Zamgululi

Zamkati

• Musanatenge selumetinib,
• Selumetinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Selumetinib imagwiritsidwa ntchito pochizira mtundu wa neurofibromatosis 1 (NF1; vuto lamanjenje lomwe limayambitsa zotupa kukula m'mitsempha) mwa ana azaka 2 kapena kupitilira apo omwe ali ndi plexiform neurofibromas (PN; zotupa zofewa) zomwe sizingachotsedwe kwathunthu ndi opareshoni. Selumetinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilengedwe omwe amawonetsa kuti zotupazo zimakula. Izi zimathandiza kuyimitsa kapena kuchepetsa kukula kwa chotupa.

Selumetinib imabwera ngati kapisozi kuti itenge pakamwa. Nthawi zambiri amatengedwa kawiri patsiku pamimba yopanda kanthu. Musadye chakudya chilichonse maola 2 kale kapena ola limodzi mutatha kumwa mankhwala. Tengani selumetinib mozungulira nthawi yofanana tsiku lililonse, pafupifupi maola 12 mutasiyana. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani selumetinib ndendende monga momwe mwalamulira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osatsegula, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga selumetinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira mankhwala ndi selumetinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge selumetinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la selumetinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu selumetinib capsules. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('opopera magazi') monga warfarin (Coumadin, Jantoven); antifungals monga fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), ndi voriconazole (Vfend); Aprepitant (Emend); clarithromycin (Biaxin, mu Prevpac); clopidogrel (Plavix); corticosteroids monga betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, ena), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, ena), prednisolone (Prelisolone (Prelisolone (Prelisolone) ), ndi prednisone (Rayos); diltiazem (Cardizem, Dilacor, Tiazac, ena); erythromycin (EES, E-Mycin, Erythrocin); mankhwala ena a HIV kuphatikiza indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Fortovase, Invirase); idelalisib (Zydelig); nefazodone; phenobarbital; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); verapamil (Calan, Covera); ndi zowonjezera mavitamini E. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati mwakhala mukukumana ndi vuto la masomphenya, kuvutika kumeza, kapena matenda amtima kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa sabata limodzi mutangomaliza kumwa mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira mankhwala a selumetinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga selumetinib, itanani dokotala wanu mwachangu. Selumetinib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa selumetinib komanso kwa sabata limodzi mutalandira mankhwala omaliza.

Pewani kudya zipatso zamtengo wapatali kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili mkati mwa maola 6 a mlingo wotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Selumetinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kusanza
• kudzimbidwa
• kupweteka m'mimba
• nseru
• khungu lowuma
• mutu
• Zilonda zam'kamwa
• kuyabwa
• kufiira kozungulira zikhadabo
• mphuno kutuluka magazi
• kutopa
• kusowa chilakolako
• tsitsi kapena tsitsi limasintha

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• malungo
• magazi osazolowereka
• wotumbululuka khungu kapena kutopa
• kusawona bwino; kutaya masomphenya; mawanga amdima m'masomphenya anu; kapena masomphenya ena amasintha
• kutsegula m'mimba
• zotupa, zotupa pakhungu kapena khungu
• kupweteka kwa minofu, kupweteka, kapena kufooka; kapena mkodzo wakuda
• kutsokomola kapena kupuma; kupuma movutikira; kutupa kwa akakolo ndi mapazi; kapena kutopa kwambiri

Selumetinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Musachotse desiccant (paketi yaying'ono yophatikizidwa ndi makapisozi oyamwa chinyezi) kuchokera mu botolo lanu.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu, dotolo wamaso, ndi labotale. Dokotala wanu adzaitanitsa mayeso ena a labu, kuphatikiza mayeso amaso, musanadye, nthawi, komanso mutalandira chithandizo chanu kuti muwone kuyankha kwa thupi lanu ku selumetinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Koselugo^®