Palbociclib

Zamkati

• Musanatenge palbociclib,
• Palbociclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

[Wolemba 09/13/2019]

Omvera: Wodwala, Zaumoyo, Oncology

NKHANI: FDA ikuchenjeza kuti palbociclib (Ibrance^®), ribociclib (Kisqali^®), ndi abemaciclib (Verzenio^®) omwe amathandizira odwala ena omwe ali ndi khansa ya m'mawere amatha kuyambitsa mapapo osowa koma owopsa. A FDA avomereza machenjezo atsopano okhudzana ndi chiopsezo ichi pakufotokozera zambiri ndi Patient Package Insert kwa gulu lonse la mankhwala ozungulira kinase 4/6 (CDK 4/6) oletsa cyclin. Phindu lonse la CDK 4/6 inhibitors ndilobe kuposa zoopsa zikagwiritsidwa ntchito monga mwalamulo.

MALANGIZO: CDK 4/6 inhibitors ndi gulu la mankhwala omwe amagwiritsidwa ntchito limodzi ndi mankhwala a mahomoni kuti athandize achikulire omwe ali ndi mahomoni receptor (HR) -osintha, khansa ya m'mimba ya kukula kwa 2 (HER2) -khansa ya m'mawere yoyipa kapena yamatenda yomwe yafalikira ku ziwalo zina za thupi. Ma CDK 4/6 inhibitors amaletsa mamolekyulu ena omwe amathandizira kulimbikitsa kukula kwa maselo a khansa. FDA idavomereza palbociclib mu 2015, ndipo onse ribociclib ndi abemaciclib mu 2017. CDK 4/6 inhibitors awonetsedwa kuti apititsa patsogolo nthawi kuyambira pomwe chithandizo cha khansa sichikula kwambiri ndipo wodwalayo ali moyo, wotchedwa kupulumuka kopanda kupita patsogolo (Onani Mndandanda wa CDK 4/6 Inhibitors Wovomerezeka ndi FDA pansipa).

Malangizo:Odwala Muyenera kudziwitsa akatswiri azaumoyo nthawi yomweyo ngati muli ndi zisonyezo zatsopano kapena zoyipa zomwe zikukhudzana ndi mapapu anu, chifukwa zitha kuwonetsa zomwe zili zosowa koma zowopsa zomwe zingayambitse imfa. Zizindikiro zofunika kuziyang'ana zikuphatikizapo:

• Zovuta kapena zovuta kupuma
• Kupuma pang'ono panthawi yopuma kapena ndi ntchito zochepa

Osasiya kumwa mankhwala anu musanalankhule ndi dokotala. Mankhwala onse amakhala ndi zotsatirapo zake ngakhale atagwiritsidwa ntchito moyenera monga momwe akunenera, koma kwakukulu phindu lakumwa mankhwalawa limaposa ngozi izi. Ndikofunika kudziwa kuti anthu amayankha mosiyanasiyana mankhwala onse kutengera thanzi lawo, matenda omwe ali nawo, majini, mankhwala ena omwe akumwa, ndi zina zambiri. Zowopsa zapadera kuti mudziwe kuthekera kwake kuti munthu wina atha kutupa m'mapapo atatenga palbociclib, ribociclib, kapena abemaciclib sizikudziwika.

Ogwira ntchito zaumoyo amayenera kuwunika odwala pafupipafupi ngati ali ndi matenda am'mapapo mwanga omwe amawonetsa matenda am'mapapo (ILD) ndi / kapena pneumonitis. Zizindikiro zingaphatikizepo:

• hypoxia
• chifuwa
• ziphuphu
• kulowerera mkati mwa mayeso a radiologic mwa odwala omwe amapatsirana, zotupa m'mimba, ndi zifukwa zina sizinapezeke.

Kulepheretsa CDK 4/6 mankhwala oletsa odwala omwe ali ndi zizindikiro zatsopano kapena zowonjezereka, ndipo amasiya kuchipatala kwa odwala omwe ali ndi ILD komanso / kapena pneumonitis.

Kuti mumve zambiri pitani patsamba la FDA ku: http://www.fda.gov/Safety/MedWatch/SafetyInformation ndi http://www.fda.gov/Drugs/DrugSafety.

Palbociclib imagwiritsidwa ntchito limodzi ndi anastrozole (Arimidex), exemestane (Aromasin), kapena letrozole (Femara) yothandizira mtundu wina wa khansa yolandila mahomoni, khansa ya m'mawere (khansa ya m'mawere yomwe imadalira mahomoni monga estrogen kuti ikule) kapena bere khansa yomwe yafalikira mbali zina za thupi mwa amayi omwe adasamba (kusintha kwa moyo, kutha msambo) kapena mwa abambo. Palbociclib imagwiritsidwanso ntchito limodzi ndi fulvestrant (Faslodex) kuchiza mtundu wina wa khansa yotulutsa mahomoni, khansa ya m'mawere (khansa ya m'mawere yomwe imadalira mahomoni monga estrogen kukula) kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi mu anthu omwe adalandira mankhwala a antiestrogen monga tamoxifen (Nolvadex). Palbociclib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Palbociclib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya kamodzi tsiku lililonse kwa masiku 21 oyambira masiku 28. Dokotala wanu adzasankha kangati momwe muyenera kubwereza izi. Tengani palbociclib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani palbociclib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya. Musamamwe makapisozi osweka kapena osweka.

Ngati musanza mutamwa palbociclib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha palbociclib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge palbociclib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la palbociclib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a palbociclib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal monga itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), ndi voriconazole (Vfend); mankhwala ena ochiza matenda a khunyu monga carbamazepine (Carbatrol, Equetro, Epitol, Tegretol, ena) ndi phenytoin (Dilantin, Phenytek); kumvetsetsa; enzalutamide (Xtandi); ergot alkaloids monga dihydroergotamine (DHH 45, Migranal) ndi ergotamine (Ergomar, ku Cafergot, ku Migergot); mankhwala ena a kachirombo ka HIV (HIV) kapena matenda a immunodeficiency (AIDS) kuphatikiza indinavir (Crixivan), lopinavir (ku Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra, ku Viekira Pak), saquinavir (Invirase), ndi telaprevir (sakupezeka ku US); fentanyl (Abstral, Fentora, Lazanda, Subsys, ena); ma immunosuppressants monga cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), ndi tacrolimus (Astagraf XL, Envarsus XR, Prograf); masewera; nefazodone; pimozide (Orap); quinidine (mu Nuedexta); rifampin (Rimactane, Rifadin, ku Rifater, ku Rifamate); ndi telithromycin (Ketek). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi palbociclib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu komanso wazamankhwala zomwe mumamwa mankhwala azitsamba, makamaka wort ya St.
• uzani dokotala wanu ngati muli ndi matenda kapena ngati mwakhalapo ndi matenda a chiwindi kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa milungu itatu mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamamwa mankhwala a palbociclib komanso kwa miyezi itatu mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mutenga pakati mukatenga palbociclib, itanani dokotala wanu mwachangu. Palbociclib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa palbociclib komanso kwa masabata atatu mutalandira mankhwala omaliza.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa palbociclib.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kwakumwa palbociclib.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musamamwe kawiri pa tsiku lomwelo kuti mupange omwe mwaphonya.

Palbociclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kutsegula m'mimba
• kusanza
• kuchepa kudya
• kusintha kwa kukoma
• kutopa
• dzanzi kapena kumva kulasalasa m'manja, manja, miyendo, ndi mapazi
• zilonda pamilomo, mkamwa, kapena pakhosi
• kutsitsa tsitsi kosazolowereka kapena kutayika tsitsi
• khungu lowuma
• zidzolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• malungo, kuzizira, kapena zizindikiro za matenda
• kupuma movutikira
• chizungulire
• kuthamanga, kusasinthasintha, kapena kugunda kwamtima
• kufooka
• kutuluka mwachilendo kapena kuphwanya
• mwazi wa m'mphuno

Palbociclib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana.Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira palbociclib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Ibrance^®