Olaparib

Zamkati

• Asanatenge olaparib,
• Olaparib angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

Mapiritsi a Olaparib amagwiritsidwa ntchito kuthandiza kuthandizira mitundu ina yamchiberekero (ziwalo zoberekera zachikazi komwe mazira amapangidwira), chubu (chotengera chomwe chimanyamula mazira otulutsidwa ndi thumba losunga mazira kupita kuchiberekero), ndi peritoneal (wosanjikiza wa minofu yomwe imayala pamimba khansa mwa anthu omwe adayankha kwathunthu kapena pang'ono poyankha mankhwala awo oyamba kapena amtsogolo a chemotherapy. Mapiritsi a Olaparib amagwiritsidwanso ntchito pochiza mitundu ina ya khansa ya m'mawere yomwe yafalikira mbali zina za thupi ndipo sinasinthe kapena yaipiraipira atalandira chithandizo ndi mankhwala ena. Mapiritsi a Olaparib amagwiritsidwanso ntchito kuthana ndi mtundu wina wa khansa ya prostate yomwe yafalikira mbali zina za thupi, sakuyankhanso kuchipatala kapena kuchiritsa kuti muchepetse kuchuluka kwa testosterone, ndipo wapita patsogolo atalandira chithandizo ndi enzalutamide (Xtandi) kapena abiraterone (Yonsa , Zytiga). Mapiritsi a Olaparib ndi makapisozi amagwiritsidwanso ntchito pochiza khansa ya m'mimba yomwe sinasinthe kapena yaipiraipira atalandira chithandizo chamankhwala ena atatu. Mapiritsi a Olaparib amagwiritsidwanso ntchito kuthandizira kuyankha kwa mtundu wina wa khansa ya kapamba yomwe siidafalikire kapena kupita patsogolo pambuyo pa mankhwala oyamba a chemotherapy. Olaparib ndi polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor. Zimagwira ntchito popha ma cell a khansa.

Olaparib amabwera ngati piritsi kapena kapisozi kuti amwe pakamwa kawiri tsiku lililonse kapena wopanda chakudya. Yesetsani kuyika mlingo wanu pafupifupi maola 12 padera. Tengani olaparib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani olaparib ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza piritsi kapena kapisozi lonse; osaphwanya kutafuna, kugawaniza, kapena kuwataya.

Olaparib amapezeka ngati piritsi komanso kapisozi. Mapiritsi ndi makapisozi amakhala ndi olaparib osiyanasiyana ndipo sayenera kusinthana wina ndi mnzake. Lankhulani ndi dokotala wanu kapena wamankhwala ngati muli ndi mafunso okhudza piritsi ndi kapisozi kukonzekera.

Dokotala wanu akhoza kuchepetsa kuchuluka kwanu kwa olaparib kapena kukuwuzani kuti musiye kumwa olaparib kwakanthawi mukamamwa mankhwala. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zina zomwe mungakumane nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira olaparib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi olaparib. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kuti mupeze Chithandizo cha Mankhwala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanatenge olaparib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la olaparib, mankhwala ena aliwonse, kapena zina zilizonse zomwe zingaphatikizidwe ndi mapiritsi kapena makapisozi a olaparib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maantibayotiki monga ciprofloxacin (Cipro), clarithromycin (Biaxin, ku Prevpac), erythromycin (E.E.S., Erythrocin, ena), nafcillin, ndi telithromycin (sipezekanso ku U.S. antifungals monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), posaconazole (Noxafil), ndi voriconazole (Vfend); Aprepitant (Emend); mankhwala ena ochizira matenda monga carbamazepine (Carbatrol, Epitol, Tegretol, Teril), ndi phenytoin (Dilantin, Phenytek); chifuwa (Tracleer); crizotinib (Xalkori); diltiazem (Cardizem, Cartia, Tiazac, ena); mankhwala ena ochizira matenda a hepatitis C monga boceprevir (sakupezekanso ku U.S., Victrelis) ndi telaprevir (sikupezeka ku U.S., Incivek); mankhwala ena ochizira kachilombo ka HIV (kachilombo ka HIV) kapena matenda a immunodeficiency (AIDS) monga amprenavir (omwe sapezeka ku US, Agenerase), atazanavir (Reyataz, ku Evotaz), darunavir (Prezista), efavirenz (Sustiva, ku Atripla) , etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); imatinib (Gleevec); modafinil (Provigil); nefazodone; mankhwala ena a chemotherapy a khansa, rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater), ndi verapamil (Calan, Verelan, ku Tarka). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. Simuyenera kutenga wort ya St. John mukamamwa olaparib.
• uzani dokotala wanu ngati mwakhalapo ndi vuto la m'mapapo kapena kupuma, kapena matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena konzekerani kukhala ndi mwana. Mungafunike kukayezetsa mimba musanayambe chithandizo, Simuyenera kutenga pakati mukatenga olaparib. Muyenera kugwiritsa ntchito njira yolerera yoletsa kutenga mimba mukamamwa mankhwala olaparib komanso kwa miyezi isanu ndi umodzi mutangomaliza kumwa mankhwala. Ngati ndinu wamwamuna ndipo mnzanu atha kukhala ndi pakati, muyenera kugwiritsa ntchito njira yoletsa pochiza ndi mapiritsi a olaparib komanso kwa miyezi itatu mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga olaparib, itanani dokotala wanu mwachangu. Olaparib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Osamayamwa mukamamwa olaparib komanso kwa mwezi umodzi mutamwa mankhwala omaliza.
• muyenera kudziwa kuti simuyenera kupereka umuna mukamamwa mapiritsi a olaparib komanso kwa miyezi itatu mutalandira mankhwala anu omaliza.

Musadye zipatso zamphesa kapena malalanje a Seville (omwe nthawi zina amagwiritsidwa ntchito mu marmalade), kapena kumwa madzi amphesa kapena madzi a lalanje a Seville mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Olaparib angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kutentha pa chifuwa
• mutu
• kuchepa kudya
• minofu, olowa, kapena kupweteka kwa msana
• kutopa
• kupweteka m'mimba kapena kusapeza bwino
• kusintha kwa kukoma
• kupweteka pakamwa kapena zilonda
• nkhawa
• kukhumudwa
• khungu lowuma
• kuyabwa
• zidzolo
• kuvuta kugona kapena kugona
• kupweteka kukodza

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• malungo, kupuma movutikira, kutsokomola, kapena kupuma
• kupuma movutikira
• kufooka
• kutopa kwambiri
• kuonda
• kuvulaza kapena kutuluka mwachilendo
• khungu lotumbululuka
• magazi mkodzo kapena chopondapo
• malungo, kuzizira, chifuwa, zilonda zapakhosi, kapena zizindikilo zina za matenda
• kupweteka, kukoma mtima, kufiira, kapena kutupa mwendo umodzi
• kupweteka pachifuwa kapena kulimba; kupuma movutikira; kutsokomola magazi; kapena kupuma mofulumira

Olaparib amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu akhoza kuyitanitsa mayeso a labu musanayambe mankhwala anu kuti muwone ngati matenda anu angathe kuthandizidwa ndi olaparib. Dokotala wanu adzaitanitsa mayeso ena a labu mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira olaparib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Lynparza^®