Dolutegravir

Zamkati

• Musanatenge dolutegravir,
• Dolutegravir itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi kapena zomwe zalembedwa mu gawo la SPECIAL PRECAUTIONS, siyani kumwa dolutegravir ndikuyimbira dokotala nthawi yomweyo kapena kupita kuchipatala mwadzidzidzi:

Dolutegravir imagwiritsidwa ntchito ndi mankhwala ena kuchiza matenda opatsirana pogonana mwa akulu ndi ana azaka 4 zakubadwa kapena kupitilira apo omwe amalemera pafupifupi 6.6 lbs (3 kg). Amagwiritsidwanso ntchito limodzi ndi rilpivirine (Edurant) kuchiza kachilombo ka HIV mwa anthu ena achikulire kuti abwezeretse mankhwala omwe ali nawo a HIV omwe amamwa kwa miyezi isanu ndi umodzi. Dolutegravir ali mgulu la mankhwala otchedwa HIV integrase inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka HIV m'magazi mwanu ndikuwonjezera kuchuluka kwa maselo amthupi omwe amathandiza kulimbana ndi matenda mthupi lanu. Ngakhale dolutegravir sachiza kachilombo ka HIV, kuyigwiritsa ntchito limodzi ndi mankhwala ena kumachepetsa mwayi wanu wopeza matenda a immunodeficiency (AIDS) ndi matenda okhudzana ndi HIV monga matenda akulu kapena khansa. Kumwa mankhwalawa pamodzi ndi kugonana mosatekeseka ndikusintha zina pamoyo wanu kumachepetsa chiopsezo chotenga (kufalitsa) kachirombo ka HIV kwa anthu ena.

Dolutegravir imabwera ngati piritsi komanso piritsi loyimitsira (piritsi losungunuka m'madzi) kuti mutenge pakamwa. Nthawi zambiri amatengedwa kamodzi kapena kawiri patsiku kapena wopanda chakudya. Tengani dolutegravir mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani dolutegravir ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Osatafuna, kudula, kapena kuphwanya mapiritsiwa kuti ayimitsidwe pakamwa. Mutha kumeza piritsi lonse lathunthu, kapena kusakaniza ndi madzi akumwa musanagwiritse ntchito.

Ngati mutasakaniza mapiritsi oyimitsidwa pakamwa m'madzi akumwa, onjezerani kuchuluka kwa mapiritsi mu kapu ya dosing. Ngati mukumwa mapiritsi 1 kapena 3 oimitsa pakamwa, onjezerani supuni 1 (5 ml) ya madzi akumwa mu chikho. Ngati mukumwa mapiritsi 4, 5, kapena 6 osayimitsidwa pakamwa, onjezerani supuni 2 (10 ml) zamadzi akumwa mu chikho. Musagwiritse ntchito madzi ena aliwonse kuti asungunule piritsi. Sungani chikho kwa mphindi imodzi kapena ziwiri kapena mpaka mutasakaniza kwathunthu; chisakanizocho chidzawoneka mitambo. Piritsi (kapena) la kuyimitsidwa litasungunuka kwathunthu, imwani chisakanizo mutangosakaniza. Ngati papita mphindi 30 mutasakaniza chisakanizocho, siyani chisakanizocho.

Ngati mukuwapatsa ana mapiritsi a kuyimitsidwa koyimitsidwa, onetsetsani kuti akuwongoka mukamamwa. Ngati pali chikho chotsalira mu chikho, onjezerani supuni imodzi (5 ml) ya madzi akumwa mu chikho, swirl, ndipo perekani zonse kwa mwana kuti atsimikizire kuti mwana alandira mlingo wonse.

Ngati mupatsa mwana wakhanda mapiritsi a kuyimitsidwa, gwiritsani ntchito syringe yapakamwa yoperekedwa kuti muyese ndikupatsanso mlingo. Ikani nsonga ya syringe mu chikho cha dosing ndi chisakanizo chokonzekera kuti mutenge mu syringe. Ikani nsonga ya syringe yam'kamwa mkamwa mwa mwana motsutsana ndi mkati mwa tsaya. Pepani pang'onopang'ono pa plunger kuti mupatse mlingo pang'onopang'ono. Lolani nthawi kuti khanda limenye kusakaniza. Onjezerani supuni imodzi (5 ml) ya madzi akumwa mu chikho ndikuzungulira.Jambulani zosakaniza zotsalira mu syringe ndikupereka zonse kwa khanda. Bwerezani ngati chisakanizo chilichonse chikatsalira mu syringe kuti muwonetsetse kuti khanda lalandila mlingo wonse. Chosakanizacho chiyenera kuperekedwa kwa mwana pasanathe mphindi 30 kuchokera pamene anasakaniza. Pambuyo pa mlingo, tsukani kapu ndi jekeseni padera ndi madzi. Lolani ziwalo kuti ziume kwathunthu musanapanganso ndi kusunga.

Osasinthira mapiritsi ndi mapiritsi oimitsira osalankhula ndi dokotala.

Pitilizani kumwa dolutegravir ngakhale mukumva bwino. Osasiya kumwa dolutegravir osalankhula ndi dokotala. Katundu wanu wa dolutegravir akatsika, pezani zambiri kuchokera kwa dokotala kapena wamankhwala. Mukasiya kumwa dolutegravir kapena kuphonya Mlingo, matenda anu amatha kukulirakulira ndikuvutirapo kuchiza ndi mankhwala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge dolutegravir,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la dolutegravir, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a dolutegravir. Funsani wamankhwala wanu kapena onani zomwe wodwala akupanga kuti muwone mndandanda wazosakaniza.
• Uzani dokotala wanu ngati mukumwa dofetilide (Tikosyn). Dokotala wanu angakuuzeni kuti musamwe dolutegravir ngati mukumwa mankhwalawa.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe mumalandira kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: dalfampridine (Ampyra); Mankhwala ena a HIV kuphatikiza efavirenz (Sustiva, ku Atripla), etravirine (Intelence), fosamprenavir (Lexiva) yotengedwa ndi ritonavir (Norvir), nevirapine (Viramune), ndi tipranavir (Aptivus) yotengedwa ndi ritonavir (Norvir); mankhwala ena okomoka kuphatikiza carbamazepine (Carbatrol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, ndi phenytoin (Dilantin, Phenytek); metformin (Glumetza, Glucophage, Riomet); ndi rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• ngati mukumwa maantacid, laxatives, kapena ma multivitamini omwe ali ndi aluminium, magnesium, kapena calcium; zowonjezera calcium; zowonjezera zitsulo; sucralfate (Carafate); kapena mankhwala omwenso amamwa buffered monga aspirin yoledzeretsa, imwanireni maola awiri mutadwala kapena mutadutsa maola 6 musanamwe dolutegravir. Komabe, ngati mutenga dolutegravir ndi chakudya, mutha kumwa zowonjezerazo nthawi yomweyo zomwe mumamwa dolutegravir.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati mwakhalapo ndi matenda a impso kapena mukulandira mankhwala a dialysis kapena matenda a chiwindi kuphatikiza hepatitis B kapena hepatitis C.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kukayezetsa mimba musanayambe kumwa mankhwala. Lankhulani ndi dokotala wanu za njira zothandiza zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukatenga dolutegravir, itanani dokotala wanu mwachangu. Dolutegravir itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa ngati muli ndi kachilombo ka HIV kapena ngati mukumwa dolutegravir.
• muyenera kudziwa kuti pamene mukumwa mankhwala ochizira kachilombo ka HIV, chitetezo chanu cha mthupi chingakhale champhamvu ndikuyamba kulimbana ndi matenda ena omwe anali kale mthupi lanu. Izi zitha kukupangitsani kukhala ndi zizindikilo za matendawa. Ngati muli ndi zizindikilo zatsopano kapena zoyipa mutayamba kulandira chithandizo ndi dolutegravir, onetsetsani kuti mwauza dokotala wanu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Dolutegravir itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuvuta kugona kapena kugona
• mutu
• kupweteka m'mimba
• mpweya
• kutsegula m'mimba
• kunenepa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi kapena zomwe zalembedwa mu gawo la SPECIAL PRECAUTIONS, siyani kumwa dolutegravir ndikuyimbira dokotala nthawi yomweyo kapena kupita kuchipatala mwadzidzidzi:

• zidzolo
• malungo
• kumva kudwala
• kutopa kwambiri
• kupweteka kwa minofu kapena molumikizana
• khungu kapena khungu
• matuza kapena zilonda mkamwa
• ofiira kapena otupa maso
• kutupa kwa maso, nkhope, milomo, pakamwa, lilime, kapena pakhosi
• kuvuta kupuma kapena kumeza
• chikasu cha maso kapena khungu
• mkodzo wakuda
• matumbo achikuda otumbululuka
• nseru
• kusanza
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwam'mimba

Dolutegravir ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Musachotse desiccant (paketi yaying'ono yomwe ili ndi chinthu chomwe chimamwa chinyezi kuti mankhwala asamaume) m'botolo.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu atha kuyitanitsa mayeso ena a labu kuti aone momwe thupi lanu lingayankhire pa dolutegravir.

Sungani ndalama za dolutegravir m'manja. Musayembekezere mpaka mutatsala pang'ono kumwa mankhwala kuti mudzaze mankhwala anu.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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• Juluca^® (monga chinthu chophatikizira chomwe chili ndi dolutegravir, rilpivirine)