Glasdegib

Zamkati

• Musanatenge glasdegib,
• Glasdegib itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo:

Glasdegib sayenera kutengedwa ndi odwala omwe ali ndi pakati kapena omwe angakhale ndi pakati. Pali chiopsezo chachikulu kuti glasdegib imayambitsa zolepheretsa kubadwa (zovuta zomwe zimakhalapo pobadwa) kapena kufa kwa mwana wosabadwa.

Ngati ndinu mayi yemwe angatenge mimba, muyenera kukhala ndi mayeso olakwika pakati pa masiku asanu ndi awiri musanayambe mankhwala ndi glasdegib. Muyenera kugwiritsa ntchito njira yolerera yoyenera mukamamwa mankhwala a glasdegib komanso kwa masiku osachepera 30 mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zakulera zomwe zingakuthandizeni.

Ngati ndinu wamwamuna wokhala ndi bwenzi lachikazi lomwe lingatenge mimba kapena amene ali ndi pakati, muyenera kudziwa kuti glasdegib atha kupezeka mu umuna ndipo atha kuvulaza mwana wosabadwa. Gwiritsani ntchito kondomu mukamamwa mankhwalawa ndi glasdegib komanso kwa masiku osachepera 30 mutatha kumwa komaliza ngakhale mutakhala ndi vasectomy (opareshoni yoteteza umuna kuti usatuluke mthupi lanu ndikupangitsa kuti mukhale ndi pakati). Osapereka umuna mukamalandira chithandizo komanso kwa masiku osachepera 30 mutapatsidwa mankhwala.

Ngati mwakhala mukugonana mosadziteteza, ganizirani kuti njira zakulera zalephera, kapena mukuganiza kuti inu kapena mnzanuyo mungakhale ndi pakati itanani dokotala wanu nthawi yomweyo.

Osapereka magazi kapena zopangira magazi mukamamwa mankhwalawa ndi glasdegib komanso kwa masiku osachepera 30 mutapatsidwa mankhwala omaliza.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso zaopanga (Medication Guide) mukayamba mankhwala ndi glasdegib ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Glasdegib imagwiritsidwa ntchito limodzi ndi cytarabine ngati chithandizo choyamba cha matenda a khansa ya myeloid (AML; mtundu wa khansa womwe umayambira m'maselo oyera a magazi) mwa anthu azaka zopitilira 75, kapena achikulire omwe ali ndi matenda ena ndipo sangachiritsidwe ndi mankhwala ena a chemotherapy. Glasdegib ali mgulu la mankhwala otchedwa hedgehog pathway inhibitors. Zimagwira ntchito poletsa ntchito ya puloteni yomwe imafotokoza kuti maselo a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Glasdegib amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amaperekedwa popanda kapena chakudya kamodzi patsiku kwa miyezi yosachepera 6, kapena bola ngati dokotala akuvomereza chithandizo. Tengani glasdegib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani glasdegib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutamwa glasdegib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angafunike kusokoneza chithandizo chanu, kuchepetsa mlingo wanu, kapena kuyimitsa chithandizo chanu kutengera kuyankha kwanu kwa mankhwala ndi zovuta zina zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira mankhwala ndi glasdegib.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge glasdegib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la glasdegib, mankhwala aliwonse, kapena chilichonse chama piritsi a glasdegib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, ena), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil (Acepezil) dronedarone (Multaq), efavirenz (Sustiva, ku Atripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivan), Itraconazole ), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), Actoglit, pioglit , Duetact, Actoplus Met), procainamide, quinidine (ku Nuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ku Rifater, Rifamate), ritonavir (Norvir, ku Viekira Pak, Kaletra, Technivie), sotaloline Betapace , Sotylize), ndi thioridazine. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi glasdegib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mwakhala mukukhala ndi nthawi yayitali ya QT (vuto la mtima losowa lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi), kulephera kwamtima (momwe mtima sungapope magazi okwanira mbali zina za thupi) , kapena michere yotsika ya magnesium kapena potaziyamu m'magazi anu.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mukamamwa mankhwala ndi glasdegib komanso kwa masiku osachepera 30 mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kotenga glasdegib.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ndi ochepera maola 12 mpaka mulingo wina wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Glasdegib itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutuluka kwa minofu
• kupweteka kwa minofu, fupa kapena kulumikizana
• kutopa kwambiri
• nseru
• kusanza
• kupweteka m'mimba
• kudzimbidwa
• kupweteka kapena zilonda mkamwa kapena mmero
• kuchepa kudya
• sintha momwe zinthu zimamvekera
• kuonda
• mutu
• zidzolo
• kutupa kwa manja kapena miyendo
• kutayika tsitsi
• Dzino likundiwawa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kumverera kukomoka, mutu wopepuka, kapena chizungulire; kuthamanga kapena kusakhazikika kwamtima
• kuvulaza kapena kutuluka mwachilendo
• malungo okha kapena limodzi ndi kuzizira, kufooka. kapena zizindikiro zina za matenda
• kuchepa pokodza
• kupweteka pachifuwa

Glasdegib itha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• nseru
• kusanza
• kutopa kwambiri
• chizungulire

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu monga ma electrocardiograms (EKG, mayeso omwe amalemba zamagetsi mumtima) komanso kuyesa magazi musanachitike komanso munthawi ya mankhwala kuti muwonetsetse kuti ndi bwino kuti mutenge glasdegib ndikuwunika momwe thupi lanu likuyankhira kuchipatala .

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Daurismo^®