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Zamkati

• Musanatenge selpercatinib,
• Selpercatinib ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Selpercatinib imagwiritsidwa ntchito pochiza khansa ina yaying'ono (NSCLC) mwa akulu yomwe yafalikira mbali zina za thupi mwa akulu. Amagwiritsidwanso ntchito kuchiritsa mtundu wina wa khansa ya chithokomiro mwa akulu ndi ana azaka 12 kapena kupitilira zomwe zafalikira mbali zina za thupi. Selpercatinib imagwiritsidwanso ntchito kuthana ndi khansa ina yamtundu wa chithokomiro yomwe yafalikira mbali zina za thupi mwa akulu ndi ana azaka 12 kapena kupitilira apo omwe adachitidwa bwino ndi ayodini wa radioactive. Selpercatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Selpercatinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kawiri tsiku lililonse (maola 12 aliwonse) kapena wopanda chakudya. Tengani selpercatinib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani selpercatinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga selpercatinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu, kapena kukusokonezani kapena kusiya mankhwala anu. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kumwa selpercatinib ngakhale mutakhala bwino. Osasiya kumwa selpercatinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge selpercatinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la selpercatinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a selpercatinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungals monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, ndi voriconazole (Vfend); Aprepitant (Emend); carbamazepine (Carbatrol, Tegretol, Equetro, ena); clarithromycin (Biaxin, mu Prevpac); diltiazem (Cardizem, Cartia, Tiazac, ena); erythromycin (EES, E-Mycin, Erythrocin); mankhwala ena a kachirombo ka HIV (HIV) kapena matenda a immunodeficiency (AIDS) kuphatikiza efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase) ; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); quinidine (mu Nuedexta); repaglinide (Prandin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); ndi verapamil (Calan, Verelan, ena). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi selpercatinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukugwiritsa ntchito H₂ mankhwala a blocker a kudzimbidwa, kutentha pa chifuwa, kapena zilonda monga cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), kapena ranitidine (Zantac), tengani selpercatinib osachepera maola 2 isanathe kapena maola 10 mutamwa imodzi mwa mankhwalawa.
• ngati mukumwa mankhwala omwe ali ndi aluminium, magnesium, calcium, kapena simethicone; kapena mankhwala osokoneza bongo monga buffered aspirin, tengani selpercatinib osachepera maola 2 musanadye kapena osachepera maola awiri mutamwa imodzi mwa mankhwalawa.
• ngati mukumwa proton-pump inhibitor monga esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ndi rabeprazole (AcipHex), tengani mlingo uliwonse wa selpercatinib pamodzi ndi chakudya.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mwakhala mukugunda pang'onopang'ono, mwachangu, kapena mosasinthasintha; nthawi yayitali ya QT (vuto losowa la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi); kuthamanga kwa magazi; kutaya magazi; kapena matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Simuyenera kutenga pakati mukatenga selpercatinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala a selpercatinib komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamamwa mankhwala a selpercatinib komanso kwa sabata limodzi mutatha kumwa. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga selpercatinib, itanani dokotala wanu mwachangu. Selpercatinib imatha kupweteketsa mwana.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa selpercatinib komanso kwa sabata limodzi mutamwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito selpercatinib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa selpercatinib. Dokotala wanu angakuuzeni kuti musamwe selpercatinib masiku 7 musanachite opareshoni kapena njira yanu ndipo angakuuzeni nthawi yomwe muyenera kuyambiranso kumwa mankhwalawo.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 6 a mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Selpercatinib ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• pakamwa pouma
• kutsegula m'mimba
• kudzimbidwa
• nseru
• kusanza
• kupweteka m'mimba
• mutu
• kutopa
• chifuwa
• kupuma movutikira
• kutupa kwa mikono, miyendo, manja, ndi mapazi anu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kupweteka kumtunda kwamanja kwam'mimba; kuvulaza kapena kutuluka mwachilendo; mkodzo wamdima; kapena chikasu pakhungu ndi diso
• kugunda kwa mtima
• chizungulire kapena mutu wopepuka
• kukomoka
• kutsokomola kapena kusanza magazi kapena zinthu zomwe zimawoneka ngati malo a khofi; kutuluka mwachilendo kapena kufinya, pinki; mkodzo wofiira, kapena wakuda wakuda; kapena kutuluka kofiira kapena kofiyira kwakuda
• nseru; kusanza; kupuma movutikira; kukokana kwa minofu; kufooka; kugwidwa; kapena kutupa kwa mikono ndi miyendo
• malungo, zidzolo, kapena kupweteka kwa mafupa kapena minofu

Selpercatinib ingayambitse mafupa kuti asiye kukula msanga mwa achinyamata omwe akukula. Lankhulani ndi dokotala wa mwana wanu za kuopsa kopereka mankhwalawa kwa mwana wanu.

Selpercatinib ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amayang'ana kuthamanga kwa magazi kwanu pafupipafupi ndikuitanitsa mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku selpercatinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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