Anayankha

Zamkati

• Ibrutinib imagwiritsidwa ntchito:
• Musanatenge ibrutinib,
• Ibrutinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Ibrutinib imagwiritsidwa ntchito:

• kuchiza anthu omwe ali ndi mantle cell lymphoma (MCL; khansa yomwe ikukula mwachangu yomwe imayamba m'maselo amthupi) omwe amathandizidwa kale ndi mankhwala ena amodzi a chemotherapy,
• kuchiza anthu omwe ali ndi khansa ya m'magazi (CLL; mtundu wa khansa womwe umayambira m'maselo oyera) ndi ma lymphocytic lymphoma (SLL; mtundu wa khansa womwe umayamba makamaka m'ma lymph node),
• kuchitira anthu omwe ali ndi Waldenstrom's macroglobulinemia (WM; khansa yomwe ikukula pang'onopang'ono yomwe imayamba m'maselo oyera am'mafupa anu),
• kuchiza anthu omwe ali ndi marginal zone lymphoma (MZL; khansa yomwe ikukula pang'onopang'ono yomwe imayamba ndi mtundu wamagazi oyera omwe amalimbana ndi matenda) omwe adalandira kale mtundu wina wa mankhwala a chemotherapy,
• ndikuchiza anthu omwe ali ndi matenda amtengowo (cGVHD; vuto la kupatsirana kwa hematopoietic stem-cell [HSCT; njira yomwe imalowa m'malo mwa mafupa omwe ali ndi matenda ndi mafupa athanzi] yomwe imatha kuyamba kwakanthawi ndikukhazikitsanso ndikukhala kwakanthawi mutalandira chithandizo chimodzi kapena zingapo osapambana.

Ibrutinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Ibrutinib imabwera ngati kapisozi ndi piritsi kuti mutenge pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse. Tengani ibrutinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ibrutinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi kapu yamadzi; osatsegula, kuswa, kapena kutafuna. Kumeza mapiritsi lonse ndi kapu yamadzi; osazidula, kuziphwanya kapena kuzitafuna.

Ngati mukulandira jakisoni wa obinutuzumab (Gazyva) kapena jekeseni wa rituximab (Rituxan), adokotala angakuuzeni kuti mutenge imbrutinib yanu musanalandire jakisoni wanu.

Dokotala wanu akhoza kuchepetsa mlingo wanu, kapena kusokoneza kapena kusiya pangano lanu. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kumwa ibrutinib ngakhale mutakhala bwino. Osasiya kumwa ibrutinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ibrutinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ibrutinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mabotolo a ibrutinib kapena mapiritsi. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('opopera magazi') monga warfarin (Coumadin, Jantoven); antifungals monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); mankhwala antiplatelet monga clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), ndi ticlopidine; Aprepitant (Emend); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); clarithromycin (Biaxin, Prevpac), digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, ena); erythromycin (EES, Erythrocin, ena), mankhwala ena ochizira kachilombo ka HIV (kachilombo ka HIV) kapena matenda a immunodeficiency (AIDS) monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); nefazodone; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rifamate, Rimactane, ena); verapamil (Calan, Covera, ku Tarka, ena); ndi telithromycin (sikupezeka ku US; Ketek). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• Uzani dokotala wanu ngati muli ndi matenda kapena mwachitidwa opaleshoni posachedwapa. Komanso muuzeni dokotala ngati mumasuta kapena ngati mwakhalapo ndi matenda ashuga, kugunda kwamtima mosasinthasintha, kuthamanga kwa magazi (kuthamanga kwa magazi), cholesterol, mavuto akuchucha magazi, kapena matenda a mtima, impso, kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, mukuyamwitsa, kapena ngati mukufuna kukhala ndi mwana. Simuyenera kutenga pakati mukamamwa ibrutinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kumwa mankhwala ndipo muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala a ibrutinib komanso kwa mwezi umodzi mutasiya kumwa mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamamwa mankhwala ndi ibrutinib ndikupitiliza mwezi umodzi mutatha kumwa. Ngati inu kapena mnzanu mumakhala ndi pakati mukatenga ibrutinib, itanani dokotala wanu mwachangu. Ibrutinib imatha kupweteketsa mwana.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa ibrutinib. Dokotala wanu angakuuzeni kuti musiye kumwa ibrutinib masiku atatu kapena asanu musanachite opaleshoni kapena njira.

Musadye zipatso zamphesa kapena malalanje a Seville (omwe nthawi zina amagwiritsidwa ntchito mu marmalade), kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Onetsetsani kuti mumamwa madzi ambiri kapena madzi ena tsiku lililonse mukamamwa ibrutinib.

Tengani mlingo womwe mwaphonya mukangokumbukira tsiku lomwelo. Komabe, ngati simukumbukira mpaka tsiku lotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ibrutinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• nseru
• kudzimbidwa
• kusanza
• kupweteka m'mimba
• kutentha pa chifuwa kapena kudzimbidwa
• kuchepa kudya
• kutopa kwambiri kapena kufooka
• kupweteka kwa minofu, mafupa, ndi mafupa
• kutuluka kwa minofu
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• zidzolo
• kuyabwa
• zilonda mkamwa ndi pakhosi
• nkhawa
• kuvuta kugona kapena kugona
• chifuwa, chimfine kapena modzaza mphuno
• kusawona bwino
• maso owuma kapena amadzi
• diso la pinki

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kutupa kwa nkhope, mmero, lilime, milomo, ndi maso
• zovuta kumeza kapena kupuma
• ming'oma
• kuvulaza kapena kutuluka mwachilendo
• pinki, wofiira, kapena mkodzo wakuda
• wamagazi kapena wakuda, malo obisalira
• mphuno kutuluka magazi
• kusanza kwamagazi; kapena kusanza magazi kapena zinthu zofiirira zomwe zikufanana ndi khofi
• kugwidwa
• kuthamanga kapena kusakhazikika kwamtima
• kupuma movutikira
• kusapeza bwino pachifuwa
• chizungulire, mutu wopepuka kapena kumva kukomoka
• masomphenya amasintha
• mutu (womwe umakhala nthawi yayitali)
• malungo, kuzizira, chifuwa, khungu lofiira, lofunda, kapena zizindikilo zina za matenda
• chisokonezo
• amasintha kalankhulidwe kanu
• kuchepa pokodza
• pokodza mopweteka, pafupipafupi, kapena mwachangu

Ibrutinib ingawonjezere chiopsezo chanu chokhala ndi mitundu ina ya khansa kuphatikiza khansa yapakhungu kapena ziwalo zina. Lankhulani ndi dokotala wanu za kuopsa kotenga ibrutinib.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi osati kubafa.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu ndikuwunika kuthamanga kwa magazi kwanu kuti muwone momwe thupi lanu likuyankhira ibrutinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Imbruvica^®