Pexidartinib

Zamkati

• Musanatenge pexidartinib,
• Pexidartinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Pexidartinib itha kuwononga chiwindi chachikulu kapena kuwononga moyo. Uzani dokotala wanu ngati mwakhalapo ndi matenda a chiwindi. Uzani dokotala wanu komanso wamankhwala zamankhwala omwe mukumwa kuti athe kuwona ngati mankhwala aliwonse angawonjezere chiwopsezo kuti chiwindi chanu chiwonjezeke mukamachiza ndi pexidartinib. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: kutopa kwambiri, kusowa kwa njala, kuchepa thupi, nseru, kusanza, kutuluka mwazi kosazolowereka kapena kufinya, khungu lachikaso kapena maso, mkodzo wakuda wachikaso kapena bulauni, mipando yotumbululuka , kapena kupweteka kumtunda chakumanja kwam'mimba. Dokotala wanu ayenera kuchepetsa mlingo wa pexidartinib kapena kuimitsa kwamuyaya kapena kwakanthawi.

Pulogalamu yotchedwa Turalio Risk Evaluation and Mitigation Strategy (REMS) yakhazikitsidwa kuti ithetse ngozi za mankhwalawa. Mutha kulandila pexidartinib ngati inu ndi adokotala omwe akupatseni mankhwala anu mwalembetsa. Mutha kulandila mankhwalawo kuchokera ku pharmacy yomwe imatenga nawo gawo pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza kutenga nawo mbali pulogalamuyi kapena momwe mungapezere mankhwala anu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanadye komanso mukamalandira chithandizo kuti muwone ngati zili bwino kuti mutenge pexidartinib ndikuwunika momwe thupi lanu lingayankhire mankhwala.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi pexidartinib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kwa kutenga pexidartinib.

Pexidartinib imagwiritsidwa ntchito pochizira zotupa zazikuluzikulu za tenosynovial (TGCT; zotupa mkati kapena mozungulira cholumikizira chomwe chimatha kupweteka, kutupa, komanso kuchepetsa kuyenda) kwa achikulire omwe sangachiritsidwe ndi opaleshoni. Pexidartinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe angathandize chotupacho kuchepa.

Pexidartinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kawiri tsiku lililonse pamimba yopanda ola limodzi ola limodzi asanadutse kapena maola awiri mutadya. Tengani pexidartinib mozungulira nthawi imodzimodzi tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani pexidartinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga pexidartinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge pexidartinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la pexidartinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse za makapisozi pexidartinib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clarithromycin (Biaxin, ku Prevpac); ma antifungal ena monga itraconazole (Onmel, Sporanox) kapena ketoconazole; enzalutamide (Xtandi); mankhwala ena opatsirana pogonana (HIV) kapena matenda opatsirana m'thupi (AIDS) monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); modafinil (Provigil); nefazodone; pioglitazone (Actos, ku Duetact, Oseni); zofufuza (Probalan); proton-pump inhibitors monga esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ndi rabeprazole (AcipHex); rifabutin (Mycobutin); mfuti (Rifadin); mankhwala ena ogwidwa monga carbamazepine (Equetro, Tegretol, Teril), phenobarbital, ndi phenytoin (Dilantin, Phenytek); kapena steroids pakamwa monga dexamethasone, methylprednisolone (Medrol), ndi prednisone. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi pexidartinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa maantacid okhala ndi magnesium kapena aluminium (Maalox, Mylanta, Tums, ena), tengani mankhwalawa musanatenge kapena 2 maola mutatenga pexidartinib.
• ngati mukumwa mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda monga cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), kapena ranitidine (Zantac), imwani osachepera maola 10 isanakwane kapena osachepera 2 maola mutatenga pexidartinib.
• uzani dokotala wanu komanso wazamankhwala zomwe mumamwa mankhwala azitsamba, makamaka wort ya St. Simuyenera kutenga wort ya St. John mukamamwa mankhwala a pexidartinib.
• uzani dokotala wanu ngati mwakhalapo ndi matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso mwezi umodzi mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamachiza pexidartinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Pexidartinib imachepetsa kubereka mwa abambo ndi amai. Komabe, musaganize kuti inu kapena mnzanuyo simungakhale ndi pakati. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga pexidartinib, itanani dokotala wanu mwachangu. Pexidartinib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa pexidartinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Pexidartinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• tsitsi limasintha
• kusintha kwa kukoma
• kutopa
• kudzimbidwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• zidzolo
• kuyabwa
• kutupa kwa manja, mapazi, miyendo kapena akakolo
• kupweteka kwa mikono kapena miyendo
• kutupa mkati kapena mozungulira diso

Pexidartinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Musachotse desiccant (paketi yaying'ono yophatikizidwa ndi mankhwala oti mutenge chinyezi) kuchokera mu botolo, ngati wina waperekedwa.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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