Cryoglobulinemia

Cryoglobulinemia ndiko kupezeka kwa mapuloteni osazolowereka m'magazi. Mapuloteniwa amathira kuzizira kozizira.

Cryoglobulins ndi ma antibodies. Sizikudziwikabe chifukwa chake amakhala olimba kapena ofanana ndi gel osachedwa kutentha mu labotale. Thupi, ma antibodies awa amatha kupanga ma chitetezo cha mthupi omwe angayambitse kutupa ndikuletsa mitsempha yamagazi. Izi zimatchedwa cryoglobulinemic vasculitis. Izi zitha kubweretsa mavuto kuyambira pakhungu mpaka impso.

Cryoglobulinemia ndi gawo limodzi la matenda omwe amawononga komanso kutupa mitsempha yamagazi mthupi lonse (vasculitis). Pali mitundu itatu yayikulu yamtunduwu. Amagawidwa potengera mtundu wa antibody omwe amapangidwa:

• Lembani I
• Mtundu Wachiwiri
• Mtundu Wachitatu

Mitundu II ndi III imadziwikanso kuti cryoglobulinemia yosakanikirana.

Mtundu I cryoglobulinemia nthawi zambiri umakhudzana ndi khansa yamagazi kapena chitetezo chamthupi.

Mitundu yachiwiri ndi yachitatu imapezeka kwambiri mwa anthu omwe ali ndi vuto lotupa (lokhalitsa), monga matenda obwera chifukwa cha autoimmune kapena hepatitis C. Anthu ambiri omwe ali ndi mtundu wachiwiri wa cryoglobulinemia ali ndi matenda a hepatitis C.

Zina zomwe zitha kukhala zokhudzana ndi cryoglobulinemia ndizo:

• Khansa ya m'magazi
• Myeloma yambiri
• Macroglobulinemia woyambirira
• Matenda a nyamakazi
• Njira lupus erythematosus

Zizindikiro zimasiyanasiyana, kutengera mtundu wamatenda omwe muli nawo komanso ziwalo zomwe zikukhudzidwa. Zizindikiro zimaphatikizapo:

• Mavuto opumira
• Kutopa
• Glomerulonephritis
• Ululu wophatikizana
• Kupweteka kwa minofu
• Zolemba
• Chodabwitsa cha Raynaud
• Imfa ya khungu
• Zilonda pakhungu

Wothandizira zaumoyo adzayesa. Mudzayang'anitsitsa ngati muli ndi chiwindi komanso ndulu.

Mayeso a cryoglobulinemia ndi awa:

• Kuwerengera kwathunthu kwa magazi (CBC).
• Phatikizani kuyesa - manambala azikhala otsika.
• Mayeso a Cryoglobulin - atha kuwonetsa kupezeka kwa ma cryoglobulins. (Iyi ndi njira yovuta yothandizira ma laboratory yomwe imakhudza njira zambiri. Ndikofunikira kuti labu lomwe limayesa lidziwe bwino njirayi.)
• Kuyesa kwa chiwindi - kumatha kukhala kwakukulu ngati hepatitis C ilipo.
• Rheumatoid factor - zabwino pamitundu yachiwiri ndi yachitatu.
• Kukopa khungu - kumatha kuwonetsa kutupa m'mitsempha yamagazi, vasculitis.
• Mapuloteni electrophoresis - magazi - atha kuwonetsa mapuloteni oteteza thupi.
• Kusinkhasinkha - kumatha kuwonetsa magazi mkodzo ngati impso zakhudzidwa.

Mayesero ena atha kuphatikizira:

• Angiogram
• X-ray pachifuwa
• ESR
• Mayeso a Hepatitis C.
• Kuyesa kwamitsempha, ngati munthuyo ali ndi zofooka m'manja kapena m'miyendo

MAFUNSO A CRYOGLOBULINEMIA (MTUNDU Wachiwiri NDI Wachitatu)

Mitundu yochepa ya cryoglobulinemia imatha kuchiritsidwa pochita zinthu kuti athane ndi vutoli.

Mankhwala omwe akugwira ntchito mwachindunji a hepatitis C amachotsa kachilomboka pafupifupi kwa anthu onse. Matenda a hepatitis C akamatha, ma cryoglobulins adzatha pafupifupi theka la anthu onse m'miyezi 12 ikubwerayi. Wothandizira anu apitiliza kuwunika ma cryoglobulins atalandira chithandizo.

Kuchuluka kwa cryoglobulinemia vasculitis kumakhudza ziwalo zofunika kapena malo akulu akhungu. Amathandizidwa ndi corticosteroids ndi mankhwala ena omwe amalepheretsa chitetezo cha mthupi.

• Rituximab ndi mankhwala othandiza ndipo ali ndi zoopsa zochepa kuposa mankhwala ena.
• Cyclophosphamide imagwiritsidwa ntchito m'malo owopsa omwe rituximab sikugwira ntchito kapena sikupezeka. Mankhwalawa amagwiritsidwa ntchito nthawi zambiri m'mbuyomu.
• Chithandizo chotchedwa plasmapheresis chimagwiritsidwanso ntchito. Poterepa, madzi am'magazi amachotsedwa m'magazi ndipo mapuloteni oteteza ku cryoglobulin amachotsedwa. Plasma imalowetsedwa ndi madzi amadzimadzi, mapuloteni, kapena plasma.

TYPE I CRYOGLOBULINEMIA

Matendawa amayamba chifukwa cha khansa yamagazi kapena chitetezo chamthupi monga multipleeloma. Chithandizochi chimayang'aniridwa ndi maselo amtundu wa khansa omwe amatulutsa cryoglobulin.

Nthawi zambiri, cryoglobulinemia yosakanikirana siyambitsa imfa. Maonekedwe akhoza kukhala osauka ngati impso zakhudzidwa.

Zovuta zimaphatikizapo:

• Kutuluka magazi m'mimba (osowa)
• Matenda a mtima (osowa)
• Matenda a zilonda
• Impso kulephera
• Kulephera kwa chiwindi
• Imfa ya khungu
• Imfa

Itanani omwe akukuthandizani ngati:

• Mumakhala ndi zizindikilo za cryoglobulinemia.
• Muli ndi hepatitis C ndipo mumakhala ndi matenda a cryoglobulinemia.
• Muli ndi cryoglobulinemia ndipo mumakhala ndi zizindikilo zatsopano kapena zoyipa.

Palibe chodziwika chopewa vutoli.

• Kutalikirana ndi kutentha kwazizira kumatha kupewa zizindikiro zina.
• Kuyesedwa ndi chithandizo cha matenda a hepatitis C kumachepetsa chiopsezo chanu.

• Cryoglobulinemia wazala
• Cryoglobulinemia - zala
• Maselo amwazi

Patterson ER, Winters JL. Hemapheresis. Mu: McPherson RA, Pincus MR, olemba., Eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. Wachitatu. St Louis, MO: Elsevier; 2017: mutu 37.

Roccatello D, Saadoun D, ​​Ramos-Casals M, ndi al. Cryoglobulinaemia. Nat Rev Dis Oyambirira. 2018; 4 (1): 11. PMID: 30072738 adatulutsidwa.ncbi.nlm.nih.gov/30072738/.

Mwala JH. Chitetezo chachitetezo chazovuta zazing'ono zazing'ono vasculitis. Mu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, olemba. Kelley ndi Firestein's Bookbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: chap 91.