a fungus amapezeka kwambiri. Funsani dokotala wanu ngati simukudziwa ngati matendawa ndiofala m'dera lanu. Uzani dokotala ngati mukumwa mankhwala omwe amachepetsa chitetezo chamthupi monga awa: abatacept (Orencia); adalimumab (Humira); anakinra (Kineret); azathioprine (Azasan, Imuran); certolizumab (Cimzia); cyclosporine (Gengraf, Neoral, Sandimmune); etanercept (Enbrel); golimumab (Simponi); infliximab (Remicade); methotrexate (Otrexup, Rasuvo, Trexall); rituximab (Rituxan); steroids kuphatikizapo dexamethasone, methylprednisolone (Medrol), prednisolone (Prelone), ndi prednisone (Rayos); tacrolimus (Astagraf, Envarsus XR, Prograf); ndi tocilizumab (Actemra).

Dokotala wanu adzakuyang'anirani ngati muli ndi matendawa mukamalandira chithandizo chake. Ngati muli ndi zizindikiro zotsatirazi musanayambe kumwa mankhwala kapena ngati mukukumana ndi zizindikiro zotsatirazi mukamalandira chithandizo kapena mutangochoka kumene, pitani kuchipatala nthawi yomweyo: malungo; thukuta; kuzizira; kupweteka kwa minofu; kumeza kowawa kapena kovuta; chifuwa; kupuma movutikira; kuonda; khungu lofunda, lofiira, kapena lopweteka; zidzolo zopweteka; kupweteka kwa mutu, kuzindikira kuwala, kuuma kwa khosi, chisokonezo; kumverera pafupipafupi, kupweteka, kapena kutentha nthawi yokodza; kupweteka m'mimba; kutsegula m'mimba; kapena kutopa kwambiri.

Mutha kukhala kuti mwadwala kale chifuwa chachikulu (TB; matenda akulu am'mapapo) koma mulibe zizindikiro zilizonse za matendawa. Poterepa, kugwiritsa ntchito tofacitinib kungapangitse matenda anu kukhala owopsa ndikupangitsani kukhala ndi zizindikilo. Dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi kachilombo koyambitsa matenda a TB musanayambe kumwa mankhwala ndi tofacitinib. Ngati ndi kotheka, dokotala wanu adzakupatsani mankhwala ochizira matendawa musanayambe kugwiritsa ntchito tofacitinib. Uzani dokotala ngati mwadwalapo kapena munakhalapo ndi TB, ngati munakhalako kapena munapitako kudziko kumene TB imafala, kapena ngati munakhalapo ndi munthu amene ali ndi TB. Ngati muli ndi zizindikiro zotsatirazi za chifuwa chachikulu cha TB, kapena ngati muli ndi zina mwazizindikiro mukamalandira chithandizo, pitani kuchipatala nthawi yomweyo: kutsokomola, kutsokomola ntchofu zamagazi, kuonda, kuchepa kwa minofu, kapena malungo.

Kutenga tofacitinib muyezo waukulu kuposa momwe mungalimbikitsire kungayambitse mavuto owopsa kapena owopsa pamoyo wanu mukamalandira chithandizo. Uzani dokotala wanu ngati muli ndi zaka 50 kapena kupitirirapo kapena ngati mumasuta, komanso ngati muli ndi cholesterol, kuthamanga magazi, kapena matenda ashuga. Tengani tofacitinib ndendende momwe mwalangizira. Musamamwe zochuluka kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kutenga tofacitinib kungapangitse chiopsezo kuti mukhale ndi lymphoma (khansa yomwe imayamba m'maselo amwazi omwe amalimbana ndi matenda) kapena mitundu ina ya khansa, kuphatikiza khansa yapakhungu. Anthu ena omwe amamwa tofacitinib ndi mankhwala ena atamuika impso adayamba chifukwa chomwe chimapangitsa kuti matupi awo apange maselo oyera ambiri. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi khansa yamtundu uliwonse kapena kudalilatu impso.

Kutenga tofacitinib muyezo waukulu kuposa momwe angapangire kumachulukitsa chiopsezo cha magazi omwe angawopsyeze moyo. Uzani dokotala wanu ngati muli ndi zaka 50 kapena kupitirira ndipo muli pachiwopsezo cha matenda amtima kapena am'magazi. Komanso, uzani dokotala ngati mwakhalapo ndi magazi m'miyendo, mikono, kapena mapapo, kapena mumitsempha. Tengani tofacitinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala. Ngati mukumane ndi zizindikiro izi siyani kumwa tofacitinib ndikuyimbira dokotala nthawi yomweyo: kupuma mwadzidzidzi kapena kupuma movutikira, kupweteka pachifuwa, kutupa kwa mwendo kapena mkono, kupweteka kwa mwendo, kufiira, kusintha kwa khungu, kapena kutentha kwamiyendo kapena mikono .

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi tofacitinib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Tofacitinib imagwiritsidwa ntchito yokha kapena ndi mankhwala ena kuchiza nyamakazi (momwe thupi limagwirira mafupa ake omwe amachititsa kupweteka, kutupa, ndi kutayika kwa ntchito) mwa anthu omwe sanayankhe methotrexate (Otrexup, Rasuvo, Trexall). Amagwiritsidwanso ntchito limodzi ndi methotrexate, sulfasalazine (Azulfidine), kapena leflunomide (Arava) yochizira nyamakazi ya psoriatic (vuto lomwe limayambitsa kupweteka kwa mafupa ndi kutupa ndi masikelo pakhungu) mwa anthu omwe sanayankhe mankhwalawa okha. Tofacitinib imagwiritsidwa ntchito pochiza ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda m'mbali mwa kholingo [matumbo akulu] ndi zotsekemera) mwa anthu omwe sangathe kutenga kapena omwe sanayankhe mankhwala a chotupa necrosis factor (TNF). Amagwiritsidwanso ntchito pochiza matenda opatsirana a ana omwe ali ndi ana (PJIA; mtundu wamatenda aunyamata omwe amakhudza ziwalo zisanu kapena zingapo m'miyezi isanu ndi umodzi yoyambirira ya vutoli, zomwe zimapweteka, kutupa, komanso kutha kwa ntchito) mwa ana azaka ziwiri kapena kupitilira apo. Tofacitinib ali mgulu la mankhwala otchedwa Janus kinase (JAK) inhibitors. Zimagwira ntchito pochepetsa magwiridwe antchito amthupi.

Tofacitinib imabwera ngati piritsi, pulogalamu yotulutsira (yotenga nthawi yayitali), komanso ngati yankho lakumwa (madzi) kuti mutenge pakamwa. Pofuna kuchiza ulcerative colitis, nyamakazi ya nyamakazi, kapena psoriatic nyamakazi, piritsi limamwedwa kawiri tsiku lililonse popanda kapena chakudya ndipo piritsi lotulutsira nthawi zambiri limatengedwa kamodzi tsiku lililonse popanda kapena chakudya. Pofuna kuchiza matenda opatsirana pogonana a ana, piritsi kapena njira yothetsera vutoli imamwa kawiri tsiku lililonse popanda chakudya. Tengani tofacitinib mozungulira nthawi imodzimodzi tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani tofacitinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi otulutsidwa otalikiratu; osagawana, kutafuna, kapena kuwaphwanya.

Nthawi zonse mugwiritse ntchito sirinji ya pakamwa yomwe imabwera ndi yankho la tofacitinib kuti muyese mlingo wanu. Lankhulani ndi dokotala kapena wamankhwala ngati muli ndi mafunso okhudza momwe mungayesere mlingo wa tofacitinib solution.

Ngati inu kapena mwana wanu mukumwa mankhwala a tofacitinib, funsani wamankhwala kapena dokotala kuti akupatseni malangizo a wopanga. Werengani mosamala malangizowa.

Dokotala wanu angafunike kuchepetsa mlingo wanu kapena kuimitsa chithandizo chanu mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge tofacitinib,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la tofacitinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a tofacitinib, mapiritsi otulutsidwa, kapena yankho la m'kamwa. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgulu la CHENJEZO CHENJEZO ndi zina mwa izi: mankhwala ena ophera fungal monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ndi ketoconazole; aspirin ndi mankhwala ena osagwiritsa ntchito zotupa (NSAIDs) monga ibuprofen (Advil, Motrin) ndi naproxen (Naprosyn, Aleve); carbamazepine (Carbatrol, Tegretol, Equetro, ena); clarithromycin (Biaxin, mu Prevpac); mankhwala ena a HIV kuphatikiza indinavir (Crixivan), nelfinavir (Viracept), ndi ritonavir (Norvir, ku Kaletra); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); ndi rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• Uzani dokotala ngati muli ndi ululu wam'mimba womwe sunapezeke ndipo ngati muli ndi zilonda zam'mimba (zilonda zamkati mwa m'mimba kapena m'matumbo), diverticulitis (kutupa kwamkati wamatumbo akulu), matenda a chiwindi kuphatikiza hepatitis B kapena hepatitis C, khansa, kuchepa magazi (kuchuluka kochepera kwama cell ofiira ofiira), dialysis (chithandizo chamankhwala chotsuka magazi impso zikugwira ntchito bwino), kapena matenda a impso. Ngati mukumwa mapiritsi otulutsidwa, auzeni dokotala ngati mukuchepetsa kapena kutsekeka kwa gawo lanu lakugaya chakudya.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga pakati mukamamwa tofacitinib. Mukakhala ndi pakati mukatenga tofacitinib, itanani dokotala wanu.
• Uzani dokotala wanu ngati mukuyamwitsa. Musamayamwitse mukamamwa mapiritsi a tofacitinib kapena yankho la m'kamwa komanso kwa maola osachepera 18 mutapatsidwa piritsi lomaliza kapena kwa maola osachepera 36 pambuyo pomaliza mapiritsi otulutsidwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amayi. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito tofacitinib.
• uzani dokotala wanu ngati mwalandira kumene kapena mukuyenera kulandira katemera uliwonse. Ngati mukufuna katemera aliyense, mungafunike kulandira katemerayu ndikudikirira kaye musanamwe mankhwala ndi tofacitinib. Musakhale ndi katemera uliwonse mukamalandira chithandizo popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Tofacitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• mutu
• yothina kapena yothamanga m'mphuno

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• ming'oma, kutupa kwa nkhope, maso, milomo, kapena mmero, kuvutika kumeza kapena kupuma
• kupweteka m'mimba, makamaka ngati kubwera ndi malungo ndi kutsegula m'mimba kapena kudzimbidwa
• chikasu cha khungu kapena maso
• kusowa chilakolako
• mkodzo wakuda
• matumbo akuda
• kusanza
• zidzolo
• khungu lotumbululuka
• kupuma movutikira

Tofacitinib ingayambitse kuchuluka kwa mafuta m'magazi a cholesterol. Dokotala wanu adzayitanitsa mayeso kuti awone kuchuluka kwa cholesterol yanu mukamamwa mankhwala ndi tofacitinib. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Tofacitinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Chotsani yankho lililonse lomwe silinagwiritsidwe ntchito patatha masiku 60 mutatsegula botolo.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira tofacitinib.

Ngati mukumwa mapiritsi otulutsira kwina mutha kuwona china chake chomwe chikuwoneka ngati piritsi pakhungu lanu. Ili ndiye chipolopolo chopanda kanthu, ndipo sizitanthauza kuti simunalandire mankhwala anu onse.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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