Ponesimod

Zamkati

• Ponesimod imagwiritsidwa ntchito popewa zizindikilo ndikuchepetsa kukulirakulira kwa anthu achikulire omwe abwereranso mitundu yambiri ya sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, ndi mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo), kuphatikiza: Ponesimod ali mgulu la mankhwala otchedwa sphingosine l-phosphate receptor modulators. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.
• Musanatenge ponesimod,
• Ponesimod ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:
• Zizindikiro za bongo zingaphatikizepo:

Ponesimod imagwiritsidwa ntchito popewa zizindikilo ndikuchepetsa kukulirakulira kwa anthu achikulire omwe abwereranso mitundu yambiri ya sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, ndi mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo), kuphatikiza: Ponesimod ali mgulu la mankhwala otchedwa sphingosine l-phosphate receptor modulators. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

• matenda opatsirana (CIS; chizindikiro choyamba cha mitsempha chomwe chimakhala pafupifupi maola 24),
• matenda obwerezabwereza (matenda omwe matenda amawonekera nthawi ndi nthawi),
• Matenda otsogola omwe amapita patsogolo (pambuyo pake matenda ndi kuwonjezeka kwa zizindikilo.)

Ponesimod imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku kapena wopanda chakudya. Tengani ponesimod mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ponesimod ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu mwina angakuyambitseni pamlingo wochepa wa ponesimod ndipo pang'onopang'ono muwonjezere mlingo wanu kwa masiku 15 oyamba.

Ponesimod ingayambitse kugunda kwa mtima, makamaka pakadutsa maola 4 mutangotenga gawo lanu loyamba. Mutenga mlingo wanu woyamba wa ponesimod muofesi ya dokotala kapena chipatala china. Mudzalandira electrocardiogram (ECG; mayeso omwe amalemba zochitika zamagetsi zamtima) musanamwe mankhwala anu oyamba komanso maola 4 mutamwa. Muyenera kukhala kuchipatala kwa maola osachepera 4 mutamwa mankhwala kuti athe kuyang'aniridwa. Mungafunike kukhala kuchipatala kwa nthawi yayitali kuposa maola 4 kapena usiku wonse ngati muli ndi vuto linalake kapena kumwa mankhwala ena omwe angapangitse kuti kugunda kwa mtima kwanu kuzengeke kapena ngati kugunda kwanu kukucheperako kuposa momwe amayembekezera kapena kukupitilira kuchepa pambuyo pa 4 yoyamba maola. Mwinanso mungafunike kukhala kuchipatala kwa maola osachepera 4 mutatenga mlingo wanu wachiwiri ngati kugunda kwa mtima kwanu kumachedwa kwambiri mukamamwa mankhwala anu oyamba. Uzani dokotala wanu ngati mukuchita chizungulire, kutopa, kupweteka pachifuwa, kapena kugunda kwapang'onopang'ono kapena kosagwirizana nthawi iliyonse mukamalandira chithandizo.

Ponesimod itha kuthandizira kuwongolera sclerosis koma singachiritse. Osasiya kumwa ponesimod osalankhula ndi dokotala.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi ponesimod ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ponesimod,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ponesimod, mankhwala ena aliwonse, kapena zosakaniza zilizonse pamapiritsi a ponesimod. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers monga atenolol (Tenormin, mu Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, ku Dutoprol, ku Lopressor HCT), nadolol (Corgard, ku Corzide), nebivolol (Bystolic, ku Byvalson ), propranolol (Inderal LA, Innopran XL), sotalol (Betapace, Sorine, Sotylize) ndi timolol; carbamazepine (Carbatrol, Equetro, Tegretol, ena); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, ena); modafinil (Provigil); phenytoin (Dilantin); kupeza; quinidine (mu Nuedexta); rifampin (Rifadin, Rimactane, ku Rifamate, ena); ndi verapamil (Calan, Verelan, ku Tarka). Muuzeni dokotala ngati mukumwa mankhwala aliwonse otsatirawa, kapena ngati munawagwiritsapo kale ntchito: corticosteroids monga dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos); mankhwala a khansa; ndi mankhwala ofooketsa kapena kuwongolera chitetezo cha mthupi monga glatiramer acetate (Copaxone, Glatopa) ndi interferon beta (Betaseron, Extavia, Plegridy). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi ponesimod, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati mwakhala mukukumana ndi izi m'miyezi isanu ndi umodzi yapita: matenda amtima, angina (kupweteka pachifuwa), sitiroko kapena sitiroko yaying'ono, kapena kulephera kwa mtima. Komanso muuzeni dokotala ngati muli ndi vuto la mtima wosakhazikika kapena mitundu ina yamitima, pokhapokha mutakhala ndi pacemaker. Dokotala wanu angakuuzeni kuti musatenge ponesimod.
• uzani dokotala wanu ngati muli ndi malungo kapena matenda kapena ngati muli ndi matenda omwe amabwera ndikutha kapena omwe samatha. Komanso, uzani dokotala ngati mwadwalapo kapena munayambapo matenda a mtima, sitiroko, sitiroko yaying'ono, matenda ashuga, matenda obanika kutulo (vuto lomwe mumasiya kupuma kangapo usiku) kapena mavuto ena opuma, kuthamanga kwa magazi, uveitis (kutupa kwa diso) kapena mavuto ena amaso, khansa yapakhungu, kapena matenda amtima kapena chiwindi. Komanso muuzeni dokotala ngati muli ndi matenda a QT (zomwe zimawonjezera chiopsezo chokhala ndi kugunda kwamtima kosafunikira, komwe kumatha kukomoka kapena kufa mwadzidzidzi), mayimbidwe amtima osagwirizana, kapena ngati mwalandira katemera posachedwa.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati, kapena mukuyamwitsa.Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa sabata limodzi mutangomaliza kumwa mankhwala. Mukakhala ndi pakati mukatenga ponesimod kapena pasanathe sabata limodzi mutatha kumwa mankhwala, pitani kuchipatala. Ponesimod ikhoza kuvulaza mwana wosabadwayo.
• mulibe katemera kwa mwezi umodzi musanayambe mankhwala anu ndi ponesimod, mukamalandira chithandizo, komanso kwa 1 mpaka 2 masabata mutatha kumwa komaliza musanalankhule ndi dokotala. Lankhulani ndi dokotala wanu za katemera omwe mungafunike kuti mulandire musanayambe mankhwala anu ndi ponesimod.
• uzani dokotala wanu ngati simunakhalepo ndi nthomba ndipo simunalandire katemera wa nthomba. Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti muwone ngati mwapezapo kachilombo ka nkhuku. Mungafunike kulandira katemera wa nthomba ndikudikirira milungu inayi musanamwe mankhwala ndi ponesimod.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya masiku 1 mpaka 3 a ponesimod munthawi yobwereza (paketi yoyambira ya masiku 14), tengani piritsi lomwe mwaphonya mukangokumbukira ndikupitiliza chithandizo chanu potenga piritsi limodzi patsiku mu sitata yomwe mudapangira. Ngati mwaphonya kutenga masiku 4 kapena kupitilira apo ponesimod munthawi yamaphunziro (masiku 14 oyambira), itanani dokotala wanu momwe mungafunikire kuyambiranso chithandizo ndi phukusi latsopano la masiku 14. Ngati muli ndi vuto linalake la mtima, mungafunike kuyang'aniridwa ndi dokotala wanu kwa maola osachepera 4 mukamamwa mankhwala ena.

Ngati mwaphonya masiku 1 mpaka 3 a ponesimod pambuyo pa nthawi yobweretsera (mlingo wosamalira) imwani piritsi lomwe mwaphonya mukangokumbukira ndikupitiliza kumwa mankhwala. Ngati mwaphonya kutenga masiku 4 kapena kupitilira apo ponesimod pambuyo pa nthawi yobweretsera (mlingo wosamalira), itanani dokotala wanu momwe mungafunikire kuyambiranso chithandizo ndi phukusi latsopano la masiku 14. Ngati muli ndi vuto linalake la mtima, mungafunike kuyang'aniridwa ndi dokotala wanu kwa maola osachepera 4 mukamamwa mankhwala ena.

Ponesimod ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chizungulire
• chifuwa
• kupweteka m'manja kapena m'mapazi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kugunda kochedwa mtima
• zilonda zapakhosi, kupuma pang'ono, kupweteka kwa thupi, malungo, kutentha ndi kukodza, kuzizira, kutsokomola, ndi zizindikilo zina za matendawa mukamachiza komanso kwa milungu 1 mpaka 2 mutalandira chithandizo
• kufooka mbali imodzi ya thupi kapena kusakhazikika kwa mikono kapena miyendo yomwe imakulira pakapita nthawi; kusintha kwa malingaliro anu, kukumbukira, kapena kulinganiza; chisokonezo kapena kusintha kwa umunthu; kapena kutaya mphamvu
• blurry, mithunzi, kapena malo akhungu pakati pa masomphenya anu; kutengeka ndi kuwala; mtundu wachilendo pamasomphenya anu kapena zovuta zina zamasomphenya
• nseru, kusanza, kusowa chilakolako, kupweteka m'mimba, chikasu cha khungu kapena maso, kapena mkodzo wakuda
• kupuma kwatsopano kapena kukulira

Ponesimod imatha kuwonjezera chiopsezo chokhala ndi khansa yapakhungu. Uzani dokotala wanu ngati mukusintha pa mole yomwe ilipo kale; malo amdima watsopano pakhungu; zilonda zosachiritsa; zophuka pakhungu lanu monga bampu yomwe imatha kukhala yowala, yoyera, yoyera khungu, kapena pinki, kapena kusintha kulikonse pakhungu lanu. Dokotala wanu amayenera kuyang'ana khungu lanu ngati lingasinthe mukamalandira chithandizo cha ponesimod. Chepetsani nthawi yomwe mumagwiritsa ntchito kuwala kwa dzuwa komanso ma ultraviolet (UV). Valani zovala zokutetezani ndikugwiritsanso ntchito zoteteza ku dzuwa ndi zoteteza ku dzuwa. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Ponesimod ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Ngati mankhwala anu abwera ndi paketi ya desiccant (paketi yaying'ono yomwe ili ndi chinthu chomwe chimatenga chinyezi kuti mankhwala asamaume), siyani paketiyo mu botolo koma samalani kuti musayimeze.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• kugunda kwapang'onopang'ono kapena kosasintha

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu ndi mayeso am'maso, ndipo adzawunika kuthamanga kwa magazi anu musanachitike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti muyambe kumwa kapena kupitiriza kumwa ponesimod.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zowonjezera^®