Saquinavir

Zamkati

• Musanatenge saquinavir,
• Saquinavir imatha kubweretsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:
• Zizindikiro za bongo zingaphatikizepo izi:

Saquinavir imagwiritsidwa ntchito limodzi ndi ritonavir (Norvir) ndi mankhwala ena othandiza kuchiza kachilombo ka HIV. Saquinavir ali mgulu la mankhwala otchedwa protease inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka HIV m'magazi. Ngakhale saquinavir sachiza kachilombo ka HIV, imatha kuchepetsa mwayi wanu wopeza matenda a immunodeficiency syndrome (AIDS) ndi matenda okhudzana ndi HIV monga matenda akulu kapena khansa. Kumwa mankhwalawa pamodzi ndi kugonana mosatekeseka ndikusintha zina pamoyo wanu kumachepetsa chiopsezo chotenga kachirombo ka HIV kwa anthu ena.

Saquinavir imabwera ngati kapisozi komanso piritsi yomwe imamwa. Nthawi zambiri amatengedwa nthawi yofanana ndi ritonavir (Norvir) kawiri patsiku mkati mwa maola awiri mutatha kudya. Zingakhale zosavuta kukumbukira kutenga saquinavir ngati mutadya ndi chakudya. Tengani saquinavir mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani saquinavir ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; musatafune, kapena kuwaphwanya.

Ngati simungathe kumeza kapisozi wathunthu, mutha kumwa saquinavir potsegula kapisozi ndikusakaniza zomwe zili ndi madzi a shuga, sorbitol, kapena kupanikizana. Kuti mukonzekere mlingo uliwonse, onjezerani supuni 3 (15 ml) ya manyuchi a shuga, sorbitol, kapena kupanikizana mumtsuko wopanda kanthu. Tsegulani kapisozi wa saquinavir ndikuwonjezera zomwe zili muchidebecho. Onetsetsani kusakaniza kwa masekondi 30 mpaka 60. Ngati munkagwiritsa ntchito madzi ozizira, sorbitol, kapena kupanikizana, dikirani kuti chisakanizocho chibwere firiji musanadye. Onetsetsani kuti mudye chisakanizo chonse kuti mulandire kuchuluka kwathunthu.

Pitirizani kumwa saquinavir ngakhale mutakhala bwino. Osasiya kumwa saquinavir osalankhula ndi dokotala. Ngati mwaphonya Mlingo, tengani zosakwana mlingo woyenera kapena siyani kumwa saquinavir, matenda anu akhoza kukhala ovuta kuchiza.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi saquinavir ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Saquinavir nthawi zina amagwiritsidwa ntchito ndi ritonavir (Norvir) ndi mankhwala ena othandiza kupewa matenda kwa ogwira ntchito zaumoyo kapena anthu ena omwe ali ndi kachilombo ka HIV. Lankhulani ndi dokotala wanu za kuopsa kotenga mankhwalawa chifukwa cha matenda anu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge saquinavir,

• uzani dokotala ndi wamankhwala ngati muli ndi vuto la saquinavir, mankhwala ena aliwonse, lactose, kapena zina zilizonse zosakaniza mu makapisozi a saquinavir kapena mapiritsi. Dokotala wanu angakuuzeni kuti musatenge saquinavir. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa mankhwala aliwonse awa: alfuzosin (Uroxatral); atazanavir (Reyataz, ku Evotaz); clarithromycin (Biaxin, mu Prevpac); clozapine (Clozaril, Fazaclo, Versacloz); dasatinib (Sprycel); mankhwala a ergot monga dihydroergotamine (DHE 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Ergomar, ku Cafergot, ku Migergot, ena), ndi methylergonovine (Methergine); erythromycin (EES, E-mycin, Erythrocin, ena); halofantrine; haloperidol (Haldol); mankhwala ena osagunda pamtima monga amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), lidocaine (Xylocaine), propafenone (Rhythmol), ndi quinidine (ku Nuedexta); lovastatin (Altoprev); lurasidone (Latuda); mankhwala a matenda amisala ndi nseru monga chlorpromazine, ndi thioridazine; midazolam pakamwa; pentamidine (Nebupent, Pentam); pimozide (Orap); quinine (Qualaquin); rifampin (Rifadin, Rimactane, ku Rifamate, Rifater); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); simvastatin (Zocor, Flolopid, ku Vytorin); sunatinib (Sutent); tacrolimus (Astagraf XL, Envarsus XR, Prograf); trazodone; katatu (Halcion); kapena ziprasidone (Geodon). Komanso uzani dokotala wanu kapena wamankhwala ngati mukumwa rilpivirine (Edurant, ku Juluca, Odefsey, Complera) kapena ngati mwasiya kumwa pasabata ziwiri zapitazi. Dokotala wanu angakuuzeni kuti musamwe saquinavir ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('opopera magazi') monga warfarin (Coumadin, Jantoven); antifungals monga itraconazole (Onmel, Sporanox) ndi ketoconazole benzodiazepines monga alprazolam (Xanax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), ndi flurazepam; zotchinga beta monga atenolol (Tenormin, mu Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, ku Dutoprol, ku Loressor HCT), nadolol (Corgard, ku Corzide), ndi propranolol (Hemangeol, Inderal, Innopran); chifuwa (Tracleer); zotseka za calcium monga amlodipine (Norvasc, ku Caduet, Lotrel, ena), diltiazem (Cardizem, Cartia, Tiazac, ena), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize ), nisoldipine (Sular), ndi verapamil (Calan, Verelan, ku Tarka); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet); cobicistat (Tybost, ku Evotaz, Genvoya, Prezcobix, ndi Stribild); corticosteroids monga betamethasone, budesonide (Entocort, Pulmicort, Uceris, ku Symbicort), ciclesonide (Alvesco, Zetonna, Omnaris), dexamethasone, fluticasone (Arnuity Ellipta, Flonase, Flovent, ku Advair, ena), methylprednisone, Asmana ), prednisone (Rayos), ndi triamcinolone (Kenalog); colchicine (Colcrys, Mitigare); digoxin (Lanoxin); fentanyl (Abstral, Actiq, Duragesic, ena); ma immunosuppressants ena monga cyclosporine (Gengraf, Neoral, Sandimmune), ndi sirolimus (Rapamune); Mankhwala ochizira HIV kapena Edzi kuphatikiza indinavir (Crixivan), lopinavir ndi ritonavir (Kaletra), maraviroc (Selzentry), nelfinavir (Viracept), kapena tipranavir yokhala ndi ritonavir (Aptivus); mankhwala ena osagunda pamtima monga ibutilide (Corvert), ndi sotalol (Betapace, Sorine, Sotylize); mankhwala othandiza kugwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenytoin (Dilantin, Phenytek), ndi phenobarbital; methadone (Dolophine, Methadose); nefazodone; omeprazole (Prilosec, ku Yosprela, Zegerid); ena a phosphodiesterase (PDE5) inhibitors monga sildenafil (Viagra), tadalafil (Adcirca, Cialis), ndi vardenafil (Levitra, Staxyn); quetiapine (Seroquel); quinupristin ndi dalfopristin (Synercid); rifabutin (Mycobutin); salmeterol (Serevent, ku Advair); ndi ma tricyclic antidepressants ena kuphatikiza amitriptyline, clomipramine (Anafranil), imipramine (Surmontil, Tofranil), ndi maprotiline. Mankhwala ena amatha kulumikizana ndi saquinavir, chifukwa chake onetsetsani kuti mumauza dokotala ndi wazamankhwala zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa kapena mukukonzekera, makamaka wort ya St. John, ndi makapisozi a adyo.
• auzeni adotolo ngati mumamwa kapena mudamwa mowa wambiri, komanso ngati inu kapena wina aliyense m'banja mwanu adadwala matenda a shuga. Komanso muuzeni dokotala ngati mwakhalapo ndi kugunda kwamtima kosafunikira, cholesterol kapena triglycerides (mafuta m'magazi); hemophilia (matenda otuluka magazi); mikhalidwe yomwe thupi silimatha kupanga lactase yokwanira kapena silingalekerere lactose, kapena matenda amtima kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukatenga saquinavir, itanani dokotala wanu. Simuyenera kuyamwa ngati muli ndi kachilombo ka HIV kapena mukumwa saquinavir.
• muyenera kudziwa kuti saquinavir imachepetsa kugwira ntchito kwa njira zolerera za mahomoni (mapiritsi oletsa kubala, zigamba, mphete, kapena jakisoni). Lankhulani ndi dokotala wanu za kugwiritsa ntchito njira ina yolerera.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa saquinavir.
• muyenera kudziwa kuti mafuta anu amthupi amatha kuchuluka kapena kusunthira mbali zosiyanasiyana za thupi lanu, monga msana wanu wam'mwamba, khosi ('' njati hump ''), mabere, komanso mozungulira m'mimba mwanu. Mutha kuwona kutaya mafuta m'thupi, kumaso, miyendo, ndi mikono.
• muyenera kudziwa kuti mutha kukhala ndi hyperglycemia (kuchuluka kwa shuga m'magazi anu) mukamamwa mankhwalawa, ngakhale mulibe matenda ashuga. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi mukamamwa saquinavir: ludzu lokwanira, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kapena kufooka. Ndikofunika kuyimbira dokotala wanu mukangomva izi, chifukwa shuga wambiri yemwe samalandira mankhwala amatha kuyambitsa vuto lalikulu lotchedwa ketoacidosis. Ketoacidosis imatha kukhala pangozi ngati singachiritsidwe koyambirira. Zizindikiro za ketoacidosis zimaphatikizira pakamwa pouma, nseru ndi kusanza, kupuma movutikira, mpweya womwe umanunkhira zipatso, ndikuchepetsa chidziwitso.
• muyenera kudziwa kuti pamene mukumwa mankhwala ochizira kachilombo ka HIV, chitetezo chanu cha mthupi chingakhale champhamvu ndikuyamba kulimbana ndi matenda ena omwe anali kale mthupi lanu kapena amayambitsa zina. Izi zitha kukupangitsani kukhala ndi zizindikilo za matendawa kapena mikhalidwe. Ngati muli ndi zizindikilo zatsopano kapena zoyipa mukayamba kumwa mankhwala a saquinavir, onetsetsani kuti mwauza dokotala.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Saquinavir imatha kubweretsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kupweteka m'mimba
• nseru
• kusanza
• kudzimbidwa
• kutopa
• kupweteka kwa msana
• milomo youma kapena khungu
• malungo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• zidzolo, kuyabwa, kutupa kwa maso, nkhope, pakamwa, pakhosi, kapena milomo, kupuma movutikira kapena kumeza
• khungu kapena khungu
• chikasu cha khungu kapena maso, kusowa kwa njala, chimfine ngati zizindikilo, kutopa kwambiri, mkodzo wamdima wakuda, mipando yoyera, kupweteka kumtunda kwakumimba kwam'mimba
• chizungulire, mutu wopepuka, wosakwiya, wosasinthasintha, kapena kugunda kwamtima, kukomoka

Saquinavir imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kupweteka kwa mmero

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone kuyankha kwa thupi lanu ku saquinavir. Dokotala wanu amathanso kuyitanitsa electrocardiogram (ECG; kuyesa komwe kumayesa magetsi mumtima) musanachitike komanso mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Invirase^®