Utsi wa Esketamine Nasal

Zamkati

• Musanagwiritse ntchito kutsitsi la esketamine,
• Kutulutsa mphuno kwa Esketamine kumatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

Kugwiritsa ntchito esketamine nasal kutsitsi kumatha kuyambitsa kutopa, kukomoka, chizungulire, nkhawa, kutengeka, kapena kumva kulumikizidwa m'thupi lanu, malingaliro, malingaliro, malo ndi nthawi. Mudzagwiritsa ntchito mankhwala amphongo a esketamine nokha kuchipatala, koma dokotala wanu amakuyang'anirani kale, nthawi, komanso kwa maola 2 mutalandira chithandizo. Muyenera kukonzekera wosamalira kapena wachibale wanu kuti adzakuyendetsani kunyumba mukamagwiritsa ntchito esketamine. Mutagwiritsa ntchito mankhwala amphuno a esketamine, osayendetsa galimoto, kugwiritsa ntchito makina, kapena kuchita chilichonse komwe muyenera kukhala atcheru mpaka tsiku lotsatira mutagona tulo tofa nato. Uzani dokotala wanu nthawi yomweyo ngati mwatopa kwambiri, kukomoka, kupweteka pachifuwa, kupuma movutikira, kupweteka mutu modzidzimutsa, kusintha masomphenya, kugwedezeka kosalamulirika kwa gawo lina la thupi, kapena kugwidwa.

Esketamine ikhoza kukhala chizolowezi. Uzani dokotala wanu ngati inu kapena wina aliyense m'banja mwanu amamwa mowa kapena amamwa mowa wambiri, amagwiritsa ntchito mankhwala osokoneza bongo, kapena amamwa mankhwala osokoneza bongo.

Chiwerengero chochepa cha ana, achinyamata, komanso achikulire achichepere (mpaka zaka 24) omwe adatenga mankhwala opatsirana pogonana ('mood lifters') panthawi yamaphunziro azachipatala adadzipha (kuganiza zodzipweteka kapena kudzipha kapena kukonzekera kapena kuyesa kutero). Ana, achinyamata, komanso achikulire omwe amamwa mankhwala opanikizika kuti athetse kuvutika maganizo kapena matenda ena amisala atha kukhala ofuna kudzipha kuposa ana, achinyamata, komanso achikulire omwe samamwa mankhwala opatsirana kuti athetse vutoli. Komabe, akatswiri sakudziwa kuti chiwopsezo chake ndi chachikulu bwanji komanso kuti chikuyenera kuganiziridwa bwanji posankha ngati mwana kapena wachinyamata ayenera kumwa mankhwala opatsirana. Ana ayenera ayi gwiritsani ntchito esketamine.

Muyenera kudziwa kuti thanzi lanu lamisala lingasinthe m'njira zosayembekezereka mukamagwiritsa ntchito esketamine kapena mankhwala ena opatsirana ngakhale mutakhala wamkulu zaka zopitilira 24. Mutha kudzipha, makamaka kumayambiriro kwa chithandizo chanu komanso nthawi iliyonse yomwe mankhwala anu asinthidwa. Inu, banja lanu, kapena amene amakusamalirani muyenera kuyimbira dokotala nthawi yomweyo mukakumana ndi izi: kukhumudwa kwatsopano kapena kukulira; kuganiza zodzipweteka kapena kudzipha, kapena kukonzekera kapena kuyesa kutero; kuda nkhawa kwambiri; kusakhazikika; mantha; zovuta kugona kapena kugona; nkhanza; kukwiya; kuchita mosaganizira; kusakhazikika kwakukulu; ndi chisangalalo chachilendo. Onetsetsani kuti banja lanu kapena amene akukusamalirani akudziwa zomwe zingakhale zovuta kuti athe kuyimbira dokotala ngati mukulephera kupeza chithandizo chanokha.

Chifukwa cha kuopsa kwa mankhwalawa, esketamine imangopezeka pokhapokha mu pulogalamu yapadera yogawa yogawa. Pulogalamu yotchedwa Spravato Risk Evaluation and Mitigation Strategies (REMS). Inu, dokotala wanu, ndi pharmacy yanu muyenera kulembetsa nawo pulogalamu ya Spravato REMS musanalandire mankhwalawa. Mudzagwiritsa ntchito mankhwala amphuno a esketamine kuchipatala moyang'aniridwa ndi adotolo kapena akatswiri ena azaumoyo.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amayang'ana kuthamanga kwa magazi musanathe komanso osachepera maola 2 mutagwiritsa ntchito esketamine nthawi iliyonse.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso zaopanga (Medication Guide) mukayamba kulandira mankhwala ndi esketamine ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) kapena tsamba laopanga kuti mupeze Chithandizo cha Mankhwala.

Esketamine nasal spray amagwiritsidwa ntchito limodzi ndi mankhwala ena opatsirana pogonana, omwe amatengedwa pakamwa, kuti athetse vuto la kupsinjika kwa mankhwala (TRD; kukhumudwa komwe sikusintha ndi chithandizo) mwa akulu. Amagwiritsidwanso ntchito limodzi ndi mankhwala ena opanikizika, omwe amatengedwa pakamwa, kuthana ndi zodandaula kwa achikulire omwe ali ndi vuto lalikulu la kukhumudwa (MDD) komanso malingaliro kapena zochita zodzipha. Esketamine ali mgulu la mankhwala otchedwa NMDA receptor antagonists. Zimagwira ntchito posintha zochitika za zinthu zina zachilengedwe muubongo.

Esketamine amabwera ngati yankho (madzi) opopera m'mphuno. Kwa kasamalidwe ka kukhumudwa kosagwirizana ndi mankhwala, nthawi zambiri amapopera mphuno kawiri pa sabata mkati mwa masabata 1-4, kamodzi pamlungu pamasabata 5-8, kenako kamodzi pa sabata kapena kamodzi pamasabata awiri mkati mwa sabata la 9 komanso kupitirira apo. Pofuna kuchiza matenda okhumudwa mwa akulu omwe ali ndi vuto lalikulu lachisoni komanso malingaliro ofuna kudzipha kapena zochita zawo, nthawi zambiri amapopera mphuno kawiri pa sabata mpaka milungu inayi. Esketamine iyenera kugwiritsidwa ntchito kuchipatala.

Musadye osachepera maola 2 kapena kumwa zakumwa kwa mphindi zosachepera 30 musanagwiritse ntchito kutsitsi la esketamine.

Chida chilichonse chothira m'mphuno chimapereka zopopera ziwiri (kutsitsi limodzi pamphuno). Madontho awiri obiriwira pachipangizocho amakuwuzani kuti kutsitsi kwadzaza, dontho limodzi lobiriwira limakuwuzani kuti kagwiritsidwe kamodzi kanagwiritsidwa ntchito, ndipo palibe madontho obiriwira omwe akuwonetsa kuti mankhwala opopera awiri adagwiritsidwa ntchito.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito kutsitsi la esketamine,

• uzani dokotala wanu komanso wamankhwala ngati mankhwala a esketamine, ketamine, mankhwala ena aliwonse, kapena zina zilizonse mu esketamine nasal spray. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amphetamines, mankhwala a nkhawa, armodafinil (Nuvigil), MAO inhibitors monga phenelzine (Nardil), procarbazine (Matulane), tranylcypromine (Parnate), ndi selegiline (Eldepryl, Emsam, Zelapar); mankhwala ena a matenda amisala, methylphenidate (Aptension, Jornay, Metadate, ena), modafanil, opioid (chomwa mankhwalawa) mankhwala opweteka, mankhwala opha ziwalo, mankhwala ogonetsa, mapiritsi ogona, ndi zotonthoza. Uzani dokotala wanu ngati mwangomwapo kumene mankhwalawa.
• ngati mukugwiritsa ntchito nasal corticosteroid monga ciclesonide (Alvesco, Omnaris, Zetonna) ndi mometasone (Asmanex) kapena decampant wammphuno monga oxymetazoline (Afrin) ndi phenylephrine (Neosynephrine), gwiritsani ntchito ola limodzi musanagwiritse ntchito mankhwala a nasketamine nasal spray.
• uzani dokotala wanu ngati muli ndi matenda amtsinje wamagazi muubongo, pachifuwa, m'mimba, mikono kapena miyendo; khalani ndi malteriovenous malformation (kulumikizana kwachilendo pakati pa mitsempha yanu ndi mitsempha); kapena mukhale ndi mbiri yakukha magazi muubongo wanu. Dokotala wanu mwina angakuuzeni kuti musagwiritse ntchito kutsitsi la esketamine.
• uzani adotolo ngati munadwalapo sitiroko, matenda amtima, kuvulala muubongo, kapena vuto lina lililonse lomwe limayambitsa kukakamizidwa kwa ubongo. Uzani dokotala wanu ngati mukuwona, kumva, kapena kumva zinthu zomwe kulibe; kapena khulupirirani zinthu zomwe sizili zoona. Komanso, auzeni dokotala ngati mwakhalapo ndi matenda a valavu ya mtima, kulephera kwa mtima, kuthamanga kwa magazi (kuthamanga kwa magazi), kugunda kwamtima pang'ono kapena kosasinthasintha, kupuma pang'ono, kupweteka pachifuwa, kapena chiwindi kapena matenda amtima.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukamagwiritsa ntchito mankhwala amphuno a esketamine, itanani dokotala wanu mwachangu. Esketamine nasal spray akhoza kuvulaza mwana wosabadwayo.
• uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamagwiritsa ntchito utsi wa esketamine nasal.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena wamankhwala kuti mukugwiritsa ntchito esketamine nasal spray.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Mukaphonya gawo lazachipatala funsani adotolo nthawi yomweyo kuti mupange nthawi yokumana. Ngati mwaphonya chithandizo ndipo kukhumudwa kwanu kukukulira, dokotala angafunikire kusintha mlingo wanu kapena ndandanda ya chithandizo.

Kutulutsa mphuno kwa Esketamine kumatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kukodza pafupipafupi, mwachangu, kuwotcha, kapena kupweteka
• kudzimbidwa
• kutsegula m'mimba
• pakamwa pouma
• nseru
• kusanza
• kuvuta kuganiza kapena kumva kuledzera
• mutu
• kulawa kwachilendo kapena kwachitsulo mkamwa
• Kupweteka kwa mphuno
• Kupsa pakhosi
• thukuta lowonjezeka

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi zina mwazizindikiro zomwe zalembedwa MUCHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi.

Kutulutsa mphuno kwa Esketamine kumatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Spravato^®