Kulondola

Zamkati

• Musanatenge entrectinib,
• Entrectinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Entrectinib imagwiritsidwa ntchito pochiza khansa ina yaying'ono (NSCLC) mwa achikulire yomwe yafalikira mbali zina za thupi. Amagwiritsidwanso ntchito pochiza mitundu ina ya zotupa zolimba kwa akulu ndi ana azaka 12 kapena kupitilira apo zomwe sizingachiritsidwe ndi opaleshoni kapena zomwe zafalikira mbali zina za thupi ndipo zidakulirakulira atalandira chithandizo ndi mankhwala ena a chemotherapy. Entrectinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Entrectinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani entrectinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani entrectinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya.

Ngati musanza mutangotenga entrectinib, imwani mlingo wina posachedwa.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge entrectinib,

• Uzani dokotala ndi wamankhwala ngati muli ndi vuto la entrectinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a entrectinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: aprepitant (Emend), mankhwala ena oletsa mafungal monga fluconazole (Diflucan), itraconazole (Omel, Sporanox), kapena ketoconazole; mankhwala ena a arrhythmias monga amiodarone (Nexterone, Pacerone), procainamide, quinidine (ku Nuedexta), ndi sotalol (Betapace, Sorine, Sotylize); azithromycin (Zithromax); clarithromycin (Biaxin, mu Prevpac); diltiazem (Cardizem, Tiazac, ena); erythromycin (EES, Erythrocin, ena); enzalutamide (Xtandi); mankhwala ena a HIV monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra, ena), kapena saquinavir (Invirase); lifiyamu (Lithobid); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, ku Actoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, mu Rifater); oral steroids monga dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos); ndi verapamil (Calan). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi entrectinib, choncho onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• auzeni adotolo ngati mudakhalapo ndi vuto lamanjenje, nthawi yayitali ya QT (vuto losowa mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi), kugunda kwamtima pang'ono kapena kosasinthasintha, matenda amtima, mtima kulephera, kapena matenda a mtima kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa milungu ingapo isanu mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira mankhwala a entrectinib komanso kwa miyezi itatu mutalandira mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mumakhala ndi pakati mukatenga entrectinib, itanani dokotala wanu mwachangu. Entrectinib ikhoza kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simukuyenera kuyamwa mukamamwa entrectinib komanso masiku asanu ndi awiri mutalandira mankhwala omaliza.
• muyenera kudziwa kuti entrectinib imatha kuyambitsa chizungulire kapena kusokonezeka. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mwaphonya mlingo osakwana maola 12, tengani mlingo womwe mwaphonya mukangokumbukira kenako mutenge mlingo wotsatira panthawiyo. Komabe, ngati mwaphonya mlingo wa maola opitilira 12, tulukani mulingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Entrectinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa
• kudzimbidwa
• kutsegula m'mimba
• kusintha kwa kukoma
• mutu
• chifuwa, malungo, kapena zizindikiro zina za matenda
• kupweteka kwa minofu kapena molumikizana
• kupweteka kwa msana
• kulemera kumasintha
• zidzolo
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• zovuta ndi kuphunzira, kukumbukira, chidwi, kapena kuthetsa mavuto
• zosintha monga nkhawa, kukhumudwa, kusokonezeka, kapena kukhumudwa
• kupweteka kwa mafupa kapena kuyenda movutikira
• mavuto owonera kapena kusintha masomphenya
• kupweteka pamodzi, kuuma, kufiira, kapena kutupa
• kupweteka kumtunda chakumanja kwa m'mimba, chikaso cha khungu kapena maso, kusowa kwa njala, kapena kutuluka magazi kapena kuvulala mosavuta
• kupuma movutikira; kuvuta kupuma pogona; kapena kutupa kwa mikono, miyendo, manja, kapena mapazi

Entrectinib ingayambitse zotsatira zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu imatha kuthandizidwa ndi entrectinib. Dokotala wanu amatha kuyitanitsa mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone kuyankha kwa thupi lanu ku entrectinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Alireza^®