Lenvatinib

Zamkati

• Musanatenge lenvatinib,
• Lenvatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Lenvatinib amagwiritsidwa ntchito pochiza khansa yamtundu wa chithokomiro yomwe yabwerera kapena yomwe yafalikira mbali zina za thupi ndipo singathe kuchiritsidwa ndi ayodini wa radioactive. Lenvatinib imagwiritsidwanso ntchito limodzi ndi everolimus (Afinitor, Zortress) kuchiza renal cell carcinoma (RCC, mtundu wa khansa womwe umayamba mu impso) mwa anthu omwe adalandirapo mankhwala ndi mankhwala ena a chemotherapy. Lenvatinib imagwiritsidwanso ntchito kuchiza hepatocellular carcinoma (HCC; mtundu wa khansa ya chiwindi) yomwe singachiritsidwe ndi opaleshoni. Lenvatinib imagwiritsidwanso ntchito limodzi ndi pembrolizumab (Keytruda) kuchiza mtundu wina wa khansa ya endometrium (kuyala kwa chiberekero) yomwe yafalikira mbali zina za thupi kapena kuipiraipira panthawi yamankhwala kapena mankhwala a chemotherapy kapena omwe sangachiritsidwe opaleshoni kapena mankhwala a radiation. Lenvatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Lenvatinib amabwera ngati kapisozi woti amutenge pakamwa. Nthawi zambiri amatengedwa kamodzi tsiku lililonse kapena wopanda chakudya. Tengani lenvatinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani lenvatinib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya.

Ngati mukulephera kumeza makapisozi, aikeni mu galasi yaying'ono ndikuwonjezera supuni imodzi yamadzi kapena msuzi wa apulo. Osathyola kapena kuphwanya makapisozi. Siyani makapisozi m'madzi kwa mphindi zosachepera 10 ndikusunthira zomwe zili mkati osachepera mphindi zitatu. Imwani chisakanizo. Mukamwa chisakanizocho, onjezerani supuni imodzi yamadzi kapena madzi apulo ku galasi. Sinthanitsani zomwe zili mkatimo kangapo ndi kumeza chisakanizo.

Dokotala wanu akhoza kuchepetsa mlingo wanu wa lenvatinib kapena kukuuzani kuti musiye kumwa mankhwalawo kwakanthawi kapena kwamuyaya mukakumana ndi zovuta zina. Onetsetsani kuti mwalankhula ndi dokotala za momwe mukumvera mukamalandira mankhwala a lenvatinib.

Kutalika kwa chithandizo chanu kumadalira momwe mumayankhira mankhwalawo ndi zotsatirapo zomwe mumakumana nazo. Pitilizani kumwa lenvatinib ngakhale mukumva bwino. Osasiya kumwa lenvatinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge lenvatinib,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi lenvatinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a lenvatinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa.Onetsetsani kuti mwatchulapo izi: mankhwala ena am'magazi osagwirizana kuphatikiza amiodarone (Nexterone, Pacerone), disopyramide (Norpace), procainamide, quinidine (ku Nuedexta), ndi sotalol (Betapace, Betapace AF, Sorine, Sotylize) Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mudagwidwa kapena kudwalapo, kuthamanga kwa magazi, kupwetekedwa mtima, matenda amtima, kupweteka mutu, kusintha masomphenya, makamaka chifukwa cha magazi, kuphwanya (kulumikizana kwachilendo pakati pa ziwalo ziwiri mkati mwa thupi lanu kapena pakati pa chiwalo ndi kunja kwa thupi lanu), kung'ambika khoma la m'mimba kapena m'matumbo, kutalikirana kwa nthawi ya QT (mtima wosagwirizana wamtima womwe ungayambitse kukomoka, kutaya chidziwitso, kugwidwa, kapena kufa mwadzidzidzi), kulephera kwa mtima, kutsika pang'ono kashiamu, potaziyamu, kapena magnesium m'magazi anu, mavuto akutuluka magazi, kapena mtima, impso, kapena matenda a chiwindi. Komanso uzani dokotala wanu ngati munalandirapo mankhwala a radiation.
• Muyenera kudziwa kuti lenvatinib ichepetsa kuchepa kwa abambo ndi amai. Komabe, musaganize kuti inu kapena mnzanuyo simungakhale ndi pakati. Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyezetsa asanayambe kulandira mankhwala ndi lenvatinib. Ngati mutha kukhala ndi pakati, muyenera kugwiritsa ntchito njira yolerera mukamamwa mankhwala ndi lenvatinib komanso kwa milungu 4 mutatha kumwa. Mukakhala ndi pakati mukatenga lenvatinib, itanani dokotala wanu mwachangu. Lenvatinib atha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa lenvatinib
• Uzani dokotala wanu ngati mukufuna kuchitidwa opaleshoni iliyonse, kuphatikizapo opaleshoni ya mano. Dokotala wanu angakuuzeni kuti musiye mankhwala anu ndi lenvatinib masiku osachepera 6 musanachite opareshoni yanu chifukwa imatha kukhudza machiritso a zilonda. Dokotala wanu angakuuzeni nthawi yoyamba kumwa lenvatinib mukatha opaleshoni.
• muyenera kudziwa kuti kuthamanga kwa magazi kwanu kumatha kuchulukanso mukamalandira mankhwala a lenvatinib. Dokotala wanu angayang'anire kuthamanga kwa magazi anu mukamalandira chithandizo.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mulingo wanu wotsatira ukukwana maola 12 kapena kupitilira apo, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mlingo wotsatira udzatengeke pasanathe maola 12, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Lenvatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa kapena kutopa
• zidzolo, kufiira, kuyabwa, kapena khungu la zikhatho ndi mapazi (okha)
• nseru
• kudzimbidwa
• kutentha pa chifuwa
• kuchepa kudya
• kuonda
• kusintha kwa kulawa chakudya
• chifuwa
• ukali
• zilonda mkamwa
• pakamwa pouma
• mutu
• kulumikizana ndi minofu
• kuvuta kugona kapena kugona
• kutayika tsitsi
• malungo
• kutentha pa nthawi yokodza
• zidzolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kupuma movutikira
• kutupa kwa miyendo ndi akakolo
• kupweteka pachifuwa
• dzanzi kapena kufooka kwa nkhope, mkono, kapena mwendo mbali imodzi ya thupi lanu
• kupweteka m'manja, kumbuyo, m'khosi, kapena nsagwada
• mwadzidzidzi, mutu wopweteka kwambiri
• mawu odekha kapena ovuta
• kusintha kwadzidzidzi m'masomphenya
• kutsegula m'mimba kwambiri
• chikasu cha khungu kapena maso
• kupweteka m'mimba
• mkodzo wakuda (wa tiyi)
• mipando yoyera
• kugwidwa
• kufooka
• chisokonezo
• Mphuno yayikulu komanso yosalekeza imatuluka magazi
• masanzi amagazi
• wakuda, wodikira, kapena chimbudzi chamagazi
• kutsokomola magazi kapena magazi aundana
• kutuluka magazi msambo kolemera
• kusanza, kutsegula m'mimba, kapena zizindikiro zakusowa madzi m'thupi
• mabala omwe sachira

Lenvatinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu likuyankhira ku lenvatinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Lenvima^®