Lorlatinib

Zamkati

• Musanatenge lorlatinib,
• Lorlatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Lorlatinib amagwiritsidwa ntchito pochiza khansa ina yam'mapapo (NSCLC) yomwe yafalikira mbali zina za thupi ndipo yawonjezeka atalandira chithandizo ndi mankhwala ena a chemotherapy. Lorlatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Lorlatinib amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani lorlatinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani lorlatinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati musanza mutamwa mankhwala, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya. Osamwa mapiritsi omwe asweka kale kapena akusweka.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha malinga ndi zomwe mukukumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha lorlatinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge lorlatinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la lorlatinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a lorlatinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, ku Atripla), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actop, in Actop, in Actop ), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ku Rifamate, Rifater), kapena wort ya St. Dokotala wanu angakuuzeni kuti musamwe lorlatinib ngati mukumwa mankhwala amodzi kapena angapo.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: alprazolam (Xanax); calcium blockers monga amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), ndi verapamil (Calan, Covera); mankhwala ena ochiza cholesterol wambiri monga atorvastatin (Lipitor) ndi lovastatin (Mevacor); clarithromycin (Biaxin, mu Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S, Erytab, Yotulutsidwa); mankhwala ena ochizira HIV kuphatikiza atazanavir (Reyataz, ku Evotaz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra, ku Technivie), kapena saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole; masewera; nefazodone; njira zakulera zam'kamwa (mapiritsi olera); quinidine (mu Nuedexta); sildenafil (Revatio, Viagra); mankhwala (Rapamune); tacrolimus (Prograf); tadalafil (Adcirca, Cialis); trazodone; katatu (Halcion); kapena vardenafil (Levitra, Staxyn). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi lorlatinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati mwakhala mukugunda pamtima mosafunikira, kukhumudwa, kukomoka, kuchuluka kwama cholesterol ndi zinthu zina zamafuta m'magazi, kapena matenda am'mapapo.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena konzekerani kukhala ndi mwana. Lorlatinib itha kusokoneza zochita za njira zolerera za mahomoni (mapiritsi oletsa kubala, zigamba, mphete, zopangira, kapena jakisoni), chifukwa chake simuyenera kugwiritsa ntchito njira yokhayo yolerera panthawi yachipatala. Muyenera kugwiritsa ntchito njira yolera yopanda mahomoni monga chotchinga (chotchinga chomwe chimatseketsa umuna kuti usalowe muchiberekero monga kondomu kapena diaphragm). Funsani dokotala wanu kuti akuthandizeni kusankha njira yolerera yomwe ingakuthandizeni. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kumwa mankhwala ndipo muyenera kugwiritsa ntchito njira yoletsa yopanda mahomoni kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi 6 mutalandira mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa miyezi itatu mutalandira mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu muli ndi pakati mukatenga lorlatinib, itanani dokotala wanu mwachangu. Lorlatinib atha kuvulaza mwana wosabadwayo.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwitsa mukamamwa lorlatinib komanso masiku asanu ndi awiri mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna kwakanthawi. Lankhulani ndi dokotala wanu za kuopsa kotenga lorlatinib.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili mkati mwa maola 4 a mlingo wotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Lorlatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kunenepa
• minofu, olowa, kapena kupweteka kwa msana
• kutsegula m'mimba
• kudzimbidwa
• nseru
• kusanza
• kutopa
• mutu
• masomphenya amasintha
• zidzolo kapena kuyabwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kutupa mmanja mwanu, miyendo, manja ndi mapazi
• kuvuta kupuma
• kupuma movutikira, kutsokomola, kapena malungo
• dzanzi ndi kumva kulasalasa m'malumikizidwe anu kapena mikono ndi miyendo
• kuvuta kuganiza kapena kusokonezeka
• kugwidwa
• kuwona zinthu kapena kumva mawu omwe kulibe
• kusintha kwa malingaliro, kumva chisoni kapena kuda nkhawa
• mavuto pakulankhula
• kuvuta kugona kapena kugona
• maloto achilendo kapena maloto owopsa
• chizungulire, kukomoka, kapena kugunda kwamtima kosazolowereka

Lorlatinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena a labu ndi electrocardiogram (ECG; mayeso omwe amayesa magetsi mumtima) musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku lorlatinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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